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Employment (5)

Wellcome Sanger Institute: Cambridge, GB

2020-05-01 to present | Senior Group Leader (Human Genetics Programme)
Employment
Source: Self-asserted source
Carl Anderson

Wellcome Sanger Institute: Hinxton, Cambridgeshire, GB

2014-05-01 to 2020-04-30 | Group Leader (Human Genetics Programme)
Employment
Source: Self-asserted source
Carl Anderson

Wellcome Sanger Institute: Hinxton, Cambridgeshire, GB

2009-09-01 to 2014-04-30 | CDF Group Leader (Human Genetics Programme)
Employment
Source: Self-asserted source
Carl Anderson

Wellcome Trust Centre for Human Genetics: Oxford, Oxfordshire, GB

2007-01-05 to 2008-12-31 | Postdoctoral Fellow
Employment
Source: Self-asserted source
Carl Anderson

Wellcome Trust Centre for Human Genetics: Oxford, Oxfordshire, GB

2008-01-01 to 2008-08-31 | Senior Postdoctoral Fellow
Employment
Source: Self-asserted source
Carl Anderson

Education and qualifications (3)

University of Edinburgh: Edinburgh, GB

2003-09-01 to 2006-12-31 | PhD student (Cell, Animal and Population Biology)
Qualification
Source: Self-asserted source
Carl Anderson

The University of Sheffield: Sheffield, Sheffield, GB

2001-09-01 to 2002-07-31 | MSc student (Genetic Epidemiology)
Qualification
Source: Self-asserted source
Carl Anderson

The University of Sheffield: Sheffield, Sheffield, GB

1998-09-01 to 2001-05-31 | BSc student (Biomedical Science)
Qualification
Source: Self-asserted source
Carl Anderson

Professional activities (1)

Wellcome Sanger Institute: Hinxton, Cambridgeshire, GB

2014-10-01 to present | Director of Graduate Studies
Service
Source: Self-asserted source
Carl Anderson

Works (50 of 63)

Items per page:
Page 1 of 2

Performance of deep-learning based approaches to improve polygenic scores

2024-10-23 | Preprint
Contributors: Martin Kelemen; Yu Xu; Tao Jiang; Jing Hua Zhao; Carl Anderson; Chris Wallace; Adam Butterworth; Michael Inouye
Source: check_circle
Crossref

Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine

BMJ Open
2024-04 | Journal article
Contributors: Nicola J Wyatt; Hannah Watson; Carl A Anderson; Nicholas A Kennedy; Tim Raine; Tariq Ahmad; Dean Allerton; Michelle Bardgett; Emma Clark; Dawn Clewes et al.
Source: check_circle
Crossref

Genomic diagnosis and care co-ordination for monogenic inflammatory bowel disease in children and adults: consensus guideline on behalf of the British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition

The Lancet Gastroenterology & Hepatology
2023-03 | Journal article
Contributors: Jochen Kammermeier; Christopher A Lamb; Kelsey D J Jones; Carl A Anderson; Emma L Baple; Chrissy Bolton; Helen Braggins; Tanya I Coulter; Kimberly C Gilmour; Vicki Gregory et al.
Source: check_circle
Crossref

ShaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores

2021-12-11 | Preprint
Contributors: M. Kelemen; E. Vigorito; L. Fachal; C. A. Anderson; C. Wallace
Source: check_circle
Crossref

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Nature Genetics
2021-11 | Journal article
Contributors: Chris Eijsbouts; Tenghao Zheng; Nicholas A. Kennedy; Ferdinando Bonfiglio; Carl A. Anderson; Loukas Moutsianas; Joanne Holliday; Jingchunzi Shi; Suyash Shringarpure; Michelle Agee et al.
Source: check_circle
Crossref

Somatic mutations provide important and unique insights into the biology of complex diseases

Trends in Genetics
2021-10 | Journal article
Contributors: Sigurgeir Olafsson; Carl A. Anderson
Source: check_circle
Crossref

Network expansion of genetic associations defines a pleiotropy map of human cell biology

2021-07-19 | Other
Contributors: Inigo Barrio-Hernandez; Jeremy Schwartzentruber; Anjali Shrivastava; Noemi del-Toro; Qian Zhang; Glyn Bradley; Henning Hermjakob; Sandra Orchard; Ian Dunham; Carl A. Anderson et al.
Source: check_circle
Crossref

Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort.

Gastroenterology
2020-12-24 | Journal article
Source: Self-asserted source
Carl Anderson

Underpowered PANTS: A Response to the Conclusions of "Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab".

Gastroenterology
2020-10 | Journal article
Contributors: Sazonovs A; Ahmad T; Anderson CA
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Somatic Evolution in Non-neoplastic IBD-Affected Colon.

Cell
2020-07 | Journal article
Contributors: Olafsson S; McIntyre RE; Coorens T; Butler T; Jung H; Robinson PS; Lee-Six H; Sanders MA; Arestang K; Dawson C et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.

Nature communications
2020-02 | Journal article
Contributors: Serra EG; Schwerd T; Moutsianas L; Cavounidis A; Fachal L; Pandey S; Kammermeier J; Croft NM; Posovszky C; Rodrigues A et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles

Science Immunology
2019-11 | Journal article
Contributors: Velislava N. Petrova; Bevan Sawatsky; Alvin X. Han; Brigitta M. Laksono; Lisa Walz; Edyth Parker; Kathrin Pieper; Carl A. Anderson; Rory D. de Vries; Antonio Lanzavecchia et al.
Source: check_circle
Crossref

HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Gastroenterology
2019-10 | Journal article
Contributors: Sazonovs A; Kennedy NA; Moutsianas L; Heap GA; Rice DL; Reppell M; Bewshea CM; Chanchlani N; Walker GJ; Perry MH et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System.

Hepatology (Baltimore, Md.)
2019-03 | Journal article
Contributors: Goode EC; Clark AB; Mells GF; Srivastava B; Spiess K; Gelson WTH; Trivedi PJ; Lynch KD; Castren E; Vesterhus MN et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

JAMA
2019-02 | Journal article
Contributors: Walker GJ; Harrison JW; Heap GA; Voskuil MD; Andersen V; Anderson CA; Ananthakrishnan AN; Barrett JC; Beaugerie L; Bewshea CM et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

PLoS genetics
2018-12 | Journal article
Contributors: Darlay R; Ayers KL; Mells GF; Hall LS; Liu JZ; Almarri MA; Alexander GJ; Jones DE; Sandford RN; Anderson CA et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central
grade
Preferred source (of 2)‎

Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.

JCI insight
2018-10 | Journal article
Contributors: Cangul H; Liao XH; Schoenmakers E; Kero J; Barone S; Srichomkwun P; Iwayama H; Serra EG; Saglam H; Eren E et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia.

Frontiers in immunology
2018-08 | Journal article
Contributors: Petrova VN; Muir L; McKay PF; Vassiliou GS; Smith KGC; Lyons PA; Russell CA; Anderson CA; Kellam P; Bashford-Rogers RJM
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

Gastroenterology
2018-06 | Journal article
Contributors: Quaranta M; Wilson R; Gonçalves Serra E; Pandey S; Schwerd T; Gilmour K; Klenerman P; Powrie F; Keshav S; Travis SPL et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes.

Nature communications
2018-06 | Journal article
Contributors: Momozawa Y; Dmitrieva J; Théâtre E; Deffontaine V; Rahmouni S; Charloteaux B; Crins F; Docampo E; Elansary M; Gori AS et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

PLoS genetics
2018-05 | Journal article
Contributors: Rivas MA; Avila BE; Koskela J; Huang H; Stevens C; Pirinen M; Haritunians T; Neale BM; Kurki M; Ganna A et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.

Mucosal immunology
2017-11 | Journal article
Contributors: Schwerd T; Bryant RV; Pandey S; Capitani M; Meran L; Cazier JB; Jung J; Mondal K; Parkes M; Mathew CG et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut
2017-08 | Journal article
Contributors: Alberts R; de Vries EMG; Goode EC; Jiang X; Sampaziotis F; Rombouts K; Böttcher K; Folseraas T; Weismüller TJ; Mason AL et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

Nature
2017-06 | Journal article
Contributors: Huang H; Fang M; Jostins L; Umićević Mirkov M; Boucher G; Anderson CA; Andersen V; Cleynen I; Cortes A; Crins F et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

Nature genetics
2017-01 | Journal article
Contributors: Luo Y; de Lange KM; Jostins L; Moutsianas L; Randall J; Kennedy NA; Lamb CA; McCarthy S; Ahmad T; Edwards C et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

Nature genetics
2017-01 | Journal article
Contributors: Lee JC; Biasci D; Roberts R; Gearry RB; Mansfield JC; Ahmad T; Prescott NJ; Satsangi J; Wilson DC; Jostins L et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

Nature genetics
2017-01 | Journal article
Contributors: de Lange KM; Moutsianas L; Lee JC; Lamb CA; Luo Y; Kennedy NA; Jostins L; Rice DL; Gutierrez-Achury J; Ji SG et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nature genetics
2016-12 | Journal article
Contributors: Ji SG; Juran BD; Mucha S; Folseraas T; Jostins L; Melum E; Kumasaka N; Atkinson EJ; Schlicht EM; Liu JZ et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nature communications
2016-08 | Journal article
Contributors: Rivas MA; Graham D; Sulem P; Stevens C; Desch AN; Goyette P; Gudbjartsson D; Jonsdottir I; Thorsteinsdottir U; Degenhardt F et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

A reference panel of 64,976 haplotypes for genotype imputation.

Nature genetics
2016-08 | Journal article
Contributors: McCarthy S; Das S; Kretzschmar W; Delaneau O; Wood AR; Teumer A; Kang HM; Fuchsberger C; Danecek P; Sharp K et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Comprehensive Screening of Eight Known Causative Genes in Congenital Hypothyroidism With Gland-in-Situ.

The Journal of clinical endocrinology and metabolism
2016-08 | Journal article
Contributors: Nicholas AK; Serra EG; Cangul H; Alyaarubi S; Ullah I; Schoenmakers E; Deeb A; Habeb AM; Almaghamsi M; Peters C et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci.

BMC medical genetics
2016-04 | Journal article
Contributors: Saadati HR; Wittig M; Helbig I; Häsler R; Anderson CA; Mathew CG; Kupcinskas L; Parkes M; Karlsen TH; Rosenstiel P et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.

Lancet (London, England)
2015-10 | Journal article
Contributors: Cleynen I; Boucher G; Jostins L; Schumm LP; Zeissig S; Ahmad T; Andersen V; Andrews JM; Annese V; Brand S et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Class II HLA interactions modulate genetic risk for multiple sclerosis.

Nature genetics
2015-09 | Journal article
Contributors: Moutsianas L; Jostins L; Beecham AH; Dilthey AT; Xifara DK; Ban M; Shah TS; Patsopoulos NA; Alfredsson L; Anderson CA et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Nature communications
2015-09 | Journal article
Contributors: Cordell HJ; Han Y; Mells GF; Li Y; Hirschfield GM; Greene CS; Xie G; Juran BD; Zhu D; Qian DC et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

The UK10K project identifies rare variants in health and disease.

Nature
2015-09 | Journal article
Contributors: UK10K Consortium; Walter K; Min JL; Huang J; Crooks L; Memari Y; McCarthy S; Perry JR; Xu C; Futema M et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

Nature genetics
2015-07 | Journal article
Contributors: Liu JZ; van Sommeren S; Huang H; Ng SC; Alberts R; Takahashi A; Ripke S; Lee JC; Jostins L; Shah T et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

Nature genetics
2015-01 | Journal article
Contributors: Goyette P; Boucher G; Mallon D; Ellinghaus E; Jostins L; Huang H; Ripke S; Gusareva ES; Annese V; Hauser SL et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.

PloS one
2014-10 | Journal article
Contributors: Houldcroft CJ; Petrova V; Liu JZ; Frampton D; Anderson CA; Gall A; Kellam P
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

American journal of human genetics
2014-06 | Journal article
Contributors: Rainger J; Pehlivan D; Johansson S; Bengani H; Sanchez-Pulido L; Williamson KA; Ture M; Barker H; Rosendahl K; Spranger J et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

Gut
2014-05 | Journal article
Contributors: Raine T; Liu JZ; Anderson CA; Parkes M; Kaser A
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genetic studies of Crohn's disease: past, present and future.

Best practice & research. Clinical gastroenterology
2014-05 | Journal article
Contributors: Liu JZ; Anderson CA
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

American journal of human genetics
2014-01 | Journal article
Contributors: Williamson KA; Rainger J; Floyd JA; Ansari M; Meynert A; Aldridge KV; Rainger JK; Anderson CA; Moore AT; Hurles ME et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.

PLoS genetics
2013-09 | Journal article
Contributors: Beaudoin M; Goyette P; Boucher G; Lo KS; Rivas MA; Stevens C; Alikashani A; Ladouceur M; Ellinghaus D; Törkvist L et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

Cell
2013-09 | Journal article
Contributors: Lee JC; Espéli M; Anderson CA; Linterman MA; Pocock JM; Williams NJ; Roberts R; Viatte S; Fu B; Peshu N et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nature genetics
2013-04 | Journal article
Contributors: Liu JZ; Hov JR; Folseraas T; Ellinghaus E; Rushbrook SM; Doncheva NT; Andreassen OA; Weersma RK; Weismüller TJ; Eksteen B et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Nature
2012-11 | Journal article
Contributors: Jostins L; Ripke S; Weersma RK; Duerr RH; McGovern DP; Hui KY; Lee JC; Schumm LP; Sharma Y; Anderson CA et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Genome-wide association meta-analysis identifies new endometriosis risk loci.

Nature genetics
2012-10 | Journal article
Contributors: Nyholt DR; Low SK; Anderson CA; Painter JN; Uno S; Morris AP; MacGregor S; Gordon SD; Henders AK; Martin NG et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

Nature genetics
2012-09 | Journal article
Contributors: Liu JZ; Almarri MA; Gaffney DJ; Mells GF; Jostins L; Cordell HJ; Ducker SJ; Day DB; Heneghan MA; Neuberger JM et al.
Source: Self-asserted source
Carl Anderson via Europe PubMed Central

optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants.

Bioinformatics (Oxford, England)
2012-04 | Journal article
Contributors: Shah TS; Liu JZ; Floyd JA; Morris JA; Wirth N; Barrett JC; Anderson CA
Source: Self-asserted source
Carl Anderson via Europe PubMed Central
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Peer review (3 reviews for 3 publications/grants)

Review activity for Nature communications (1)
Review activity for Nature genetics. (1)
Review activity for PLOS genetics. (1)