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Conformational Dynamics, Computational Simulations, Biophysical Methods

Activities

Employment (3)

Case Western Reserve University: Cleveland, US

2025-01-01 to present | Assistant Professor (Pharmacology)
Employment
Source: Self-asserted source
Wei Huang

Case Western Reserve University School of Medicine: Cleveland, OH, US

2022-07-01 to 2024-12-31 | Instructor (Pharmacology)
Employment
Source: Self-asserted source
Wei Huang

Case Western Reserve Univeristy: Cleveland, Ohio, US

2019-07-01 to 2022-06-30 | Research Scientist (Pharmacology)
Employment
Source: Self-asserted source
Wei Huang

Education and qualifications (4)

Case Western Reserve University: Cleveland, Ohio, US

2016-01-01 to 2019-06-30 | Postdoctoral Scholar (Pharmacology)
Qualification
Source: Self-asserted source
Wei Huang

Case Western Reserve University: Cleveland, OH, US

2012-01-01 to 2015-12-31 | Postdoctoral Scholar (Center for Proteomics and Bioinformatics)
Education
Source: Self-asserted source
Wei Huang

Louisiana State University: Baton Rouge, LA, US

2007-08-17 to 2011-12-14 | PhD (Biological Science)
Education
Source: Self-asserted source
Wei Huang

Xi'an Jiaotong University: Xi'an, Shaanxi, CN

2002-09-01 to 2007-07-01 | BE (Bioengineering)
Education
Source: Self-asserted source
Wei Huang

Works (18)

Structural diversity of axonemes across mammalian motile cilia

Nature
2025-01-30 | Journal article
Contributors: Miguel Ricardo Leung; Chen Sun; Jianwei Zeng; Jacob R. Anderson; Qingwei Niu; Wei Huang; Willem E. M. Noteborn; Alan Brown; Tzviya Zeev-Ben-Mordehai; Rui Zhang
Source: check_circle
Crossref

Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function

Nature Communications
2024-07-28 | Journal article
Contributors: Xin Lan; Wei Huang; Su Bin Kim; Dechen Fu; Thilini Abeywansha; Jiemin Lou; Udayakumaran Balamurugan; Yong Tae Kwon; Chang Hoon Ji; Derek J. Taylor et al.
Source: check_circle
Crossref

Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1

Nature Communications
2024-02-13 | Journal article
Contributors: Kristy Rochon; Brianna L. Bauer; Nathaniel A. Roethler; Yuli Buckley; Chih-Chia Su; Wei Huang; Rajesh Ramachandran; Maria S. K. Stoll; Edward W. Yu; Derek J. Taylor et al.
Source: check_circle
Crossref

Oligomerization-mediated activation of a short prokaryotic Argonaute

Nature
2023-09-07 | Journal article
Contributors: Zhangfei Shen; Xiao-Yuan Yang; Shiyu Xia; Wei Huang; Derek J. Taylor; Kotaro Nakanishi; Tian-Min Fu
Source: check_circle
Crossref

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

2023-06-22 | Preprint
Contributors: Kristy Rochon; Brianna L. Bauer; Nathaniel A. Roethler; Yuli Buckley; Chih-Chia Su; Wei Huang; Rajesh Ramachandran; Maria S. K. Stoll; Edward W. Yu; Derek J. Taylor et al.
Source: check_circle
Crossref

The structural basis of tRNA recognition by arginyl-tRNA-protein transferase

Nature Communications
2023-04-19 | Journal article
Contributors: Thilini Abeywansha; Wei Huang; Xuan Ye; Allison Nawrocki; Xin Lan; Eckhard Jankowsky; Derek J. Taylor; Yi Zhang
Source: check_circle
Crossref

Integrated model of the vertebrate augmin complex

Nature Communications
2023-04-13 | Journal article
Contributors: Sophie M. Travis; Brian P. Mahon; Wei Huang; Meisheng Ma; Michael J. Rale; Jodi Kraus; Derek J. Taylor; Rui Zhang; Sabine Petry
Source: check_circle
Crossref

Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system

Nature Communications
2023-02-11 | Journal article
Contributors: Wei Huang; Hongyun Li; Janna Kiselar; Stephen P. Fink; Sagar Regmi; Alexander Day; Yiyuan Yuan; Mark Chance; Joseph M. Ready; Sanford D. Markowitz et al.
Source: check_circle
Crossref

Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators

Journal of Biological Chemistry
2022-09 | Journal article
Contributors: Eden M. Gallegos; Tanner D. Reed; Forge A. Mathes; Nelson V. Guevara; David B. Neau; Wei Huang; Marcia E. Newcomer; Nathaniel C. Gilbert
Source: check_circle
Crossref

Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P

Nature Communications
2022-08-31 | Journal article
Contributors: Jiaqiang Zhu; Wei Huang; Jing Zhao; Loc Huynh; Derek J. Taylor; Michael E. Harris
Source: check_circle
Crossref

Pack a STRIPAK with hubs inside a hub

Nature Structural & Molecular Biology
2021-03-03 | Journal article
Contributors: Wei Huang; Daniel Leonard; Derek J. Taylor
Source: check_circle
Crossref

A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses

Cell Research
2021-02-05 | Journal article
Contributors: Yuxin Wang; Qiaoling Song; Wei Huang; Yuxi Lin; Xin Wang; Chenyao Wang; Belinda Willard; Chenyang Zhao; Jing Nan; Elise Holvey-Bates et al.
Source: check_circle
Crossref

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

Cell
2020-04 | Journal article
Part of ISSN: 0092-8674
Source: Self-asserted source
Wei Huang

Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development

mBio
2020-01-21 | Journal article
Part of ISSN: 2150-7511
Source: Self-asserted source
Wei Huang

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

mBio
2019-07-02 | Journal article
Part of ISSN: 2150-7511
Source: Self-asserted source
Wei Huang

A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity

PLOS Biology
2019-04-05 | Journal article
Contributors: Wilnelly Hernandez-Sanchez; Agata Smogorzewska; Wei Huang; Brian Plucinsky; Nelson Garcia-Vazquez; Nathaniel J. Robinson; William P. Schiemann; Anthony J. Berdis; Emmanuel Skordalakes; Derek J. Taylor
Source: check_circle
Crossref

Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Nature Communications
2018-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Wei Huang

Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation

Protein Science
2018-09 | Journal article
Part of ISSN: 0961-8368
Source: Self-asserted source
Wei Huang

Peer review (2 reviews for 2 publications/grants)

Review activity for Communications biology. (1)
Review activity for eLife (1)