Personal information

United Kingdom

Activities

Education and qualifications (2)

University of Liverpool: Liverpool, Liverpool, GB

1984-10 to 1988-08 | PhD (Biochemistry)
Education
Source: Self-asserted source
Eric Lam

University of Liverpool: Liverpool, Liverpool, GB

1981-10-01 to 1984-08-31 | BSc(Hons) (Biochemistry)
Education
Source: Self-asserted source
Eric Lam

Funding (10)

Targeting the FOXM1 signature for early diagnosis and treatment in cholangiocarcinoma

SUMO modification of FOXM1 in genotoxic drug resistance and DNA damage response

Source: Self-asserted source
Eric Lam via DimensionsWizard

Deciphering the role of the FOXO3a-FOXM1 axis in breast cancer angiogenesis and metastasis

Source: Self-asserted source
Eric Lam via DimensionsWizard

A novel Rac1/PAK1/BCL-6 pathway to regulate gene expression: genome-wide screening for target genes

2012-03-01 to 2013-08-31 | Grant
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, PT)
GRANT_NUMBER: 119586
Source: Self-asserted source
Eric Lam via DimensionsWizard

Role and regulation of FOXM1 in breast cancer endocrine therapy and resistance

Source: Self-asserted source
Eric Lam via DimensionsWizard

Regulation of intracellular anti-viral defense factor APOBEC3G as therapeutic strategy to control HIV-1 infection.

2008-03-01 to 2011-07-31 | Grant
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, PT)
GRANT_NUMBER: 74613
Source: Self-asserted source
Eric Lam via DimensionsWizard

Role of FOXO3a in mediating the cytotoxic effects and resistance to EGFR inhibitors in breast cancer

Source: Self-asserted source
Eric Lam via DimensionsWizard

The role and regulation of FOXO transcription factors and their targets cyclin D2, p27kip1 and p130 in normal and malignant haemopoietic cells

The roles and regulation of cyclin D2 and p27 in mediating the signals from the antigen and CD40 receptors in both normal and malignant B cells

MOLECULAR AND FUNCTIONAL ANALYSIS OF THE PROLIFERATIVE AND APOPTOTIC SIGNALS MEDIATED BY IG RECEPTOR AND CD40 IN NORMAL AND MALIGNANT B LYMPHOCYTES

Works (50 of 245)

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Page 1 of 5

High expression of cytoplasmic FOXO3 protein associated with poor prognosis of rectal cancer patients: A study from Swedish clinical trial of preoperative radiotherapy to big database analysis

Heliyon
2023-05 | Journal article
Contributors: Weiyingqi Cui; Ning Xie; Eric W.-F. Lam; Victoria Hahn-Stromberg; Na Liu; Hong Zhang; Xiao-Feng Sun
Source: check_circle
Crossref

Chemically Tunable FOXM1-D Sensor Revealed FOXM1 Direct Influence on Cell Cycle

2023-03-02 | Preprint
Contributors: Kriengkrai Phongkitkarun; Porncheera Chusorn; Maliwan Kamkaew; Eric W.-F. Lam; Chamras Promptmas; Somponnat Sampattavanich
Source: check_circle
Crossref

Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance

Oncogene
2022-11-03 | Journal article
Contributors: Changxu Wang; Qilai Long; Qiang Fu; Qixia Xu; Da Fu; Yan Li; Libin Gao; Jianming Guo; Xiaoling Zhang; Eric W.-F. Lam et al.
Source: check_circle
Crossref

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

Science Advances
2022-10-07 | Journal article
Contributors: Philip Chiu-Tsun Tang; Jeff Yat-Fai Chung; Jinyue Liao; Max Kam-Kwan Chan; Alex Siu-Wing Chan; Guangyao Cheng; Chunjie Li; Xiao-Ru Huang; Calvin Sze-Hang Ng; Eric W-F Lam et al.
Source: check_circle
Crossref

USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages

Molecular Therapy - Oncolytics
2021-12 | Journal article
Contributors: Vivian Weiwen Xue; Jeff Yat-Fai Chung; Philip Chiu-Tsun Tang; Alex Siu-Wing Chan; Travis Hoi-Wai To; Justin Shing-Yin Chung; Francis Mussal; Eric W.-F. Lam; Chunjie Li; Ka-Fai To et al.
Source: check_circle
Crossref

MCF-7 Drug Resistant Cell Lines Switch Their Lipid Metabolism to Triple Negative Breast Cancer Signature

Cancers
2021-11-23 | Journal article
Contributors: Jose Adriá-Cebrián; Sandra Guaita-Esteruelas; Eric W.-F. Lam; Marta Rodríguez-Balada; Jordi Capellades; Josefa Girona; Ana Maria Jimenez-Santamaria; Oscar Yanes; Luís Masana; Josep Gumà
Source: check_circle
Crossref
grade
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Cancer cell immune mimicry delineates onco-immunologic modulation

iScience
2021-10 | Journal article
Contributors: Rui Gao; Bin He; Qitao Huang; Zifeng Wang; Min Yan; Eric Wing-Fai Lam; Suxia Lin; Bo Wang; Quentin Liu
Source: check_circle
Crossref

Altered Serum Metabolic Profile Assessed by Advanced 1H-NMR in Breast Cancer Patients

Cancers
2021-08-25 | Journal article
Contributors: Josep Gumà; Jose Adriá-Cebrián; Belen Ruiz-Aguado; Cinta Albacar; Josefa Girona; Ricardo Rodríguez-Calvo; Neus Martínez-Micaelo; Eric W. F. Lam; Luis Masana; Sandra Guaita-Esteruelas
Source: check_circle
Crossref
grade
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ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development

Cell Death Discovery
2021-01-22 | Journal article
Contributors: Dachuan Shen; Lili Tian; Fangyu Yang; Jun Li; Xiaodong Li; Yiqun Yao; Eric W.-F. Lam; Peng Gao; Bilian Jin; Ruoyu Wang
Source: check_circle
Crossref

Therapeutic strategies targeting FOXO transcription factors

Nature Reviews Drug Discovery
2021-01-10 | Journal article
Contributors: Giampaolo Calissi; Eric W.-F. Lam; Wolfgang Link
Source: check_circle
Crossref

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Cancers
2020-10-23 | Journal article
Contributors: Vivian Weiwen Xue; Jeff Yat-Fai Chung; Cristina Alexandra García Córdoba; Alvin Ho-Kwan Cheung; Wei Kang; Eric W.-F. Lam; Kam-Tong Leung; Ka-Fai To; Hui-Yao Lan; Patrick Ming-Kuen Tang
Source: check_circle
Crossref

Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

Cancers
2020-08-24 | Journal article
Contributors: Diana Azenha; Santiago Hernandez-Perez; Yuse Martin; Marta S. Viegas; Alexandra Martins; Maria C. Lopes; Eric W. -F. Lam; Raimundo Freire; Teresa C. Martins
Source: check_circle
Crossref
grade
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NEDDylation negatively regulates ERRβ expression to promote breast cancer tumorigenesis and progression

Cell Death & Disease
2020-08-24 | Journal article
Contributors: Sanoj K. Naik; Eric W.-F. Lam; Monalisa Parija; Surya Prakash; Yannasittha Jiramongkol; Amit K. Adhya; Dilip K. Parida; Sandip K. Mishra
Source: check_circle
Crossref

Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer

Oncogene
2020-04-09 | Journal article
Contributors: Chun Gong; Ho Tsoi; Ka Chun Mok; Jenny Cheung; Ellen P. S. Man; Kazunari Fujino; Ashely Wong; Eric W. F. Lam; Ui-Soon Khoo
Source: check_circle
Crossref

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin

Nucleic Acids Research
2020-03-18 | Journal article
Contributors: Iris Tanaka; Alina Chakraborty; Olivier Saulnier; Clara Benoit-Pilven; Sophie Vacher; Dalila Labiod; Eric W F Lam; Ivan Bièche; Olivier Delattre; Frédéric Pouzoulet et al.
Source: check_circle
Crossref

A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2

Cancers
2020-02-26 | Journal article
Contributors: Man-Hong Leung; Ho Tsoi; Chun Gong; Ellen PS Man; Stefania Zona; Shang Yao; Eric W.-F. Lam; Ui-Soon Khoo
Source: check_circle
Crossref
grade
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Characterization of FOXO acetylation

Methods in Molecular Biology
2019 | Book
EID:

2-s2.0-85056409569

Contributors: Yao, S.; Mahmud, Z.; Sachini, N.; Aimjongjun, S.; Saavedra-García, P.; Lam, E.W.-F.
Source: Self-asserted source
Eric Lam via Scopus - Elsevier

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

BMC Cancer
2019-12 | Journal article
Contributors: Sathid Aimjongjun; Zimam Mahmud; Yannasittha Jiramongkol; Glowi Alasiri; Shang Yao; Ernesto Yagüe; Tavan Janvilisri; Eric W.-F. Lam
Source: check_circle
Crossref

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

2019-10-30 | Preprint
Contributors: Sathid Aimjongjun; Zimam Mahmud; Yannasittha Jiramongkol; Glowi Alasiri; Shang Yao; Ernesto Yague; Tavan Janvilisri; Eric W.-F. Lam
Source: check_circle
Crossref

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

2019-10-02 | Preprint
Contributors: Sathid Aimjongjun; Zimam Mahmud; Yannasittha Jiramongkol; Glowi Alasiri; Shang Yao; Ernesto Yague; Tavan Janvilisri; Eric W.-F. Lam
Source: check_circle
Crossref

Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells

Oncogene
2019-09-16 | Journal article
Contributors: Glowi Alasiri; Yannasittha Jiramongkol; Stefania Zona; Lavender Y. -N. Fan; Zimam Mahmud; Gyungyub Gong; Hee Jin Lee; Eric W. -F. Lam
Source: check_circle
Crossref

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

2019-07-19 | Preprint
Contributors: Eric W.-F. Lam; Zimam Mahmud; Sathid Aimjongjun; Yannasittha Jiramongkol; Glowi Alasiri; Shang Yao; Ernesto Yague; Tavan Janvilisri
Source: check_circle
Crossref

FOXK2 Transcription Factor and Its Emerging Roles in Cancer

Cancers
2019-03 | Journal article | Author
Contributors: Gabriela Nestal de Moraes; Luciana da Torre Carneiro; Raquel Ciuvalschi Maia; Eric Lam; Andrew David Sharrocks
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression

Scientific Reports
2019-02-06 | Journal article
Contributors: Vidhya Varghese; Luca Magnani; Narumi Harada-Shoji; Francesco Mauri; Richard M. Szydlo; Shang Yao; Eric W.-F. Lam; Laura M. Kenny
Source: check_circle
Crossref

Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence

Journal of Cell Science
2018 | Journal article
EID:

2-s2.0-85049595436

Contributors: Laphanuwat, P.; Likasitwatanakul, P.; Sittithumcharee, G.; Thaphaengphan, A.; Chomanee, N.; Suppramote, O.; Ketaroonrut, N.; Charngkaew, K.; Lam, E.W.-F.; Okada, S. et al.
Source: Self-asserted source
Eric Lam via Scopus - Elsevier

FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance

Cell Death and Disease
2018 | Journal article
EID:

2-s2.0-85058403896

Contributors: Intuyod, K.; Saavedra-García, P.; Zona, S.; Lai, C.-F.; Jiramongkol, Y.; Vaeteewoottacharn, K.; Pairojkul, C.; Yao, S.; Yong, J.-S.; Trakansuebkul, S. et al.
Source: Self-asserted source
Eric Lam via Scopus - Elsevier

Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer

Cancer Immunology, Immunotherapy
2018-11-24 | Journal article
Contributors: John Wahba; Marina Natoli; Lynsey M. Whilding; Ana C. Parente-Pereira; Youngrock Jung; Stefania Zona; Eric W.-F. Lam; J. Richard Smith; John Maher; Sadaf Ghaem-Maghami
Source: check_circle
Crossref

O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1

Oncogene
2018-10-18 | Journal article
Contributors: Chatchai Phoomak; Atit Silsirivanit; Dayoung Park; Kanlayanee Sawanyawisuth; Kulthida Vaeteewoottacharn; Chaisiri Wongkham; Eric W.-F. Lam; Chawalit Pairojkul; Carlito B. Lebrilla; Sopit Wongkham
Source: check_circle
Crossref

Cellular Senescence: The Sought or the Unwanted?

Trends in molecular medicine
2018-08 | Journal article
Contributors: Sun Y; Coppé JP; Lam EW
Source: Self-asserted source
Eric Lam via Europe PubMed Central
grade
Preferred source (of 2)‎

Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence.

Journal of cell science
2018-06 | Journal article
Contributors: Laphanuwat P; Likasitwatanakul P; Sittithumcharee G; Thaphaengphan A; Chomanee N; Suppramote O; Ketaroonrut N; Charngkaew K; Lam EW; Okada S et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

Nature communications
2018-04 | Journal article
Contributors: Zhang B; Fu D; Xu Q; Cong X; Wu C; Zhong X; Ma Y; Lv Z; Chen F; Han L et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

SUMOylation modulates FOXK2-mediated paclitaxel sensitivity in breast cancer cells

Oncogenesis
2018-03-13 | Journal article
Contributors: Gabriela Nestal de Moraes; Zongling Ji; Lavender Y.-N. Fan; Shang Yao; Stefania Zona; Andrew D. Sharrocks; Eric W.-F. Lam
Source: check_circle
Crossref

BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research
2018-02 | Journal article
Contributors: Gong C; Man EPS; Tsoi H; Lee TKW; Lee P; Ma ST; Wong LS; Luk MY; Rakha EA; Green AR et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central
grade
Preferred source (of 2)‎

ER stress and cancer: The FOXO forkhead transcription factor link

Molecular and Cellular Endocrinology
2018-02 | Journal article
Contributors: Glowi Alasiri; Lavender Yuen-Nam Fan; Stefania Zona; Isabella Galeno Goldsbrough; Hui-Ling Ke; Holger Werner Auner; Eric Wing-Fai Lam
Source: check_circle
Crossref

Multifaceted link between metabolism and cancer

Molecular and Cellular Endocrinology
2018-02 | Journal article
Contributors: Paula Saavedra-García; Lavender Yuen-Nam Fan; Eric W-F. Lam
Source: check_circle
Crossref

Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis

Molecular and Cellular Endocrinology
2018-02 | Journal article
Contributors: Paula Saavedra-García; Katie Nichols; Zimam Mahmud; Lavender Yuen-Nam Fan; Eric W-F. Lam
Source: check_circle
Crossref

Correction to: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.

Breast cancer research and treatment
2018-01 | Journal article
Contributors: Asaduzzaman M; Constantinou S; Min H; Gallon J; Lin ML; Singh P; Raguz S; Ali S; Shousha S; Charles Coombes R et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia.

Reproductive sciences (Thousand Oaks, Calif.)
2018-01 | Journal article
Contributors: Monteiro LJ; Cubillos S; Sanchez M; Acuña-Gallardo S; Venegas P; Herrera V; Lam EW; Varas-Godoy M; Illanes SE
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.

Oncogene
2017-12 | Journal article
Contributors: Peng F; Wang JH; Fan WJ; Meng YT; Li MM; Li TT; Cui B; Wang HF; Zhao Y; An F et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Metabolomics reveals novel blood plasma biomarkers associated to the BRCA1-mutated phenotype of human breast cancer

Scientific Reports
2017-12-19 | Journal article
Contributors: Bàrbara Roig; Marta Rodríguez-Balada; Sara Samino; Eric W.-F. Lam; Sandra Guaita-Esteruelas; Ana R. Gomes; Xavier Correig; Joan Borràs; Oscar Yanes; Josep Gumà
Source: check_circle
Crossref

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.

Oncogene
2017-11 | Journal article
Contributors: Peng F; Wang JH; Fan WJ; Meng YT; Li MM; Li TT; Cui B; Wang HF; Zhao Y; An F et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance.

Seminars in cancer biology
2017-11 | Journal article
Contributors: Yao S; Fan LY; Lam EW
Source: Self-asserted source
Eric Lam via Europe PubMed Central

p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis.

Carcinogenesis
2017-10 | Journal article
Contributors: Li SS; Xu LZ; Zhou W; Yao S; Wang CL; Xia JL; Wang HF; Kamran M; Xue XY; Dong L et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways.

Leukemia
2017-04 | Journal article
Contributors: Lyu Y; Lou J; Yang Y; Feng J; Hao Y; Huang S; Yin L; Xu J; Huang D; Ma B et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.

Scientific reports
2017-04 | Journal article
Contributors: Lau CE; Tredwell GD; Ellis JK; Lam EW; Keun HC
Source: Self-asserted source
Eric Lam via Europe PubMed Central
grade
Preferred source (of 2)‎

Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism.

Data in brief
2017-03 | Journal article
Contributors: Fan LY; Saavedra-García P; Lam EW
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer.

Breast cancer research and treatment
2017-03 | Journal article
Contributors: Asaduzzaman M; Constantinou S; Min H; Gallon J; Lin ML; Singh P; Raguz S; Ali S; Shousha S; Coombes RC et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

Oncogenesis
2017-02 | Journal article
Contributors: Kamran M; Long ZJ; Xu D; Lv SS; Liu B; Wang CL; Xu J; Lam EW; Liu Q
Source: Self-asserted source
Eric Lam via Europe PubMed Central

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.

Journal of medicinal chemistry
2017-02 | Journal article
Contributors: Sundriyal S; Moniot S; Mahmud Z; Yao S; Di Fruscia P; Reynolds CR; Dexter DT; Sternberg MJ; Lam EW; Steegborn C et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central

FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells.

Oncogene
2017-01 | Journal article
Contributors: Yang N; Wang C; Wang Z; Zona S; Lin SX; Wang X; Yan M; Zheng FM; Li SS; Xu B et al.
Source: Self-asserted source
Eric Lam via Europe PubMed Central
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Peer review (5 reviews for 4 publications/grants)

Review activity for Cell death and differentiation. (2)
Review activity for Cell death and disease. (1)
Review activity for Journal of molecular medicine. (1)
Review activity for Nature reviews. (1)