Geert Martens (0000-0003-1208-6289)

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Biography

Geert A. Martens studied medicine at Ghent University (1994-2001) and obtained a PhD in biomedical sciences at Brussels Free University (2008). From 2001 to 2008 he conducted fundamental research on pancreatic beta cell physiology, survival, function and replication with focus on biochemical mechanisms of glucose sensing and nutrient-regulation of gene expression and proteomic phenotype. From 2008 to 2016 he developed a research program at the Center for Beta Cell Therapy in Diabetes (VUB) focusing on the discovery of new biomarkers for beta cell injury using integrated omics-technologies, and their translation into clinically grade blood tests (nucleic acid- and immunoassays). Since 2016, he works at AZ Delta General Hospital (Roeselare, Belgium) and coordinates a clinical molecular diagnostics IVDR lab with focus on next-generation sequencing in oncology, NIPT and microbial sequencing. Since 2020 he is appointed as visiting scholar at Ghent University. Present research interests are focused on liquid biopsies in cancer as a tool for detection of early recurrence and universal primary screening.

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Universiteit Gent: Gent, BE

2020-05-01 to present | Visiting scholar (Department of biomolecular medicine)

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Geert Martens

https://orcid.org/0000-0003-1208-6289

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Employment (6)

Universiteit Gent: Gent, BE

AZ DELTA: Roeselare, BE

Vrije Universiteit Brussel: Brussels, BE

Vrije Universiteit Brussel: Brussels, BE

Fonds Wetenschappelijk Onderzoek Vlaanderen: Brussel, BE

Universitair Ziekenhuis Brussel: Brussels, BE

Education and qualifications (4)

Vrije Universiteit Brussel: Brussels, BE

Universitair Ziekenhuis Brussel: Brussels, BE

Vrije Universiteit Brussel - Campus Jette: Brussel, BE

Universiteit Gent: Gent, BE

Works (50 of 108)

Development of a General Purpose Targeted LC-MS Method for Accurate Quantification of the SARS-CoV-2 Spike Protein Expression

Surveillance of Disease Progression in Metastatic Breast Cancer by Molecular Counting of Circulating Tumor DNA Using Plasma-SeqSensei Breast Cancer in Vitro Diagnostics Assay

Rational thresholding of circulating tumor DNA concentration for improved surveillance of metastatic breast cancer

Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data

Two Years of Genomic Surveillance in Belgium during the SARS-CoV-2 Pandemic to Attain Country-Wide Coverage and Monitor the Introduction and Spread of Emerging Variants

Pitfalls of SARS-CoV-2 antigen testing at emergency department

From Delta to Omicron SARS-CoV-2 variant

Cycle Threshold Probability Score for Immediate and Sensitive Detection of B.1.351 SARS-CoV-2 Lineage

From Delta to Omicron SARS-CoV-2 variant: switch to saliva sampling for higher detection rate

Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant

Lessons from the Belgian experience with regulatory control during the COVID-19 pandemic for the implementation of the European IVD regulation 2017/746

The MicroRNA Landscape of Acute Beta Cell Destruction in Type 1 Diabetic Recipients of Intraportal Islet Grafts

Cov-MS

Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer

Belgian rare diseases plan in clinical pathology

Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality

Oxidative Stress, Glutathione Metabolism, and Liver Regeneration Pathways Are Activated in Hereditary Tyrosinemia Type 1 Mice upon Short-Term Nitisinone Discontinuation

Diagnostic Performance of Chest CT for SARS-CoV-2 Infection in Individuals with or without COVID-19 Symptoms

Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence

Humoral Immune Response to SARS-CoV-2

Kinetics of the humoral immune response to SARS-CoV-2: comparative analytical performance of seven commercial serology tests

Diagnostic power of chest CT for COVID-19: to screen or not to screen

Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics

Impact of nitisinone treatment and discontinuation on the metabolome of wildtype and hereditary tyrosinemia type 1 mice

Markers for beta cell loss.

Clinical implementation of gene panel testing for lysosomal storage diseases

Combined analysis of GAD65, miR-375, and unmethylated insulin DNA following islet transplantation in patients with T1D

Human skin-derived mesenchymal stromal cells do not rescue hereditary tyrosinemia type 1 mice after permanent nitisinone withdrawal

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65

CD99 as surface anchor for human islet endocrine cell purification

Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds

X-Linked Cobalamin Disorder ( HCFC1 ) Mimicking Nonketotic Hyperglycinemia With Increased Both Cerebrospinal Fluid Glycine and Methylmalonic Acid

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

In vitro profiling of endocrine cell death using UCHL1 and GAD65 as soluble biomarkers

Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury

Species-Related Differences in the Proteome of Rat and Human Pancreatic Beta Cells

Development of an enhanced sensitivity bead-based immunoassay for real-time in vivo detection of pancreatic beta cell death

Plasma GAD65, Marker for Early Beta Cell Loss following Intraportal Islet Cell Transplantation in Diabetic Patients

Potential of UCHL1 as biomarker for destruction of pancreatic beta cells

Quantitative proteomics of rat and human pancreatic beta cells

Functional characteristics of neonatal rat beta cells with distinct markers.

Early treatment of a child with NAGS deficiency using N-carbamyl glutamate results in a normal neurological outcome

Glucose Regulates Rat Beta Cell Number through Age-Dependent Effects on Beta Cell Survival and Proliferation

Acute respiratory muscle weakness and apnea in a critically ill patient induced by colistin neurotoxicity: key potential role of hemoadsorption elimination during continuous venovenous hemofiltration.

Enzymatic Pyruvate Measurement by Cobas&reg;6000 Open Channel Assay

Evaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function

LC-MS/MS identification of doublecortin as abundant beta-cell selective protein discharged by damaged beta cells in vitro

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

Potential of protein phosphatase inhibitor 1 as biomarker of pancreatic beta cell injury in vitro and in vivo

Peer review (1 review for 1 publication/grant)

Enzymatic Pyruvate Measurement by Cobas®6000 Open Channel Assay