Xianmin Zhu (0000-0003-1405-9700)

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In multicellular organisms, all the components at different levels, such as molecules, cells, tissues and organs, collaborate in one united pattern during each physiological or pathological process, while they have their own identity and function, aka “heterogeneity”. My research mainly focuses on how to interpret such heterogeneity by integrated biological technologies which involve single-cell omics and transgenic animal models.

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Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in <i>Leptin</i>-Deficient Rats

Cells

2025-01 | Journal article | Author

DOI: 10.3390/cells14020096

Contributors: xin xiaoming; Yaohua Ni; Jing Wang; Fenglin Wu; Meichen Liu; Lingjuan Wu; Jiaxing Dai; Chenglin Wu; Xiaolei Song; Wang Zhang et al.

Xianmin Zhu

https://orcid.org/0000-0003-1405-9700

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Works (20)

Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in <i>Leptin</i>-Deficient Rats

Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing

Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.

Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses.

A novel immunodeficient rat model supports human lung cancer xenografts.

Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor.

Integrated transcriptome analysis of human iPS cells derived from a fragile X syndrome patient during neuronal differentiation.

Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons.

The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.

Recent advances in preimplantation genetic diagnosis and screening.

Simultaneous profiling of transcriptome and DNA methylome from a single cell.

Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis.

Cav1.2 of L-type Calcium Channel Is a Key Factor for the Differentiation of Dental Pulp Stem Cells.

Integrated analysis of DNA methylation and RNA transcriptome during in vitro differentiation of human pluripotent stem cells into retinal pigment epithelial cells.

Machine learning classification of cell-specific cardiac enhancers uncovers developmental subnetworks regulating progenitor cell division and cell fate specification.

Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos.

Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors.

Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism.

The cloning and characterization of the histone acetyltransferase human homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 is essential for multicellular development.

Peer review (6 reviews for 5 publications/grants)