Personal information

Emails & domains

Verified email addresses

Keywords

Aging; Innate immunity; Cancer; Infectious diseases; Pharmacology

Countries

China

Biography

I am mainly engaged in tumor molecular biology, innate immunity and anti-aging molecular mechanism research and new drug development.

Activities

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Employment (1)

Zunyi Medical University: Zunyi, Guizhou, CN

Employment
Source: Self-asserted source
Yi Xiao

Works (29)

Ginkgolide B promotes fat-lowering and lifespan in Caenorhabditis elegans via DAF-2/DAF-16 signaling pathway

Journal of Functional Foods
2025-03 | Journal article
DOI: 10.1016/j.jff.2025.106708
Part of ISSN: 1756-4646
Contributors: Yan Zhang; Han Zhang; Wenqiao Fu; Yi Xiao
Source: Self-asserted source
Yi Xiao

Asperuloside promotes innate immunity via IRE-1/XBP-1 mediated unfolded protein response

Bioorganic Chemistry
2025-02 | Journal article
DOI: 10.1016/j.bioorg.2025.108318
Part of ISSN: 0045-2068
Contributors: Hanlin Zhou; Yu Shen; Chunli Dong; Wentao Feng; Yuan Tian; Yi Xiao
Source: Self-asserted source
Yi Xiao

Berberine hydrochloride enhances innate immunity to protect against pathogen infection via p38 MAPK pathway

Frontiers in Immunology
2025-02-28 | Journal article
Contributors: Yi Xiao; Yingwen Cui; Yan Zhang; Wenqiao Fu; Yun Liu; Fang Liu
Source: Self-asserted source
Yi Xiao

Chlorogenic acid inhibits Pseudomonas toxin pyocyanin and activates mitochondrial UPR to protect host against pathogen infection

Scientific Reports
2025-02-14 | Journal article
DOI: 10.1038/s41598-025-90255-1
Part of ISSN: 2045-2322
Contributors: Yi Xiao; Linlu Li; Chao Han; Tingyun Huang; Shuangjie Ren; Xiaoqin Wang; Qianlu Xing; Fang Liu
Source: Self-asserted source
Yi Xiao

Berberine extends healthspan and delays neurodegenerative diseases in Caenorhabditis elegans through ROS-dependent PMK-1/SKN-1 activation

Archives of Gerontology and Geriatrics
2025-01 | Journal article
DOI: 10.1016/j.archger.2024.105644
Contributors: Yi Xiao; Li Zhang; Hanlin Zhou; Yingwen Cui; Keer Chen; Han Zhang; Qinyi Wu; Fang Liu
Source: check_circle
Crossref

DEAD-box RNA helicase DDX-23 mediates dietary restriction induced health span in Caenorhabditis elegans

GeroScience
2024-11-23 | Journal article
DOI: 10.1007/s11357-024-01434-3
Contributors: Yi Xiao; Hongjiao Zhang; Xiaocong Li; Chao Han; Fang Liu
Source: check_circle
Crossref

Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity.

Scientific reports
2024-11-09 | Journal article
DOI: 10.1038/s41598-024-79194-5
PMID: 39521925
PMC: PMC11550443
Contributors: Meng L; Cao Q; Du X; Lv H; Li C; Zhang X; Jiang N; Xiao Y
Source: Self-asserted source
Yi Xiao

The combination of paeoniflorin and metformin synergistically inhibits the progression of liver fibrosis in mice

European Journal of Pharmacology
2024-10 | Journal article
DOI: 10.1016/j.ejphar.2024.176917
Contributors: Lingjie Meng; Huijing Lv; Qinghong Kong; Sanhua Li; Nian Jiang; Changyan Yu; Zhen Duan; Yi Xiao; Yun Liu
Source: check_circle
Crossref

S-Adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex.

International immunopharmacology
2024-03-11 | Journal article
DOI: 10.1016/j.intimp.2024.111837
PMID: 38471365
Contributors: Xiao Y; Han C; Li X; Zhu X; Li S; Jiang N; Yu C; Liu Y; Liu F
Source: Self-asserted source
Yi Xiao

Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans.

Archives of gerontology and geriatrics
2024-02-20 | Journal article
DOI: 10.1016/j.archger.2024.105377
PMID: 38412790
Contributors: Xiao Y; Zhang Y; Li L; Jiang N; Yu C; Li S; Zhu X; Liu F; Liu Y
Source: Self-asserted source
Yi Xiao

Caffeic acid activates mitochondrial UPR to resist pathogen infection in <i>Caenorhabditis elegans</i> via the transcription factor ATFS-1.

Infection and immunity
2024-01-31 | Journal article | Author
DOI: 10.1128/iai.00494-23
PMID: 38294242
Contributors: Yi Xiao; Hong C-a; Liu F; Shi D; Zhu X; Yu C; Jiang N; Li S; Liu Yun
Source: Self-asserted source
Yi Xiao

Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3.

European journal of pharmacology
2024-01-30 | Journal article
DOI: 10.1016/j.ejphar.2024.176372
PMID: 38301817
Contributors: Jiang N; Li S; Meng L; Zhang Y; Yu C; Xiao Y; Liu Y
Source: Self-asserted source
Yi Xiao

Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway.

International immunopharmacology
2024-01-03 | Journal article
DOI: 10.1016/j.intimp.2023.111472
PMID: 38176342
Contributors: Xiao Y; Zhou H; Cui Y; Zhu X; Li S; Yu C; Jiang N; Liu L; Liu F
Source: Self-asserted source
Yi Xiao

The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1.

Cellular and molecular life sciences : CMLS
2023-10-05 | Journal article | Author
DOI: 10.1007/s00018-023-04970-x
PMID: 37796333
Contributors: Liu F; Zhang H; Wang H; Zhu X; Li S; Jiang N; Yu C; Liu Y; Yi Xiao
Source: Self-asserted source
Yi Xiao

Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in <i>Caenorhabditis elegans</i> via IRE-1/XBP-1 pathway

The Journal of Infectious Diseases
2023-07-27 | Journal article | Author
DOI: 10.1093/infdis/jiad294
Part of ISSN: 0022-1899
Part of ISSN: 1537-6613
Contributors: Yi Xiao; Fang Liu; Qinyi Wu; Xinting Zhu; Changyan Yu; Nian Jiang; Sanhua Li; Yun Liu
Source: Self-asserted source
Yi Xiao

Protocol for assessing the healthspan of Caenorhabditis elegans after potential anti-aging drug treatment.

STAR protocols
2023-05-05 | Journal article
DOI: 10.1016/j.xpro.2023.102285
PMID: 37148246
Contributors: Xiao Y; Zhang L; Liu Y
Source: Self-asserted source
Yi Xiao

Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1/SBP-1 dependent manner.

iScience
2023-02-24 | Journal article
DOI: 10.1016/j.isci.2023.106265
PMID: 36936783
PMC: PMC10014289
Contributors: Xiao Y; Liu F; Zhu X; Li S; Meng L; Jiang N; Yu C; Wang H; Qin Y; Hui J et al.
Source: Self-asserted source
Yi Xiao

Luteolin promotes pathogen resistance in Caenorhabditis elegans via DAF-2/DAF-16 insulin-like signaling pathway.

International immunopharmacology
2023-01-12 | Journal article
DOI: 10.1016/j.intimp.2023.109679
PMID: 36640711
Contributors: Xiao Y; Zhang L; Zhu X; Qin Y; Yu C; Jiang N; Li S; Liu F; Liu Y
Source: Self-asserted source
Yi Xiao

Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in <i>Caenorhabditis elegans</i>.

iScience
2022-11-09 | Journal article
DOI: 10.1016/j.isci.2022.105539
PMID: 36425761
PMC: PMC9679492
Contributors: Yi Xiao; Xiao Y; Zhang H; Sheng Y; Liu F; Gao J; Liu G; Li S; Jiang N; Yu C et al.
Source: Self-asserted source
Yi Xiao

Brevilin A enhances innate immunity and the resistance of oxidative stress in Caenorhabditis elegans via p38 MAPK pathway.

International immunopharmacology
2022-10-30 | Journal article
DOI: 10.1016/j.intimp.2022.109385
PMID: 36330917
Contributors: Yi Xiao; Zhu X; Liu F; Wu Q; Li S; Ruan G; Yang J; Yu C; Jiang N; Xiao Y et al.
Source: Self-asserted source
Yi Xiao

Metformin induces S-adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers.

Aging cell
2022-02-11 | Journal article | Author
DOI: 10.1111/acel.13567
PMID: 35146893
PMC: PMC8920454
Contributors: Yi Xiao; Liu F; Kong Q; Zhu X; Wang H; Li S; Jiang N; Yu C; Liu Yun
Source: Self-asserted source
Yi Xiao

Sanguinarine promotes healthspan and innate immunity through a conserved mechanism of ROS-mediated PMK-1/SKN-1 activation.

iScience
2022-02-04 | Journal article | Author
DOI: 10.1016/j.isci.2022.103874
PMID: 35243236
PMC: PMC8857505
Contributors: Liu F; Wang H; Zhu X; Jiang N; Pan F; Song C; Yu C; Yu C; Qin Y; Hui J et al.
Source: Self-asserted source
Yi Xiao

Magnesium demethylcantharidate inhibits hepatocellular carcinoma cell invasion and metastasis via activation transcription factor FOXO1.

European journal of pharmacology
2021-10-08 | Journal article | Author
DOI: 10.1016/j.ejphar.2021.174558
PMID: 34634308
Contributors: Liu F; Zhu XT; Li Y; Wang CJ; Fu JL; Hui J; Yi Xiao; Liu L; Yan R; Li XF et al.
Source: Self-asserted source
Yi Xiao

Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway.

Virulence
2020-12-01 | Journal article | Author
DOI: 10.1080/21505594.2019.1706305
PMID: 31851866
PMC: PMC6961722
Contributors: Yi Xiao; Liu F; Li S; Jiang N; Yu C; Zhu X; Qin Y; Hui J; Meng L; changwei song et al.
Source: Self-asserted source
Yi Xiao

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.

Cancer cell international
2020-08-05 | Journal article | Author
DOI: 10.1186/s12935-020-01463-w
PMID: 32774165
PMC: PMC7405455
Contributors: Yi Xiao; Gong Q; Wang W; Liu F; Kong Q; Pan F; Zhang X; Yu C; Hu S; Fan F et al.
Source: Self-asserted source
Yi Xiao

Bufadienolides from the skins of Bufo melanosticus and their cytotoxic activity

Phytochemistry Letters
2019-06 | Journal article
DOI: 10.1016/j.phytol.2019.03.009
Part of ISSN: 1874-3900
Contributors: Lingjie Meng; Nian Jiang; Changyan Yu; Sanhua Li; Zeli Chun; Xinting Zhu; Changwei Song; Yi Xiao; Jing Hui; Ying Qin et al.
Source: Self-asserted source
Yi Xiao

Synergistic activity of magnolin combined with B-RAF inhibitor SB590885 in hepatocellular carcinoma cells via targeting PI3K-AKT/mTOR and ERK MAPK pathway.

American journal of translational research
2019-06-15 | Journal article | Author
PMID: 31312391
PMC: PMC6614620
Contributors: Wang W; Yi Xiao; Li S; Zhu X; Meng L; Song C; Yu C; Jiang N; Liu Y
Source: Self-asserted source
Yi Xiao

PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans.

Innate immunity
2017-09-29 | Journal article | Author
DOI: 10.1177/1753425917732822
PMID: 28958206
Contributors: Yi Xiao; Liu F; Zhao PJ; Zou CG; Zhang KQ
Source: Self-asserted source
Yi Xiao

The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans.

Scientific reports
2017-04-04 | Journal article | Author
DOI: 10.1038/s41598-017-00630-w
PMID: 28377576
PMC: PMC5428847
Contributors: Liu F; Yi Xiao; Ji XL; Zhang KQ; Zou CG
Source: Self-asserted source
Yi Xiao
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