Personal information

Emails & domains

Verified email addresses

Keywords

Nephrology, Diabetes, Metabolism, eQTL, CKD

Countries

Japan

Biography

Research interest covers all kidney diseases, especially CKD.
I am dedicated to understanding the molecular mechanism of kidney disease development.

Activities

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Employment (4)

Nagoya University Graduate School of Medicine.: Nagoya, State..., JP

2022-12 to present | Assistant Professor (Nephrology)
Employment
Source: Self-asserted source
Tomohito Doke

University of Pennsylvania: philadelphia, pennsylvania, US

2019-04 to present | Pos doc (Department of Medicine, Renal Electrolyte and Hypertension Division)
Employment
Source: Self-asserted source
Tomohito Doke

Nagoya University Hospital: Nagoya, State..., JP

2015-04 to 2019-04 | MD (Nephrology)
Employment
Source: Self-asserted source
Tomohito Doke

Nagoya University Graduate School of Medicine: Nagoya, JP

2015-04 to 2018-04 | Ph.D. student (Nephrology)
Employment
Source: Self-asserted source
Tomohito Doke

Works (20)

The key role of altered tubule cell lipid metabolism in kidney disease development

Kidney International
2024-07 | Journal article
DOI: 10.1016/j.kint.2024.02.025
Contributors: Lauren E. Lee; Tomohito Doke; Dhanunjay Mukhi; Katalin Susztak
Source: check_circle
Crossref

Endothelial–Mesenchymal Transition Switch and Diabetic Kidney Disease

Journal of the American Society of Nephrology
2024-06 | Journal article
DOI: 10.1681/ASN.0000000000000364
Contributors: Tomohito Doke; Petter Bjornstad
Source: check_circle
Crossref

ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules

Journal of Clinical Investigation
2024-02-15 | Journal article
DOI: 10.1172/JCI172963
Contributors: Dhanunjay Mukhi; Lingzhi Li; Hongbo Liu; Tomohito Doke; Lakshmi P. Kolligundla; Eunji Ha; Konstantin Kloetzer; Amin Abedini; Sarmistha Mukherjee; Junnan Wu et al.
Source: check_circle
Crossref

Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists

Journal of Clinical Investigation
2024-01-02 | Journal article
DOI: 10.1172/JCI157165
Contributors: Amin Abedini; Andrea Sánchez-Navaro; Junnan Wu; Konstantin A. Klötzer; Ziyuan Ma; Bibek Poudel; Tomohito Doke; Michael S. Balzer; Julia Frederick; Hana Cernecka et al.
Source: check_circle
Crossref

Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker

Journal of the American Society of Nephrology
2023-07 | Journal article
DOI: 10.1681/ASN.0000000000000141
Contributors: Daigoro Hirohama; Amin Abedini; Salina Moon; Aditya Surapaneni; Simon T. Dillon; Allison Vassalotti; Hongbo Liu; Tomohito Doke; Victor Martinez; Zaipul Md Dom et al.
Source: check_circle
Crossref

NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury

Nature Metabolism
2023-03-13 | Journal article
DOI: 10.1038/s42255-023-00761-7
Contributors: Tomohito Doke; Sarmistha Mukherjee; Dhanunjay Mukhi; Poonam Dhillon; Amin Abedini; James G. Davis; Karthikeyani Chellappa; Beishan Chen; Joseph A. Baur; Katalin Susztak
Source: check_circle
Crossref

Molecular pathways that drive diabetic kidney disease

Journal of Clinical Investigation
2023-02-15 | Journal article
DOI: 10.1172/JCI165654
Contributors: Samer Mohandes; Tomohito Doke; Hailong Hu; Dhanunjay Mukhi; Poonam Dhillon; Katalin Susztak
Source: check_circle
Crossref

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

Nature Genetics
2022-07 | Journal article
DOI: 10.1038/s41588-022-01097-w
Contributors: Hongbo Liu; Tomohito Doke; Dong Guo; Xin Sheng; Ziyuan Ma; Joseph Park; Ha My T. Vy; Girish N. Nadkarni; Amin Abedini; Zhen Miao et al.
Source: check_circle
Crossref

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration

Nature Communications
2022-07-11 | Journal article
DOI: 10.1038/s41467-022-31772-9
Contributors: Michael S. Balzer; Tomohito Doke; Ya-Wen Yang; Daniel L. Aldridge; Hailong Hu; Hung Mai; Dhanunjay Mukhi; Ziyuan Ma; Rojesh Shrestha; Matthew B. Palmer et al.
Source: check_circle
Crossref

Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis

Nature Immunology
2022-06 | Journal article
DOI: 10.1038/s41590-022-01200-7
Contributors: Tomohito Doke; Amin Abedini; Daniel L. Aldridge; Ya-Wen Yang; Jihwan Park; Christina M. Hernandez; Michael S. Balzer; Rojesh Shrestra; Gaia Coppock; Juan M. Inclan Rico et al.
Source: check_circle
Crossref

Genome-wide association studies identify the role of caspase-9 in kidney disease

Science Advances
2021-11-05 | Journal article
DOI: 10.1126/sciadv.abi8051
Contributors: Tomohito Doke; Shizheng Huang; Chengxiang Qiu; Xin Sheng; Matthew Seasock; Hongbo Liu; Ziyuan Ma; Matthew Palmer; Katalin Susztak
Source: check_circle
Crossref

NAD+ flux is maintained in aged mice despite lower tissue concentrations.

Cell systems
2021-09-23 | Journal article
DOI: 10.1016/j.cels.2021.09.001
PMID: 34559996
Source: Self-asserted source
Tomohito Doke
grade
Preferred source (of 2)‎

Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis

Journal of Clinical Investigation
2021-05-17 | Journal article
DOI: 10.1172/JCI141801
Contributors: Tomohito Doke; Shizheng Huang; Chengxiang Qiu; Hongbo Liu; Yuting Guan; Hailong Hu; Ziyuan Ma; Junnan Wu; Zhen Miao; Xin Sheng et al.
Source: check_circle
Crossref

DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity.

The Journal of clinical investigation
2021-05-01 | Journal article
DOI: 10.1172/jci141279
PMID: 33998601
PMC: PMC8121508
Source: Self-asserted source
Tomohito Doke
grade
Preferred source (of 2)‎

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Cell metabolism
2020-12-09 | Journal article
DOI: 10.1016/j.cmet.2020.11.011
PMID: 33301705
Source: Self-asserted source
Tomohito Doke

Comprehensive Dipeptide Profiling and Quantitation by Capillary Electrophoresis and Liquid Chromatography Coupled with Tandem Mass Spectrometry.

Analytical chemistry
2020-06-29 | Journal article
DOI: 10.1021/acs.analchem.0c01258
PMID: 32538620
Source: Self-asserted source
Tomohito Doke

Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase.

The Journal of nutritional biochemistry
2019-06-08 | Journal article
DOI: 10.1016/j.jnutbio.2019.05.017
PMID: 31276916
Source: Self-asserted source
Tomohito Doke

Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice.

Metabolism: clinical and experimental
2018-03-29 | Journal article
DOI: 10.1016/j.metabol.2018.03.020
PMID: 29604362
PMC: PMC6394855
Source: Self-asserted source
Tomohito Doke

Aging-associated renal disease in mice is fructokinase dependent.

American journal of physiology. Renal physiology
2016-07-27 | Journal article
DOI: 10.1152/ajprenal.00306.2016
PMID: 27465991
PMC: PMC5142232
Source: Self-asserted source
Tomohito Doke

Post-Transplant Membranous Nephropathy Associated with Chronic Active Antibody-Mediated Rejection and Hepatitis C Infection after Deceased Donor Renal Transplantation.

Internal medicine (Tokyo, Japan)
2016-02-15 | Journal article
DOI: 10.2169/internalmedicine.55.5468
PMID: 26875963
Source: Self-asserted source
Tomohito Doke
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