Personal information

Other IDs

SciProfiles: 2023847

Keywords

Autophagy, Chaperone Mediated Autophagy (CMA), Metabolic disorders (metabolism/diabetes/obesity), Odontoblast differentiation, Motorneuron diseases, Protein aggregation

Countries

Chile

Activities

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Employment (2)

Universidad de Chile: Santiago, RM, CL

profesor/a (Universidad de Chile)
Employment
Source: check_circle
Universidad de Chile via ORCID Member Portal

University of Chile: Santiago, Independencia, CL

2014-04-01 to present | Asistant Professor/Researcher (Faculty of Dentistry)
Employment
Source: Self-asserted source
Mauricio Fernando Budini

Education and qualifications (3)

International Centre for Genetic Engineering and Biotechnology: Trieste, Trieste, IT

2008-12-20 to 2014-03-01 | Postdoctoral training (Molecular Pathology Laboratory)
Qualification
Source: Self-asserted source
Mauricio Fernando Budini

University of Chile: Santiago, Independencia, CL

2004-03-01 to 2008-09-01 | PhD in Biomedical Sciences (Faculty of Medicine)
Education
Source: Self-asserted source
Mauricio Fernando Budini

Universidad Nacional de San Luis: San Luis, San Luis, AR

1998-03-01 to 2003-03-01 | Molecular Biologist (Chemistry, Biochemistry and Pharmacy Faculty)
Education
Source: Self-asserted source
Mauricio Fernando Budini

Professional activities (19)

Frontiers RNA: London, GB

Review Editor
Service
Source: Self-asserted source
Mauricio Fernando Budini

Frontiers in Endocrinology of Aging: London, GB

Gest Associate Editor
Service
Source: Self-asserted source
Mauricio Fernando Budini

Biomed International Research: London, GB

2020 to present | Academic Editor
Service
Source: Self-asserted source
Mauricio Fernando Budini

REPRISE Italy: Milan, IT

2019 to present | Research and postdoctoral projects reviewer
Service
Source: Self-asserted source
Mauricio Fernando Budini

Cellular Biology Society of Chile: Santiago, CL

2016 to present
Membership
Source: Self-asserted source
Mauricio Fernando Budini

Biochemistry and Molecular Biology Society of Chile: Santiago, CL

2016 to present | Academic member
Membership
Source: Self-asserted source
Mauricio Fernando Budini

Frontiers in Endocrinology of Aging: London, GB

2022 to 2022 | Topic Editor Selective and Secretory Autophagy Pathways and Molecules in the Prevention and Treatment of Complex Endocrine-metabolic Diseases of Aging
Service
Source: Self-asserted source
Mauricio Fernando Budini

Biochemistry and Molecular Biology Society of Chile: Santiago, CL

2020 to 2022 | Directive member
Membership
Source: Self-asserted source
Mauricio Fernando Budini

Scientific and Technologic Investigation Direction (DICYT): Santiago, CL

2021 to 2021 | Research project reviewer.
Service
Source: Self-asserted source
Mauricio Fernando Budini

Postgraduate Department, University of Chile: Santiago, CL

2021 to 2021 | Postgraduate projects reviewer
Service
Source: Self-asserted source
Mauricio Fernando Budini

Investigation and Development Direction, Austral University of Chile: Valdivia, CL

2021 to 2021 | Research project reviewer
Service
Source: Self-asserted source
Mauricio Fernando Budini

Fund for Scientific and Technological Research (FONCyT), Argentina: Buenos Aires, AR

2018 to 2018 | Research project reviewer
Service
Source: Self-asserted source
Mauricio Fernando Budini

U-Redes projects from University of Chile, Chile: Santiago, CL

2015 to 2015 | Research project reviewer
Service
Source: Self-asserted source
Mauricio Fernando Budini

International Centre for Genetic Engineering and Biotechnology: Trieste, IT

2008 | Post-doctoral Fellowship (ICGEB)
Distinction
Source: Self-asserted source
Mauricio Fernando Budini

Comisión Nacional de Investigación Científica y Tecnológica: Santiago, CL

2007 (CONICYT)
Distinction
Source: Self-asserted source
Mauricio Fernando Budini

Comisión Nacional de Investigación Científica y Tecnológica: Santiago, CL

2006 | Fellowship “For the Realization of PhD Thesis” (CONICYT)
Distinction
Source: Self-asserted source
Mauricio Fernando Budini

International Centre for Genetic Engineering and Biotechnology: Trieste, IT

2005 | Short Term Fellowship (Sandwich Fellowship) (ICGEB)
Distinction
Source: Self-asserted source
Mauricio Fernando Budini

MECESUP: Santiago, CL

2004 | Fellowship “For Post-graduate Studies” (Minster of Education)
Distinction
Source: Self-asserted source
Mauricio Fernando Budini

Ministry of Education: Buenos Aires, Buenos Aires, AR

1999 | National Fellowship “For University Studies”
Distinction
Source: Self-asserted source
Mauricio Fernando Budini

Funding (4)

Chaperone Mediated Autophagy as a novel regulator of odontoblast differentiation from human dental pulp stem cells

2022 to 2024 | Grant
Faculty of Dentistry Universtity of Chile (Santiago, CL)
GRANT_NUMBER:

FIOUCh 2022
Source: Self-asserted source
Mauricio Fernando Budini

Mechanisms of Autophagy in Obesity: characterization of Chaperone Mediated Autophagy (CMA) in hypothalamic cells treated with saturated fatty acids.

2017 to 2021 | Grant
Agencia Nacional de Investigación y Desarrollo (Santiago, CL)
GRANT_NUMBER:

ATC172066
Source: Self-asserted source
Mauricio Fernando Budini

Identification of factors involved or affected in TDP-43 aggregation

2016 to 2020 | Grant
International Centre for Genetic Engineering and Biotechnology (Trieste, IT)
GRANT_NUMBER:

CRP/CHI13-04RG

Source: Self-asserted source
Mauricio Fernando Budini

Regulation of TDP-43 aggregation through Chaperone Mediated Autophagy pathway (CMA): implications in neurodegenerative diseases like ALS.

2014 to 2017 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

1161123
Source: Self-asserted source
Mauricio Fernando Budini

Works (26)

Methods for studying primary cilia in heart tissue after ischemia-reperfusion injury

Methods in Cell Biology
2023 | Journal article | Author
DOI: 10.1016/bs.mcb.2022.12.013
Part of ISSN: 0091-679X
Contributors: Catalina Kretschmar; María Paz Hernández-Cáceres; 0000-0002-4116-4074; Daniel Pena-Oyarzun; Camila García-Navarrete; Rodrigo Troncoso; Francisco Díaz-Castro; Mauricio Fernando Budini; Eugenia Morselli; Jaime A Riquelme et al.
Source: Self-asserted source
Mauricio Fernando Budini

Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen

Cells
2023-02-16 | Journal article | Author
DOI: 10.3390/cells12040636
Part of ISSN: 2073-4409
Contributors: Ya-Lin Huang; Cristian De Gregorio; Verónica Silva; Álvaro A. Elorza; Patricio Léniz; Víctor Aliaga-Tobar; Vinicius Maracaja-Coutinho; Mauricio Fernando Budini; Fernando Ezquer; Marcelo Ezquer
Source: Self-asserted source
Mauricio Fernando Budini
grade
Preferred source (of 2)‎

Editorial: Selective and secretory autophagy pathways and molecules in the prevention and treatment of complex endocrine-metabolic diseases of aging

Frontiers in Endocrinology
2023-01-18 | Journal article
DOI: 10.3389/fendo.2023.1138630
Part of ISSN: 1664-2392
Contributors: Maria Ines Vaccaro; Claudio Daniel Gonzalez; Vincenzo De Tata; Jorge Quarleri; Mauricio Fernando Budini
Source: Self-asserted source
Mauricio Fernando Budini

Chaperone-mediated autophagy—mechanisms and disease role

Autophagy in Health and Disease
2022 | Book chapter
DOI: 10.1016/b978-0-12-822003-0.00004-8
Contributors: Amelina Albornoz; Alvaro Sequeida; Christian Rodríguez; Mauricio Budini
Source: Self-asserted source
Mauricio Fernando Budini

Autophagy in aging-related oral diseases

Frontiers in Endocrinology
2022-08-05 | Journal article
DOI: 10.3389/fendo.2022.903836
Part of ISSN: 1664-2392
Contributors: Daniel Peña-Oyarzún; Carla San Martin; María Paz Hernández-Cáceres; Sergio Lavandero; Eugenia Morselli; Mauricio Budini; Patricia V. Burgos; Alfredo Criollo
Source: Self-asserted source
Mauricio Fernando Budini

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism

Cell Death & Disease
2022-07-28 | Journal article
DOI: 10.1038/s41419-022-05109-9
Part of ISSN: 2041-4889
Contributors: Yenniffer Ávalos; María Paz Hernández-Cáceres; Pablo Lagos; Daniela Pinto-Nuñez; Patricia Rivera; Paulina Burgos; Francisco Díaz-Castro; Michelle Joy-Immediato; Leslye Venegas-Zamora; Erik Lopez-Gallardo et al.
Source: Self-asserted source
Mauricio Fernando Budini

Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro

Cells
2022-03 | Journal article | Author
DOI: 10.3390/cells11060920
Contributors: Rodrigo Espinosa; Karla Gutiérrez; Javiera Rios; Fernando Ormeño; Liliana Yantén; Pablo Galaz-Davison; César Ramírez; Valentina Parra; Amelina Albornoz; Ivan Alfaro et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Origanum vulgare L. essential oil inhibits virulence patterns of Candida spp. and potentiates the effects of fluconazole and nystatin in vitro

BMC Complementary Medicine and Therapies
2022-02-09 | Journal article
DOI: 10.1186/s12906-022-03518-z
Part of ISSN: 2662-7671
Contributors: Camila Cid-Chevecich; Andrea Müller-Sepúlveda; José Antonio Jara; Rodrigo López-Muñoz; Rocío Santander; Mauricio Budini; Alejandro Escobar; Raúl Quijada; Alfredo Criollo; Mario Díaz-Dosque et al.
Source: Self-asserted source
Mauricio Fernando Budini

Chaperone Mediated Autophagy Substrates and Components in Cancer

Frontiers in Oncology
2021-02-12 | Journal article
DOI: 10.3389/fonc.2020.614677
Part of ISSN: 2234-943X
Contributors: Javiera Rios; Alvaro Sequeida; Amelina Albornoz; Mauricio Budini
Source: Self-asserted source
Mauricio Fernando Budini

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>

Autophagy
2021-01-02 | Journal article
DOI: 10.1080/15548627.2020.1797280
Part of ISSN: 1554-8627
Part of ISSN: 1554-8635
Contributors: Daniel J. Klionsky; Amal Kamal Abdel-Aziz; Sara Abdelfatah; Mahmoud Abdellatif; Asghar Abdoli; Steffen Abel; Hagai Abeliovich; Marie H. Abildgaard; Yakubu Princely Abudu; Abraham Acevedo-Arozena et al.
Source: Self-asserted source
Mauricio Fernando Budini

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation

Frontiers in Molecular Neuroscience
2020-02-18 | Journal article
DOI: 10.3389/fnmol.2020.00019
Part of ISSN: 1662-5099
Contributors: Fernando Ormeño; Juan Hormazabal; José Moreno; Felipe Riquelme; Javiera Rios; Alfredo Criollo; Amelina Albornoz; Iván E. Alfaro; Mauricio Budini
Source: Self-asserted source
Mauricio Fernando Budini

Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes

Frontiers in Endocrinology
2019-05-08 | Journal article
DOI: 10.3389/fendo.2019.00280
Part of ISSN: 1664-2392
Contributors: Catalina Kretschmar; Daniel Peña-Oyarzun; Cecilia Hernando; Nadia Hernández-Moya; Alfredo Molina-Berríos; María Paz Hernández-Cáceres; Sergio Lavandero; Mauricio Budini; Eugenia Morselli; Valentina Parra et al.
Source: Self-asserted source
Mauricio Fernando Budini

Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

Frontiers in Endocrinology
2019-01-31 | Journal article
DOI: 10.3389/fendo.2018.00778
Part of ISSN: 1664-2392
Contributors: Iván E. Alfaro; Amelina Albornoz; Alfredo Molina; José Moreno; Karina Cordero; Alfredo Criollo; Mauricio Budini
Source: Self-asserted source
Mauricio Fernando Budini

New Roles of the Primary Cilium in Autophagy

BioMed Research International
2017 | Journal article
DOI: 10.1155/2017/4367019
Part of ISSN: 2314-6133
Part of ISSN: 2314-6141
Contributors: Yenniffer Ávalos; Daniel Peña-Oyarzun; Mauricio Budini; Eugenia Morselli; Alfredo Criollo
Source: Self-asserted source
Mauricio Fernando Budini

Poly(GP) proteins: a potential pharmacodynamic marker in ALS and FTD

Annals of Translational Medicine
2017-12 | Journal article
DOI: 10.21037/atm.2017.11.03
Part of ISSN: 2305-5839
Part of ISSN: 2305-5847
Contributors: Mauricio Budini; Alfredo Criollo
Source: Self-asserted source
Mauricio Fernando Budini

Hyperosmotic stress stimulates autophagy via polycystin-2

Oncotarget
2017-08-22 | Journal article
DOI: 10.18632/oncotarget.18995
Part of ISSN: 1949-2553
Contributors: Daniel Peña-Oyarzun; Rodrigo Troncoso; Catalina Kretschmar; Cecilia Hernando; Mauricio Budini; Eugenia Morselli; Sergio Lavandero; Alfredo Criollo
Source: Self-asserted source
Mauricio Fernando Budini

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72

Frontiers in Molecular Neuroscience
2017-05-30 | Journal article
DOI: 10.3389/fnmol.2017.00170
Part of ISSN: 1662-5099
Contributors: Mauricio Budini; Emanuele Buratti; Eugenia Morselli; Alfredo Criollo
Source: Self-asserted source
Mauricio Fernando Budini

TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain

Human Molecular Genetics
2015-01-01 | Journal article
DOI: 10.1093/hmg/ddu415
Part of ISSN: 0964-6906
Part of ISSN: 1460-2083
Contributors: Mauricio Budini; Valentina Romano; Zainuddin Quadri; Emanuele Buratti; Francisco E. Baralle
Source: Self-asserted source
Mauricio Fernando Budini

Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye

Neurobiology of Disease
2014-11 | Journal article
DOI: 10.1016/j.nbd.2014.07.009
Part of ISSN: 0969-9961
Contributors: Lucia Cragnaz; Raffaela Klima; Natasa Skoko; Mauricio Budini; Fabian Feiguin; Francisco E. Baralle
Source: Self-asserted source
Mauricio Fernando Budini

Targeting TDP-43 in neurodegenerative diseases

Expert Opinion on Therapeutic Targets
2014-06 | Journal article
DOI: 10.1517/14728222.2014.896905
Part of ISSN: 1472-8222
Part of ISSN: 1744-7631
Contributors: Mauricio Budini; Francisco E Baralle; Emanuele Buratti
Source: Self-asserted source
Mauricio Fernando Budini

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation

Brain Research
2012-06 | Journal article
DOI: 10.1016/j.brainres.2012.02.031
Part of ISSN: 0006-8993
Contributors: Mauricio Budini; Valentina Romano; S. Eréndira Avendaño-Vázquez; Sara Bembich; Emanuele Buratti; Francisco E. Baralle
Source: Self-asserted source
Mauricio Fernando Budini

Cellular Model of TAR DNA-binding Protein 43 (TDP-43) Aggregation Based on Its C-terminal Gln/Asn-rich Region

Journal of Biological Chemistry
2012-03 | Journal article
DOI: 10.1074/jbc.m111.288720
Part of ISSN: 0021-9258
Contributors: Mauricio Budini; Emanuele Buratti; Cristiana Stuani; Corrado Guarnaccia; Valentina Romano; Laura De Conti; Francisco E. Baralle
Source: Self-asserted source
Mauricio Fernando Budini

TDP-43 Autoregulation: Implications for Disease

Journal of Molecular Neuroscience
2011-11 | Journal article
DOI: 10.1007/s12031-011-9573-8
Part of ISSN: 0895-8696
Part of ISSN: 1559-1166
Contributors: Mauricio Budini; Emanuele Buratti
Source: Self-asserted source
Mauricio Fernando Budini

Regulation of Gene Expression by TDP-43 and FUS/TLS in Frontotemporal Lobar Degeneration

Current Alzheimer Research
2011-05-01 | Journal article
DOI: 10.2174/156720511795563719
Part of ISSN: 1567-2050
Contributors: M. Budini; F. E. Baralle; E. Buratti
Source: Self-asserted source
Mauricio Fernando Budini

Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1α

Journal of Cellular Biochemistry
2009-02-15 | Journal article
DOI: 10.1002/jcb.22019
Part of ISSN: 0730-2312
Part of ISSN: 1097-4644
Contributors: Mauricio Budini; Germaine Jacob; Ana Jedlicki; Carolina Pérez; Catherine C. Allende; Jorge E. Allende
Source: Self-asserted source
Mauricio Fernando Budini

Impaired hyperphosphorylation of rotavirus NSP5 in cells depleted of casein kinase 1α is associated with the formation of viroplasms with altered morphology and a moderate decrease in virus replication

Journal of General Virology
2007-10-01 | Journal article
DOI: 10.1099/vir.0.82922-0
Part of ISSN: 0022-1317
Part of ISSN: 1465-2099
Contributors: Michela Campagna; Mauricio Budini; Francesca Arnoldi; Ulrich Desselberger; Jorge E. Allende; Oscar R. Burrone
Source: Self-asserted source
Mauricio Fernando Budini

Peer review (1 review for 1 publication/grant)

Review activity for Communications biology. (1)
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