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GABA, inhibitory synapses, anxiety depression, homeostatic plasticity, neurogenesis, transcriptomes
United States

Activities

Employment (2)

Pennsylvania State University: University Park, PA, US

1999-01-02 to present | Professor (Biology)
Employment
Source: Self-asserted source
Bernhard Luscher

University of Zurich: Zurich, Zurich, CH

1990-04-01 to 1999-01-31 | Oberassistant (Institute of Pharmacology)
Employment
Source: Self-asserted source
Bernhard Luscher

Education and qualifications (3)

UC Berkeley: Berkeley, US

1987 to 1990
Education
Source: Self-asserted source
Bernhard Luscher

University of Zurich: Zurich, CH

1983 to 1987 | PhD (Molecular Biology)
Education
Source: Self-asserted source
Bernhard Luscher

ETH-Bereich Hochschulen: Zurich, ZH, CH

1978 to 1983 | Dipl Natw
Education
Source: Self-asserted source
Bernhard Luscher

Professional activities (2)

The Pennsylvania State University: University Park, PA, US

1999-01-02 to present | Professor (Department f Biology, Department of Biochemistry and Molecular Biology)
Invited position
Source: Self-asserted source
Bernhard Luscher

University of Zurich: Zurich, ZH, CH

1990-04-01 to 1999-01-31 | Group Leader/Oberassistant (Pharmacology)
Invited position
Source: Self-asserted source
Bernhard Luscher

Works (50 of 91)

Items per page:
Page 1 of 2

Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure

Molecular Psychiatry
2024-11-16 | Journal article
Contributors: Tong Jiang; Mengyang Feng; Alexander Hutsell; Bernhard Lüscher
Source: check_circle
Crossref

Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

Molecular Psychiatry
2024-11-16 | Journal article
Contributors: Meiyu Shao; Julia Botvinov; Deepro Banerjee; Santhosh Girirajan; Bernhard Lüscher
Source: check_circle
Crossref

γ1 GABAAReceptors in Spinal Nociceptive Circuits

The Journal of Neuroscience
2024-10-09 | Journal article
Contributors: Elena Neumann; Teresa Cramer; Mario A. Acuña; Louis Scheurer; Camilla Beccarini; Bernhard Luscher; Hendrik Wildner; Hanns Ulrich Zeilhofer
Source: check_circle
Crossref

Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

2024-10-03 | Preprint
Contributors: Bernhard Luscher; Meiyu Shao; Deepro Banerjee; Santhosh Girirajan
Source: check_circle
Crossref

Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure

2024-07-11 | Preprint
Contributors: Bernhard Luscher; Tong Jiang; Mengyang Feng; Alexander Hutsell
Source: check_circle
Crossref

Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

2024-07-10 | Preprint
Contributors: Meiyu Shao; Julia Botvinov; Deepro Banerjee; Santhosh Girirajan; Bernhard Lüscher
Source: check_circle
Crossref

Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure

2024-07-09 | Preprint
Contributors: Tong Jiang; Mengyang Feng; Alexander Hutsell; Bernhard Luscher
Source: check_circle
Crossref

GABAA receptors as targets for treating affective and cognitive symptoms of depression

Trends in Pharmacological Sciences
2023-09 | Journal article
Contributors: Bernhard Luscher; Jamie L. Maguire; Uwe Rudolph; Etienne Sibille
Source: check_circle
Crossref

GABA<sub>A</sub> receptors in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE
2023-04-26 | Journal article
Part of ISSN: 2633-1020
Contributors: Delia Belelli; Tim G. Hales; Jeremy J. Lambert; Bernhard Luscher; Richard Olsen; John Peters; Uwe Rudolph; Werner Sieghart
Source: Self-asserted source
Bernhard Luscher

GABA<sub>A</sub> receptors in GtoPdb v.2021.3

IUPHAR/BPS Guide to Pharmacology CITE
2021-09-02 | Journal article
Part of ISSN: 2633-1020
Contributors: Delia Belelli; Tim G. Hales; Jeremy J. Lambert; Bernhard Luscher; Richard Olsen; John Peters; Uwe Rudolph; Werner Sieghart
Source: Self-asserted source
Bernhard Luscher

In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties

Frontiers in Neuroscience
2021-08-02 | Journal article
Source: Self-asserted source
Bernhard Luscher

Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition

Rapid Acting Antidepressants
2020 | Book chapter
Part of ISBN: 9780128201893
Part of ISSN: 1054-3589
Source: Self-asserted source
Bernhard Luscher
grade
Preferred source (of 3)‎

Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice

Neurobiology of Stress
2020-11 | Journal article
Contributors: Sarah J. Jefferson; Mengyang Feng; URee Chon; Yao Guo; Yongsoo Kim; Bernhard Luscher
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Full function of exon junction complex factor, Rbm8a, is critical for interneuron development

Translational Psychiatry
2020-11-05 | Journal article
Contributors: Colleen McSweeney; Fengping Dong; Miranda Chen; Jessica Vitale; Li Xu; Nicole Crowley; Bernhard Luscher; Donghua Zou; Yingwei Mao
Source: check_circle
Crossref

Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels

2019-12 | Journal article
Part of ISSN: 1756-6606
Source: Self-asserted source
Bernhard Luscher
grade
Preferred source (of 3)‎

GABA<sub>A</sub> receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

IUPHAR/BPS Guide to Pharmacology CITE
2019-09-16 | Journal article
Part of ISSN: 2633-1020
Source: Self-asserted source
Bernhard Luscher

Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience

F1000Research
2019-05-29 | Journal article
Contributors: Bernhard Lüscher; Hanns Möhler
Source: check_circle
Crossref
grade
Preferred source (of 4)‎

Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine

Neuroscience
2019-03-13 | Journal article
Source: Self-asserted source
Bernhard Luscher
grade
Preferred source (of 3)‎

Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice

2019-02-08 | Journal article
Source: Self-asserted source
Bernhard Luscher
grade
Preferred source (of 3)‎

The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection.

Journal of virology
2018-02 | Journal article
Contributors: Wang S; Mott KR; Cilluffo M; Kilpatrick CL; Murakami S; Ljubimov AV; Kousoulas KG; Awasthi S; Luscher B; Ghiasi H
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central
grade
Preferred source (of 3)‎

Adolescent social stress increases anxiety-like behavior and alters synaptic transmission, without influencing nicotine responses, in a sex-dependent manner

Neuroscience
2018-01-14 | Journal article
Source: Self-asserted source
Bernhard Luscher
grade
Preferred source (of 3)‎

Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.

Journal of virology
2017-10 | Journal article
Contributors: Wang S; Mott KR; Wawrowsky K; Kousoulas KG; Luscher B; Ghiasi H
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central
grade
Preferred source (of 3)‎

Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors.

Molecular psychiatry
2017-06 | Journal article
Contributors: Fuchs T; Jefferson SJ; Hooper A; Yee PP; Maguire J; Luscher B
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central
grade
Preferred source (of 3)‎

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

Journal of Biological Chemistry
2017-02-17 | Journal article
Contributors: Keyong Du; Shoko Murakami; Yingmin Sun; Casey L. Kilpatrick; Bernhard Luscher
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Bidirectional homeostatic regulation of a depression-related brain state by gamma-aminobutyric acidergic deficits and ketamine treatment

Biol Psychiatry
2016 | Journal article
Contributors: Ren, Z.; Pribiag, H.; Jefferson, S. J.; Shorey, M.; Fuchs, T.; Stellwagen, D.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 4)‎

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

Mol Psychiatry
2016 | Journal article
Contributors: Fuchs, T.; Jefferson, S. J.; Hooper, A.; Yee, P. H.; Maguire, J.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Dissociation of Golgi-Associated DHHC-Type Zinc Finger Protein (GODZ) and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-Mediated Palmitoylation by Loss of Function Analyses in Knockout Mice

J Biol Chem
2016 | Journal article
Contributors: Kilpatrick, C. L.; Murakami, S.; Feng, M.; Wu, X.; Lal, R.; Chen, G.; Du, K.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABA<inf>A</inf> receptor γ2 subunit in the cerebellum

Frontiers in Pharmacology
2016 | Journal article
EID:

2-s2.0-84995503997

Part of ISBN:

16639812

Contributors: Leppä, E.; Linden, A.-M.; Aller, M.I.; Wulff, P.; Vekovischeva, O.; Luscher, B.; Lüddens, H.; Wisden, W.; Korpi, E.R.
Source: Self-asserted source
Bernhard Luscher via Scopus - Elsevier
grade
Preferred source (of 2)‎

Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABAA Receptor γ2 Subunit in the Cerebellum.

2016 | Journal article
Contributors: Leppä E; Linden AM; Aller MI; Wulff P; Vekovischeva O; Luscher B; Lüddens H; Wisden W; Korpi ER
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central

Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice

Neuropharmacology
2015 | Journal article
Contributors: Ren, Z.; Sahir, N.; Murakami, S.; Luellen, B. A.; Earnheart, J. C.; Lal, R.; Kim, J. Y.; Song, H.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.

2015 | Journal article
Contributors: Ebersole B; Petko J; Woll M; Murakami S; Sokolina K; Wong V; Stagljar I; Lüscher B; Levenson R
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central
grade
Preferred source (of 3)‎

GABAergic control of depression-related brain States

Adv Pharmacol
2015 | Journal article
Contributors: Luscher, B.; Fuchs, T.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

GABAergic signaling in health and disease

Neuropharmacology
2015 | Journal article
Contributors: McBain, C. J.; Kittler, J.; Luscher, B.; Mody, I.; Orser, B. A.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 4)‎

Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses

PLoS Biol
2014 | Journal article
Contributors: Dejanovic, B.; Semtner, M.; Ebert, S.; Lamkemeyer, T.; Neuser, F.; Lüscher, B.; Meier, J. C.; Schwarz, G.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Multiple molecular mechanisms for a single GABAA mutation in epilepsy

Neurology
2013 | Journal article
Contributors: Reid, C. A.; Kim, T.; Phillips, A. M.; Low, J.; Berkovic, S. F.; Luscher, B.; Petrou, S.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Adult hippocampal neurogenesis in the absence of serotonin (Commentary on Diaz et al.).

2013-09 | Journal article
Contributors: Luscher B; Fuchs T
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central
grade
Preferred source (of 3)‎

GABAA and GABAC receptors: Regulation of assembly, localization, clustering and turnover

Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels
2012 | Book chapter
EID:

2-s2.0-84939494159

Contributors: Lüscher, B.
Source: Self-asserted source
Bernhard Luscher via Scopus - Elsevier
grade
Preferred source (of 2)‎

GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice

PLoS One
2012 | Journal article
Contributors: Shen, Q.; Fuchs, T.; Sahir, N.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding site.

2012 | Journal article
Contributors: Lüscher BP; Baur R; Goeldner M; Sigel E
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Nature
2012 | Journal article
Contributors: Song, J.; Zhong, C.; Bonaguidi, M. A.; Sun, G. J.; Hsu, D.; Gu, Y.; Meletis, K.; Huang, Z. J.; Ge, S.; Enikolopov, G. et al.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting

J Biol Chem
2012 | Journal article
Contributors: Wu, X.; Wu, Z.; Ning, G.; Guo, Y.; Ali, R.; Macdonald, R. L.; De Blas, A. L.; Luscher, B.; Chen, G.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

GABAA receptor trafficking-mediated plasticity of inhibitory synapses

Neuron
2011 | Journal article
Contributors: Luscher, B.; Fuchs, T.; Kilpatrick, C. L.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Gamma-aminobutyric acidergic deficits cause melancholic depression: a reply to Markou and Geyer

Biol Psychiatry
2011 | Journal article
Contributors: Luscher, B.; Shen, Q.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

The GABAergic deficit hypothesis of major depressive disorder

Mol Psychiatry
2011 | Journal article
Contributors: Luscher, B.; Shen, Q.; Sahir, N.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression

Biol Psychiatry
2010 | Journal article
Contributors: Shen, Q.; Lal, R.; Luellen, B. A.; Earnheart, J. C.; Andrews, A. M.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Knockdown of GABA(A) receptor signaling in GnRH neurons has minimal effects upon fertility

Endocrinology
2010 | Journal article
Contributors: Lee, K.; Porteous, R.; Campbell, R. E.; Lüscher, B.; Herbison, A. E.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation

Hum Mutat
2009 | Journal article
Contributors: Kalscheuer, V. M.; Musante, L.; Fang, C.; Hoffmann, K.; Fuchs, C.; Carta, E.; Deas, E.; Venkateswarlu, K.; Menzel, C.; Ullmann, R. et al.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors

Mol Cell Neurosci
2008 | Journal article
Contributors: Yuan, X.; Yao, J.; Norris, D.; Tran, D. D.; Bram, R. J.; Chen, G.; Luscher, B.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures

J Neurosci
2007 | Journal article
Contributors: Deng, L.; Yao, J.; Fang, C.; Dong, N.; Luscher, B.; Chen, G.
Source: Self-asserted source
Bernhard Luscher via ResearcherID
grade
Preferred source (of 3)‎

GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states.

2007-04 | Journal article
Contributors: Earnheart JC; Schweizer C; Crestani F; Iwasato T; Itohara S; Mohler H; Lüscher B
Source: Self-asserted source
Bernhard Luscher via Europe PubMed Central
grade
Preferred source (of 3)‎
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