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The Ohio State University: Columbus, OH, US

2011-04-01 to present | Professor (Chemistry and Biochemistry)
Employment
Source: Self-asserted source
Dmitri Kudryashov

Funding (2)

Actin oligomers as novel toxins targeting key steps of actin dynamics

2015-09-01 to 2020-05-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://grants.uberresearch.com/100000057/R01GM114666/Actin-oligomers-as-novel-toxins-targeting-key-steps-of-actin-dynamics
GRANT_NUMBER: 5R01GM114666-02
Source: Self-asserted source
Dmitri Kudryashov via DimensionsWizard

Split-and-Splice Approach for Highly Selective Targeting of Human NSCLC Tumors

2013-09-30 to 2014-09-29 | Grant
Congressionally Directed Medical Research Programs (Fort Detrick, US)
URL: https://grants.uberresearch.com/100000090/W81XWH1310258/Split-and-Splice-Approach-for-Highly-Selective-Targeting-of-Human-NSCLC-Tumors
GRANT_NUMBER:

W81XWH1310258
Source: Self-asserted source
Dmitri Kudryashov via DimensionsWizard

Works (49)

Antagonistic Effects of Actin-Specific Toxins on Salmonella Typhimurium Invasion into Mammalian Cells

Biomolecules
2024-11-09 | Journal article
DOI: 10.3390/biom14111428
Contributors: David B. Heisler; Elena Kudryashova; Regan Hitt; Blake Williams; Michelle Dziejman; John Gunn; Dmitri S. Kudryashov
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Crossref
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Antagonistic effects of actin-specific toxins onSalmonellaTyphimurium invasion into mammalian cells

2024-07-02 | Preprint
DOI: 10.1101/2024.07.01.601609
Contributors: David B. Heisler; Elena Kudryashova; Regan Hitt; Blake Williams; Michelle Dziejman; John Gunn; Dmitri S. Kudryashov
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Crossref

Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin

Structure
2024-06 | Journal article
DOI: 10.1016/j.str.2024.02.022
Contributors: Ewa Niedzialkowska; Lucas A. Runyan; Elena Kudryashova; Edward H. Egelman; Dmitri S. Kudryashov
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Crossref

Stabilization of F-actin bySalmonellaeffector SipA resembles the structural effects of inorganic phosphate and phalloidin

2023-12-26 | Preprint
DOI: 10.1101/2023.12.26.573373
Contributors: Ewa Niedzialkowska; Lucas A. Runyan; Elena Kudryashova; Edward H. Egelman; Dmitri S. Kudryashov
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Crossref

Actin Bundles Dynamics and Architecture

Biomolecules
2023-02-28 | Journal article
DOI: 10.3390/biom13030450
Contributors: Sudeepa Rajan; Dmitri S. Kudryashov; Emil Reisler
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Crossref
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Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL

Science Advances
2022-11-16 | Journal article
DOI: 10.1126/sciadv.adc9239
Contributors: Elena Kudryashova; Ankita; Heidi Ulrichs; Shashank Shekhar; Dmitri S. Kudryashov
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Crossref

Allosteric regulation controls actin-bundling properties of human plastins

Nature Structural & Molecular Biology
2022-06 | Journal article
DOI: 10.1038/s41594-022-00771-1
Contributors: Christopher L. Schwebach; Elena Kudryashova; Richa Agrawal; Weili Zheng; Edward H. Egelman; Dmitri S. Kudryashov
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Crossref

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

International Journal of Molecular Sciences
2022-06-24 | Journal article
DOI: 10.3390/ijms23137026
Contributors: Songyu Dong; Weili Zheng; Nicholas Pinkerton; Jacob Hansen; Svetlana B. Tikunova; Jonathan P. Davis; Sarah M. Heissler; Elena Kudryashova; Edward H. Egelman; Dmitri S. Kudryashov
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Crossref
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Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode

Nature Communications
2022-04-19 | Journal article
DOI: 10.1038/s41467-022-29595-9
Contributors: Jodi Kraus; Ryan W. Russell; Elena Kudryashova; Chaoyi Xu; Nidhi Katyal; Juan R. Perilla; Dmitri S. Kudryashov; Tatyana Polenova
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Crossref

Allosteric Regulation of Human Plastins

2021-12-01 | Other
DOI: 10.1101/2021.12.01.470822
Contributors: Christopher L. Schwebach; Elena Kudryashova; Richa Agrawal; Weili Zheng; Edward H. Egelman; Dmitri S. Kudryashov
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Crossref

SARS-CoV-2 inactivation by human defensin HNP1 and retrocyclin RC-101

2021-05-27 | Other
DOI: 10.1101/2021.05.27.445985
Contributors: Elena Kudryashova; Ashley Zani; Geraldine Vilmen; Amit Sharma; Wuyuan Lu; Jacob S. Yount; Dmitri S. Kudryashov
Source: check_circle
Crossref

Opposing activities of IFITM proteins in SARS‐CoV‐2 infection

The EMBO Journal
2021-02 | Journal article
DOI: 10.15252/embj.2020106501
Contributors: Guoli Shi; Adam D Kenney; Elena Kudryashova; Ashley Zani; Lizhi Zhang; Kin Kui Lai; Luanne Hall‐Stoodley; Richard T Robinson; Dmitri S Kudryashov; Alex A Compton et al.
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Crossref

<i>Rounding Out</i> the Understanding of ACD Toxicity with the Discovery of Cyclic Forms of Actin Oligomers

International Journal of Molecular Sciences
2021-01 | Journal article | Author
DOI: 10.3390/ijms22020718
Contributors: Harper Smith; Nick Pinkerton; David Heisler; Elena Kudryashova; Aaron R. Hall; Kelly Karch; Andrew Norris; Vicki Wysocki; Marcos Sotomayor; Emil Reisler et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts

Proceedings of the National Academy of Sciences
2020-09-08 | Journal article
DOI: 10.1073/pnas.2006603117
Contributors: Vedud Purde; Elena Kudryashova; David B. Heisler; Reena Shakya; Dmitri S. Kudryashov
Source: check_circle
Crossref

Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling

Bone Research
2020-05-22 | Journal article
DOI: 10.1038/s41413-020-0095-2
Contributors: Christopher L. Schwebach; Elena Kudryashova; Weili Zheng; Matthew Orchard; Harper Smith; Lucas A. Runyan; Edward H. Egelman; Dmitri S. Kudryashov
Source: check_circle
Crossref

Oligomerization Affects the Ability of Human Cyclase-Associated Proteins 1 and 2 to Promote Actin Severing by Cofilins

International Journal of Molecular Sciences
2019-11-12 | Journal article
DOI: 10.3390/ijms20225647
Contributors: Vedud Purde; Florian Busch; Elena Kudryashova; Vicki H. Wysocki; Dmitri S. Kudryashov
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Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins.

2016 | Journal article
DOI: 10.1038/srep32499
PMID: 27581352
PMC: PMC5007486
Contributors: Kudryashova E; Koneru PC; Kvaratskhelia M; Strömstedt AA; Lu W; Kudryashov DS
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.

2016-08 | Journal article
PMID: 27505898
Contributors: Serebryannyy LA; Parilla M; Annibale P; Cruz CM; Laster K; Gratton E; Kudryashov D; Kosak ST; Gottardi CJ; de Lanerolle P
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Defensins versus pathogens: an unfolding story.

2015-10 | Journal article
DOI: 10.18632/oncotarget.5109
PMID: 26318168
PMC: PMC4745673
Contributors: Kudryashova E; Lu W; Kudryashov DS
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton.

2015-10 | Journal article
DOI: 10.1134/s0006297915100090
PMID: 26567572
Contributors: Vilitkevich EL; Khapchaev AY; Kudryashov DS; Nikashin AV; Schavocky JP; Lukas TJ; Watterson DM; Shirinsky VP
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

2015-07 | Journal article
DOI: 10.1126/science.aab4090
PMID: 26228148
PMC: PMC4648357
Contributors: Heisler DB; Kudryashova E; Grinevich DO; Suarez C; Winkelman JD; Birukov KG; Kotha SR; Parinandi NL; Vavylonis D; Kovar DR et al.
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Retrocyclins neutralize bacterial toxins by potentiating their unfolding.

2015-04 | Journal article
DOI: 10.1042/bj20150049
PMID: 25670244
Contributors: Kudryashova E; Seveau S; Lu W; Kudryashov DS
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.

2015-01 | Journal article
DOI: 10.1091/mbc.e14-07-1196
PMID: 25411334
PMC: PMC4294672
Contributors: Wang N; Wang M; Zhu YH; Grosel TW; Sun D; Kudryashov DS; Wu JQ
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Cryo-EM reveals different coronin binding modes for ADP- and ADP-BeFx actin filaments.

2014-12 | Journal article
DOI: 10.1038/nsmb.2907
PMID: 25362487
PMC: PMC4388421
Contributors: Ge P; Durer ZA; Kudryashov D; Zhou ZH; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.

2014-11 | Journal article
DOI: 10.1016/j.immuni.2014.10.018
PMID: 25517613
PMC: PMC4269836
Contributors: Kudryashova E; Quintyn R; Seveau S; Lu W; Wysocki VH; Kudryashov DS
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Thermodynamic properties of the effector domains of MARTX toxins suggest their unfolding for translocation across the host membrane.

2014-06 | Journal article
DOI: 10.1111/mmi.12615
PMID: 24724536
Contributors: Kudryashova E; Heisler D; Zywiec A; Kudryashov DS
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Calcium binding is essential for plastin 3 function in Smn-deficient motoneurons.

2014-04 | Journal article
DOI: 10.1093/hmg/ddt595
PMID: 24271012
PMC: PMC3959813
Contributors: Lyon AN; Pineda RH; Hao le T; Kudryashova E; Kudryashov DS; Beattie CE
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

ATP and ADP actin states.

2013-04 | Journal article
DOI: 10.1002/bip.22155
PMID: 23348672
PMC: PMC3670783
Contributors: Kudryashov DS; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Glutamyl phosphate is an activated intermediate in actin crosslinking by actin crosslinking domain (ACD) toxin.

2012 | Journal article
DOI: 10.1371/journal.pone.0045721
PMID: 23029200
PMC: PMC3448709
Contributors: Kudryashova E; Kalda C; Kudryashov DS
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Structural states and dynamics of the D-loop in actin.

2012-09 | Journal article
DOI: 10.1016/j.bpj.2012.07.030
PMID: 23009842
PMC: PMC3433612
Contributors: Durer ZA; Kudryashov DS; Sawaya MR; Altenbach C; Hubbell W; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Remodeling of actin filaments by ADF/cofilin proteins.

2011-12 | Journal article
DOI: 10.1073/pnas.1110109108
PMID: 22158895
PMC: PMC3251117
Contributors: Galkin VE; Orlova A; Kudryashov DS; Solodukhin A; Reisler E; Schröder GF; Egelman EH
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

A nucleotide state-sensing region on actin.

2010-08 | Journal article
DOI: 10.1074/jbc.m110.123869
PMID: 20530485
PMC: PMC2919123
Contributors: Kudryashov DS; Grintsevich EE; Rubenstein PA; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Mapping of drebrin binding site on F-actin.

2010-05 | Journal article
DOI: 10.1016/j.jmb.2010.03.039
PMID: 20347847
PMC: PMC2866048
Contributors: Grintsevich EE; Galkin VE; Orlova A; Ytterberg AJ; Mikati MM; Kudryashov DS; Loo JA; Egelman EH; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

F-actin structure destabilization and DNase I binding loop: fluctuations mutational cross-linking and electron microscopy analysis of loop states and effects on F-actin.

2010-01 | Journal article
DOI: 10.1016/j.jmb.2009.11.001
PMID: 19900461
PMC: PMC3070609
Contributors: Oztug Durer ZA; Diraviyam K; Sept D; Kudryashov DS; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.

2008-11 | Journal article
DOI: 10.1073/pnas.0808082105
PMID: 19015515
PMC: PMC2587553
Contributors: Kudryashov DS; Durer ZA; Ytterberg AJ; Sawaya MR; Pashkov I; Prochazkova K; Yeates TO; Loo RR; Loo JA; Satchell KJ et al.
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Multiple crystal structures of actin dimers and their implications for interactions in the actin filament.

2008-04 | Journal article
DOI: 10.1107/s0907444908003351
PMID: 18391412
PMC: PMC2631129
Contributors: Sawaya MR; Kudryashov DS; Pashkov I; Adisetiyo H; Reisler E; Yeates TO
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Characterization of the enzymatic activity of the actin cross-linking domain from the Vibrio cholerae MARTX Vc toxin.

2008-01 | Journal article
DOI: 10.1074/jbc.m703910200
PMID: 17951576
PMC: PMC2365471
Contributors: Kudryashov DS; Cordero CL; Reisler E; Satchell KJ
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

The Actin cross-linking domain of the Vibrio cholerae RTX toxin directly catalyzes the covalent cross-linking of actin.

2006-10 | Journal article
DOI: 10.1074/jbc.m605275200
PMID: 16954226
PMC: PMC2255562
Contributors: Cordero CL; Kudryashov DS; Reisler E; Satchell KJ
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.

2006-05 | Journal article
DOI: 10.1016/j.jmb.2006.02.029
PMID: 16530787
Contributors: Kudryashov DS; Galkin VE; Orlova A; Phan M; Egelman EH; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.

2005-11 | Journal article
DOI: 10.1016/j.jmb.2005.09.068
PMID: 16243356
Contributors: Kudryashova E; Kudryashov D; Kramerova I; Spencer MJ
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

The crystal structure of a cross-linked actin dimer suggests a detailed molecular interface in F-actin.

2005-09 | Journal article
DOI: 10.1073/pnas.0506429102
PMID: 16141336
PMC: PMC1196358
Contributors: Kudryashov DS; Sawaya MR; Adisetiyo H; Norcross T; Hegyi G; Reisler E; Yeates TO
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Actin-destabilizing factors disrupt filaments by means of a time reversal of polymerization.

2004-12 | Journal article
DOI: 10.1073/pnas.0407525102
PMID: 15591338
PMC: PMC539747
Contributors: Orlova A; Shvetsov A; Galkin VE; Kudryashov DS; Rubenstein PA; Egelman EH; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Cofilin induced conformational changes in F-actin expose subdomain 2 to proteolysis.

2004-10 | Journal article
DOI: 10.1016/j.jmb.2004.08.010
PMID: 15364581
Contributors: Muhlrad A; Kudryashov D; Michael Peyser Y; Bobkov AA; Almo SC; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Formation and destabilization of actin filaments with tetramethylrhodamine-modified actin.

2004-08 | Journal article
DOI: 10.1529/biophysj.104.042242
PMID: 15298916
PMC: PMC1304452
Contributors: Kudryashov DS; Phillips M; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain.

2004-08 | Journal article
DOI: 10.1016/j.yexcr.2004.04.025
PMID: 15265689
Contributors: Kudryashov DS; Stepanova OV; Vilitkevich EL; Nikonenko TA; Nadezhdina ES; Shanina NA; Lukas TJ; Van Eldik LJ; Watterson DM; Shirinsky VP
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Solution properties of tetramethylrhodamine-modified G-actin.

2003-10 | Journal article
DOI: 10.1016/s0006-3495(03)74669-4
PMID: 14507709
PMC: PMC1303470
Contributors: Kudryashov DS; Reisler E
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon.

2002 | Journal article
DOI: 10.1023/a:1022086228770
PMID: 12630709
Contributors: Kudryashov DS; Vorotnikov AV; Dudnakova TV; Stepanova OV; Lukas TJ; Sellers JR; Watterson DM; Shirinsky VP
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles.

2001 | Journal article
DOI: 10.1023/a:1014503604270
PMID: 11964068
Contributors: Krymsky MA; Kudryashov DS; Shirinsky VP; Lukas TJ; Watterson DM; Vorotnikov AV
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton.

1999-12 | Journal article
DOI: 10.1016/s0014-5793(99)01591-4
PMID: 10601640
Contributors: Kudryashov DS; Chibalina MV; Birukov KG; Lukas TJ; Sellers JR; Van Eldik LJ; Watterson DM; Shirinsky VP
Source: Self-asserted source
Dmitri Kudryashov via Europe PubMed Central

Peer review (15 reviews for 13 publications/grants)

Review activity for American Heart Association (2)
Review activity for Biochemical pharmacology. (1)
Review activity for Biochemistry. (1)
Review activity for Biophysics reviews. (1)
Review activity for Cell communication and signaling. (1)
Review activity for Cellular and molecular life sciences (2)
Review activity for Communications biology. (1)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Molecular pharmaceutics. (1)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (1)
Review activity for PloS one. (1)
Review activity for Science advances. (1)
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