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European Bioinformatics Institute: Cambridge, GB

Platform Coordinator (Open Targets)
Employment
Source: Self-asserted source
David Ochoa

Works (37)

Associations on the Fly, a new feature aiming to facilitate exploration of the Open Targets Platform evidence

2025-02-10 | Other
Contributors: Carlos Cruz-Castillo; Lucs Fumis; Chintan Mehta; Ricardo E Martinez-Osorio; Juan Maria Roldan-Romero; Helena Cornu; Prashant Uniyal; Antonio Solano-Roman; Miguel Carmona; David Ochoa et al.
Source: check_circle
Crossref

Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery.

Nucleic acids research
2024-12 | Journal article
Contributors: Buniello A; Suveges D; Cruz-Castillo C; Llinares MB; Cornu H; Lopez I; Tsukanov K; Roldán-Romero JM; Mehta C; Fumis L et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Associations on the Fly, a new feature aiming to facilitate exploration of the Open Targets Platform evidence

2024-09 | Preprint
Contributors: Cruz-Castillo C; Fumis L; Mehta C; Martinez-Osorio R; Roldan-Romero J; Cornu H; Uniyal P; Solano-Roman A; Carmona M; Ochoa D et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Genetic factors associated with reasons for clinical trial stoppage

Nature Genetics
2024-09 | Journal article
Contributors: Olesya Razuvayevskaya; Irene Lopez; Ian Dunham; David Ochoa
Source: check_circle
Crossref
grade
Preferred source (of 4)‎

Lit-OTAR Framework for Extracting Biological Evidences from Literature

2024-03-11 | Preprint
Contributors: Santosh Tirunagari; Shyamasree Saha; Aravind Venkatesan; Daniel Suveges; Miguel Carmona; Annalisa Buniello; David Ochoa; Johanna McEntyre; Ellen McDonagh; Melissa Harrison
Source: check_circle
Crossref

EMBL's European Bioinformatics Institute (EMBL-EBI) in 2023.

Nucleic acids research
2024-01 | Journal article
Contributors: Thakur M; Buniello A; Brooksbank C; Gurwitz KT; Hall M; Hartley M; Hulcoop DG; Leach AR; Marques D; Martin M et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Genetic support for FDA-approved drugs over the past decade.

Nature reviews. Drug discovery
2023-11 | Journal article
Contributors: Rusina PV; Falaguera MJ; Romero JMR; McDonagh EM; Dunham I; Ochoa D
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

Scientific Data
2023-09-25 | Journal article
Contributors: Clare E. West; Mohd Karim; Maria J. Falaguera; Leo Speidel; Charlotte J. Green; Lisa Logie; Jeremy Schwartzentruber; David Ochoa; Janet M. Lord; Michael A. J. Ferguson et al.
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Democratizing knowledge representation with BioCypher.

Nature biotechnology
2023-08 | Journal article
Contributors: Lobentanzer S; Aloy P; Baumbach J; Bohar B; Carey VJ; Charoentong P; Danhauser K; Doğan T; Dreo J; Dunham I et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central
grade
Preferred source (of 2)‎

Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins

2023-06 | Preprint
Contributors: Karim MA; Ariano B; Schwartzentruber J; Roldan-Romero JM; Mountjoy E; Hayhurst J; Buniello A; Mohammed ESE; Carmona M; Holmes MV et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central
grade
Preferred source (of 3)‎

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Nature Genetics
2023-03 | Journal article
Contributors: Inigo Barrio-Hernandez; Jeremy Schwartzentruber; Anjali Shrivastava; Noemi del-Toro; Asier Gonzalez; Qian Zhang; Edward Mountjoy; Daniel Suveges; David Ochoa; Maya Ghoussaini et al.
Source: check_circle
Crossref

The next-generation Open Targets Platform: reimagined, redesigned, rebuilt

Nucleic Acids Research
2023-01-06 | Journal article
Contributors: David Ochoa; Andrew Hercules; Miguel Carmona; Daniel Suveges; Jarrod Baker; Cinzia Malangone; Irene Lopez; Alfredo Miranda; Carlos Cruz-Castillo; Luca Fumis et al.
Source: check_circle
Crossref

Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs.

Nature reviews. Drug discovery
2022-08 | Journal article
Contributors: Ochoa D; Karim M; Ghoussaini M; Hulcoop DG; McDonagh EM; Dunham I
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Mondo: Unifying diseases for the world, by the world

2022-04 | Preprint
Contributors: Vasilevsky NA; Matentzoglu NA; Toro S; Flack JE; Hegde H; Unni DR; Alyea GF; Amberger JS; Babb L; Balhoff JP et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

High-throughput functional characterization of protein phosphorylation sites in yeast

Nature Biotechnology
2021-10-18 | Journal article
Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance.

Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci

Nature genetics
2021-08 | Journal article
Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

The PROTACtable genome.

Nature reviews. Drug discovery
2021-07 | Journal article
Contributors: Schneider M; Radoux CJ; Hercules A; Ochoa D; Dunham I; Zalmas LP; Hessler G; Ruf S; Shanmugasundaram V; Hann MM et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer.

Cell reports
2021-05 | Journal article
Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Nucleic acids research
2021-01 | Journal article
Contributors: Ghoussaini M; Mountjoy E; Carmona M; Peat G; Schmidt EM; Hercules A; Fumis L; Miranda A; Carvalho-Silva D; Buniello A et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Open Targets Platform: supporting systematic drug-target identification and prioritisation.

Nucleic acids research
2021-01 | Journal article
Contributors: Ochoa D; Hercules A; Carmona M; Suveges D; Gonzalez-Uriarte A; Malangone C; Miranda A; Fumis L; Carvalho-Silva D; Spitzer M et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Conserved phosphorylation hotspots in eukaryotic protein domain families

Nature Communications
2019-12 | Journal article
Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

Publisher Correction: Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

Nature Communications
2019-12 | Journal article
Contributors: N. del-Toro; M. Duesbury; M. Koch; L. Perfetto; A. Shrivastava; D. Ochoa; O. Wagih; J. Piñero; M. Kotlyar; C. Pastrello et al.
Source: check_circle
Crossref

The functional landscape of the human phosphoproteome

Nature Biotechnology
2019-12-09 | Journal article
Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

Multi-omics characterization of interaction-mediated control of human protein abundance levels

Molecular & Cellular Proteomics
2019-06-25 | Journal article
Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set.

Nature communications
2019-01 | Journal article
Contributors: IMEx Consortium Curators; Del-Toro N; Duesbury M; Koch M; Perfetto L; Shrivastava A; Ochoa D; Wagih O; Piñero J; Kotlyar M et al.
Source: Self-asserted source
David Ochoa via Europe PubMed Central
grade
Preferred source (of 4)‎

Evolution, dynamics and dysregulation of kinase signalling.

Current opinion in structural biology
2018-01 | Journal article
Contributors: Ochoa D; Bradley D; Beltrao P
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Benchmarking substrate-based kinase activity inference using phosphoproteomic data.

Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

Systematic Analysis of Transcriptional and Post-transcriptional Regulation of Metabolism in Yeast.

Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

An atlas of human kinase regulation.

Source: Self-asserted source
David Ochoa
grade
Preferred source (of 3)‎

Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs.

2016-01 | Journal article
Contributors: Juan D; Perner J; Carrillo de Santa Pau E; Marsili S; Ochoa D; Chung HR; Vingron M; Rico D; Valencia A
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Kinase-two-hybrid: towards the conditional interactome.

2015 | Journal article
Contributors: Ochoa D; Beltrao P
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Detection of significant protein co-evolution.

2015-02 | Journal article
Contributors: Ochoa D; Juan D; Valencia A; Pazos F
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Practical aspects of protein co-evolution.

2014 | Journal article
Contributors: Ochoa D; Pazos F
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Incorporating information on predicted solvent accessibility to the co-evolution-based study of protein interactions.

2013-01 | Journal article
Contributors: Ochoa D; García-Gutiérrez P; Juan D; Valencia A; Pazos F
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Selection of organisms for the co-evolution-based study of protein interactions.

2011 | Journal article
Contributors: Herman D; Ochoa D; Juan D; Lopez D; Valencia A; Pazos F
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Studying the co-evolution of protein families with the Mirrortree web server.

2010-05 | Journal article
Contributors: Ochoa D; Pazos F
Source: Self-asserted source
David Ochoa via Europe PubMed Central

Peer review (3 reviews for 3 publications/grants)

Review activity for Communications medicine. (1)
Review activity for Nature communications (1)
Review activity for Nature reviews. (1)