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University of Kentucky: Lexington, US

Professor (CESB)
Employment
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Andrew Lane

Works (26)

Challenges of Spatially Resolved Metabolism in Cancer Research

Metabolites
2024-07-11 | Journal article
DOI: 10.3390/metabo14070383
Contributors: Andrew N. Lane; Richard M. Higashi; Teresa W-M. Fan
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Crossref
grade
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Determination of fatty acid uptake and desaturase activity in mammalian cells by NMR-based stable isotope tracing

Analytica Chimica Acta
2024-05 | Journal article
DOI: 10.1016/j.aca.2024.342511
Contributors: Penghui Lin; James Sledziona; Kubra B. Akkaya-Colak; Maria M. Mihaylova; Andrew N. Lane
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Crossref

Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Nature Communications
2024-03-30 | Journal article
DOI: 10.1038/s41467-024-47096-9
Contributors: Saeed Daneshmandi; Jee Eun Choi; Qi Yan; Cameron R. MacDonald; Manu Pandey; Mounika Goruganthu; Nathan Roberts; Prashant K. Singh; Richard M. Higashi; Andrew N. Lane et al.
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Crossref

Metabolic reprogramming driven by EZH2 inhibition depends on cell–matrix interactions

Journal of Biological Chemistry
2024-01 | Journal article
DOI: 10.1016/j.jbc.2023.105485
Contributors: Teresa W-M Fan; Jahid M.M. Islam; Richard M. Higashi; Penghui Lin; Christine F. Brainson; Andrew N. Lane
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Crossref

Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes

Journal of Biological Chemistry
2023-12 | Journal article
DOI: 10.1016/j.jbc.2023.105407
Contributors: Heng Wu; Betsy T. Kren; Andrew N. Lane; Teresa A. Cassel; Richard M. Higashi; Teresa W.M. Fan; George S. Scaria; Laurie L. Shekels; Mark A. Klein; Jeffrey H. Albrecht
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Crossref

Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer

Metabolites
2023-06-21 | Journal article
DOI: 10.3390/metabo13070774
Contributors: Teresa W.-M. Fan; Jason Winnike; Ahmad Al-Attar; Alexander C. Belshoff; Pawel K. Lorkiewicz; Jin Lian Tan; Min Wu; Richard M. Higashi; Andrew N. Lane
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Crossref
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The PLOD2/succinate axis regulates the epithelial–mesenchymal plasticity and cancer cell stemness

Proceedings of the National Academy of Sciences
2023-05-16 | Journal article
DOI: 10.1073/pnas.2214942120
Contributors: Yuxin Tong; Yifei Qi; Gaofeng Xiong; Junyan Li; Timothy L. Scott; Jie Chen; Daheng He; Linzhang Li; Chi Wang; Andrew N. Lane et al.
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Crossref

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues

The Journal of Immunology
2022-11-01 | Journal article
DOI: 10.4049/jimmunol.2200178
Contributors: Teresa W-M Fan; Saeed Daneshmandi; Teresa A Cassel; Mohammad B Uddin; James Sledziona; Patrick T Thompson; Penghui Lin; Richard M Higashi; Andrew N Lane
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Crossref

GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation

Nature Metabolism
2022-10-03 | Journal article
DOI: 10.1038/s42255-022-00638-1
Contributors: Siwen Kang; Lingling Liu; Tingting Wang; Matthew Cannon; Penghui Lin; Teresa W.-M. Fan; David A. Scott; Hsin-Jung Joyce Wu; Andrew N. Lane; Ruoning Wang
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Crossref

Resolving Enantiomers of 2-Hydroxy Acids by Nuclear Magnetic Resonance

Analytical Chemistry
2022-09-13 | Journal article
DOI: 10.1021/acs.analchem.2c00490
Contributors: Penghui Lin; Daniel R. Crooks; W. Marston Linehan; Teresa W-M. Fan; Andrew N. Lane
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Crossref

A Micro-Scale Analytical Method for Determining Glycogen Turnover by NMR and FTMS

Metabolites
2022-08-18 | Journal article
DOI: 10.3390/metabo12080760
Contributors: Timothy L. Scott; Juan Zhu; Teresa A. Cassel; Sara Vicente-Muñoz; Penghui Lin; Richard M. Higashi; Andrew N. Lane; Teresa W.-M. Fan
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Crossref
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Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia

Cancers
2022-04-18 | Journal article
DOI: 10.3390/cancers14082040
Contributors: Tafadzwa Chihanga; Sara Vicente-Muñoz; Sonya Ruiz-Torres; Bidisha Pal; Mathieu Sertorio; Paul R. Andreassen; Ruby Khoury; Parinda Mehta; Stella M. Davies; Andrew N. Lane et al.
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Crossref
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NMR Analysis of Carboxylate Isotopomers of 13C-Metabolites by Chemoselective Derivatization with 15N-Cholamine

Analytical Chemistry
2021-05-04 | Journal article
DOI: 10.1021/acs.analchem.0c04220
Contributors: Sara Vicente-Muñoz; Penghui Lin; Teresa W.-M. Fan; Andrew N. Lane
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Crossref

NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics

Metabolites
2021-03-29 | Journal article
DOI: 10.3390/metabo11040202
Contributors: Penghui Lin; Li Dai; Daniel R. Crooks; Leonard M. Neckers; Richard M. Higashi; Teresa W-M. Fan; Andrew N. Lane
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Crossref
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An Ion Chromatography–Ultrahigh-Resolution-MS1/Data-Independent High-Resolution MS2 Method for Stable Isotope-Resolved Metabolomics Reconstruction of Central Metabolic Networks

Analytical Chemistry
2021-02-09 | Journal article
DOI: 10.1021/acs.analchem.0c03070
Contributors: Qiushi Sun; Teresa W.-M. Fan; Andrew N. Lane; Richard M. Higashi
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Crossref

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

Genes & Diseases
2020-06 | Journal article
DOI: 10.1016/j.gendis.2019.10.007
Contributors: Andrew N. Lane; Richard M. Higashi; Teresa W-M. Fan
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Crossref

Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective

Metabolites
2020-06-15 | Journal article
DOI: 10.3390/metabo10060249
Contributors: Teresa W. -M. Fan; Richard M. Higashi; Yelena Chernayavskaya; Andrew N. Lane
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Crossref

Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees

IEEE Journal of Biomedical and Health Informatics
2020-05 | Journal article
DOI: 10.1109/JBHI.2019.2931997
Contributors: Yi Zhang; Xiaofei Zhang; Andrew N. Lane; Teresa W.-M. Fan; Jinze Liu
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Crossref

2′-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

Nucleic Acids Research
2020-04-06 | Journal article
DOI: 10.1093/nar/gkaa086
Contributors: Jack S Hardwick; Marius M Haugland; Afaf H El-Sagheer; Denis Ptchelkine; Frank R Beierlein; Andrew N Lane; Tom Brown; Janet E Lovett; Edward A Anderson
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Crossref

Differential Abundance Analysis with Bayes Shrinkage Estimation of Variance (DASEV) for Zero-Inflated Proteomic and Metabolomic Data

Scientific Reports
2020-01-21 | Journal article
DOI: 10.1038/s41598-020-57470-4
Contributors: Zhengyan Huang; Andrew N. Lane; Teresa W-M. Fan; Richard M. Higashi; Heidi L. Weiss; Xiangrong Yin; Chi Wang
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Crossref

Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer

PROTEOMICS
2019-11 | Journal article
DOI: 10.1002/pmic.201800486
Contributors: Ronald C. Bruntz; Alex C. Belshoff; Yan Zhang; Jessica K. A. Macedo; Richard M. Higashi; Andrew N. Lane; Teresa W.‐M. Fan
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Crossref

Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS

The Analyst
2018 | Journal article
DOI: 10.1039/C8AN90009D
Contributors: Pan Deng; Richard M. Higashi; Andrew N. Lane; Ronald C. Bruntz; Ramon C. Sun; Mandapati V. Ramakrishnam Raju; Michael H. Nantz; Zhen Qi; Teresa W.-M. Fan
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Crossref

Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS

The Analyst
2018 | Journal article
DOI: 10.1039/C7AN01256J
Contributors: Pan Deng; Richard M. Higashi; Andrew N. Lane; Ronald C. Bruntz; Ramon C. Sun; Mandapati V. Ramakrishnam Raju; Michael H. Nantz; Zhen Qi; Teresa W.-M. Fan
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Crossref

Exosomal lipids for classifying early and late stage non-small cell lung cancer

Analytica Chimica Acta
2018-12 | Journal article
DOI: 10.1016/j.aca.2018.02.051
Contributors: Teresa W.M. Fan; Xiaofei Zhang; Chi Wang; Ye Yang; Woo-Young Kang; Susanne Arnold; Richard M. Higashi; Jinze Liu; Andrew N. Lane
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Crossref

Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures

Metabolites
2018-07 | Journal article
DOI: 10.3390/metabo8030040
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Multidisciplinary Digital Publishing Institute
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NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry

Archives of Biochemistry and Biophysics
2017-08 | Journal article
DOI: 10.1016/j.abb.2017.02.009
Contributors: Andrew N. Lane; Teresa W-M. Fan
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Crossref

Peer review (18 reviews for 8 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for American Heart Association (4)
Review activity for Analytical chemistry. (6)
Review activity for Biochimica et biophysica acta CR. (1)
Review activity for Journal of proteome research. (2)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Metabolomics. (2)
Review activity for Nature cancer. (1)
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