Personal information

Other IDs

ResearcherID: H-6899-2013
ResearcherID: B-8677-2019

Countries

Denmark

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Employment (4)

Clinical Microbiomics (Denmark): Copenhagen, DK

2022-07-01 to present | VP & BU Leader, Discovery and New Business Areas
Employment
Source: Self-asserted source
Jacob Bak Holm

Clinical Microbiomics (Denmark): Copenhagen, DK

2021-06-01 to 2022-06-30 | VP of Discovery Programs & Partnerships
Employment
Source: Self-asserted source
Jacob Bak Holm

Clinical Microbiomics (Denmark): Copenhagen, DK

2016-11-01 to 2021-06-01 | Director of Scientific Operations
Employment
Source: Self-asserted source
Jacob Bak Holm

University of Copenhagen: Copenhagen, DK

2012-01-15 to 2016-09-31 | Post Doc (Biology)
Employment
Source: Self-asserted source
Jacob Bak Holm

Education and qualifications (3)

University of Copenhagen: Copenhagen, DK

2012 to 2015-12 | Phd Molecular Biomedicine (Biology)
Education
Source: Self-asserted source
Jacob Bak Holm

University of Copenhagen: Copenhagen, DK

2009-08 to 2011-12 | M.Sc. Molecular Biomedicine
Education
Source: Self-asserted source
Jacob Bak Holm

University of Copenhagen: Copenhagen, DK

2006-08 to 2009-08 | B.Sc. Molecular Biomedicine
Education
Source: Self-asserted source
Jacob Bak Holm

Works (29)

The association between the gut microbiome and 24-hour blood pressure measurements in the SCAPIS study

2023-12-09 | Preprint
DOI: 10.1101/2023.12.08.23299598
Contributors: Yi-Ting Lin; Sergi Sayols-Baixeras; Gabriel Baldanzi; Koen F. Dekkers; Ulf Hammar; Diem Nguyen; Nynne Nielsen; Aron C. Eklund; Georgios Varotsis; Jacob B. Holm et al.
Source: check_circle
Crossref

OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study

CHEST
2023-08 | Journal article
DOI: 10.1016/j.chest.2023.03.010
Contributors: Gabriel Baldanzi; Sergi Sayols-Baixeras; Jenny Theorell-Haglöw; Koen F. Dekkers; Ulf Hammar; Diem Nguyen; Yi-Ting Lin; Shafqat Ahmad; Jacob Bak Holm; Henrik Bjørn Nielsen et al.
Source: check_circle
Crossref

Obstructive sleep apnea is associated with specific gut microbiota species and functions in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS)

2022-06-14 | Preprint
DOI: 10.1101/2022.06.10.22276241
Contributors: Gabriel Baldanzi; Sergi Sayols-Baixeras; Jenny Theorell-Haglöw; Koen F Dekkers; Ulf Hammar; Diem Nguyen; Yi-Ting Lin; Shafqat Ahmad; Jacob Bak Holm; Henrik Bjørn Nielsen et al.
Source: check_circle
Crossref

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.

Cell
2020-03 | Journal article
DOI: 10.1016/j.cell.2020.02.035
PMID: 32160527
Contributors: Duscha A; Gisevius B; Hirschberg S; Yissachar N; Stangl GI; Eilers E; Bader V; Haase S; Kaisler J; David C et al.
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson's Disease.

Cells
2020-02 | Journal article
DOI: 10.3390/cells9020376
PMID: 32041265
PMC: PMC7072275
Contributors: Hegelmaier T; Lebbing M; Duscha A; Tomaske L; Tönges L; Holm JB; Bjørn Nielsen H; Gatermann SG; Przuntek H; Haghikia A
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

Lysates ofMethylococcus capsulatusBath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+Tregs and improve metabolism

2019-11 | Preprint
DOI: 10.1101/855486
OTHER-ID:

PPR103612
Contributors: Jensen BAH; Holm JB; Larsen IS; von Burg N; Derer S; Rivollier A; Agrinier AL; Sulek K; Indrelid SA; Arnoldussen YJ et al.
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice.

Scientific reports
2019-10 | Journal article
DOI: 10.1038/s41598-019-52103-x
PMID: 31666597
PMC: PMC6821799
Contributors: Madsen MSA; Holm JB; Pallejà A; Wismann P; Fabricius K; Rigbolt K; Mikkelsen M; Sommer M; Jelsing J; Nielsen HB et al.
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice

The Journal of Nutritional Biochemistry
2019-04 | Journal article
DOI: 10.1016/j.jnutbio.2019.01.003
Contributors: Even Fjære; Lene Secher Myrmel; Ditte Olsen Lützhøft; Hanne Andersen; Jacob Bak Holm; Pia Kiilerich; Rita Hannisdal; Bjørn Liaset; Karsten Kristiansen; Lise Madsen
Source: check_circle
Crossref

Human Paneth cell α-defensin-5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice.

American journal of physiology. Endocrinology and metabolism
2019-03 | Journal article
DOI: 10.1152/ajpendo.00019.2019
PMID: 30860877
Contributors: Larsen IS; Fritzen AM; Carl CS; Agerholm M; Damgaard MTF; Holm JB; Marette A; Nordkild P; Kiens B; Kristiansen K et al.
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

Mechanisms Preserving Insulin Action during High Dietary Fat Intake.

Cell metabolism
2019-01 | Journal article
DOI: 10.1016/j.cmet.2018.10.002
PMID: 30625306
Contributors: Lundsgaard AM; Holm JB; Sjøberg KA; Bojsen-Møller KN; Myrmel LS; Fjære E; Jensen BAH; Nicolaisen TS; Hingst JR; Hansen SL et al.
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat

The Journal of nutritional biochemistry
2018 | Journal article
DOI: 10.1016/j.jnutbio.2017.09.026
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 3)‎

High intake of dairy during energy restriction does not affect energy balance or the intestinal microflora compared with low dairy intake in overweight individuals in a randomized controlled trial

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
2018 | Journal article
DOI: 10.1139/apnm-2017-0234
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Cell metabolism
2018 | Journal article
DOI: 10.1016/j.cmet.2018.08.022
Source: Self-asserted source
Jacob Bak Holm

Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis

International journal of obesity (2005)
2018 | Journal article
DOI: 10.1038/s41366-018-0093-2
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Acute infection with the intestinal parasite Trichuris muris has long-term consequences on mucosal mast cell homeostasis and epithelial integrity

European journal of immunology
2017 | Journal article
DOI: 10.1002/eji.201646738
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour

Reproduction (Cambridge, England)
2017 | Journal article
DOI: 10.1530/rep-17-0165
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome

Journal of nutritional science
2016 | Journal article
DOI: 10.1017/jns.2016.38
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Diet-induced obesity, energy metabolism and gut microbiota in C57BL/6J mice fed Western diets based on lean seafood or lean meat mixtures

The Journal of nutritional biochemistry
2016 | Journal article
DOI: 10.1016/j.jnutbio.2015.12.017
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

Metabolism: clinical and experimental
2016 | Journal article
DOI: 10.1016/j.metabol.2016.09.002
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Human gut microbes impact host serum metabolome and insulin sensitivity

Nature
2016 | Journal article
DOI: 10.1038/nature18646
Source: Self-asserted source
Jacob Bak Holm

Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility

Toxicological sciences : an official journal of the Society of Toxicology
2016 | Journal article
DOI: 10.1093/toxsci/kfv332
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis

Immunity
2016 | Journal article
DOI: 10.1016/j.immuni.2016.02.008
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Human gut microbes impact host serum metabolome and insulin sensitivity.

2016-07 | Journal article
PMID: 27409811
Contributors: Pedersen HK; Gudmundsdottir V; Nielsen HB; Hyotylainen T; Nielsen T; Jensen BA; Forslund K; Hildebrand F; Prifti E; Falony G et al.
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central

The protein source determines the potential of high protein diets to attenuate obesity development in C57BL / 6J mice

Adipocyte
2016-03-17 | Journal article
DOI: 10.1080/21623945.2015.1122855
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Aniline Is Rapidly Converted Into Paracetamol Impairing Male Reproductive Development

Toxicological Sciences
2015 | Journal article
DOI: 10.1093/toxsci/kfv179
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli

PloS one
2015 | Journal article
DOI: 10.1371/journal.pone.0125495
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Physiological role of taurine--from organism to organelle

Acta physiologica (Oxford, England)
2015 | Journal article
DOI: 10.1111/apha.12365
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase

American journal of physiology. Cell physiology
2013 | Journal article
DOI: 10.1152/ajpcell.00412.2012
Source: Self-asserted source
Jacob Bak Holm
grade
Preferred source (of 2)‎

Pinpointing differences in cisplatin-induced apoptosis in adherent and non-adherent cancer cells.

2010 | Journal article
DOI: 10.1159/000323990
PMID: 21220912
Contributors: Tastesen HS; Holm JB; Møller J; Poulsen KA; Møller C; Stürup S; Hoffmann EK; Lambert IH
Source: Self-asserted source
Jacob Bak Holm via Europe PubMed Central
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