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Dengue hemorrhagic fever, Flaviviruses, Immunology, Mast cells

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Employment (1)

Duke University: Durham, NC, US

2016-01-04 to present | Research Scientist (Pathology)
Employment
Source: Self-asserted source
0000-0003-2039-2964

Works (45)

Mechanisms and risk factors for perinatal allergic disease.

Current opinion in immunology
2024-11-19 | Journal article
Contributors: Balla J; Rathore AP; St John AL
Source: Self-asserted source
0000-0003-2039-2964

Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection.

Cell
2024-11-06 | Journal article
Contributors: Abdelbasset M; Saron WAA; Ma D; Rathore APS; Kozaki T; Zhong C; Mantri CK; Tan Y; Tung CC; Tey HL et al.
Source: Self-asserted source
0000-0003-2039-2964

NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics

Journal of Clinical Investigation
2024-09-17 | Journal article
Contributors: Youngjoo Choi; Wilfried A.A. Saron; Aled O’Neill; Manouri Senanayake; Annelies Wilder-Smith; Abhay P.S. Rathore; Ashley L. St. John
Source: check_circle
Crossref

Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity

Science Immunology
2024-03 | Journal article
Contributors: Byron W. Hayes; Hae Woong Choi; Abhay P.S. Rathore; Chunjing Bao; Jianling Shi; Yul Huh; Michael W. Kim; Andrea Mencarelli; Pradeep Bist; Lai Guan Ng et al.
Source: check_circle
Crossref

Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern.

EBioMedicine
2023-12-18 | Journal article
Contributors: O'Neill A; Mantri CK; Tan CW; Saron WAA; Nagaraj SK; Kala MP; Joy CM; Rathore APS; Tripathi S; Wang LF et al.
Source: Self-asserted source
0000-0003-2039-2964

Exacerbated Zika virus–induced neuropathology and microcephaly in fetuses of dengue-immune nonhuman primates

Science Translational Medicine
2023-10-25 | Journal article
Contributors: Wilfried A. A. Saron; Keerthana Shanmugam; Chi-Ching Tung; Ranjit Kumar Patmanathan; Abhay P. S. Rathore; Danielle E. Anderson; Ashley L. St. John
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Crossref

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

Journal of Clinical Investigation
2023-10-02 | Journal article
Contributors: Janessa Y.J. Tan; Danielle E. Anderson; Abhay P.S. Rathore; Aled O’Neill; Chinmay Kumar Mantri; Wilfried A.A. Saron; Cheryl Q.E. Lee; Chu Wern Cui; Adrian E.Z. Kang; Randy Foo et al.
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Crossref

Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines

Current Treatment Options in Infectious Diseases
2023-04-18 | Journal article
Contributors: Monica Palanichamy Kala; Ashley L. St. John; Abhay P. S. Rathore
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Crossref

Promises and challenges of mucosal COVID-19 vaccines.

Vaccine
2023-04-10 | Journal article
Contributors: Rathore APS; St John AL
Source: Self-asserted source
0000-0003-2039-2964

New perspectives on the origins and heterogeneity of mast cells

Nature Reviews Immunology
2023-01 | Journal article
Contributors: Ashley L. St. John; Abhay P. S. Rathore; Florent Ginhoux
Source: check_circle
Crossref

Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter

Cell Reports
2022-09 | Journal article
Part of ISSN: 2211-1247
Contributors: 0000-0003-2039-2964
Source: Self-asserted source
0000-0003-2039-2964

Mucosal vaccination for SARS-CoV-2 elicits superior systemic T central memory function and cross-neutralizing antibodies against variants of concern

2022-09-09 | Preprint
Contributors: Aled O’Neill; Monica Palanichamy Kala; Tan Chee Wah; Wilfried A.A. Saron; Chinmay Kumar Mantri; Abhay P.S. Rathore; Lin-Fa Wang; Ashley L. St. John
Source: check_circle
Crossref

Immunological and Pathological Landscape of Dengue Serotypes 1-4 Infections in Immune-Competent Mice

Frontiers in Immunology
2021-06-08 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
0000-0003-2039-2964

Signatures of mast cell activation are associated with severe COVID-19

2021-06-01 | Other
Contributors: Janessa Tan; Danielle E. Anderson; Abhay P. S. Rathore; Aled O’Neill; Chinmay Kumar Mantri; Wilfried A. A. Saron; Cheryl Lee; Chu Wern Cui; Adrian E. Z. Kang; Randy Foo et al.
Source: check_circle
Crossref

Maternal Immunity and Vaccination Influence Disease Severity in Progeny in a Novel Mast Cell-Deficient Mouse Model of Severe Dengue

Viruses
2021-05-12 | Journal article
Part of ISSN: 1999-4915
Source: Self-asserted source
0000-0003-2039-2964

Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability

Viruses
2020-12-02 | Journal article
Part of ISSN: 1999-4915
Source: Self-asserted source
0000-0003-2039-2964

Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE

Science
2020-11-20 | Journal article
Contributors: Rasha Msallam; Jozef Balla; Abhay P. S. Rathore; Hassen Kared; Benoit Malleret; Wilfried A. A. Saron; Zhaoyuan Liu; Jing Wen Hang; Charles Antoine Dutertre; Anis Larbi et al.
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Crossref

Protective and pathogenic roles for mast cells during viral infections

Current Opinion in Immunology
2020-10 | Journal article
Part of ISSN: 0952-7915
Source: Self-asserted source
0000-0003-2039-2964

Risk factors and biomarkers of severe dengue

Current Opinion in Virology
2020-08 | Journal article
Contributors: Abhay PS Rathore; Farouk S Farouk; Ashley L St. John
Source: check_circle
Crossref

Early Insights into Immune Responses during COVID-19

The Journal of Immunology
2020-08-01 | Journal article
Contributors: Ashley L. St. John; Abhay P. S. Rathore
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Crossref

Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients

Scientific Reports
2020-07-16 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
0000-0003-2039-2964

Cross-Reactive Immunity Among Flaviviruses

Frontiers in Immunology
2020-02-26 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
0000-0003-2039-2964

Dengue virus–elicited tryptase induces endothelial permeability and shock

Journal of Clinical Investigation
2019-08-26 | Journal article
Contributors: Abhay P.S. Rathore; Chinmay Kumar Mantri; Siti A.B. Aman; Ayesa Syenina; Justin Ooi; Cyril J. Jagaraj; Chi Ching Goh; Hasitha Tissera; Annelies Wilder-Smith; Lai Guan Ng et al.
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Crossref

Therapeutics for Dengue

Current Treatment Options in Infectious Diseases
2019-06 | Journal article
Part of ISSN: 1534-6250
Contributors: Mohamad Fadhli Bin Masri; Abhay P. S. Rathore; Ashley L. St. John
Source: Self-asserted source
0000-0003-2039-2964 via Crossref Metadata Search

Peripheral serotonin causes dengue virus–induced thrombocytopenia through 5HT2 receptors

Blood
2019-05-23 | Journal article
Contributors: Mohamad Fadhli Bin Masri; Chinmay Kumar Mantri; Abhay P. S. Rathore; Ashley L. St. John
Source: check_circle
Crossref

Adaptive immune responses to primary and secondary dengue virus infections

Nature Reviews Immunology
2019-04 | Journal article
Contributors: Ashley L. St. John; Abhay P. S. Rathore
Source: check_circle
Crossref

Japanese encephalitis virus neuropenetrance is driven by mast cell chymase.

Nature communications
2019-02 | Journal article
Contributors: Hsieh JT; Rathore APS; Soundarajan G; St John AL
Source: Self-asserted source
0000-0003-2039-2964 via Europe PubMed Central
grade
Preferred source (of 2)‎

Maternal immunity and antibodies to dengue virus promote infection and Zika virus–induced microcephaly in fetuses

Science Advances
2019-02 | Journal article
Contributors: Abhay P. S. Rathore; Wilfried A. A. Saron; Ting Lim; Nusrat Jahan; Ashley L. St. John
Source: check_circle
Crossref

Immune responses to dengue virus in the skin

Open Biology
2018-08 | Journal article
Contributors: Abhay P. S. Rathore; Ashley L. St. John
Source: check_circle
Crossref

Maternal immunity and antibodies to dengue promote Zika virus-induced microcephaly in fetuses

2018-07 | Other
Contributors: Abhay P.S. Rathore; Wilfried A.A. Saron; Ting Lim; Nusrat Jahan; Ashley St. John
Source: Self-asserted source
0000-0003-2039-2964 via Crossref Metadata Search

Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells

Science Advances
2018-07-06 | Journal article
Contributors: Wilfried A. A. Saron; Abhay P. S. Rathore; Lim Ting; Eng Eong Ooi; Jenny Low; Soman N. Abraham; Ashley L. St. John
Source: check_circle
Crossref

Reprograming Immunity to Food Allergens

The Journal of Allergy and Clinical Immunology
2018-02-05 | Journal article
Source: Self-asserted source
0000-0003-2039-2964

Chymase is a Predictive Biomarker of Dengue Hemorrhagic Fever in Pediatric and Adult Patients

The Journal of Infectious Diseases
2017-08-25 | Journal article
WOSUID: jix447
Source: Self-asserted source
0000-0003-2039-2964

Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model.

Journal of Virology
2017-06 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients.

PLOS Neglected Tropical Diseases
2016-08 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.

The Lancet Infectious Diseases
2014-08 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.

eLife
2013 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation.

Virology Journal
2013 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.

Antiviral Research
2013-12 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

Antiviral Research
2013-09 | Journal article
DOI:

http://dx.doi.org/10.1016/j.antiviral.2013.06.002

Source: Self-asserted source
0000-0003-2039-2964

Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.

Antiviral Research
2012-10 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model.

Journal of Virology
2012-05 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex.

Journal of Virological Methods
2012-01 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.

Antiviral Research
2011-12 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance.

PNAS
2011-05 | Journal article
Source: Self-asserted source
0000-0003-2039-2964
grade
Preferred source (of 2)‎

Peer review (3 reviews for 3 publications/grants)

Review activity for Communications biology. (1)
Review activity for Journal of general virology. (1)
Review activity for Nature communications (1)