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Diabetes, Lipidology, Hepatocellular Carcinoma, Vascular Biology
Australia

Biography

A/Prof Yanfei (Jacob) Qi is a lipid biologist. He is heading the Lipid Cell Biology Laboratory at Centenary Institute, The University of Sydney, Australia. Qi was awarded his PhD in 2013 at Sydney Medical School, The University of Sydney, followed by a postdoctoral research training at School of Biotechnology and Biomolecular Sciences, University of New South Wales, in 2014-2016. Since 2017, he has established a lipid-centric research program at the Centenary Institute, focusing on 1) understanding lipid metabolic causes of fatty liver and its related liver cancer, 2) developing lipid-targeted therapeutics for vascular inflammation and ageing in CVDs, and 3) leveraging AI-powered lipidomics to identify lipid biomarkers for diabetes diagnosis and prediction in large cohorts.

Activities

Employment (3)

Centenary Institute of Cancer Medicine and Cell Biology: Sydney, New South Wales, AU

2019-01-01 to present | Laboratory Head (Lipid Cell Biology Laboratory)
Employment
Source: Self-asserted source
Yanfei Qi

Centenary Institute of Cancer Medicine and Cell Biology: Sydney, New South Wales, AU

2017-01-01 to 2019-12-31 | Senior Research Officer (Vascular Biology)
Employment
Source: Self-asserted source
Yanfei Qi

UNSW Sydney: Sydney, AU

2014-01-01 to 2016-12-31 | Research Associate (Postdoctoral) (School of BABS)
Employment
Source: Self-asserted source
Yanfei Qi

Education and qualifications (3)

University of Sydney: Sydney, NSW, AU

2008-08 to 2013-02 | PhD in Medicine (Centenary Institute, Sydney Medical School)
Education
Source: Self-asserted source
Yanfei Qi

University of Sydney: Sydney, NSW, AU

2005-02 to 2005-11 | Master of Herbal Medicines (Faculty of Pharmacy)
Education
Source: Self-asserted source
Yanfei Qi

Jilin University: Changchun, Jilin, CN

2000-09 to 2004-07 | Bachelor of Pharmaceutical Engineering (Life Science Colleage)
Education
Source: Self-asserted source
Yanfei Qi

Professional activities (5)

Australian Association of Chinese Biomedical Scientist: Sydney, AU

2023-01-01 to present | President-elect
Membership
Source: Self-asserted source
Yanfei Qi

University of Sydney: Sydney, AU

2021-01-01 to 2024-12-31 | Senior Research Fellow (level C) (SoMS)
Invited position
Source: Self-asserted source
Yanfei Qi

Centenary Institute: Sydney, New South Wales, AU

2020-04-01 to 2022-12-31 | Executive member: selecting speakers as well as organising and hosting weekly academic seminar series. (Education Committee)
Service
Source: Self-asserted source
Yanfei Qi

University of Sydney: Sydney, AU

2017-01-01 to 2020-12-31 | Conjoint Lecturer (level B) (SoMS)
Invited position
Source: Self-asserted source
Yanfei Qi

UNSW Sydney: Sydney, AU

2017-01-01 to 2019-12-31 | Adjunct Lecturer (level B) (School of BABS)
Invited position
Source: Self-asserted source
Yanfei Qi

Funding (6)

ARC DP Grant

2024-01 to 2026-12 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

DP240103193

Source: Self-asserted source
Yanfei Qi

NHMRC Ideas Grant

2021-01 to 2024-12 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

APP2002660

Source: Self-asserted source
Yanfei Qi

NHMRC Project Grant

2019-01 to 2021-12 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

APP1162545

Source: Self-asserted source
Yanfei Qi

Centenary Future Leader Fellowship

2019-01 to 2020-12 | Grant
Centenary Institute (Sydney, AU)
Source: Self-asserted source
Yanfei Qi

Early Career Researcher Kickstart Grant

2018-01 to 2018-12 | Grant
University of Sydney (Sydney, AU)
Source: Self-asserted source
Yanfei Qi

Early-Mid Career Researcher Grant, NSW Cardiovascular Research Capacity Program

Grant
NSW Ministry of Health (Sydney, AU)
GRANT_NUMBER:

G205977

Source: Self-asserted source
Yanfei Qi

Works (46)

Trend and Burden of Vitamin A Deficiency in 1990–2021 and Projection to 2050: A Systematic Analysis for the Global Burden of Disease Study 2021

Nutrients
2025-02-04 | Journal article
Contributors: Kelly Lin; Yanfei Qi; Jing Sun
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Enzyme-mediated multifunctional self-healing lysozyme hydrogel for synergistic treatment of chronic diabetic wounds

International Journal of Biological Macromolecules
2024-12 | Journal article
Part of ISSN: 0141-8130
Contributors: Hao Hao; Juntao Hu; Ziyu Kuai; Fengjie Hao; Wantong Jiang; Nana Ran; Yuting He; Yanping Zhang; Yibing Huang; Yanfei Qi et al.
Source: Self-asserted source
Yanfei Qi

Deep serum lipidomics identifies evaluative and predictive biomarkers for individualized glycemic responses following low-energy diet-induced weight loss: a PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW) substudy

The American Journal of Clinical Nutrition
2024-10 | Journal article | Author
Part of ISSN: 0002-9165
Contributors: Yingxin Celia Jiang; Kaitao Lai; Roslyn Patricia Muirhead; Long Hoa Chung; Yu Huang; Elizaveta James; Xin Tracy Liu; Julian Wu; Fiona S Atkinson; Shuang Yan et al.
Source: Self-asserted source
Yanfei Qi

Development and applications of lipid hydrophilic headgroups for nucleic acid therapy

Biotechnology Advances
2024-09 | Journal article
Part of ISSN: 0734-9750
Contributors: Wanting Ma; Xingxing Fu; Tianyi Zhao; Yanfei Qi; Shubiao Zhang; Yinan Zhao
Source: Self-asserted source
Yanfei Qi

Independent risk factors of left ventricular hypertrophy in non-diabetic individuals in Sierra Leone - a cross-sectional study

Lipids in Health and Disease
2024-08-21 | Journal article
Part of ISSN: 1476-511X
Contributors: Yuanxin Xu; Yingxin Celia Jiang; Lihua Xu; Weiyu Zhou; Zhiying Zhang; Yanfei Qi; Hongyu Kuang; Shuang Yan
Source: Self-asserted source
Yanfei Qi

Application of machine learning for high-throughput tumor marker screening

Life Sciences
2024-07 | Journal article
Part of ISSN: 0024-3205
Contributors: Xingxing Fu; Wanting Ma; Qi Zuo; Yanfei Qi; Shubiao Zhang; Yinan Zhao
Source: Self-asserted source
Yanfei Qi

Sucrose ester embedded lipid carrier for DNA delivery

European Journal of Pharmaceutics and Biopharmaceutics
2024-05 | Journal article
Part of ISSN: 0939-6411
Contributors: Yinan Zhao; Wanting Ma; Kexin Tian; Zhe Wang; Xingxing Fu; Qi Zuo; Yanfei Qi; Shubiao Zhang
Source: Self-asserted source
Yanfei Qi

ReTimeML: a retention time predictor that supports the LC–MS/MS analysis of sphingolipids

Scientific Reports
2024-02-22 | Journal article
Part of ISSN: 2045-2322
Contributors: Michael Allwright; Boris Guennewig; Anna E. Hoffmann; Cathrin Rohleder; Beverly Jieu; Long H. Chung; Yingxin C. Jiang; Bruno F. Lemos Wimmer; Yanfei Qi; Anthony S. Don et al.
Source: Self-asserted source
Yanfei Qi

Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis

Journal of Translational Medicine
2024-01-10 | Journal article | Author
Part of ISSN: 1479-5876
Contributors: Xin Tracy Liu; Yu Huang; Da Liu; Yingxin Celia Jiang; Min Zhao; Long Hoa Chung; Xingxing Daisy Han; Yinan Zhao; Jinbiao Chen; Paul Coleman et al.
Source: Self-asserted source
Yanfei Qi

Endothelial cell senescence — understanding aging and disease

Current Opinion in Physiology
2023-10 | Journal article
Part of ISSN: 2468-8673
Contributors: Paul R Coleman; Ka K Ting; Yanfei Qi; Mathew A Vadas; Jennifer R Gamble
Source: Self-asserted source
Yanfei Qi

Development and applications of mRNA treatment based on lipid nanoparticles

Biotechnology Advances
2023-03 | Journal article
Part of ISSN: 0734-9750
Contributors: Zhe Wang; Wanting Ma; Xingxing Fu; Yanfei Qi; Yinan Zhao; Shubiao Zhang
Source: Self-asserted source
Yanfei Qi

Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.

Oncogenesis
2022-11-04 | Journal article | Author
Contributors: Liu XT; Long Hoa Chung; Da Liu; Jinbiao Chen; Huang Y; Teo JD; Han XD; Zhao Y; Guan FHX; Tran C et al.
Source: Self-asserted source
Yanfei Qi

A nanotherapy responsive to the inflammatory microenvironment for the dual-targeted treatment of atherosclerosis.

Nanomedicine : nanotechnology, biology, and medicine
2022-04-04 | Journal article
Contributors: Yanfei Qi; Li G; Xu F; Yang B; Lu X; Li X; Qi Y; Teng L; Li Y; Sun F et al.
Source: Self-asserted source
Yanfei Qi

Mechanisms and Active Compounds Polysaccharides and Bibenzyls of Medicinal Dendrobiums for Diabetes Management

Frontiers in Nutrition
2022-01-28 | Journal article
Part of ISSN: 2296-861X
Source: Self-asserted source
Yanfei Qi

Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer

International Journal of Molecular Sciences
2021-12-07 | Journal article
Contributors: Long Hoa Chung; Da Liu; Xin Tracy Liu; Yanfei Qi
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling

Biochemical Pharmacology
2021-10 | Journal article
Contributors: Yassir al-Zubaidi; Yongjuan Chen; Md. Khalilur Rahman; Bala Umashankar; Hassan Choucair; Kirsi Bourget; Long Chung; Yanfei Qi; Paul K. Witting; Robin L. Anderson et al.
Source: check_circle
Crossref

Folate receptor-targeting semiconducting polymer dots hybrid mesoporous silica nanoparticles against rheumatoid arthritis through synergistic photothermal therapy, photodynamic therapy, and chemotherapy

International Journal of Pharmaceutics
2021-09 | Journal article
Part of ISSN: 0378-5173
Source: Self-asserted source
Yanfei Qi

Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers

Frontiers in Oncology
2021-09-17 | Journal article
Part of ISSN: 2234-943X
Source: Self-asserted source
Yanfei Qi

The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking

Cancers
2021-04-06 | Journal article
Contributors: Yang Zhao; Ka Ka Ting; Paul Coleman; Yanfei Qi; Jinbiao Chen; Mathew Vadas; Jennifer Gamble
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

RNF219/α‐Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications

Advanced Science
2021-02 | Journal article
Part of ISSN: 2198-3844
Part of ISSN: 2198-3844
Source: Self-asserted source
Yanfei Qi

Role of Sphingosine Kinase in Type 2 Diabetes Mellitus.

Frontiers in endocrinology
2021-01-01 | Journal article
Source: Self-asserted source
Yanfei Qi

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2.

Proceedings of the National Academy of Sciences of the United States of America
2020-09-11 | Journal article
Source: Self-asserted source
Yanfei Qi

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids.

Metabolites
2020-06-08 | Journal article
Source: Self-asserted source
Yanfei Qi
grade
Preferred source (of 2)‎

Lipodystrophy - A Rare Condition with Serious Metabolic Abnormalities

Rare Diseases
2020-03-25 | Book chapter
Part of ISBN: 9781838800239
Part of ISBN: 9781838800246
Source: Self-asserted source
Yanfei Qi

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P <inf>2</inf> )

Molecular Cell
2019 | Journal article
EID:

2-s2.0-85061000560

Contributors: Wang, H.; Ma, Q.; Qi, Y.; Dong, J.; Du, X.; Rae, J.; Wang, J.; Wu, W.-F.; Brown, A.J.; Parton, R.G. et al.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.

Journal of neurochemistry
2019-11-19 | Journal article
Source: Self-asserted source
Yanfei Qi
grade
Preferred source (of 2)‎

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice

Oncotarget
2018 | Journal article
EID:

2-s2.0-85044214351

Contributors: Chen, J.; Qi, Y.; Zhao, Y.; Kaczorowski, D.; Couttas, T.A.; Coleman, P.R.; Don, A.S.; Bertolino, P.; Gamble, J.R.; Vadas, M.A. et al.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling

Journal of Biological Chemistry
2018 | Journal article
EID:

2-s2.0-85043695373

Contributors: Du, X.; Zadoorian, A.; Lukmantara, I.E.; Qi, Y.; Brown, A.J.; Yang, H.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
2017 | Journal article
EID:

2-s2.0-85021829700

Contributors: Qi, Y.; Sun, L.; Yang, H.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
2016 | Journal article
EID:

2-s2.0-84960417624

Contributors: Wang, M.; Gao, M.; Liao, J.; Qi, Y.; Du, X.; Wang, Y.; Li, L.; Liu, G.; Yang, H.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development

Journal of Lipid Research
2016 | Journal article
EID:

2-s2.0-84971328622

Contributors: Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
2016 | Journal article
EID:

2-s2.0-84949501358

Contributors: Chen, J.; Wang, W.; Qi, Y.; Kaczorowski, D.; McCaughan, G.W.; Gamble, J.R.; Don, A.S.; Gao, X.; Vadas, M.A.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

Cell Reports
2016 | Journal article
EID:

2-s2.0-84995610457

Contributors: Pagac, M.; Cooper, D.E.; Qi, Y.; Lukmantara, I.E.; Mak, H.Y.; Wu, Z.; Tian, Y.; Liu, Z.; Lei, M.; Du, X. et al.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

The expression of SEIPIN in the mouse central nervous system

Brain Structure and Function
2016 | Journal article
EID:

2-s2.0-84948968581

Contributors: Liu, X.; Xie, B.; Qi, Y.; Du, X.; Wang, S.; Zhang, Y.; Paxinos, G.; Yang, H.; Liang, H.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

Biochemical Journal
2015 | Journal article
EID:

2-s2.0-84943231382

Contributors: Du, X.; Zhang, Y.; Jo, S.R.; Liu, X.; Qi, Y.; Osborne, B.; Byrne, F.L.; Smith, G.C.; Turner, N.; Hoehn, K.L. et al.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Sphingosine kinase 1 protects hepatocytes from lipotoxicity via down-regulation of IRE1α protein expression

Journal of Biological Chemistry
2015 | Journal article
EID:

2-s2.0-84942895141

Contributors: Qi, Y.; Wang, W.; Chen, J.; Dai, L.; Kaczorowski, D.; Gao, X.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action

Molecular Endocrinology
2014 | Journal article
EID:

2-s2.0-84892522591

Contributors: Dai, L.; Qi, Y.; Chen, J.; Kaczorowski, D.; Di, W.; Wang, W.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Cellular inhibitor of apoptosis protein-1 and survival of beta cells undergoing endoplasmic reticulum stress.

Vitamins and hormones
2014-01-01 | Journal article
Source: Self-asserted source
Yanfei Qi
grade
Preferred source (of 2)‎

Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: Role of autophagy

International Journal of Oncology
2013 | Journal article
EID:

2-s2.0-84876567112

Contributors: Zhang, N.; Dai, L.; Qi, Y.; Di, W.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice

FASEB Journal
2013 | Journal article
EID:

2-s2.0-84885160207

Contributors: Qi, Y.; Chen, J.; Lay, A.; Don, A.; Vadas, M.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: Promoting ubiquitination and degradation of C/EBP homologous protein (CHOP)

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84866395126

Contributors: Qi, Y.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: Suppression of angiotensin II/AT1 signaling

Evidence-based Complementary and Alternative Medicine
2011 | Journal article
EID:

2-s2.0-80052655766

Contributors: Li, Y.; He, L.; Qi, Y.; Rong, X.; Jiang, J.; Yang, Q.; Yamahara, J.; Murray, M.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy

Autophagy
2010 | Journal article
EID:

2-s2.0-78649305851

Contributors: Zhang, N.; Qi, Y.; Wadham, C.; Wang, L.; Warren, A.; Di, W.; Xia, P.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats

Diabetes/Metabolism Research and Reviews
2008 | Journal article
EID:

2-s2.0-53349121312

Contributors: Li, Y.; Qi, Y.; Kim, M.S.; Xu, K.Z.-Y.; Huang, T.H.-W.; Rong, X.; Murray, M.; Yamahara, J.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Pomegranate flower: A unique traditional antidiabetic medicine with dual PPAR-α/-γ activator properties

Diabetes, Obesity and Metabolism
2008 | Journal article
EID:

2-s2.0-37349131707

Contributors: Li, Y.; Qi, Y.; Huang, T.H.W.; Yamahara, J.; Roufogalis, B.D.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: Inhibition of cardiac expression of angiotensin II type 1 receptor

Diabetes, Obesity and Metabolism
2008 | Journal article
EID:

2-s2.0-45449106631

Contributors: Huang, T.H.; He, L.; Qin, Q.; Yang, Q.; Peng, G.; Harada, M.; Qi, Y.; Yamahara, J.; Roufogalis, B.D.; Li, Y.
Source: Self-asserted source
Yanfei Qi via Scopus - Elsevier

Peer review (5 reviews for 4 publications/grants)

Review activity for CMGH. (2)
Review activity for EBioMedicine. (1)
Review activity for Immunity. (1)
Review activity for Obesity research & clinical practice. (1)