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Employment (2)

Brunel University: London, GB

2019-09-09 to present | Lecturer (Department of Life Sciences)
Employment
Source: Self-asserted source
Annabelle Lewis

University of Oxford: Oxford, Oxfordshire, GB

2019-09-09 to 2021-09-09 | Honorary visiting researcher (Wellcome Centre for Human Genetics)
Employment
Source: Self-asserted source
Annabelle Lewis

Education and qualifications (2)

University of Cambridge: Cambridge, Cambridgeshire, GB

1999-09-01 to 2003-08-30 | PhD (Babraham Institute)
Education
Source: Self-asserted source
Annabelle Lewis

University of Cambridge: Cambridge, Cambridgeshire, GB

1996-10-01 to 1999-06-30 | Natural Sciences (Genetics)
Education
Source: Self-asserted source
Annabelle Lewis

Funding (1)

Understanding how an MLH1 promoter polymorphism predisposes to colorectal cancer

Works (33)

BMP antagonist CHRDL2 enhances the cancer stem cell phenotype and increases chemotherapy resistance in Colorectal Cancer

2024-01-26 | Preprint
Contributors: Eloise Clarkson; Annabelle Lewis
Source: check_circle
Crossref

Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer

Cancers
2023-07-21 | Journal article
Contributors: Samanta Jerin; Amanda J. Harvey; Annabelle Lewis
Source: check_circle
Crossref
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Preferred source (of 2)‎

Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer

2023-05-25 | Preprint
Contributors: Samanta Jerin; Amanda Jane Harvey; Annabelle Lewis
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

Antioxidants
2021-08-28 | Journal article
Contributors: Séan M. O’Cathail; Chieh-Hsi Wu; Rachael Thomas; Maria A. Hawkins; Tim S. Maughan; Annabelle Lewis
Source: check_circle
Crossref

NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer

Cancer Genetics
2020-10 | Journal article
Contributors: Séan M. O'Cathail; Chieh-Hsi Wu; Annabelle Lewis; Chris Holmes; Maria A Hawkins; Tim Maughan
Source: check_circle
Crossref

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer

Journal of Pathology
2017 | Journal article
EID:

2-s2.0-85018959954

Contributors: Irshad, S.; Bansal, M.; Guarnieri, P.; Davis, H.; Al Haj Zen, A.; Baran, B.; Pinna, C.M.A.; Rahman, H.; Biswas, S.; Bardella, C. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Nature Communications
2017 | Journal article
EID:

2-s2.0-85037680308

Contributors: Baker, A.-M.; Huang, W.; Wang, X.-M.M.; Jansen, M.; Ma, X.-J.; Kim, J.; Anderson, C.M.; Wu, X.; Pan, L.; Su, N. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Five endometrial cancer risk loci identified through genome-wide association analysis

Nature Genetics
2016 | Journal article
EID:

2-s2.0-84965053962

Contributors: Cheng, T.H.T.; Thompson, D.J.; O'Mara, T.A.; Painter, J.N.; Glubb, D.M.; Flach, S.; Lewis, A.; French, J.D.; Freeman-Mills, L.; Church, D. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Nature Medicine
2015 | Journal article
EID:

2-s2.0-84924244580

Contributors: Davis, H.; Irshad, S.; Bansal, M.; Rafferty, H.; Boitsova, T.; Bardella, C.; Jaeger, E.; Lewis, A.; Freeman-Mills, L.; Giner, F.C. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding

Cell Reports
2014 | Journal article
EID:

2-s2.0-84908356322

Contributors: Lewis, A.; Freeman-Mills, L.; delaCalle-Mustienes, E.; Giráldez-Pérez, R.; Davis, H.; Jaeger, E.; Becker, M.; Hubner, N.C.; Nguyen, L.N.; Zeron-Medina, J. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Gut
2014 | Journal article
EID:

2-s2.0-84897959817

Contributors: Davis, H.; Lewis, A.; Behrens, A.; Tomlinson, I.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

Gut
2013 | Journal article
EID:

2-s2.0-84871156633

Contributors: Leedham, S.J.; Rodenas-Cuadrado, P.; Howarth, K.; Lewis, A.; Mallappa, S.; Segditsas, S.; Davis, H.; Jeffery, R.; Rodriguez-Justo, M.; Keshav, S. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Nature Genetics
2012 | Journal article
EID:

2-s2.0-84861584357

Contributors: Jaeger, E.; Leedham, S.; Lewis, A.; Segditsas, S.; Becker, M.; Cuadrado, P.R.; Davis, H.; Kaur, K.; Heinimann, K.; Howarth, K. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

The C-terminus of Apc does not influence intestinal adenoma development or progression

Journal of Pathology
2012 | Journal article
EID:

2-s2.0-82755192942

Contributors: Lewis, A.; Davis, H.; Deheragoda, M.; Pollard, P.; Nye, E.; Jeffery, R.; Segditsas, S.; East, P.; Poulsom, R.; Stamp, G. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

The utility of mouse models in post-GWAS research

Science
2012 | Journal article
EID:

2-s2.0-84870666697

Contributors: Lewis, A.; Tomlinson, I.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

Journal of Experimental Medicine
2011 | Journal article
EID:

2-s2.0-79951698621

Contributors: Babaei-Jadidi, R.; Li, N.; Saadeddin, A.; Spencer-Dene, B.; Jandke, A.; Muhammad, B.; Ibrahim, E.E.; Muraleedharan, R.; Abuzinadah, M.; Davis, H. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

Journal of Pathology
2011 | Journal article
EID:

2-s2.0-79955845570

Contributors: Davis, H.; Lewis, A.; Spencer-Dene, B.; Tateossian, H.; Stamp, G.; Behrens, A.; Tomlinson, I.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer

PLoS Genetics
2011 | Journal article
EID:

2-s2.0-79959851441

Contributors: Tomlinson, I.P.M.; Carvajal-Carmona, L.G.; Dobbins, S.E.; Tenesa, A.; Jones, A.M.; Howarth, K.; Palles, C.; Broderick, P.; Jaeger, E.E.M.; Farrington, S. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Severe polyposis in Apc<sup>1322T</sup>mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5

Gut
2010 | Journal article
EID:

2-s2.0-78649896525

Contributors: Lewis, A.; Segditsas, S.; Deheragoda, M.; Pollard, P.; Jeffery, R.; Nye, E.; Lockstone, H.; Davis, H.; Clark, S.; Stamp, G. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

The Apc<sup>1322T</sup>Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

Gastroenterology
2009 | Journal article
EID:

2-s2.0-66449123118

Contributors: Pollard, P.; Deheragoda, M.; Segditsas, S.; Lewis, A.; Rowan, A.; Howarth, K.; Willis, L.; Nye, E.; McCart, A.; Mandir, N. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

The long noncoding RNA Kcnq 1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing

Development
2009 | Journal article
EID:

2-s2.0-60149092541

Contributors: Redrup, L.; Branco, M.R.; Perdeaux, E.R.; Krueger, C.; Lewis, A.; Santos, F.; Nagano, T.; Cobb, B.S.; Fraser, P.; Reik, W.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA

Mammalian Genome
2007 | Journal article
EID:

2-s2.0-33846818301

Contributors: Green, K.; Lewis, A.; Dawson, C.; Dean, W.; Reinhart, B.; Chaillet, J.R.; Reik, W.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo

Development
2006 | Journal article
EID:

2-s2.0-33751538628

Contributors: Lewis, A.; Green, K.; Dawson, C.; Redrup, L.; Huynh, K.D.; Lee, J.T.; Hemberger, M.; Reik, W.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Epigenetics and Imprinting of the Trophoblast - A Workshop Report

Placenta
2006 | Journal article
EID:

2-s2.0-33645918295

Contributors: Ferguson-Smith, A.C.; Moore, T.; Detmar, J.; Lewis, A.; Hemberger, M.; Jammes, H.; Kelsey, G.; Roberts, C.T.; Jones, H.; Constancia, M.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Erratum to "Epigenetics and Imprinting of the Trophoblast - A Workshop Report" [Placenta 27, supplement A, Trophoblast Research, Vol. 20 S122-S126] (DOI:10.1016/j.placenta.2006.01.015)

Placenta
2006 | Journal article
EID:

2-s2.0-33746978753

Contributors: Ferguson-Smith, A.C.; Moore, T.; Detmar, J.; Lewis, A.; Hemberger, M.; Jammes, H.; Kelsey, G.; Roberts, C.; Jones, H.; Constancia, M.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

How imprinting centres work

Cytogenetic and Genome Research
2006 | Journal article
EID:

2-s2.0-33645460549

Contributors: Lewis, A.; Reik, W.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Co-evolution of X-chromosome inactivation and imprinting in mammals

Nature Reviews Genetics
2005 | Journal article
EID:

2-s2.0-17744391429

Contributors: Reik, W.; Lewis, A.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Genetic imprinting: Conflict at the Callipyge locus

Current Biology
2005 | Journal article
EID:

2-s2.0-18044382788

Contributors: Lewis, A.; Redrup, L.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Chromosome loops, insulators, and histone methylation: New insights into regulation of imprinting in clusters

Cold Spring Harbor Symposia on Quantitative Biology
2004 | Book
EID:

2-s2.0-23044463888

Contributors: Reik, W.; Murrell, A.; Lewis, A.; Mitsuya, K.; Umlauf, D.; Dean, W.; Higgins, M.; Feil, R.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Genomic imprinting: CTCF protects the boundaries

Current Biology
2004 | Journal article
EID:

2-s2.0-1842715884

Contributors: Lewis, A.; Murrell, A.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation

Nature Genetics
2004 | Journal article
EID:

2-s2.0-9644266664

Contributors: Lewis, A.; Mitsuya, K.; Umlauf, D.; Smith, P.; Dean, W.; Walter, J.; Higgins, M.; Feil, R.; Reik, W.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Tandem repeat hypothesis in imprinting: Deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region

Molecular and Cellular Biology
2004 | Journal article
EID:

2-s2.0-2942744502

Contributors: Lewis, A.; Mitsuya, K.; Constancia, M.; Reik, W.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions

Human Molecular Genetics
2003 | Journal article
EID:

2-s2.0-0037322392

Contributors: Lopes, S.; Lewis, A.; Hajkova, P.; Dean, W.; Oswald, J.; Forné, T.; Murrell, A.; Constância, M.; Bartolomei, M.; Walter, J. et al.
Source: Self-asserted source
Annabelle Lewis via Scopus - Elsevier

Peer review (2 reviews for 2 publications/grants)

Review activity for BMC biology. (1)
Review activity for BMC cancer (1)