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IB-UCLM (Instituto de Biomedicina de la UCLM)
Synaptic Structure Laboratory
Departamento de Ciencias Médicas

Keywords

electron microscopy, immunohistochemistry, neurotransmitter receptor, ion channel, hippocampus, cerebellum, synapse, pre-embedding immunogold, post-embedding immunogold, SDS-FRL, GABAB receptor, glutamate receptor

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Employment (1)

Universidad de Castilla-La Mancha: Campus de Albacete, Castilla-La Mancha, ES

Catedrático de Universidad (Departamento de Ciencias Médicas)
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Universidad de Castilla-La Mancha

Works (50 of 155)

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Page 1 of 4

Amyloid-beta pathology–induced nanoscale synaptic disruption: the case of the GABAB–GIRK assembly

Neural Regeneration Research
2025-05 | Journal article
DOI: 10.4103/NRR.NRR-D-24-00291
Contributors: Rafael Luján; Alejandro Martín-Belmonte; Sergi Ferré; Francisco Ciruela
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Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement

Proceedings of the National Academy of Sciences
2025-03-25 | Journal article
DOI: 10.1073/pnas.2409325122
Contributors: Stefano Zucca; Gloria Brunori; Henry A. Dunn; Colten K. Lankford; Laurie P. Sutton; Beatriz Algibez Flores; Nycole A. Maza; Omar Sial; Gogce Crynen; Rafael Luján et al.
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Two- and three-dimensional electron microscopy techniques: powerful tools for studying the brain under physiological and pathological conditions

Advanced Technology in Neuroscience
2024-12 | Journal article
DOI: 10.4103/ATN.ATN-D-24-00009
Contributors: Rafael Luján; Marta Turegano-Lopez; Carolina Aguado; Angel Merchan-Perez
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Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice

Science Signaling
2024-10 | Journal article
DOI: 10.1126/scisignal.ado4132
Contributors: Haichang Luo; Ezequiel Marron Fernandez; Benjamin Gansemer; McKinzie Frederick; Carolina Aguado; Rafael Luján; Stanley A. Thayer; Kevin Wickman
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Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

Neural Regeneration Research
2024-09 | Journal article
DOI: 10.4103/1673-5374.390963
Contributors: Carolina Aguado; Sara Badesso; José Martínez-Hernández; Alejandro Martín-Belmonte; Rocío Alfaro-Ruiz; Miriam Fernández; Ana Esther Moreno-Martínez; Mar Cuadrado-Tejedor; Ana García-Osta; Rafael Luján
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Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state and is not necessary for myelin formation and (re)myelination

Glia
2024-08 | Journal article
DOI: 10.1002/glia.24540
Contributors: Sonia Nocera; Miguel A. Marchena; Beatriz Fernández‐Gómez; Paula Gómez‐Martín; Estefanía Sánchez‐Jiménez; Alba Macías‐Castellano; Yolanda Laó; Christian Cordano; Óscar Gómez‐Torres; Rafael Luján et al.
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Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology

Biological Research
2024-08-22 | Journal article
DOI: 10.1186/s40659-024-00537-7
Contributors: Rocio Alfaro-Ruiz; Alejandro Martín-Belmonte; Carolina Aguado; Ana Esther Moreno-Martínez; Yugo Fukazawa; Rafael Luján
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Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures

Cell Reports
2024-07 | Journal article
DOI: 10.1016/j.celrep.2024.114382
Contributors: Kaoutsar Nasrallah; Coralie Berthoux; Yuki Hashimotodani; Andrés E. Chávez; Michelle C. Gulfo; Rafael Luján; Pablo E. Castillo
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Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles

2024-05-31 | Preprint
DOI: 10.1101/2024.05.29.596401
Contributors: Daehun Park; Kenshiro Fujise; Yumei Wu; Rafael Luján; Sergio Del Olmo-Cabrera; John F. Wesseling; Pietro De Camilli
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Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state but is not necessary for differentiation

2023-06-23 | Preprint
DOI: 10.1101/2023.06.23.546285
Contributors: Sonia Nocera; Miguel A. Marchena; Beatriz Fernández-Gómez; Yolanda Laó; Christian Cordano; Óscar Gómez-Torres; Rafael Luján; Fernando de Castro
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Neuronal lipofuscinosis caused by Kufs disease/CLN4DNAJC5mutations but not by a CSPα/DNAJC5 deficiency

2023-05-11 | Preprint
DOI: 10.1101/2023.05.10.540177
Contributors: Santiago López-Begines; Ángela Lavado-Roldán; Cristina Mesa-Cruz; Fabiola Mavillard; Nozha Borjini; Vera I. Wiersma; Carolina Aguado; Rafael Luján; Wiep Scheper; José L. Nieto-González et al.
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Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice

Brain Pathology
2023-01 | Journal article
DOI: 10.1111/bpa.13115
Contributors: Rocío Alfaro‐Ruiz; Carolina Aguado; Alejandro Martín‐Belmonte; Ana Esther Moreno‐Martínez; Jesús Merchán‐Rubira; Félix Hernández; Jesús Ávila; Yugo Fukazawa; Rafael Luján
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Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice

International Journal of Molecular Sciences
2022-11-04 | Journal article
DOI: 10.3390/ijms232113527
Contributors: Rocio Alfaro-Ruiz; Carolina Aguado; Alejandro Martín-Belmonte; Ana Esther Moreno-Martínez; Jesús Merchán-Rubira; Félix Hernández; Jesús Ávila; Yugo Fukazawa; Rafael Luján
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Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer’s Disease

International Journal of Molecular Sciences
2021-11 | Journal article | Author
DOI: 10.3390/ijms222111950
Contributors: Mar Cuadrado-Tejedor; Marta Pérez González; Rocío Alfaro-Ruiz; Sara Badesso; Diego Sucunza; María Espelosin; Susana Ursúa; Mercedes Lachen-Montes; Joaquin Fernandez-Irigoyen; ENRIQUE SANTAMARIA et al.
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Multidisciplinary Digital Publishing Institute

The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease

International Journal of Molecular Sciences
2021-10-14 | Journal article
DOI: 10.3390/ijms222011106
Contributors: Rocío Alfaro-Ruiz; Alejandro Martín-Belmonte; Carolina Aguado; Félix Hernández; Ana Esther Moreno-Martínez; Jesús Ávila; Rafael Luján
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The Density of Group I mGlu5 Receptors Is Reduced along the Neuronal Surface of Hippocampal Cells in a Mouse Model of Alzheimer’s Disease

International Journal of Molecular Sciences
2021-05-30 | Journal article
DOI: 10.3390/ijms22115867
Contributors: Alejandro Martín-Belmonte; Carolina Aguado; Rocío Alfaro-Ruiz; José Luis Albasanz; Mairena Martín; Ana Esther Moreno-Martínez; Yugo Fukazawa; Rafael Luján
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Cellular and Subcellular Localisation of Kv4-Associated KChIP Proteins in the Rat Cerebellum

International Journal of Molecular Sciences
2020-09-03 | Journal article
DOI: 10.3390/ijms21176403
Contributors: Rocío Alfaro-Ruíz; Carolina Aguado; Alejandro Martín-Belmonte; Ana Esther Moreno-Martínez; Rafael Luján
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Sensory neuron–derived Na V 1.7 contributes to dorsal horn neuron excitability

Science Advances
2020-02-21 | Journal article
DOI: 10.1126/sciadv.aax4568
Contributors: Sascha R. A. Alles; Filipe Nascimento; Rafael Luján; Ana P. Luiz; Queensta Millet; M. Ali Bangash; Sonia Santana-Varela; Xuelong Zhou; James J. Cox; Andrei L. Okorokov et al.
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Crossref

Inhibitory signaling to ion channels in hippocampal neurons is differentially regulated by alternative macromolecular complexes of RGS7.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2018-10 | Journal article
DOI: 10.1523/jneurosci.1378-18.2018
PMID: 30315127
Contributors: Ostrovskaya OI; Orlandi C; Fajardo-Serrano A; Young SM; Lujan R; Martemyanov KA
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.

Human molecular genetics
2018-10 | Journal article
DOI: 10.1093/hmg/ddy264
PMID: 30010864
Contributors: Morató X; Luján R; Gonçalves N; Watanabe M; Altafaj X; Carvalho AL; Fernández-Dueñas V; Cunha RA; Ciruela F
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

SK2 Channels Associate With mGlu1α Receptors and CaV2.1 Channels in Purkinje Cells.

Frontiers in Cellular Neuroscience
2018-09 | Journal article
DOI: 10.3389/fncel.2018.00311
PMID: 30283304
PMC: PMC6156379
Contributors: Luján R; Aguado C; Ciruela F; Arus XM; Martín-Belmonte A; Alfaro-Ruiz R; Martínez-Gómez J; de la Ossa L; Watanabe M; Adelman JP et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Differential association of GABAB receptors with their effector ion channels in Purkinje cells

Brain Structure and Function
2018-04-25 | Journal article
DOI: 10.1007/s00429-017-1568-y
Contributors: Rafael Luján; Carolina Aguado; Francisco Ciruela; Javier Cózar; David Kleindienst; Luis de la Ossa; Bernhard Bettler; Kevin Wickman; Masahiko Watanabe; Ryuichi Shigemoto et al.
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Transcriptome analysis in tissue sectors with contrasting crocins accumulation provides novel insights into apocarotenoid biosynthesis and regulation during chromoplast biogenesis.

Scientific reports
2018-02 | Journal article
DOI: 10.1038/s41598-018-21225-z
PMID: 29434251
PMC: PMC5809551
Contributors: Ahrazem O; Argandoña J; Fiore A; Aguado C; Luján R; Rubio-Moraga Á; Marro M; Araujo-Andrade C; Loza-Alvarez P; Diretto G et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Bidirectional modulation of glutamatergic synaptic transmission by metabotropic glutamate type 7 receptors at Schaffer collateral-CA1 hippocampal synapses.

The Journal of physiology
2018-01 | Journal article
DOI: 10.1113/jp275371
PMID: 29280494
Contributors: Martín R; Ferrero JJ; Collado-Alsina A; Aguado C; Luján R; Torres M; Sánchez-Prieto J
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.

Scientific reports
2017-08 | Journal article
DOI: 10.1038/s41598-017-10147-x
PMID: 28842709
PMC: PMC5573386
Contributors: Morató X; Luján R; López-Cano M; Gandía J; Stagljar I; Watanabe M; Cunha RA; Fernández-Dueñas V; Ciruela F
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.

Molecular psychiatry
2017-07 | Journal article
DOI: 10.1038/mp.2017.137
PMID: 28696429
PMC: PMC5822454
Contributors: Benamer N; Marti F; Lujan R; Hepp R; Aubier TG; Dupin AAM; Frébourg G; Pons S; Maskos U; Faure P et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals.

Scientific reports
2017-01 | Journal article
DOI: 10.1038/srep40257
PMID: 28071723
PMC: PMC5223132
Contributors: Huang Z; Li G; Aguado C; Lujan R; Shah MM
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Rafael Luján via Europe PubMed Central

Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex.

Frontiers in neuroanatomy
2016-11 | Journal article
DOI: 10.3389/fnana.2016.00114
PMID: 27965545
PMC: PMC5127842
Contributors: Aguado C; Orlandi C; Fajardo-Serrano A; Gil-Minguez M; Martemyanov KA; Luján R
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Rafael Luján via Europe PubMed Central

L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia.

Cerebral cortex (New York, N.Y. : 1991)
2016-10 | Journal article
DOI: 10.1093/cercor/bhw263
PMID: 27613437
PMC: PMC5066835
Contributors: Suarez LM; Solis O; Aguado C; Lujan R; Moratalla R
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Excitatory and Inhibitory Neurons in the Hippocampus Exhibit Molecularly Distinct Large Dense Core Vesicles.

Frontiers in cellular neuroscience
2016-08 | Journal article
DOI: 10.3389/fncel.2016.00202
PMID: 27630542
PMC: PMC5005380
Contributors: Ramírez-Franco JJ; Munoz-Cuevas FJ; Luján R; Jurado S
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Rafael Luján via Europe PubMed Central

Ontogenic Changes and Differential Localization of T-type Ca(2+) Channel Subunits Cav3.1 and Cav3.2 in Mouse Hippocampus and Cerebellum.

Frontiers in neuroanatomy
2016-08 | Journal article
DOI: 10.3389/fnana.2016.00083
PMID: 27616982
PMC: PMC4999439
Contributors: Aguado C; García-Madrona S; Gil-Minguez M; Luján R
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Rafael Luján via Europe PubMed Central

Erratum to: Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness.

Brain structure & function
2016-04 | Journal article
DOI: 10.1007/s00429-015-1016-9
PMID: 25764077
Contributors: Murcia-Belmonte V; Esteban PF; Martínez-Hernández J; Gruart A; Luján R; Delgado-García JM; de Castro F
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Examination of the hippocampal contribution to serotonin 5-HT2A receptor-mediated facilitation of object memory in C57BL/6J mice.

Neuropharmacology
2016-04 | Journal article
DOI: 10.1016/j.neuropharm.2016.04.033
PMID: 27114257
Contributors: Zhang G; Cinalli D; Cohen SJ; Knapp KD; Rios LM; Martínez-Hernández J; Luján R; Stackman RW
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Distinct expression patterns of inwardly rectifying potassium currents in developing cerebellar granule cells of the hemispheres and the vermis.

The European journal of neuroscience
2016-03 | Journal article
DOI: 10.1111/ejn.13219
PMID: 26921581
Contributors: Brandalise F; Lujan R; Leone R; Lodola F; Cesaroni V; Romano C; Gerber U; Rossi P
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function.

eLife
2016-02 | Journal article
DOI: 10.7554/eLife.12637
PMID: 26880549
PMC: PMC4764564
Contributors: Kim G; Luján R; Schwenk J; Kelley MH; Aguado C; Watanabe M; Fakler B; Maylie J; Adelman JP
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice.

Nature medicine
2016-01 | Journal article
DOI: 10.1038/nm.4037
PMID: 26808347
Contributors: Lecca S; Pelosi A; Tchenio A; Moutkine I; Lujan R; Hervé D; Mameli M
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Erratum to: Glutamate receptors of the delta family are widely expressed in the adult brain.

Brain structure & function
2015-11 | Journal article
DOI: 10.1007/s00429-014-0879-5
PMID: 25139626
Contributors: Hepp R; Hay YA; Aguado C; Lujan R; Dauphinot L; Potier MC; Nomura S; Poirel O; El Mestikawy S; Lambolez B et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2015-11 | Journal article
DOI: 10.1523/jneurosci.2970-15.2015
PMID: 26609150
Contributors: Eisenhardt M; Leixner S; Luján R; Spanagel R; Bilbao A
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Sex differences in GABA(B)R-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex.

Neuropharmacology
2015-04 | Journal article
DOI: 10.1016/j.neuropharm.2015.03.029
PMID: 25843643
PMC: PMC4466052
Contributors: Marron Fernandez de Velasco E; Hearing M; Xia Z; Victoria NC; Luján R; Wickman K
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

Journal of neurochemistry
2015-04 | Journal article
DOI: 10.1111/jnc.13109
PMID: 25824528
Contributors: Lopes JP; Morató X; Souza C; Pinhal C; Machado NJ; Canas PM; Silva HB; Stagljar I; Gandía J; Fernández-Dueñas V et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.

The Journal of biological chemistry
2015-03 | Journal article
DOI: 10.1074/jbc.M115.645374
PMID: 25792749
PMC: PMC4447942
Contributors: Orlandi C; Xie K; Masuho I; Fajardo-Serrano A; Lujan R; Martemyanov KA
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness.

Brain structure & function
2015-02 | Journal article
DOI: 10.1007/s00429-014-0977-4
PMID: 25662897
Contributors: Murcia-Belmonte V; Esteban PF; Martínez-Hernández J; Gruart A; Luján R; Delgado-García JM; de Castro F
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells.

Neuron
2015-01 | Journal article
DOI: 10.1016/j.neuron.2014.12.030
PMID: 25578363
PMC: PMC4306544
Contributors: Martinello K; Huang Z; Lujan R; Tran B; Watanabe M; Cooper EC; Brown DA; Shah MM
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Localization and Targeting of GIRK Channels in Mammalian Central Neurons.

International review of neurobiology
2015-01 | Journal article
DOI: 10.1016/bs.irn.2015.05.009
PMID: 26422985
Contributors: Luján R; Aguado C
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2014-12 | Journal article
DOI: 10.1038/npp.2014.332
PMID: 25547714
PMC: PMC4397405
Contributors: Weber T; Vogt MA; Gartside SE; Berger SM; Lujan R; Lau T; Herrmann E; Sprengel R; Bartsch D; Gass P
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Localization of SK2 channels relative to excitatory synaptic sites in the mouse developing Purkinje cells.

Frontiers in Neuroanatomy
2014-12 | Journal article
DOI: 10.3389/fnana.2014.00154
PMID: 25565979
PMC: PMC4266016
Contributors: Ballesteros-Merino C; Martínez-Hernández J; Aguado C; Watanabe M; Adelman JP; Luján R
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

Proceedings of the National Academy of Sciences of the United States of America
2014-12 | Journal article
DOI: 10.1073/pnas.1420252111
PMID: 25489075
PMC: PMC4280602
Contributors: Devesa I; Ferrándiz-Huertas C; Mathivanan S; Wolf C; Luján R; Changeux JP; Ferrer-Montiel A
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Netrin-G/NGL complexes encode functional synaptic diversification.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2014-11 | Journal article
DOI: 10.1523/jneurosci.1141-14.2014
PMID: 25411505
Contributors: Matsukawa H; Akiyoshi-Nishimura S; Zhang Q; Luján R; Yamaguchi K; Goto H; Yaguchi K; Hashikawa T; Sano C; Shigemoto R et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats.

Disease models & mechanisms
2014-11 | Journal article
DOI: 10.1242/dmm.018143
PMID: 25398851
PMC: PMC4283650
Contributors: Fernández-Dueñas V; Taura JJ; Cottet M; Gómez-Soler M; López-Cano M; Ledent C; Watanabe M; Trinquet E; Pin JP; Luján R et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central

Coassembly and coupling of SK2 channels and mGlu5 receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2014-10 | Journal article
DOI: 10.1523/jneurosci.2038-14.2014
PMID: 25355231
Contributors: García-Negredo G; Soto D; Llorente J; Morató X; Galenkamp KM; Gómez-Soler M; Fernández-Dueñas V; Watanabe M; Adelman JP; Shigemoto R et al.
Source: Self-asserted source
Rafael Luján via Europe PubMed Central
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