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Employment (4)

University of South Carolina: Columbia, SC, US

2024-05 to present | Research Associate Professor (Drug Discovery and Biomedical Sciences (DDBS), College of Pharmacy)
Employment
Source: Self-asserted source
Mengqian Chen

Senex Biotechnology, Inc.: Columbia, South Carolina, US

2020-06-01 to present | Director of Research
Employment
Source: Self-asserted source
Mengqian Chen

University of South Carolina: Columbia, SC, US

2011-06 to 2024-05 | Research Assistant Professor (Department of Drug Discovery and Biomedical Sciences, College of Pharmacy)
Employment
Source: Self-asserted source
Mengqian Chen

Ordway Research Institute: Albany, NY, US

2007 to 2011 | Research Associate (Cancer Center)
Employment
Source: Self-asserted source
Mengqian Chen

Education and qualifications (2)

University of Central Florida: Orlando, FL, US

2002 to 2007 | Ph.D. (Biomolecular Sciences)
Education
Source: Self-asserted source
Mengqian Chen

Fudan University: Shanghai, Shanghai, CN

1997 to 2001 | B.S. (Biology)
Education
Source: Self-asserted source
Mengqian Chen

Works (29)

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics.

Journal of medicinal chemistry
2022-02-03 | Journal article
DOI: 10.1021/acs.jmedchem.1c01951
PMID: 35114084
Source: Self-asserted source
Mengqian Chen
grade
Preferred source (of 2)‎

Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition.

Cells
2019-11-09 | Journal article
DOI: 10.3390/cells8111413
PMID: 31717492
PMC: PMC6912361
Source: Self-asserted source
Mengqian Chen

Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay.

Cells
2019-10-06 | Journal article
DOI: 10.3390/cells8101208
PMID: 31590445
PMC: PMC6830309
Source: Self-asserted source
Mengqian Chen

Identifying Cancers Impacted by CDK8/19.

Cells
2019-08-03 | Journal article
DOI: 10.3390/cells8080821
PMID: 31382571
PMC: PMC6721656
Source: Self-asserted source
Mengqian Chen

Role of transcription-regulating kinase CDK8 in colon cancer metastasis.

Oncotarget
2019-01-18 | Journal article
DOI: 10.18632/oncotarget.26593
PMID: 30774756
PMC: PMC6363006
Source: Self-asserted source
Mengqian Chen

CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases.

Cancer research
2018-09-05 | Journal article
DOI: 10.1158/0008-5472.can-18-1583
PMID: 30185549
PMC: PMC6279600
Source: Self-asserted source
Mengqian Chen

A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia.

BMC cancer
2018-02-13 | Journal article
DOI: 10.1186/s12885-018-4097-z
PMID: 29439669
PMC: PMC5811974
Source: Self-asserted source
Mengqian Chen

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

Proceedings of the National Academy of Sciences of the United States of America
2017-08-30 | Journal article
DOI: 10.1073/pnas.1710467114
PMID: 28855340
PMC: PMC5617299
Source: Self-asserted source
Mengqian Chen

Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance.

Oncotarget
2017-03-01 | Journal article
DOI: 10.18632/oncotarget.14850
PMID: 28145883
PMC: PMC5386661
Source: Self-asserted source
Mengqian Chen

Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.

Scientific reports
2017-02-22 | Journal article
DOI: 10.1038/srep43023
PMID: 28223711
PMC: PMC5320502
Source: Self-asserted source
Mengqian Chen

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.

Oncotarget
2017-02-01 | Journal article
DOI: 10.18632/oncotarget.14894
PMID: 28147342
PMC: PMC5355036
Source: Self-asserted source
Mengqian Chen

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.

Current cancer drug targets
2015-01-01 | Journal article
DOI: 10.2174/156800961508151001105814
PMID: 26452386
PMC: PMC4755306
Source: Self-asserted source
Mengqian Chen

Determinants of Gli2 co-activation of wildtype and naturally truncated androgen receptors.

The Prostate
2014-08-11 | Journal article
DOI: 10.1002/pros.22855
PMID: 25132524
Source: Self-asserted source
Mengqian Chen

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

Proceedings of the National Academy of Sciences of the United States of America
2012-08-06 | Journal article
DOI: 10.1073/pnas.1206906109
PMID: 22869755
PMC: PMC3427077
Source: Self-asserted source
Mengqian Chen

The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor.

Molecular and cellular biology
2012-06-04 | Journal article
DOI: 10.1128/mcb.00159-12
PMID: 22665497
PMC: PMC3434546
Source: Self-asserted source
Mengqian Chen

Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner.

The Prostate
2011-10-24 | Journal article
DOI: 10.1002/pros.21500
PMID: 22025366
Source: Self-asserted source
Mengqian Chen

Effects of androgen receptor and androgen on gene expression in prostate stromal fibroblasts and paracrine signaling to prostate cancer cells.

PloS one
2011-01-18 | Journal article
DOI: 10.1371/journal.pone.0016027
PMID: 21267466
PMC: PMC3022749
Source: Self-asserted source
Mengqian Chen

The hedgehog/Gli signaling paradigm in prostate cancer.

Expert review of endocrinology & metabolism
2011-01-01 | Journal article
DOI: 10.1586/eem.11.2
PMID: 21776292
PMC: PMC3137913
Source: Self-asserted source
Mengqian Chen
grade
Preferred source (of 2)‎

Gli2 expression and human bladder transitional carcinoma cell invasiveness.

The Journal of urology
2010-05-20 | Journal article
DOI: 10.1016/j.juro.2010.03.007
PMID: 20488474
Source: Self-asserted source
Mengqian Chen

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells.

Molecular cancer
2010-04-26 | Journal article
DOI: 10.1186/1476-4598-9-89
PMID: 20420697
PMC: PMC2873440
Source: Self-asserted source
Mengqian Chen

Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.

Molecular and cellular biochemistry
2010-04-01 | Journal article
DOI: 10.1007/s11010-009-0307-y
PMID: 19911255
Source: Self-asserted source
Mengqian Chen

Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway.

Human reproduction (Oxford, England)
2010-01-20 | Journal article
DOI: 10.1093/humrep/dep457
PMID: 20089521
Source: Self-asserted source
Mengqian Chen

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells.

Cell cycle (Georgetown, Tex.)
2009-01-01 | Journal article
DOI: 10.4161/cc.8.1.7532
PMID: 19158486
PMC: PMC2633936
Source: Self-asserted source
Mengqian Chen

Editorial comment on: Hedgehog signalling in androgen independent prostate cancer.

European urology
2008-02-04 | Journal article
DOI: 10.1016/j.eururo.2008.01.071
PMID: 18262714
Source: Self-asserted source
Mengqian Chen

The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.

Biochimica et biophysica acta
2007-11-12 | Journal article
DOI: 10.1016/j.bbamcr.2007.10.019
PMID: 18054338
PMC: PMC3214967
Source: Self-asserted source
Mengqian Chen

Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3.

Biochimica et biophysica acta
2007-05-01 | Journal article
DOI: 10.1016/j.bbamcr.2007.04.013
PMID: 17532063
PMC: PMC1950849
Source: Self-asserted source
Mengqian Chen

Mechanisms of sterol regulatory element-binding protein-2 (SREBP-2) regulation of human prostasin gene expression.

Biochemical and biophysical research communications
2006-06-16 | Journal article
DOI: 10.1016/j.bbrc.2006.06.049
PMID: 16806080
Source: Self-asserted source
Mengqian Chen

Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.

The Prostate
2006-06-01 | Journal article
DOI: 10.1002/pros.20325
PMID: 16541421
Source: Self-asserted source
Mengqian Chen

Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation.

American journal of physiology. Renal physiology
2006-04-25 | Journal article
DOI: 10.1152/ajprenal.00047.2006
PMID: 16638913
Source: Self-asserted source
Mengqian Chen

Peer review (1 review for 1 publication/grant)

Review activity for Cellular and molecular life sciences (1)
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