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Biography

Cancer Research: Dr. Feng is Director of the Laboratory of Zebrafish Genetics and Cancer Therapeutics. Dr. Feng’s research interests focus on identifying novel genes and pathways that are essential for MYC-related tumor transformation and progression, particularly for T-Lymphoblastic Lymphoma/Leukemia and Neuroblastoma. The research strategy of Dr. Feng’s research is to combine the analysis of human cancer genomic databases with the genetic and imaging capacities of the zebrafish system.

Current research areas in Dr. Feng’s laboratory include:
1) To determine the molecular mechanisms underlying tumor cell intravasation and tumor progression.
2) To test the identified genes’ therapeutic potential in treating MYC-related cancers and to characterize their molecular relevance to MYC.
3) To identify additional genes and pathways that, when mutated, delay the initiation and progression of MYC-related cancers.

The long-term goal of Dr. Feng’s research is to discover novel molecular therapies to target critical components of MYC-driven oncogenic pathways, thus providing treatment alternatives that are more specific and less toxic.

Activities

Employment (1)

Boston University: Boston, MA, US

2011-10-01 to present | faculty (Pharmacology)
Employment
Source: Self-asserted source
Hui Feng

Education and qualifications (2)

University of Georgia: Athens, GA, US

1997-09-01 to 2002-12-20 | PhD (Cell Biology)
Education
Source: Self-asserted source
Hui Feng

Peking University: Beijing, Beijing, CN

1989 to 1994 | MD (Preventive Medicine)
Education
Source: Self-asserted source
Hui Feng

Funding (1)

The Role of DLST in Leukemogenesis

Award
National Cancer Institute (Md., Md., US)
Source: Self-asserted source
Hui Feng

Works (50 of 53)

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Page 1 of 2

S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720

Cells
2023-03 | Journal article | Author
Contributors: Fabrice J. F. Laroche; Sheng Li; Ning Shen; Soo Kyung Hwang; Gina Nguyen; Wenling Yu; Chen Khuan Wong; Ryan J. Quinton; Jason Berman; Ching-Ti Liu et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

Cancers
2022-06-16 | Journal article
Contributors: Yanwu Wang; Ning Shen; Gervase Spurlin; Sovannarith Korm; Sarah Huang; Nicole M. Anderson; Leah N. Huiting; Hudan Liu; Hui Feng
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Fishing for drugs.

eLife
2022-02-08 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer.

Communications biology
2021-11-16 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Failure to Guard: Mitochondrial Protein Quality Control in Cancer

International Journal of Molecular Sciences
2021-08-02 | Journal article
Contributors: Joseph E. Friedlander; Ning Shen; Aozhuo Zeng; Sovannarith Korm; Hui Feng
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma.

Cancer research
2021-07-07 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Tipping the Scales With Zebrafish to Understand Adaptive Tumor Immunity.

Frontiers in cell and developmental biology
2021-05-20 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia.

Haematologica
2021-05-01 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Unraveling the regulatory role of endoplasmic-reticulum-associated degradation in tumor immunity.

Critical reviews in biochemistry and molecular biology
2020-07-07 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish.

Journal of visualized experiments : JoVE
2020-05-08 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity

Cell Death & Disease
2020-04-03 | Journal article
Contributors: Chinaemere Igwebuike; Julia Yaglom; Leah Huiting; Hui Feng; Joshua D. Campbell; Zhiyong Wang; Andrea Havasi; David Pimentel; Michael Y. Sherman; Steven C. Borkan
Source: check_circle
Crossref

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.

Cancer cell
2020-02-01 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

Molecular cancer research : MCR
2020-01-13 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Ultrabright fluorescent silica nanoparticles for in vivo targeting of xenografted human tumors and cancer cells in zebrafish

Nanoscale
2019 | Journal article
Contributors: Saquib Ahmed M. A. Peerzade; Xiaodan Qin; Fabrice J. F. Laroche; Shajesh Palantavida; Maxim Dokukin; Berney Peng; Hui Feng; Igor Sokolov
Source: check_circle
Crossref

Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.

The Journal of biological chemistry
2019-10-28 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.

Cell reports
2019-10-01 | Journal article
Contributors: Hui Feng
Source: Self-asserted source
Hui Feng

Cellulose-based photonic nanomaterials for biomedical imaging

Abstracts of Papers of the American Chemical Society
2018 | Journal article
WOSUID:

WOS:000447600004395

Contributors: Peng, B.; Almeqdadi, M.; Laroche, F.; Palantavida, S.; Peerzade, S. A.; Dokukin, M.; Roper, J.; Feng, H.; Sokolov, I.
Source: Self-asserted source
Hui Feng via ResearcherID

Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.

Data in brief
2018-12 | Journal article
Contributors: Peng B; Almeqdadi M; Laroche F; Palantavida S; Dokukin M; Roper J; Yilmaz OH; Feng H; Sokolov I
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.

Nature communications
2018-10 | Journal article
Contributors: Su H; Hu J; Huang L; Yang Y; Thenoz M; Kuchmiy A; Hu Y; Li P; Feng H; Zhou Y et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 3)‎

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.

Genome medicine
2018-07 | Journal article
Contributors: Kartha VK; Alamoud KA; Sadykov K; Nguyen BC; Laroche F; Feng H; Lee J; Pai SI; Varelas X; Egloff AM et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor.

International journal of molecular sciences
2018-05 | Journal article
Contributors: Narasimhan S; Stanford Zulick E; Novikov O; Parks AJ; Schlezinger JJ; Wang Z; Laroche F; Feng H; Mulas F; Monti S et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response.

Leukemia
2018-04 | Journal article
Contributors: Huiting LN; Samaha Y; Zhang GL; Roderick JE; Li B; Anderson NM; Wang YW; Wang L; Laroche F; Choi JW et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

The emerging role and targetability of the TCA cycle in cancer metabolism.

Protein & cell
2017-07 | Journal article
Contributors: Anderson NM; Mucka P; Kern JG; Feng H
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes.

Journal of immunology (Baltimore, Md. : 1950)
2017-07 | Journal article
Contributors: Liu X; Li YS; Shinton SA; Rhodes J; Tang L; Feng H; Jette CA; Look AT; Hayakawa K; Hardy RR
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 3)‎

The TCA cycle transferase DLST is critical for MYC-mediated leukemogenesis

Cancer Research
2016 | Journal article
WOSUID:

WOS:000389969800112

Contributors: Anderson, N.; Li, D.; Peng, H. L.; Mansour, M.; Laroche, F.; Gjini, E.; Helman, D.; Harrold, I.; Meng, L.; Sanda, T. et al.
Source: Self-asserted source
Hui Feng via ResearcherID

Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.

Leukemia
2016-12 | Journal article
Contributors: Liau WS; Tan SH; Ngoc PCT; Wang CQ; Tergaonkar V; Feng H; Gong Z; Osato M; Look AT; Sanda T
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 3)‎

CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.

Haematologica
2016-10 | Journal article
Contributors: Lian H; Li D; Zhou Y; Landesman-Bollag E; Zhang G; Anderson NM; Tang KC; Roderick JE; Kelliher MA; Seldin DC et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.

Leukemia
2016-02 | Journal article
Contributors: Anderson NM; Li D; Peng HL; Laroche FJ; Mansour MR; Gjini E; Aioub M; Helman DJ; Roderick JE; Cheng T et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Efficient transgenesis mediated by pigmentation rescue in zebrafish.

BioTechniques
2016-01 | Journal article
Contributors: Harrold I; Carbonneau S; Moore BM; Nguyen G; Anderson NM; Saini AS; Kanki JP; Jette CA; Feng H
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights.

Advances in experimental medicine and biology
2016-01 | Journal article
Contributors: Harrison NR; Laroche FJ; Gutierrez A; Feng H
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.

Angiogenesis
2015-06 | Journal article
Contributors: Srinivasan S; Chitalia V; Meyer RD; Hartsough E; Mehta M; Harrold I; Anderson N; Feng H; Smith LE; Jiang Y et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

The Zebrafish as a Tool to Cancer Drug Discovery.

Austin journal of pharmacology and therapeutics
2015-05 | Journal article
Contributors: Huiting LN; Laroche F; Feng H
Source: Self-asserted source
Hui Feng via Europe PubMed Central

The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway.

The Journal of biological chemistry
2015-03 | Journal article
Contributors: Shivanna S; Harrold I; Shashar M; Meyer R; Kiang C; Francis J; Zhao Q; Feng H; Edelman ER; Rahimi N et al.
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.

British journal of haematology
2014-04 | Journal article
Contributors: Gutierrez A; Feng H; Stevenson K; Neuberg DS; Calzada O; Zhou Y; Langenau DM; Look AT
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

Blood
2013 | Journal article
WOSUID:

WOS:000331385002396

Contributors: Anderson, N. M.; Peng, H. L.; Helman, D.; Harrold, I.; Sanda, T.; Grant, T.; Nagykery, N.; Samaha, Y.; Le, M.; Amsterdam, A. et al.
Source: Self-asserted source
Hui Feng via ResearcherID

BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines.

Leukemia
2013-12 | Journal article
Contributors: Anderson NM; Harrold I; Mansour MR; Sanda T; McKeown M; Nagykary N; Bradner JE; Lan Zhang G; Look AT; Feng H
Source: Self-asserted source
Hui Feng via Europe PubMed Central
grade
Preferred source (of 2)‎

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis

Cancer Research
2012 | Journal article
WOSUID:

WOS:000209701505163

Contributors: Zhu, S. Z.; Lee, J. S.; Guo, F.; Shin, J. M.; Perez-Atayde, A. R.; Kutok, J. L.; Rodig, S. J.; Neuberg, D. S.; Helman, D.; Feng, H. et al.
Source: Self-asserted source
Hui Feng via ResearcherID

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.

2012-04-27 | Standards or policy
DOI:

10.1038/leu.2012.116

PMID:

22538478

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

2012-03-20 | Standards or policy
DOI:

10.1016/j.ccr.2012.02.010

PMID:

22439933

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

Activated ALK accelerates the onset of neuroblastoma in MYCN-transgenic zebrafish

Cancer Research
2011 | Journal article
WOSUID:

WOS:000209701301305

Contributors: Zhu, S. Z.; Lee, J. S.; Shin, J.; Perez-Atayde, A. R.; Kutok, J. L.; Rodig, S. J.; Neuberg, D. S.; Guo, F.; Helman, D.; Feng, H. et al.
Source: Self-asserted source
Hui Feng via ResearcherID

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.

2011-07-04 | Standards or policy
DOI:

10.1084/jem.20101691

PMID:

21727187

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

2010-10-19 | Standards or policy
DOI:

10.1016/j.ccr.2010.09.009

PMID:

20951945

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.

2010-07-24 | Standards or policy
DOI:

10.1016/j.ydbio.2010.07.020

PMID:

20659444

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

Pten Inactivating Mutations Promote Loss of MYC "Oncogene Addiction" in a Conditional Zebrafish Model of T-ALL

Blood
2009 | Journal article
WOSUID:

WOS:000272725804641

Contributors: Gutierrez, A.; Feng, H.; Faucherre, A.; Den Hertog, J.; Prochownik, E. V.; Testa, J. R.; Kanki, J.; Look, A. T.
Source: Self-asserted source
Hui Feng via ResearcherID

Construction and application of a zebrafish array comparative genomic hybridization platform.

2009-02-01 | Standards or policy
DOI:

10.1002/gcc.20623

PMID:

18973135

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.

2007-07-01 | Standards or policy
DOI:

10.1111/j.1365-2141.2007.06625.x

PMID:

17593023

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway.

2007-05-17 | Standards or policy
DOI:

10.1016/j.cub.2007.04.055

PMID:

17509881

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

Emi1 is required for normal cell cycle progression in zebrafish myelopoiesis and likely functions as a haploinsufficient tumor suppressor on chromosome 6q in human leukmias

Blood
2006 | Journal article
WOSUID:

WOS:000242440001664

Contributors: Rhodes, J.; Amsterdam, A.; Ho, K.; Heinrichs, S.; Kinki, J. P.; O'Neil, J. E.; Gutierrez, A.; McKenna, K.; Feng, H.; Fleming, M. et al.
Source: Self-asserted source
Hui Feng via ResearcherID

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.

2005-04-12 | Standards or policy
DOI:

10.1073/pnas.0408708102

PMID:

15827121

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎

Preventing DNA re-replication--divergent safeguards in yeast and metazoa.

2003-09-01 | Standards or policy
DOI:

10.4161/cc.2.5.527

PMID:

12963835

Source: Self-asserted source
Hui Feng
grade
Preferred source (of 2)‎
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Peer review (11 reviews for 9 publications/grants)

Review activity for Advanced science. (1)
Review activity for Cell death discovery. (1)
Review activity for eLife (1)
Review activity for iScience. (1)
Review activity for JoVE. (1)
Review activity for Leukemia (1)
Review activity for Nature communications (1)
Review activity for Oncogene. (3)
Review activity for Oncogenesis. (1)