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Employment (4)

Fred Hutchinson Cancer Research Center: Seattle, WA, US

2017 to present | Assistant Member (Vaccine and Infectious Disease Division)
Employment
Source: Self-asserted source
Andrew McGuire

Fred Hutchinson Cancer Research Center: Seattle, WA, US

2014 to 2017 | Associate (Vaccine and Infectious Disease Division)
Employment
Source: Self-asserted source
Andrew McGuire

Seattle Biomed: Seattle, WA, US

2011 to 2014 | Postdoctoral Scientist (Laboratory of Leonidas Stamatatos)
Employment
Source: Self-asserted source
Andrew McGuire

University of Guelph: Guelph, ON, CA

2010 to 2011 | Postdoctoral Scientist (Laboratory of Dr. Dev Mangroo)
Employment
Source: Self-asserted source
Andrew McGuire

Education and qualifications (2)

University of Guelph: Guelph, ON, CA

2004 to 2011 | Ph.D. Molecular and Cellular Biology
Education
Source: Self-asserted source
Andrew McGuire

University of Guelph: Guelph, ON, CA

2000 to 2004 | B.S. Molecular Biology and Genetics
Education
Source: Self-asserted source
Andrew McGuire

Funding (4)

Defining the protective efficacy of antibodies against the EBV gH/gL glycoprotein complex

2019-08-09 to 2024-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.8557185
GRANT_NUMBER: R01AI147846
Source: Self-asserted source
Andrew McGuire via DimensionsWizard

Expansion and targeted maturation of germline HIV-1 bNAb-associated BCRs

2018-12-06 to 2023-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.7910519
GRANT_NUMBER: P01AI138212
Source: Self-asserted source
Andrew McGuire via DimensionsWizard

Germline-targeting anti-idiotype antibodies as novel HIV-1 immunogens

2016-06-01 to 2018-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.5244077
GRANT_NUMBER: R21AI127249
Source: Self-asserted source
Andrew McGuire via DimensionsWizard

Development of humanized mice to evaluate HIV vaccine candidates

2013-07-01 to 2015-12-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7648350
GRANT_NUMBER:

N/A
Source: Self-asserted source
Andrew McGuire via DimensionsWizard

Works (29)

Anti-idiotypic antibodies elicit anti-HIV-1-specific B cell responses.

The Journal of experimental medicine
2019-07-25 | Journal article
DOI: 10.1084/jem.20190446
PMID: 31345931
Source: Self-asserted source
Andrew McGuire

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes.

The Journal of experimental medicine
2019-07-25 | Journal article
DOI: 10.1084/jem.20190164
PMID: 31345930
Source: Self-asserted source
Andrew McGuire

Targeting broadly neutralizing antibody precursors: a naïve approach to vaccine design.

Current opinion in HIV and AIDS
2019-07-01 | Journal article
DOI: 10.1097/coh.0000000000000548
PMID: 30946041
Source: Self-asserted source
Andrew McGuire

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Nature
2019-05-29 | Journal article
DOI: 10.1038/s41586-019-1250-z
PMID: 31142836
Source: Self-asserted source
Andrew McGuire

HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells.

The Journal of experimental medicine
2019-04-11 | Journal article
DOI: 10.1084/jem.20190287
PMID: 30975893
Source: Self-asserted source
Andrew McGuire

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.

Immunity
2018-12-11 | Journal article
DOI: 10.1016/j.immuni.2018.10.015
PMID: 30552024
PMC: PMC6303191
Source: Self-asserted source
Andrew McGuire

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core.

eLife
2018-11-07 | Journal article
DOI: 10.7554/eLife.37688
PMID: 30403372
PMC: PMC6237438
Source: Self-asserted source
Andrew McGuire

Live rubella vectors can express native HIV envelope glycoproteins targeted by broadly neutralizing antibodies and prime the immune response to an envelope protein boost.

Vaccine
2018-07-20 | Journal article
DOI: 10.1016/j.vaccine.2018.07.010
PMID: 30037665
Source: Self-asserted source
Andrew McGuire

Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity.

Proceedings of the National Academy of Sciences of the United States of America
2018-04-16 | Journal article
DOI: 10.1073/pnas.1803457115
PMID: 29666227
PMC: PMC5939114
Source: Self-asserted source
Andrew McGuire

An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.

Immunity
2018-04-01 | Journal article
DOI: 10.1016/j.immuni.2018.03.026
PMID: 29669253
PMC: PMC5909843
Source: Self-asserted source
Andrew McGuire

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and its Idiotope

2017-12 | Journal article
DOI: 10.1016/j.celrep.2017.11.056
PMID: 29241550
Source: Self-asserted source
Andrew McGuire

Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections

2017-11 | Journal article
DOI: 10.1128/JVI.01628-17
PMC: PMC5790929
PMID: 29093093
Source: Self-asserted source
Andrew McGuire

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

2017-09 | Journal article
DOI: 10.1084/jem.20161160
PMC: PMC5584115
PMID: 28847869
Source: Self-asserted source
Andrew McGuire

Differences in allelic frequency and CDRH3 composition limit the engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

2016-11 | Journal article
DOI: 10.1016/j.celrep.2016.10.017
PMC: PMC5207042
PMID: 27806295
Source: Self-asserted source
Andrew McGuire

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

2016-09 | Journal article
DOI: 10.1016/j.cell.2016.07.029
PMC: PMC5103708
PMID: 27610571
Source: Self-asserted source
Andrew McGuire

Structural basis for germline antibody recognition of HIV-1 immunogens

2016-03 | Journal article
DOI: 10.7554/eLife.13783
PMC: PMC4811768
PMID: 26997349
Source: Self-asserted source
Andrew McGuire

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

2016-02 | Journal article
DOI: 10.1038/ncomms10618
PMC: PMC4770077
PMID: 26907590
Source: Self-asserted source
Andrew McGuire

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

2015-06 | Journal article
DOI: 10.1016/j.cell.2015.06.003
PMC: PMC4604566
PMID: 26091035
Source: Self-asserted source
Andrew McGuire

Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies

2014-12 | Journal article
DOI: 10.1126/science.1259206
PMC: PMC4290850
PMID: 25504724
Source: Self-asserted source
Andrew McGuire

Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses

2014-05 | Journal article
DOI: 10.1371/journal.ppat.1004103
PMC: PMC4006906
PMID: 24788925
Source: Self-asserted source
Andrew McGuire

Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D

2014-03 | Journal article
DOI: 10.1128/JVI.03228-13
PMC: PMC3958080
PMID: 24352455
Source: Self-asserted source
Andrew McGuire

Rational HIV immunogen design to target specific germline B cell receptors

2013-05 | Journal article
DOI: 10.1126/science.1234150
PMC: PMC3689846
PMID: 23539181
Source: Self-asserted source
Andrew McGuire

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

2013-04 | Journal article
DOI: 10.1084/jem.20122824
PMC: PMC3620356
PMID: 23530120
Source: Self-asserted source
Andrew McGuire

Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs

2013-01 | Journal article
DOI: 10.1371/journal.ppat.1003106
PMC: PMC3536657
PMID: 23300456
Source: Self-asserted source
Andrew McGuire

Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex

2012-02 | Journal article
DOI: 10.1111/j.1600-0854.2011.01304.x
PMID: 22008473
Source: Self-asserted source
Andrew McGuire

Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms

2011-09 | Journal article
DOI: 10.1091/mbc.E09-07-0594
PMC: PMC3069012
PMID: 21289100
Source: Self-asserted source
Andrew McGuire

Utp9p facilitates Msn5p-mediated nuclear reexport of retrograded tRNAs in Saccharomyces cerevisiae

2009-12 | Journal article
DOI: 10.1091/mbc.E09-06-0490
PMC: PMC2785743
PMID: 19812255
Source: Self-asserted source
Andrew McGuire

Structural modeling identified the tRNA-binding domain of Utp8p, an essential nucleolar component of the nuclear tRNA export machinery of Saccharomyces cerevisiae

2009-04 | Journal article
DOI: 10.1139/o08-145
PMID: 19370060
Source: Self-asserted source
Andrew McGuire

Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.

2007-01 | Journal article
DOI: 10.1038/sj.emboj.7601493
PMC: PMC1783447
PMID: 17203074
Source: Self-asserted source
Andrew McGuire
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