Personal information

Keywords

PBPK, Ophthalmic, Otic, Formulation, Locally acting, DDI, Renal impairment, Pharmacogenetics

Activities

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Employment (2)

United States Food and Drug Administration: Silver Spring, Maryland, US

2015-12-21 to present | Senior Pharmacokineticist
Employment
Source: Self-asserted source
Ming-Liang Tan

Georgetown University: Washington D.C., District of Columbia, US

2008-08-28 to 2015-12-20 | Senior Scientist
Employment
Source: Self-asserted source
Ming-Liang Tan

Works (14)

Regulatory and Industry Perspective on the Model Master File Framework for Locally Acting Drug Products

Pharmaceutical Research
2025-02-26 | Journal article
DOI: 10.1007/s11095-025-03823-5
Part of ISSN: 0724-8741
Part of ISSN: 1573-904X
Contributors: Ross L. Walenga; Khondoker Alam; James F. Clarke; Jan De Backer; Markus Fridén; Abdullah Hamadeh; Jay Mowli; Sujatha Sonti; Jessica Spires; Ming-Liang Tan et al.
Source: Self-asserted source
Ming-Liang Tan

Clinical Ocular Exposure Extrapolation for a Complex Ophthalmic Suspension Using Physiologically Based Pharmacokinetic Modeling and Simulation

Pharmaceutics
2024-07-09 | Journal article
DOI: 10.3390/pharmaceutics16070914
Part of ISSN: 1999-4923
Contributors: Maxime Le Merdy; Jessica Spires; Ming-Liang Tan; Liang Zhao; Viera Lukacova
Source: Self-asserted source
Ming-Liang Tan

Use of physiologically‐based pharmacokinetic modeling to understand the effect of omeprazole administration on the pharmacokinetics of oral extended‐release nifedipine

CPT: Pharmacometrics & Systems Pharmacology
2024-02 | Journal article
DOI: 10.1002/psp4.13075
Contributors: Ming‐Liang Tan; Zongming Gao; Andrew Babiskin; Myong‐Jin Kim; Lanyan Fang; Lei Zhang; Liang Zhao
Source: check_circle
Crossref

Effect of Omeprazole Administration on the Pharmacokinetics of Oral Extended‐Release Nifedipine in Healthy Subjects

Clinical Pharmacology & Therapeutics
2023-11 | Journal article
DOI: 10.1002/cpt.3043
Contributors: Liang Zhao; Dajun Sun; Ming‐Liang Tan; Mingjiang Xu; Minori Kinjo; Kairui Feng; Hezhen Wang; Robert Lionberger
Source: check_circle
Crossref

Topical pharmacokinetics of brinzolamide suspensions in rabbits and variability analysis for sample size and design considerations

International Journal of Pharmaceutics
2023-07 | Journal article | Author
DOI: 10.1016/j.ijpharm.2023.123183
Part of ISSN: 0378-5173
Contributors: Vatsala Naageshwaran; Hélène Bigonne; Glenwood Gum; Spundana Malla; Charity del Sol; Charles Bon; Xiaoming Xu; Anh Vo; William Smith; Andre O'Reilly Beringhs et al.
Source: Self-asserted source
Ming-Liang Tan

Mechanistic modeling of ophthalmic, nasal, injectable, and implant generic drug products: A workshop summary report

CPT: Pharmacometrics & Systems Pharmacology
2023-05 | Journal article
DOI: 10.1002/psp4.12952
Contributors: Ming‐Liang Tan; Sajeev Chandran; Rebeka Jereb; Khondoker Alam; Robert Bies; Darby Kozak; Ross Walenga; Maxime Le Merdy; Andrew Babiskin
Source: check_circle
Crossref

Computational Model of In Vivo Corneal Pharmacokinetics and Pharmacodynamics of Topically Administered Ophthalmic Drug Products

Pharmaceutical Research
2023-03-23 | Journal article
DOI: 10.1007/s11095-023-03480-6
Part of ISSN: 0724-8741
Part of ISSN: 1573-904X
Contributors: Carrie German; Zhijian Chen; Andrzej Przekwas; Ross Walenga; Andrew Babiskin; Liang Zhao; Jianghong Fan; Ming-Liang Tan
Source: Self-asserted source
Ming-Liang Tan

Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches: A Workshop Overview

CPT: Pharmacometrics & Systems Pharmacology
2023-01-11 | Journal article | Author
DOI: 10.1002/psp4.12920
Part of ISSN: 2163-8306
Part of ISSN: 2163-8306
Contributors: Andrew Babiskin; Fang Wu; Youssef Mousa; Ming-Liang Tan; Eleftheria Tsakalozou; Ross L. Walenga; Miyoung Yoon; Sam G. Raney; James Polli; Anna Schwendeman et al.
Source: Self-asserted source
Ming-Liang Tan
grade
Preferred source (of 2)‎

Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation

Pharmaceutical Research
2022-09-23 | Journal article
DOI: 10.1007/s11095-022-03390-z
Part of ISSN: 0724-8741
Part of ISSN: 1573-904X
Contributors: Maxime Le Merdy; Farah AlQaraghuli; Ming-Liang Tan; Ross Walenga; Andrew Babiskin; Liang Zhao; Viera Lukacova
Source: Self-asserted source
Ming-Liang Tan

Physiologically Based Pharmacokinetic Modeling Approach to Identify the Drug–Drug Interaction Mechanism of Nifedipine and a Proton Pump Inhibitor, Omeprazole

European Journal of Drug Metabolism and Pharmacokinetics
2021-01 | Journal article
DOI: 10.1007/s13318-020-00649-x
Part of ISSN: 0378-7966
Part of ISSN: 2107-0180
Contributors: Maxime Le Merdy; Ming-Liang Tan; Dajun Sun; Zhanglin Ni; Sue-Chih Lee; Andrew Babiskin; Liang Zhao
Source: Self-asserted source
Ming-Liang Tan

Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations

Pharmaceutical Research
2020-12 | Journal article
DOI: 10.1007/s11095-020-02965-y
Part of ISSN: 0724-8741
Part of ISSN: 1573-904X
Contributors: Maxime Le Merdy; Jessica Spires; Viera Lukacova; Ming-Liang Tan; Andrew Babiskin; Xiaoming Xu; Liang Zhao; Michael B. Bolger
Source: Self-asserted source
Ming-Liang Tan

Physiologically Based Pharmacokinetic Model to Support Ophthalmic Suspension Product Development

The AAPS Journal
2020-03 | Journal article
DOI: 10.1208/s12248-019-0408-9
Part of ISSN: 1550-7416
Contributors: Maxime Le Merdy; Ming-Liang Tan; Andrew Babiskin; Liang Zhao
Source: Self-asserted source
Ming-Liang Tan

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Clinical Pharmacology & Therapeutics
2019-03 | Journal article
DOI: 10.1002/cpt.1205
Part of ISSN: 0009-9236
Part of ISSN: 1532-6535
Contributors: Ming‐Liang Tan; Ping Zhao; Lei Zhang; Yunn‐Fang Ho; Manthena V.S. Varma; Sibylle Neuhoff; Thomas D. Nolin; Aleksandra Galetin; Shiew‐Mei Huang
Source: Self-asserted source
Ming-Liang Tan

Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP

Clinical Pharmacology & Therapeutics
2018-05 | Journal article
DOI: 10.1002/cpt.807
Part of ISSN: 0009-9236
Contributors: Ming-Liang Tan; Kenta Yoshida; Ping Zhao; Lei Zhang; Thomas D. Nolin; Micheline Piquette-Miller; Aleksandra Galetin; Shiew-Mei Huang
Source: Self-asserted source
Ming-Liang Tan
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