Personal information

paramyxovirus vaccine pathogenesis
United States

Biography

The overarching goal of my research program is to understand the molecular basis of paramyxovirus pathogenesis and attenuation with a view to translating this knowledge into the development and delivery of safe and efficacious vectored vaccines. I have over fifteen years experience as a molecular virologist and I and my laboratory have developed reverse genetics systems for both positive and negative strand RNA viruses. Currently my group focuses on respiratory paramyxoviruses.

Activities

Works (50 of 77)

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Characterization of neural infection by Oropouche orthobunyavirus

2024-10-12 | Preprint
Contributors: Kaleigh A. Connors; Maris R. Pedlow; Zachary D. Frey; Jackson J. McGaughey; Gaya K. Amarasinghe; W. Paul Duprex; Leonardo D’Aiuto; Zachary P. Wills; Amy L. Hartman
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A reporter Oropouche virus expressing ZsGreen from the M segment enables pathogenesis studies in mice

Journal of Virology
2024-09-17 | Journal article
Contributors: Krista Gunter; Dorcus Omoga; James M. Bowen; Lorimar Robledo Gonzalez; Sydney Severt; Mackenzie Davis; Megan Szymanski; George Sandusky; W. Paul Duprex; Natasha L. Tilston-Lunel et al.
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Influenza H5N1 and H1N1 viruses remain infectious in unpasteurized milk on milking machinery surfaces

2024-05-22 | Preprint
Contributors: Valerie Le Sage; A.J. Campbell; Douglass Reed; W Paul Duprex; Seema Lakdawala
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Rational attenuation of canine distemper virus (CDV) to develop a morbillivirus animal model that mimics measles in humans

Journal of Virology
2024-03-19 | Journal article
Contributors: Katharina S. Schmitz; Linda J. Rennick; Natasha L. Tilston-Lunel; Anouskha D. Comvalius; Brigitta M. Laksono; Daryl Geers; Peter van Run; Rory D. de Vries; Rik L. de Swart; W. Paul Duprex et al.
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Paramyxoviruses: Pathogenesis, Vaccines, Antivirals, and Prototypes for Pandemic Preparedness

The Journal of Infectious Diseases
2023-10-18 | Journal article
Contributors: W Paul Duprex; Rebecca Ellis Dutch
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Crossref

Infection of ferrets with wild type-based recombinant canine distemper virus overwhelms the immune system and causes fatal systemic disease

mSphere
2023-08-24 | Journal article
Contributors: Brigitta M. Laksono; Dagmar Roelofs; Anouskha D. Comvalius; Katharina S. Schmitz; Laurine C. Rijsbergen; Daryl Geers; Sham Nambulli; Peter van Run; W. Paul Duprex; Judith M. A. van den Brand et al.
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Inoculation of raccoons with a wild-type-based recombinant canine distemper virus results in viremia, lymphopenia, fever, and widespread histological lesions

mSphere
2023-08-24 | Journal article
Contributors: Dagmar Roelofs; Katharina S. Schmitz; Geert van Amerongen; Laurine C. Rijsbergen; Brigitta M. Laksono; Anouskha D. Comvalius; Sham Nambulli; Linda J. Rennick; Peter van Run; W. Paul Duprex et al.
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Human Respiratory Syncytial Virus Subgroup A and B Infections in Nasal, Bronchial, Small-Airway, and Organoid-Derived Respiratory Cultures

mSphere
2021-06-30 | Journal article
Contributors: L. C. Rijsbergen; M. M. Lamers; A. D. Comvalius; R. W. Koutstaal; D. Schipper; W. P. Duprex; B. L. Haagmans; R. D. de Vries; R. L. de Swart; Rebecca Ellis Dutch
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Crossref

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Science Advances
2021-05-28 | Journal article
Contributors: Sham Nambulli; Yufei Xiang; Natasha L. Tilston-Lunel; Linda J. Rennick; Zhe Sang; William B. Klimstra; Douglas S. Reed; Nicholas A. Crossland; Yi Shi; W. Paul Duprex
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Crossref

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

Science
2021-03-12 | Journal article
Contributors: Kevin R. McCarthy; Linda J. Rennick; Sham Nambulli; Lindsey R. Robinson-McCarthy; William G. Bain; Ghady Haidar; W. Paul Duprex
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Crossref

Deletion disrupts a conserved antibody epitope in a SARS-CoV-2 variant of concern

2021-03-08 | Other
Contributors: Linda J. Rennick; Lindsey R. Robinson-McCarthy; Sham Nambulli; W. Paul Duprex; Kevin R. McCarthy
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Crossref

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Science
2020-12-18 | Journal article
Contributors: Yufei Xiang; Sham Nambulli; Zhengyun Xiao; Heng Liu; Zhe Sang; W. Paul Duprex; Dina Schneidman-Duhovny; Cheng Zhang; Yi Shi
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Crossref

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

2020-11-19 | Preprint
Contributors: Kevin R. McCarthy; Linda J. Rennick; Sham Nambulli; Lindsey R. Robinson-McCarthy; William G. Bain; Ghady Haidar; W. Paul Duprex
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Crossref

Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis

PLOS Pathogens
2020-10-08 | Journal article
Contributors: Brigitta M. Laksono; Rachel Fearns; Paola Fortugno; Bernadien M. Nijmeijer; Rory D. de Vries; Sonia Cordisco; Thijs Kuiken; Teunis B. H. Geijtenbeek; W. Paul Duprex; Francesco Brancati et al.
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In vivo comparison of a laboratory-adapted and clinical-isolate-based recombinant human respiratory syncytial virus

Journal of General Virology
2020-10-01 | Journal article
Contributors: Laurine C. Rijsbergen; Linda J. Rennick; Brigitta M. Laksono; Peter R.W.A. van Run; Thijs Kuiken; W. Paul Duprex; Rik L. de Swart; Rory D. de Vries
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Crossref

Recombinant subtype A and B human respiratory syncytial virus clinical isolates co-infect the respiratory tract of cotton rats

Journal of General Virology
2020-10-01 | Journal article
Contributors: Linda J. Rennick; Sham Nambulli; Ken Lemon; Grace Y. Olinger; Nicholas A. Crossland; Emma L. Millar; W. Paul Duprex
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Crossref

Inhibition of Nipah Virus by Defective Interfering Particles

The Journal of Infectious Diseases
2020-05-11 | Journal article
Contributors: Stephen R Welch; Natasha L Tilston; Michael K Lo; Shannon L M Whitmer; Jessica R Harmon; Florine E M Scholte; Jessica R Spengler; W Paul Duprex; Stuart T Nichol; Christina F Spiropoulou
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Crossref

Measles skin rash: infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to keratinocytes in the epidermis

2019-12-06 | Other
Contributors: Brigitta M. Laksono; Paola Fortugno; Bernadien M. Nijmeijer; Rory D. de Vries; Sonia Cordisco; Stefan van Nieuwkoop; Thijs Kuiken; Teunis B. H. Geijtenbeek; W. Paul Duprex; Francesco Brancati et al.
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Crossref

mSphere of Influence: the View from the Microbiologists of the Future

mSphere
2019-06-26 | Journal article
Contributors: Aaron Mitchell; Ira Blader; Patricia Bradford; Sarah D’Orazio; W. Paul Duprex; Craig D. Ellermeier; Ana Fernandez-Sesma; Michael J. Imperiale; Katherine McMahon; Marcela F. Pasetti et al.
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Crossref

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

Nature Communications
2017-07-12 | Journal article
Contributors: Ilona Rissanen; Asim A. Ahmed; Kristopher Azarm; Shannon Beaty; Patrick Hong; Sham Nambulli; W. Paul Duprex; Benhur Lee; Thomas A. Bowden
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Crossref

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus.

2013-06-19 | Standards or policy
DOI:

10.1099/vir.0.054650-0

PMID:

23784446

Source: Self-asserted source
W Paul Duprex

Paramyxovirus infections in ex vivo lung slice cultures of different host species.

2013-06-15 | Standards or policy
DOI:

10.1016/j.jviromet.2013.06.016

PMID:

23777750

Source: Self-asserted source
W Paul Duprex

Measles virus infection of epithelial cells in the macaque upper respiratory tract is mediated by subepithelial immune cells.

2013-01-30 | Standards or policy
DOI:

10.1128/JVI.03258-12

PMID:

23365435

Source: Self-asserted source
W Paul Duprex

Determination of Spontaneous Mutation Frequencies in Measles Virus under Nonselective Conditions.

2012-12-19 | Standards or policy
DOI:

10.1128/JVI.02146-12

PMID:

23255805

Source: Self-asserted source
W Paul Duprex

A Prominent Role for DC-SIGN(+) Dendritic Cells in Initiation and Dissemination of Measles Virus Infection in Non-Human Primates.

2012-12-05 | Standards or policy
DOI:

10.1371/journal.pone.0049573

PMID:

23227146

Source: Self-asserted source
W Paul Duprex

Modification of measles virus and application to pathogenesis studies

2012-12-01 | Standards or policy
DOI:

Not found

Source: Self-asserted source
W Paul Duprex
grade
Preferred source (of 7)‎

Measles immune suppression: lessons from the macaque model.

2012-08-30 | Standards or policy
DOI:

10.1371/journal.ppat.1002885

PMID:

22952446

Source: Self-asserted source
W Paul Duprex

Evaluation of synthetic infection-enhancing lipopeptides as adjuvants for a live-attenuated canine distemper virus vaccine administered intra-nasally to ferrets.

2012-06-21 | Standards or policy
DOI:

10.1016/j.vaccine.2012.05.079

PMID:

22705079

Source: Self-asserted source
W Paul Duprex

Live-cell visualization of transmembrane protein oligomerization and membrane fusion using two-fragment haptoEGFP methodology.

2012-06-01 | Standards or policy
DOI:

10.1042/BSR20110100

PMID:

22385277

Source: Self-asserted source
W Paul Duprex

Recombinant canine distemper virus strain Snyder Hill expressing green or red fluorescent proteins causes meningoencephalitis in the ferret.

2012-05-02 | Standards or policy
DOI:

10.1128/JVI.06725-11

PMID:

22553334

Source: Self-asserted source
W Paul Duprex

The pathogenesis of measles.

2012-04-05 | Standards or policy
DOI:

10.1016/j.coviro.2012.03.005

PMID:

22483507

Source: Self-asserted source
W Paul Duprex

Rinderpest eradication: lessons for measles eradication?

2012-03-20 | Standards or policy
DOI:

10.1016/j.coviro.2012.02.010

PMID:

22709518

Source: Self-asserted source
W Paul Duprex

The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.

2011-12-14 | Standards or policy
DOI:

10.1099/vir.0.038919-0

PMID:

22170635

Source: Self-asserted source
W Paul Duprex

Recent mumps outbreaks in vaccinated populations: no evidence of immune escape.

2011-11-09 | Standards or policy
DOI:

10.1128/JVI.06125-11

PMID:

22072778

Source: Self-asserted source
W Paul Duprex

New concepts in measles virus replication: getting in and out in vivo and modulating the host cell environment.

2011-10-06 | Standards or policy
DOI:

10.1016/j.virusres.2011.09.021

PMID:

22001568

Source: Self-asserted source
W Paul Duprex

Towards ambient temperature-stable vaccines: The identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay.

2011-05-25 | Standards or policy
DOI:

10.1016/j.vaccine.2011.04.079

PMID:

21616113

Source: Self-asserted source
W Paul Duprex

Gene-specific contributions to mumps virus neurovirulence and neuroattenuation.

2011-05-04 | Standards or policy
DOI:

10.1128/JVI.00245-11

PMID:

21543475

Source: Self-asserted source
W Paul Duprex

Discrimination of mumps virus small hydrophobic gene deletion effects from gene translation effects on virus virulence.

2011-04-06 | Standards or policy
DOI:

10.1128/JVI.02686-10

PMID:

21471236

Source: Self-asserted source
W Paul Duprex

Early target cells of measles virus after aerosol infection of non-human primates.

2011-01-27 | Standards or policy
DOI:

10.1371/journal.ppat.1001263

PMID:

21304593

Source: Self-asserted source
W Paul Duprex

Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus.

2010-07-20 | Standards or policy
DOI:

10.1074/mcp.M110.001859

PMID:

20647383

Source: Self-asserted source
W Paul Duprex

In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques.

2010-02-24 | Standards or policy
DOI:

10.1128/JVI.02633-09

PMID:

20181691

Source: Self-asserted source
W Paul Duprex

Wild-type measles virus infection of primary epithelial cells occurs via the basolateral surface without syncytium formation or release of infectious virus.

2009-11-18 | Standards or policy
DOI:

10.1099/vir.0.016428-0

PMID:

19923259

Source: Self-asserted source
W Paul Duprex

Molecular differences between two Jeryl Lynn mumps virus vaccine component strains, JL5 and JL2.

2009-08-05 | Standards or policy
DOI:

10.1099/vir.0.013946-0

PMID:

19656963

Source: Self-asserted source
W Paul Duprex

Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence.

2009-08-04 | Standards or policy
DOI:

10.1016/j.vaccine.2009.07.051

PMID:

19660591

Source: Self-asserted source
W Paul Duprex

Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist.

2009-07-22 | Standards or policy
DOI:

10.1099/vir.0.013722-0

PMID:

19625458

Source: Self-asserted source
W Paul Duprex

A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.

2009-04-22 | Standards or policy
DOI:

10.1128/JVI.00596-09

PMID:

19386700

Source: Self-asserted source
W Paul Duprex

Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro.

2008-08-27 | Standards or policy
DOI:

10.1128/JVI.00907-08

PMID:

18753210

Source: Self-asserted source
W Paul Duprex

Advantages of using recombinant measles viruses expressing a fluorescent reporter gene with vibratome slice technology in experimental measles neuropathogenesis.

2007-11-07 | Standards or policy
DOI:

10.1111/j.1365-2990.2007.00900.x

PMID:

17986184

Source: Self-asserted source
W Paul Duprex

Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques.

2007-11-01 | Standards or policy
DOI:

10.1371/journal.ppat.0030178

PMID:

18020706

Source: Self-asserted source
W Paul Duprex

Two functionally linked amino acids in the stem 2 region of measles virus haemagglutinin determine infectivity and virulence in the rodent central nervous system.

2007-11-01 | Standards or policy
DOI:

10.1099/vir.0.83235-0

PMID:

17947537

Source: Self-asserted source
W Paul Duprex
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