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Biography

Associate Professor in Microbiology (SD BIO/19) at the University of Catania.
LabMMAR via Santa Sofia 97, 95123, tel: 095-2504732
Email: m.santagati@unict.it

Scientific activity
The main activity of her research is aimed at studying Gram-positive bacteria, in particular: i) study of streptococcal bacteriocin-like inhibitory activity against potential pathogens: bacteriocin production by deferred antagonism test and characterization of their genetic elements and oral microbiome; ii) screening and use of microorganisms in the prevention of infections of the upper respiratory tract. In particular, research is directed to the use of a strain of S.salivarius 24SMBc for use in the prevention of acute otitis chronic pediatric. In particular, the study including the characterization of strains producing bacteriocins by inhibition assays evaluated with the deferred antagonism test, adhesion test cell lines, characterization of the genetic elements that carry genes involved in the production of bacteriocins;iii) molecular mechanisms responsible for antibiotic resistance in Gram-positive bacteria; iv) characterization of genetic elements such as transposons, plasmids carrying resistance determinants and their mobility by conjugation and transformation; iv) molecular identification of pathogens (S. pyogenes and S.pneumoniae) directly from biological samples by use of platforms for Real Time–PCR and identification of virulence genes and expression studies using real-time PCR; v) Within the project PON collaborates with c-Lab, Materials and Microsystems Laboratory (Polytechnical Collage of Turin) and FBK-Bruno Kessler Foundation, Center for Materials and Microsystems Biofunctional Surfaces and Interfaces (Trento) for the development of microfluidic modules (LOC) for the implementation of PCR and real-time PCR to be used for automated molecular diagnostics based on Lab-on-chip. She characterized the genetic elements carrying mef(A) responsible for macrolide resistance, Tn1207.1, Tn1207.3 in S.pneumoniae and S.pyogenes, mega element in S.salivarius and phage phi1207.3 in S.pyogenes (GenBank accession no AF227520; AF227521; AY657002; FJ236311, AY657002).

Academic and institutional roles
Member of the Register of expert auditors MIUR - Evaluation of research projects and research products (2012 / in progress).
Member of the Academic Board of the XXIX cycle PhD in Translational Biomedicine (2014 / in progress)
Member Teachers Graduate College: in "Biology, Human genetics and bioinformatics: cellular and molecular basis of phenotype (200/2014)
Reviewer: Journal of Antimicrobial Chemotherapy, Annals of Clinical Microbiology and Antimicrobials (ACMA) and Applied and Environmental Microbiology, International Journal Antimicrobiol Angents, Jare (Journal of Applied Research)
Member of the following Scientific Societies: Italian Society of General Microbiology and Microbial Biotechnology (SIMGBM), Italian Society of Microbiology (SIM); European Society of Clinical Microbiology and Infectious Diseases (ESCMID)

Activities

Employment (1)

University of Catania: Catania, IT

2000 to present | researcher in Microbiology (Biomedical and Biotechnological sciences)
Employment
Source: Self-asserted source
Maria Carmela SANTAGATI

Education and qualifications (3)

Università di Catania: Catania, IT

2000 | Dottorato in Discipline microbiologiche (Dipartimento di Scienze Biomediche e Biotecnologiche)
Education
Source: Self-asserted source
Maria Carmela SANTAGATI

Università di Catania: Catania, IT

1994 | Specializzazione in Microbiologia e Virologia (Dipartimento di Scienze Biomediche e Biotecnologiche)
Education
Source: Self-asserted source
Maria Carmela SANTAGATI

Università di Catania: Catania, IT

1990 | Laurea in Scienze Biologiche (Dipartimento di Scienze Biomediche e Biotecnologiche)
Education
Source: Self-asserted source
Maria Carmela SANTAGATI

Works (49)

Differential Nasal Recolonization and Microbial Profiles in Chronic Rhinosinusitis With Nasal Polyps Patients After Endoscopic Sinus Surgery or Dupilumab Treatment: A Prospective Observational Study

Clinical Otolaryngology
2024-10-23 | Journal article
Contributors: Antonino Maniaci; Gaia Vertillo Aluisio; Stefania Stefani; Salvatore Cocuzza; Jerome Rene Lechien; Thomas Radulesco; Justin Michel; Maria Santagati; Ignazio La Mantia
Source: check_circle
Crossref

Biofilm and bacterial membrane vesicles: recent advances

Expert Opinion on Therapeutic Patents
2024-06-02 | Journal article
Contributors: Valentina Puca; Beatrice Marinacci; Benedetta Pellegrini; Floriana Campanile; Maria Santagati; Rossella Grande
Source: check_circle
Crossref

Interactions of Gram-Positive Bacterial Membrane Vesicles and Hosts: Updates and Future Directions

International Journal of Molecular Sciences
2024-03-01 | Journal article
Contributors: Giuseppe Sangiorgio; Emanuele Nicitra; Dalida Bivona; Carmelo Bonomo; Paolo Bonacci; Maria Santagati; Nicolò Musso; Dafne Bongiorno; Stefania Stefani
Source: check_circle
Crossref
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Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant

Journal of Translational Medicine
2023-03-14 | Journal article
Part of ISSN: 1479-5876
Contributors: Rossella Salemi; Silvia Vivarelli; Daria Ricci; Marina Scillato; Maria Santagati; Giuseppe Gattuso; Luca Falzone; Massimo Libra
Source: Self-asserted source
Maria Carmela SANTAGATI

Streptococcus salivarius 24SMBc Genome Analysis Reveals New Biosynthetic Gene Clusters Involved in Antimicrobial Effects on Streptococcus pneumoniae and Streptococcus pyogenes

Microorganisms
2022-10-16 | Journal article
Contributors: Gaia Vertillo Aluisio; Ambra Spitale; Luca Bonifacio; Grete Francesca Privitera; Aldo Stivala; Stefania Stefani; Maria Santagati
Source: check_circle
Crossref
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Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research

Internal and Emergency Medicine
2022-04 | Journal article
Source: Self-asserted source
Maria Carmela SANTAGATI

Microbiome differences in periodontal, peri-implant, and healthy sites: a cross-sectional pilot study

Clinical Oral Investigations
2022-03 | Journal article
Contributors: Giovanni Barbagallo; Maria Santagati; Alaa Guni; Paolo Torrisi; Ambra Spitale; Stefania Stefani; Sebastiano Ferlito; Luigi Nibali
Source: check_circle
Crossref

Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes

Harm Reduction Journal
2021-12 | Journal article
Part of ISSN: 1477-7517
Source: Self-asserted source
Maria Carmela SANTAGATI
grade
Preferred source (of 2)‎

Single‐nucleotide polymorphism in chronic rhinosinusitis: A systematic review

Clinical Otolaryngology
2021-11-07 | Journal article
Part of ISSN: 1749-4478
Part of ISSN: 1749-4486
Source: Self-asserted source
Maria Carmela SANTAGATI

Antimicrobial properties of Lactobacillus cell‐free supernatants against multidrug‐resistant urogenital pathogens

MicrobiologyOpen
2021-04 | Journal article
Contributors: Marina Scillato; Ambra Spitale; Gino Mongelli; Grete Francesca Privitera; Katia Mangano; Antonio Cianci; Stefania Stefani; Maria Santagati
Source: check_circle
Crossref

Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children

International Journal of Molecular Sciences
2020-08-27 | Journal article
Contributors: Marco Ragusa; Maria Santagati; Federica Mirabella; Giovanni Lauretta; Matilde Cirnigliaro; Duilia Brex; Cristina Barbagallo; Carla Noemi Domini; Mariangela Gulisano; Rita Barone et al.
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Crossref
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Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a oral spray for children with recurrent streptococcal pharyngotonsillitis: a randomized placebo-controlled clinical study.

Eur Arch Otorhinolaryngol
2019-02-15 | Journal article
Source: Self-asserted source
Maria Carmela SANTAGATI

Gut Microbiota and Cancer: From Pathogenesis to Therapy

Cancers
2019-01 | Journal article | Author
Contributors: Silvia Vivarelli; Rossella Salemi; Saverio Candido; Luca Falzone; Maria Carmela SANTAGATI; STEFANIA STEFANI; Francesco Torino; Giuseppe Luigi Banna; Giuseppe Tonini; Massimo Libra
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Genetic organization of Streptococcus salivarius 24SMBc blp-like bacteriocin locus

Frontiers in bioscience (Scholar edition)
2018 | Journal article
EID:

2-s2.0-85038017863

Contributors: Santagati, M.; Scillato, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily.

2018-07-31 | Journal article
Source: Self-asserted source
Maria Carmela SANTAGATI
grade
Preferred source (of 2)‎

Immunomodulatory effects of bifidobacterium longum W11 produced exopolysaccharide on cytokine production

Current Pharmaceutical Biotechnology
2017 | Journal article
EID:

2-s2.0-85042292129

Contributors: Inturri, R.; Mangano, K.; Santagati, M.; Intrieri, M.; di Marco, R.; Blandino, G.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Lactobacillus rhamnosus GG: An overview to explore the rationale of its use in cancer

Frontiers in Pharmacology
2017 | Journal article
EID:

2-s2.0-85028944723

Contributors: Banna, G.L.; Torino, F.; Marletta, F.; Santagati, M.; Salemi, R.; Cannarozzo, E.; Falzone, L.; Ferraù, F.; Libra, M.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Colonization, safety, and tolerability study of the Streptococcus salivarius 24SMBc nasal spray for its application in upper respiratory tract infections

European Journal of Clinical Microbiology and Infectious Diseases
2015 | Journal article
EID:

2-s2.0-84941415769

Contributors: Santagati, M.; Scillato, M.; Muscaridola, N.; Metoldo, V.; La Mantia, I.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Insights and clinical perspectives of daptomycin resistance in Staphylococcus aureus: A review of the available evidence

International Journal of Antimicrobial Agents
2015 | Journal article
EID:

2-s2.0-84940453231

Contributors: Stefani, S.; Campanile, F.; Santagati, M.; Mezzatesta, M.L.; Cafiso, V.; Pacini, G.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children

European Journal of Clinical Microbiology and Infectious Diseases
2015 | Journal article
EID:

2-s2.0-84947867289

Contributors: Marchisio, P.; Santagati, M.; Scillato, M.; Baggi, E.; Fattizzo, M.; Rosazza, C.; Stefani, S.; Esposito, S.; Principi, N.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes

Frontiers in Microbiology
2014 | Journal article
EID:

2-s2.0-84920662944

Contributors: Iannelli, F.; Santagati, M.; Santoro, F.; Oggioni, M.R.; Stefani, S.; Pozzi, G.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Rapidly fatal hemorrhagic pneumonia and group A streptococcus serotype M1

Emerging Infectious Diseases
2014 | Journal article
EID:

2-s2.0-84890911540

Contributors: Santagati, M.; Spanu, T.; Scillato, M.; Santangelo, R.; Cavallaro, F.; Arena, V.; Castiglione, G.; Falcone, M.; Venditti, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Emergence of an extensively drug-resistant armA- and KPC-2-producing st101 klebsiella pneumoniae clone in Italy

Journal of Antimicrobial Chemotherapy
2013 | Journal article
EID:

2-s2.0-84880708682

Contributors: Mezzatesta, M.L.; Gona, F.; Caio, C.; Adembri, C.; Dell'utri, P.; Santagati, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Bacteriocin-producing oral streptococci and inhibition of respiratory pathogens

FEMS Immunology and Medical Microbiology
2012 | Journal article
EID:

2-s2.0-84860533825

Contributors: Santagati, M.; Scillato, M.; Patanè, F.; Aiello, C.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Genomic diversification of enterococci in hosts: The role of the mobilome

Frontiers in Microbiology
2012 | Journal article
EID:

2-s2.0-84869096938

Contributors: Santagati, M.; Campanile, F.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Polyclonal diffusion of beta-lactamase-producing Enterococcus faecium

Journal of Clinical Microbiology
2012 | Journal article
EID:

2-s2.0-84555188040

Contributors: Sarti, M.; Campanile, F.; Sabia, C.; Santagati, M.; Gargiulo, R.; Stefani, A.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in Italy

Journal of Antimicrobial Chemotherapy
2010 | Journal article
EID:

2-s2.0-77957878162

Contributors: Bongiorno, D.; Campanile, F.; Mongelli, G.; Baldi, M.T.; Provenzani, R.; Reali, S.; Lo Russo, C.; Santagati, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Methicillin resistance and vancomycin heteroresistance in Staphylococcus aureus in cystic fibrosis patients

European Journal of Clinical Microbiology and Infectious Diseases
2010 | Journal article
EID:

2-s2.0-77957316698

Contributors: Cafiso, V.; Bertuccio, T.; Spina, D.; Campanile, F.; Bongiorno, D.; Santagati, M.; Sciacca, A.; Sciuto, C.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Conjugal mobilization of the mega element carrying mef(E) from Streptococcus salivarius to Streptococcus pneumoniae

FEMS Microbiology Letters
2009 | Journal article
EID:

2-s2.0-57449083998

Contributors: Santagati, M.; Lupo, A.; Scillato, M.; Di Martino, A.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

The apoptotic machinery as a biological complex system: Analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

BMC Medical Genomics
2009 | Journal article
EID:

2-s2.0-66249089843

Contributors: Di Pietro, C.; Ragusa, M.; Barbagallo, D.; Duro, L.R.; Guglielmino, M.R.; Majorana, A.; Angelica, R.; Scalia, M.; Statello, L.; Salito, L. et al.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Evaluation of the in vitro activity of tigecycline against multiresistant Gram-positive cocci containing tetracycline resistance determinants

International Journal of Antimicrobial Agents
2008 | Journal article
EID:

2-s2.0-38949209070

Contributors: Borbone, S.; Lupo, A.; Mezzatesta, M.L.; Campanile, F.; Santagati, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

agr-Genotyping and transcriptional analysis of biofilm-producing Staphylococcus aureus

FEMS Immunology and Medical Microbiology
2007 | Journal article
EID:

2-s2.0-34548579184

Contributors: Cafiso, V.; Bertuccio, T.; Santagati, M.; Demelio, V.; Spina, D.; Nicoletti, G.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Bactericidal activity of ertapenem against major intra-abdominal pathogens

International Journal of Antimicrobial Agents
2006 | Journal article
EID:

2-s2.0-33750327399

Contributors: Borbone, S.; Cascone, C.; Santagati, M.; Mezzatesta, M.L.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Activity of telithromycin against multi-drug resistant Streptococcus pneumoniae and molecular characterization of macrolide and tetracycline resistance determinants

Journal of Chemotherapy
2005 | Journal article
EID:

2-s2.0-28144445001

Contributors: Cascone, C.; Mezzatesta, M.L.; Santagati, M.; Cafiso, V.; Nicoletti, G.; Stefani, S.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Clonal types and multidrug resistance patterns of methicillin-resistant Staphylococcus aureus (MRSA) recovered in Italy during the 1990s

Microbial Drug Resistance
2004 | Journal article
EID:

2-s2.0-3042849986

Contributors: Mato, R.; Campanile, F.; Stefani, S.; Crisóstomo, M.I.; Santagati, M.; Santos Sanches, I.; De Lencastre, H.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Genetic elements carrying macrolide efflux genes in Streptococci

Current Drug Targets - Infectious Disorders
2004 | Journal article
EID:

2-s2.0-4544384074

Contributors: Pozzi, G.; Iannelli, F.; Oggioni, M.R.; Santagati, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Presence of the ica operon in clinical isolates of Staphylococcus epidermidis and its role in biofilm production

Clinical Microbiology and Infection
2004 | Journal article
EID:

2-s2.0-19944368738

Contributors: Cafiso, V.; Bertuccio, T.; Santagati, M.; Campanile, F.; Amicosante, G.; Perilli, M.G.; Selan, L.; Artini, M.; Nicoletti, G.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Conservation of the mosaic structure of the four internal transcribed spacers and localisation of the rrn operons on the Streptococcus pneumoniae genome

FEMS Microbiology Letters
2003 | Journal article
EID:

2-s2.0-0037757535

Contributors: Gianninò, V.; Santagati, M.; Guardo, G.; Cascone, C.; Rappazzo, G.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

The novel conjugative transposon Tn1207.3 carries the macrolide efflux gene mef(A) in Streptococcus pyogenes

Microbial Drug Resistance
2003 | Journal article
EID:

2-s2.0-0041854368

Contributors: Santagati, M.; Iannelli, F.; Cascone, C.; Campanile, F.; Oggioni, M.R.; Stefani, S.; Pozzi, G.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae

Journal of Clinical Microbiology
2002 | Journal article
EID:

2-s2.0-0036195264

Contributors: Del Grosso, M.; Iannelli, F.; Messina, C.; Santagati, M.; Petrosillo, N.; Stefani, S.; Pozzi, G.; Pantosti, A.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Macrolide-resistance genes in clinical isolates of Streptococcus pyogenes

Microbial Drug Resistance
2002 | Journal article
EID:

2-s2.0-0035988091

Contributors: Cascone, C.; Santagati, M.; Noviello, S.; Iannelli, F.; Esposito, S.; Pozzi, G.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Correlation between methicillin-resistance and resistance to fluoroquinolones in Staphylococcus aureus and Staphylococcus epidermidis | Correlazione della resistenza alia meticillina e ai fluorochinoloni in Staphylococcus aureus e Staphylococcus epidermidis

Infezioni in Medicina
2001 | Journal article
EID:

2-s2.0-0034947834

Contributors: Cafiso, V.; Campanile, F.; Borbone, S.; Caia, A.; Cascone, C.; Santagati, M.; Stefania, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

In vitro activity of levofloxacin against coagulase-positive and -negative staphylococci

Drugs under Experimental and Clinical Research
2001 | Journal article
EID:

2-s2.0-0034962642

Contributors: Cafiso, V.; Messina, C.; Santagati, M.; Campanile, F.; Bonfiglio, G.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Rapid method for detection of gyrA and grlA mutations in unrelated strains of Staphylococci susceptible and resistant to levofloxacin

New Microbiologica
2001 | Journal article
EID:

2-s2.0-0035491764

Contributors: Messina, C.; Cafiso, V.; Campanile, F.; Santagati, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

rrn operons in Haemophilus parainfluenzae and mosaicism of conserved and species-specific sequences in the 16S-23S rDNA long spacer

Research in Microbiology
2001 | Journal article
EID:

2-s2.0-0034981695

Contributors: Gianninò, V.; Rappazzo, G.; Scuto, A.; Di Marco, O.; Privitera, A.; Santagati, M.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy
2000 | Journal article
EID:

2-s2.0-0033845020

Contributors: Santagati, M.; Iannelli, F.; Oggioni, M.R.; Stefani, S.; Pozzi, G.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

In vitro selection of glycopeptide-resistant variants of Enterococci

International Journal of Antimicrobial Agents
1999 | Journal article
EID:

2-s2.0-0033178932

Contributors: Puntorieri, M.; Cafiso, V.; Santagati, M.; Messina, C.; Azzarelli, C.; Catalano, V.; Bonfiglio, G.; Giuseppe, N.; Stefania, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

In vitro activity of biapenem against recent gram-negative and gram-positive clinical isolates

Chemotherapy
1997 | Journal article
EID:

2-s2.0-0030787171

Contributors: Bonfiglio, G.; Maccarone, G.; Mezzatesta, M.L.; Privitera, A.; Carciotto, V.; Santagati, M.; Stefani, S.; Nicoletti, G.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier

Molecular Epidemiology of Enterococci with High-Level Resistance to Aminoglycosides

Microbial Drug Resistance
1995 | Journal article
EID:

2-s2.0-0029420293

Contributors: Privitera, O.; Agodi, A.; Puntorieri, M.; Primavera, A.; Santagati, M.; Privitera, A.; Mezzatesta, M.L.; Giuffrida, E.; Stefani, S.
Source: Self-asserted source
Maria Carmela SANTAGATI via Scopus - Elsevier