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Scopus Author ID: 24465873500
SciProfiles: 2079034

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University Hospital Olomouc: Olomouc, CZ

2018-09-01 to present | Senior Consultant (Department of Oncology)
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Source: Self-asserted source
hana studentova

Works (50 of 100)

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Neopterin as a potential prognostic and predictive biomarker in metastatic renal cell carcinoma treated with immune checkpoint inhibitors

Expert Review of Anticancer Therapy
2024-06-02 | Journal article
DOI: 10.1080/14737140.2024.2341734
Contributors: Hana Studentova; Katerina Hola; Bohuslav Melichar; Martina Spisarova
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The Evolving Landscape of Cytoreductive Nephrectomy in Metastatic Renal Cell Carcinoma

Cancers
2023-07-29 | Journal article
DOI: 10.3390/cancers15153855
Contributors: Hana Studentova; Martina Spisarova; Andrea Kopova; Anezka Zemankova; Bohuslav Melichar; Vladimir Student, Jr.
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Development and extensive analytical validation of deep amplicon sequencing for detecting KRAS and NRAS mutations in metastatic colorectal cancer samples

Neoplasma
2022 | Journal article
DOI: 10.4149/NEO_2021_210907N1276
WOSUID: WOS:000823580800003
Contributors: Slavkovsk, Rastislav; Stranska, Jana; Venskova, Veronika; Jancik, Sylwia; Kotkova, Lucie; Slmova, Jarmila; Vojta, Petr; Flodr, Patrik; Bartouskova, Marie; Studentova, Hana et al.
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Patients with metastatic renal cell carcinoma treated with cabozantinib in the Czech Republic: analysis of four cancer centers

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
2022 | Journal article
DOI: 10.5507/BP.2020.055
WOSUID: WOS:000731338900001
Contributors: Richter, Igor; Poprach, Alexandr; Zemankova, Anezka; Buchler, Tomas; Bartos, Jiri; Samal, Vladimir; Studentova, Hana; Rozsypalova, Aneta; Dvorak, Josef; Brom, Ondrej et al.
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Single-course bleomycin, etoposide, and cisplatin (1xBEP) as adjuvant treatment in testicular nonseminoma clinical stage 1: outcome, safety, and risk factors for relapse in a population-based study

Therapeutic Advances in Medical Oncology
2022 | Journal article
DOI: 10.1177/17588359221086813
WOSUID: WOS:000778006500001
Contributors: Dieckmann, Klaus-Peter; Pokrivcak, Tomas; Geczi, Lajos; Niehaus, David; Dralle-Filiz, Inken; Matthies, Cord; Dienes, Tamas; Zschaebitz, Stefanie; Paffenholz, Pia; Gschliesser, Tanja et al.
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Severe tyrosine-kinase inhibitor induced liver injury in metastatic renal cell carcinoma patients: two case reports assessed for causality using the updated RUCAM and review of the literature

BMC Gastroenterology
2022-12 | Journal article
DOI: 10.1186/s12876-022-02121-3
Contributors: Hana Studentova; Jindriska Volakova; Martina Spisarova; Anezka Zemankova; Kvetoslava Aiglova; Tomas Szotkowski; Bohuslav Melichar
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The role of carboplatin in combination with paclitaxel in patients with castration-resistant prostate cancer

Future Oncology
2022-12 | Journal article
DOI: 10.2217/fon-2022-0914
Contributors: Nikol Rusarova; Denisa Vitaskova; Hana Kalabova; Andrea Ondruskova; Dana Purova; Bohuslav Melichar; Hana Studentova
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Altered Plasma, Urine, and Tissue Profiles of Sulfatides and Sphingomyelins in Patients with Renal Cell Carcinoma

Cancers
2022-09-23 | Journal article
DOI: 10.3390/cancers14194622
Contributors: Robert Jirásko; Jakub Idkowiak; Denise Wolrab; Aleš Kvasnička; David Friedecký; Krzysztof Polański; Hana Študentová; Vladimír Študent; Bohuslav Melichar; Michal Holčapek
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The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature

Current Oncology
2022-08-03 | Journal article
DOI: 10.3390/curroncol29080433
Contributors: Hana Studentova; Nikol Rusarova; Andrea Ondruskova; Anezka Zemankova; Vladimir Student, Jr.; Daniela Skanderova; Bohuslav Melichar
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A Pathological Complete Response to the Combination of Ipilimumab and Nivolumab in a Patient with Metastatic Renal Cell Carcinoma

Medicina
2022-02-23 | Journal article
DOI: 10.3390/medicina58030336
Contributors: Hana Studentova; Anezka Zemankova; Martina Spisarova; Daniela Skanderova; Zbynek Tudos; Bohuslav Melichar; Vladimir Student, Jr.
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Altered plasma, urine, and tissue profiles of sulfatides and sphingomyelins in patients with renal cell carcinoma

2022-01-10 | Preprint
DOI: 10.1101/2022.01.10.21268223
Contributors: Robert Jirásko; Jakub Idkowiak; Denise Wolrab; Aleš Kvasnička; David Friedecký; Krzysztof Polański; Hana Študentová; Vladimír Študent; Bohuslav Melichar; Michal Holčapek
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Administration of Nivolumab in Metastatic Renal Cell Cancer Following Treatment With mTOR Inhibitors

In Vivo
2021 | Journal article
DOI: 10.21873/INVIVO.12593
WOSUID: WOS:000686122800008
Contributors: Kopecky, Jindrich; Kubecek, Ondrej; Buchler, Tomas; Melichar, Bohuslav; Poprach, Alexandr; Zemanova, Milada; Katolicka, Jana; Kiss, Igor; Hajek, Jaroslav; Studentova, Hana et al.
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Changes in expression of lysosomal membrane proteins in leucocytes of cancer patients treated with tyrosine kinase inhibitors

Cancer Chemotherapy and Pharmacology
2021 | Journal article
DOI: 10.1007/s00280-021-04266-6
EID:

2-s2.0-85103965456

Part of ISSN: 14320843 03445704
Contributors: Pastvova, N.; Havlasek, J.; Dolezel, P.; Kikalova, K.; Studentova, H.; Zemankova, A.; Melichar, B.; Mlejnek, P.
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hana studentova via Scopus - Elsevier
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Changes in expression of lysosomal membrane proteins in leucocytes of cancer patients treated with tyrosine kinase inhibitors (Mar, 10.1007/s00280-021-04266-6, 2021)

Cancer Chemotherapy and Pharmacology
2021 | Journal article
DOI: 10.1007/S00280-021-04282-6
WOSUID: WOS:000648198300001
Contributors: Pastvova, N.; Havlasek, J.; Dolezel, P.; Kikalova, K.; Studentova, H.; Zemankova, A.; Melichar, B.; Mlejnek, P.
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Intra-laboratory comparison of four analytical platforms for lipidomic quantitation using hydrophilic interaction liquid chromatography or supercritical fluid chromatography coupled to quadrupole - time-of-flight mass spectrometry

Talanta
2021 | Journal article
DOI: 10.1016/j.talanta.2021.122367
EID:

2-s2.0-85104073129

Part of ISSN: 00399140
Contributors: Chocholoušková, M.; Wolrab, D.; Jirásko, R.; Študentová, H.; Melichar, B.; Holčapek, M.
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hana studentova via Scopus - Elsevier
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Pembrolizumab plus axitinib combination and the paradigm change in the treatment of advanced renal cell carcinoma

Future Oncology
2021 | Journal article
DOI: 10.2217/fon-2020-0079
EID:

2-s2.0-85100014930

Part of ISSN: 17448301 14796694
Contributors: Spisarová, M.; Melichar, B.; Vitásková, D.; Študentová, H.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Pembrolizumab plus axitinib for the treatment of advanced renal cell carcinoma

Expert Review of Anticancer Therapy
2021 | Journal article
DOI: 10.1080/14737140.2021.1903321
EID:

2-s2.0-85103652854

Part of ISSN: 17448328 14737140
Contributors: Spisarová, M.; Melichar, B.; Vitásková, D.; Študentová, H.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Plasma lipidomic profiles of kidney, breast and prostate cancer patients differ from healthy controls

Scientific Reports
2021 | Journal article
DOI: 10.1038/S41598-021-99586-1
WOSUID: WOS:000707032500083
Contributors: Wolrab, Denise; Jirasko, Robert; Peterka, Ondrej; Idkowiak, Jakub; Chocholouskova, Michaela; Vankova, Zuzana; Horejsi, Karel; Brabcova, Ivana; Vrana, David; Studentova, Hana et al.
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PET/CT-tailored treatment of locally advanced oesophago-gastric junction adenocarcinoma: a report on the feasibility of the multicenter GastroPET study

Therapeutic Advances in Medical Oncology
2021-01 | Journal article
DOI: 10.1177/17588359211065153
Contributors: Radka Obermannova; Iveta Selingerova; Zdenek Rehak; Vaclav Jedlicka; Marek Slavik; Pavel Fabian; Ivo Novotny; Milada Zemanova; Hana Studentova; Peter Grell et al.
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Determination of one year stability of lipid plasma profile and comparison of blood collection tubes using UHPSFC/MS and HILIC-UHPLC/MS

Analytica Chimica Acta
2020 | Journal article
DOI: 10.1016/j.aca.2020.08.061
EID:

2-s2.0-85090714631

Part of ISSN: 18734324 00032670
Contributors: Wolrab, D.; Chocholoušková, M.; Jirásko, R.; Peterka, O.; Mužáková, V.; Študentová, H.; Melichar, B.; Holčapek, M.
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hana studentova via Scopus - Elsevier
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Potential utilization of neopterin measurements in the assessment of pyrexia in metastatic melanoma treated with combined targeted therapy: A case report

Pteridines
2020 | Journal article
DOI: 10.1515/pteridines-2020-0009
EID:

2-s2.0-85091665399

Part of ISSN: 09334807 21954720
Contributors: Bartoušková, M.; Hrouzková, M.; ÄŒtvrtlík, F.; Petrová, P.; Rušarová, N.; Kučerová, K.; Vernerová, A.; Melichar, B.; Študentová, H.
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hana studentova via Scopus - Elsevier
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Application of dual-energy ct to distinguish adrenal adenomas from non-adenomas – first experience,Využití ct s duální energií pro odlišení adenomů a non-adenomů nadledvin – první zkušenosti

Ceska Radiologie
2019 | Journal article
EID:

2-s2.0-85075602978

Part of ISSN: 12107883
Contributors: Szász, P.; Čtvrtlík, F.; Kučera, P.; Odstrčil, F.; Langová, K.; Kovář, R.; Študentová, H.; Hruška, F.; Tüdös, Z.
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hana studentova via Scopus - Elsevier

Hepatic arterial infusion in liver tumors of unknown, uncertain or unusual primary: single-center experience

Journal of B.U.ON. : official journal of the Balkan Union of Oncology
2019 | Journal article
EID:

2-s2.0-85064219580

Part of ISSN: 22416293
Contributors: Melichar, B.; Dvorak, J.; Kamaradova, K.; Krajina, A.; Studentova, H.
Source: Self-asserted source
hana studentova via Scopus - Elsevier

Hepatic arterial infusion in liver tumors of unknown, uncertain or unusual primary: single-center experience

Journal of B.U.ON.
2019 | Journal article
WOSUID: WOS:000458202600018
Contributors: Melichar, Bohuslav; Dvorak, Josef; Kamaradova, Katerina; Krajina, Antonin; Studentova, Hana
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Hepatic arterial infusion in liver tumors of unknown, uncertain or unusual primary: Single-center experience

Journal of B.U.ON.
2019 | Journal article
EID:

2-s2.0-85062421582

Part of ISSN: 11070625
Contributors: Melichar, B.; Dvorak, J.; Kamaradova, K.; Krajina, A.; Studentova, H.
Source: Self-asserted source
hana studentova via Scopus - Elsevier

Testicular tumours,Testikulární nádory

Onkologie (Czech Republic)
2019 | Journal article
EID:

2-s2.0-85063647563

Part of ISSN: 18035345 18024475
Contributors: Rušarová, N.; Študentová, H.; Bartoušková, M.
Source: Self-asserted source
hana studentova via Scopus - Elsevier

Tyrosine kinase inhibitors in the first-line treatment for metastatic nonclear cell renal carcinoma: A retrospective analysis of a national database

Urologic Oncology: Seminars and Original Investigations
2019 | Journal article
DOI: 10.1016/j.urolonc.2018.12.017
EID:

2-s2.0-85060274330

Part of ISSN: 18732496 10781439
Contributors: Poprach, A.; Rumanova, K.; Lakomý, R.; Chloupková, R.; Stanik, M.; Pokrivcak, T.; Kiss, I.; Slaby, O.; Studentova, H.; Melichar, B. et al.
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hana studentova via Scopus - Elsevier
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Current status of cytoreductive surgery (CRS) and intraperitoneal hyperthermic chemotherapy (HIPEC) in the multimodal treatment of peritoneal surface malignancies,Současné postavení cytoredukční chirurgie (CRS) a intraperitoneální hypertermické chemoterapie (HIPEC) v multimodální léčbĕ nádorů peritoneálního povrchu

Casopis Lekaru Ceskych
2018 | Journal article
EID:

2-s2.0-85061480919

Part of ISSN: 18054420 00087335
Contributors: Klos, D.; Riško, J.; Stašek, M.; Loveček, M.; Hanuliak, J.; Skalický, P.; Lemstrová, R.; Duchoňová-Mohelníková, B.; Študentová, H.; Neora, C. et al.
Source: Self-asserted source
hana studentova via Scopus - Elsevier

Immunotherapy in mucosal melanoma: A case report and review of the literature

Oncotarget
2018 | Journal article
DOI: 10.18632/oncotarget.24727
EID:

2-s2.0-85044825458

Part of ISSN: 19492553
Contributors: Studentova, H.; Kalabova, H.; Koranda, P.; Chytilova, K.; Kucerova, L.; Melichar, B.; Vrana, D.
Source: Self-asserted source
hana studentova via Scopus - Elsevier

Lenvatinib for the treatment of kidney cancer

Expert Review of Anticancer Therapy
2018 | Journal article
DOI: 10.1080/14737140.2018.1470506
EID:

2-s2.0-85046622262

Part of ISSN: 17448328 14737140
Contributors: Študentová, H.; Vitásková, D.; Melichar, B.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Pazopanib for metastatic renal cell carcinoma: A registry-based analysis of 426 patients

Anticancer Research
2018 | Journal article
DOI: 10.21873/anticanres.12243
EID:

2-s2.0-85039776678

Part of ISSN: 17917530 02507005
Contributors: Poprach, A.; Fiala, O.; Chloupkova, R.; Melichar, B.; Lakomy, R.; Petrakova, K.; Zemanova, M.; Kopeckova, K.; Slaby, O.; Studentova, H. et al.
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hana studentova via Scopus - Elsevier
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Treatment patterns and outcomes of pertuzumab in combination with trastuzumab and docetaxel as first-line treatment of metastatic HER-2 positive breast cancer : Comparison of Czech clinical registry and CLEOPATRA trial data

Cancer Research
2018 | Journal article
WOSUID: WOS:000425489402065
Contributors: Studentova, Hana; Petrakova, Katarina; Tesarova, Petra; Buchler, Tomas; Chloupkova, Renata; Hejduk, Karel; Melichar, Bohuslav
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Association of peripheral blood cell count-derived ratios, biomarkers of inflammatory response and tumor growth with outcome in previously treated metastatic colorectal carcinoma patients receiving cetuximab

Pteridines
2017 | Journal article
DOI: 10.1515/pterid-2017-0016
EID:

2-s2.0-85037850210

Part of ISSN: 09334807 21954720
Contributors: Melichar, B.; Hrůzová, K.; Krčmová, L.K.; Javorská, L.; Pešková, E.; Solichová, D.; Hyšpler, R.; Malířová, E.; Vošmik, M.; Bartoušková, M. et al.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

Pteridines
2017 | Journal article
DOI: 10.1515/pterid-2017-0005
EID:

2-s2.0-85038004175

Part of ISSN: 09334807 21954720
Contributors: Melichar, B.; Vitásková, D.; Bartoušková, M.; Javorská, L.; Kujovská Krčmová, L.; Pešková, E.; Hyšpler, R.; Solichová, D.; Hrůzová, K.; Študentová, H.
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hana studentova via Scopus - Elsevier
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Concentrations of neopterin, kynurenine and tryptophan in wound secretions of patients with breast cancer and malignant melanoma: A pilot study

Pteridines
2017 | Journal article
DOI: 10.1515/pterid-2017-0018
EID:

2-s2.0-85037864177

Part of ISSN: 09334807 21954720
Contributors: Mergancová, J.; Javorská, L.; Šiller, J.; Sákra, L.; Mergancová, J.; Solichová, D.; Krčmová, L.K.; Melichar, B.; Mohelníková-Duchoňová, B.; Študentová, H. et al.
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hana studentova via Scopus - Elsevier
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Current treatment management of metastatatic castration-resistant prostate cancer,Současné možnosti léčby metastatického kastračně rezistentního karcinomu prostaty

Onkologie (Czech Republic)
2017 | Journal article
EID:

2-s2.0-85042649450

Part of ISSN: 18035345 18024475
Contributors: Rušarová, N.; Študentová, H.
Source: Self-asserted source
hana studentova via Scopus - Elsevier

Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: A case report and biomarker study

Pteridines
2017 | Journal article
DOI: 10.1515/pterid-2017-0017
EID:

2-s2.0-85037580693

Part of ISSN: 09334807 21954720
Contributors: Vitásková, D.; Melichar, B.; Bartoušková, M.; Vlachová, Z.; Vrána, D.; Janková, J.; Adam, T.; Juráňová, J.; Zlámalová, N.; Kujovská Krčmová, L. et al.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Neopterin as a biomarker of immune response in cancer patients

Annals of Translational Medicine
2017 | Journal article
DOI: 10.21037/atm.2017.06.29
EID:

2-s2.0-85024884256

Part of ISSN: 23055847 23055839
Contributors: Melichar, B.; Spisarová, M.; Bartoušková, M.; Krcmová, L.K.; Javorská, L.; Študentová, H.
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hana studentova via Scopus - Elsevier
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Outcome of Patients with Renal Cell Carcinoma and Multiple Glandular Metastases Treated with Targeted Agents

Oncology (Switzerland)
2017 | Journal article
DOI: 10.1159/000455970
EID:

2-s2.0-85013625460

Part of ISSN: 14230232 00302414
Contributors: Grassi, P.; Doucet, L.; Giglione, P.; Grünwald, V.; Melichar, B.; Galli, L.; De Giorgi, U.; Sabbatini, R.; Ortega, C.; Santoni, M. et al.
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hana studentova via Scopus - Elsevier
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Outcomes of Patients With Long-Term Treatment Response to Vascular Endothelial Growth Factor-Targeted Therapy for Metastatic Renal Cell Cancer

Clinical Genitourinary Cancer
2017 | Journal article
DOI: 10.1016/j.clgc.2017.06.006
EID:

2-s2.0-85023629332

Part of ISSN: 19380682 15587673
Contributors: Buchler, T.; Poprach, A.; Bortlicek, Z.; Lakomy, R.; Chloupková, R.; Vyzula, R.; Zemanova, M.; Kopeckova, K.; Svoboda, M.; Slaby, O. et al.
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hana studentova via Scopus - Elsevier
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Utilization and efficacy of second-line targeted therapy in metastatic renal cell carcinoma: Data from a national registry

BMC Cancer
2017 | Journal article
DOI: 10.1186/s12885-017-3901-5
EID:

2-s2.0-85038953106

Part of ISSN: 14712407
Contributors: Lakomy, R.; Poprach, A.; Bortlicek, Z.; Melichar, B.; Chloupkova, R.; Vyzula, R.; Zemanova, M.; Kopeckova, K.; Svoboda, M.; Slaby, O. et al.
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hana studentova via Scopus - Elsevier
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Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer

Pteridines
2016 | Journal article
DOI: 10.1515/pterid-2016-0001
EID:

2-s2.0-85001969662

Part of ISSN: 09334807 21954720
Contributors: Melichar, B.; Študentová, H.; Vitásková, D.; Šrámek, V.; Krčmová, L.K.; Pešková, E.; Solichová, D.; Kalábová, H.; Ryška, A.; Hrůzová, K. et al.
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hana studentova via Scopus - Elsevier
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Clinical impact of Pancreatic metastases from renal cell carcinoma: A multicenter retrospective analysis

PLoS ONE
2016 | Journal article
DOI: 10.1371/journal.pone.0151662
EID:

2-s2.0-84963784539

Part of ISSN: 19326203
Contributors: Grassi, P.; Doucet, L.; Giglione, P.; Grünwald, V.; Melichar, B.; Galli, L.; De Giorgi, U.; Sabbatini, R.; Ortega, C.; Santoni, M. et al.
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hana studentova via Scopus - Elsevier
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Efficacy of Sunitinib in Elderly Patients with Metastatic Renal Cell Carcinoma: Data from Real-World Clinical Practice

Drugs and Aging
2016 | Journal article
DOI: 10.1007/s40266-016-0390-1
EID:

2-s2.0-84982273742

Part of ISSN: 11791969 1170229X
Contributors: Poprach, A.; Lakomy, R.; Bortlicek, Z.; Melichar, B.; Pavlik, T.; Slaby, O.; Vyzula, R.; Svoboda, M.; Kiss, I.; Studentova, H. et al.
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hana studentova via Scopus - Elsevier
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Outcome of patients with multiple glandular metastases from renal cell carcinoma treated with targeted agents

Annals of Oncology
2016 | Journal article
DOI: 10.1093/ANNONC/MDW373.49
WOSUID: WOS:000393912500817
Contributors: Grassi, P.; Doucet, L.; Giglione, P.; Gruenwald, V.; Melichar, B.; Galli, L.; De Giorgi, U.; Guida, A.; Ortega, C.; Santoni, M. et al.
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Prolonged response to pemetrexed-based chemotherapy in a patient with peritoneal mesothelioma: A case report and review of the literature

Pteridines
2016 | Journal article
DOI: 10.1515/pterid-2015-0015
EID:

2-s2.0-84974851007

Part of ISSN: 09334807 21954720
Contributors: Studentova, H.; Vitásková, D.; Čtvrtlík, F.; Melichar, B.; Havlík, R.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor

Oncology Letters
2016 | Journal article
DOI: 10.3892/ol.2015.4017
EID:

2-s2.0-84954357981

Part of ISSN: 17921082 17921074
Contributors: Študentová, H.; Indráková, J.; Petrová, P.; Kamínek, M.; Kalábová, H.; Šrámek, V.; Adam, T.; Melichar, B.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Safety of mTOR inhibitors in breast cancer

Expert Opinion on Drug Safety
2016 | Journal article
DOI: 10.1080/14740338.2016.1192604
EID:

2-s2.0-84979980461

Part of ISSN: 1744764X 14740338
Contributors: Študentová, H.; Vitásková, D.; Melichar, B.
Source: Self-asserted source
hana studentova via Scopus - Elsevier
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Treatment of brain metastases of renal cell cancer with combined hypofractionated stereotactic radiotherapy and whole brain radiotherapy with hippocampal sparing

Oncology Letters
2016 | Journal article
DOI: 10.3892/ol.2016.4440
EID:

2-s2.0-84966762962

Part of ISSN: 17921082 17921074
Contributors: Vrána, D.; Študentová, H.; Matzenauer, M.; Vlachová, Z.; Cwiertka, K.; Gremlica, D.; Kalita, O.
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hana studentova via Scopus - Elsevier
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Brain metastases of parathyroid carcinoma: Review of the literature and a case report

Biomedical Papers
2015 | Journal article
DOI: 10.5507/bp.2015.001
EID:

2-s2.0-84942913683

Part of ISSN: 18047521 12138118
Contributors: Studentova, H.; Melichar, B.; Cincibuch, J.; Kaminek, M.; Frysak, Z.; Geierova, M.; Klein, J.
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hana studentova via Scopus - Elsevier
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