Amalia Enríquez-de-Salamanca (0000-0003-1274-7796)

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Biography

Amalia Enríquez-de-Salamanca (1969) graduated in Biochemistry in 1992, and obtained her Ph.D. in Biochemistry in 1998 at the Complutense University (UCM; Madrid, Spain). In 2000 she became Associate Researcher in the Ocular Surface Group at IOBA, where she currently is Principal Investigator. She is also the Scientific Director of the Ocular-facial pain Unit (UniDOF) at the IOBA since 2017. Additionally, she is member of the Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) since 2006.

Her main research field is ocular surface inflammation, where she investigates about characterization of potential biomarkers (disease, activity, therapeutic…), in tears and/or epithelial cells in immune-based chronic inflammatory diseases of the ocular surface, such as Dry Eye syndrome, chronic allergy (atopic keratoconjunctivits and vernal keratoconjunctivits) and ocular chronic pain. Her research also includes the study of the role of corneal and conjunctival epithelial cells for these diseases. She has authored 65 publications in peer reviewed indexed journals. She has been Principal investigator of 7 regional and 4 national competitive projects, and participates in the European Marie Curie project IT-DED3. She has also collaborated in 54 R&D projects.
Besides her research work, she also participates in postgraduate teaching. She has directed seven doctoral theses and she currently co-directs four more in progress.

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Universidad de Valladolid: Valladolid, ES

2015 to present | COlaborador honorífico (IOBA)

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Amalia Enríquez-de-Salamanca

https://orcid.org/0000-0003-1274-7796

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Employment (3)

Universidad de Valladolid: Valladolid, ES

CIBER-BBN: Valladolid, ES

Institute of Applied Ophthalmobiology (IOBA): Valladolid, ES

Education and qualifications (2)

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

Professional activities (2)

EUROPEAN DRY EYE SOCIETY (EuDES): Paris, FR

The Association for Research in Vision and Ophthalmology Inc: Rockville, MD, US

Funding (8)

Desarrollo de un dispositivo de inmunocromatografía (ICT) multiplexado basado en biomarcadores moleculares para el diagnóstico de la enfermedad ojo seco (SOS). Dry-Eye Alert. Ref: PDC2021-121035-I00.

Biomarcadores de dolor ocular neuropático en la superficie ocular para la detección de nuevas dianas terapéuticas. Ref: SAF2016-77080-P

Biomarcadores moleculares y dianas terapéuticas en inflamación de la superficie ocular” SAF2010-15361

“Estudio in vitro de una posible terapia con péptidos anti-TGF en los procesos de inflamación crónica y grave de la superficie ocular.SAN126/VA02/09

TGFb en la inflamación crónica y grave de la superficie ocular; Participación del epitelio en su producción y respuesta in vitro de las células epiteliales” SAN673/VA09/08

Inflamación Crónica y grave de la superficie ocular: participación de las células epiteliales conjunctivales

“Células epiteliales como nueva diana terapéutica en inflamación crónica y grave de la superficie ocular” SAF2006-61636

Desarrollo de un modelo in vitro de alergia ocular para la búsqueda de fármacos antialérgicos más potentes y selectivos.SAN/1052/VA19/05 .

Works (50 of 80)

A comprehensive scoping review of methodological approaches and clinical applications of tear fluid biomarkers

Tear Cytokines as Predictive Biomarkers of Success in Contact Lens Discomfort Management

Short-Term Efficacy of Ophthalmic Cyclosporine: A 0.1% Cationic Emulsion in Dry Eye Patients Assessed Under Controlled Environment

Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation

Gene expression changes in conjunctival cells associated with contact lens wear and discomfort

Influence of controlled environmental conditions in potential salivary ocular pain biomarkers for enhancing the assessment of ocular pain

Tear and Plasma Levels of Cytokines in Patients with Uveitis: Search for Active Disease Biomarkers

Effect of a single vectored thermal pulsation treatment of Meibomian gland dysfunction patients under controlled environmental conditions

Olive Pomace Phenolic Compounds: From an Agro-Industrial By-Product to a Promising Ocular Surface Protection for Dry Eye Disease

Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study

Special Issue on “Potential Biomarkers in Tears”

Conjunctival Intraepithelial Lymphocytes, Lacrimal Cytokines and Ocular Commensal Microbiota: Analysis of the Three Main Players in Allergic Conjunctivitis

Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease

Diurnal variation on tear stability and correlation with tear cytokine concentration.

Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems

Olive Pomace Phenolic Compounds Stability and Safety Evaluation: From Raw Material to Future Ophthalmic Applications

Age- and Sex-Adjusted Reference Intervals in Tear Cytokine Levels in Healthy Subjects

Ocular Surface Pathology in Patients Suffering from Mercury Intoxication

Olive Pomace Phenolic Compounds and Extracts Can Inhibit Inflammatory- and Oxidative-Related Diseases of Human Ocular Surface Epithelium

A Pilot Proteomic Study of Normal Human Tears: Leptin as a Potential Biomarker of Metabolic Disorders

Pressurized Liquid Extraction Optimization from Supercritical Defatted Olive Pomace: A Green and Selective Phenolic Extraction Process

Conjunctival Neuropathic and Inflammatory Pain-Related Gene Expression with Contact Lens Wear and Discomfort

Ocular Surface Pathology in Patients Suffering From Mercury Intoxication Is Consistent With Neurogenic Dry Eye Disease

Substance P Level in Tears as a Potential Biomarker for Contact Lens Discomfort

Development of a Questionnaire for Detecting Changes in Dry Eye Disease-Related Symptoms.

Inflammatory status predicts contact lens discomfort under adverse environmental conditions.

Clinical and tear cytokine profiles after advanced surface ablation refractive surgery: A six-month follow-up.

Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review.

Topical Quercetin and Resveratrol Protect the Ocular Surface in Experimental Dry Eye Disease

Response profiles to a controlled adverse desiccating environment based on clinical and tear molecule changes

The ability of the Contact Lens Dry Eye Questionnaire (CLDEQ)-8 to detect ocular surface alterations in contact lens wearers

Severity, therapeutic, and activity tear biomarkers in dry eye disease: An analysis from a phase III clinical trial

Are Contact Lens Discomfort or Soft Contact Lens Material Properties Associated with Alterations in the Corneal Sub-Basal Nerve Plexus?

Effects of the External Environment on Dry Eye Disease.

Re: Pinto-Fraga et al.: Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: a randomized controlled clinical trial (Ophthalmology 2016;123:141-153) REPLY

Prehematopoietic Stem Cell Transplantation Tear Cytokines as Potential Susceptibility Biomarkers for Ocular Chronic Graft-Versus-Host Disease.

Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears.

Cytokine and chemokine tear levels in patients with uveitis

Reply.

RNA Collection From Human Conjunctival Epithelial Cells Obtained With a New Device for Impression Cytology.

Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine.

Effect of Environmental Conditions on the Concentration of Tear Inflammatory Mediators During Contact Lens Wear.

Biomarkers in Ocular Chronic Graft Versus Host Disease: Tear Cytokine- and Chemokine-Based Predictive Model.

Topical Fluorometholone Protects the Ocular Surface of Dry Eye Patients from Desiccating Stress: A Randomized Controlled Clinical Trial.

Gene Expression-Based Predictive Models of Graft Versus Host Disease-Associated Dry Eye.

Quercetin and Resveratrol Decrease the Inflammatory and Oxidative Responses in Human Ocular Surface Epithelial Cells

Corneal Sensitivity and Inflammatory Biomarkers in Contact Lens Discomfort.

Clinical and Molecular Inflammatory Response in Sjogren Syndrome-Associated Dry Eye Patients under Desiccating Stress.

Basal values, intra-day and inter-day variations in tear film osmolarity and tear fluorescein clearance