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Employment (5)

Zhejiang University: Hangzhou, Zhejiang, CN

2022-01 to present | Professor (School of Medicine)
Employment
Source: Self-asserted source
Yan Zhang

Zhejiang University: Hangzhou, Zhejiang, CN

2018-01 to 2022-01 | Principle Investigator (School of Medicine)
Employment
Source: Self-asserted source
Yan Zhang

Stanford University: Stanford, CA, US

2017-06 to 2018-01 | Postdoctoral Research Fellow (Department of Molecular and Cellular Physiology)
Employment
Source: Self-asserted source
Yan Zhang

University of Michigan: Ann Arbor, MI, US

2013-11 to 2017-05 | Postdoctoral Research Fellow (Life Sciences Institute)
Employment
Source: Self-asserted source
Yan Zhang

Shanghai Institute of Organic Chemistry: Shanghai, CN

2013-07 to 2013-10 | Research Fellow
Employment
Source: Self-asserted source
Yan Zhang

Education and qualifications (1)

Shanghai Institute of Organic Chemistry: Shanghai, CN

2007-09 to 2013-06 | Doctor
Education
Source: Self-asserted source
Yan Zhang

Works (37)

Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS

Nature Structural Biology
2025 | Journal article
DOI: 10.1038/S41594-024-01470-9
WOSUID: WOS:001399428100001
Contributors: Zhao, Jie; Shen, Qingya; Yong, Xihao; Li, Xin; Tian, Xiaowen; Sun, Suyue; Xu, Zheng; Zhang, Xiaoyu; Zhang, Lu; Yang, Hao et al.
Source: check_circle
Web of Science Researcher Profile Sync

Harnessing the power of structure-based design: A new lease on life for cardiovascular drug development with apelin receptor modulators

Clinical and Translational Medicine
2024 | Journal article
DOI: 10.1002/CTM2.70116
WOSUID: WOS:001374149100001
Contributors: Zhang, Junxia; Dong, Erdan; Zhang, Yan; Zhang, Yan.
Source: check_circle
Web of Science Researcher Profile Sync

Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs

Advanced Science
2024 | Journal article
DOI: 10.1002/ADVS.202310120
WOSUID: WOS:001206822500001
Contributors: Shen, Qingya; Tang, Xinyan; Wen, Xin; Cheng, Shizhuo; Xiao, Peng; Zang, Shao-Kun; Shen, Dan-Dan; Jiang, Lei; Zheng, Yanrong; Zhang, Huibing et al.
Source: check_circle
Web of Science Researcher Profile Sync

Molecular insights into the activation mechanism of GPR156 in maintaining auditory function

Nature Communications
2024 | Journal article
DOI: 10.1038/S41467-024-54681-5
WOSUID: WOS:001372601000017
Contributors: Ma, Xiangyu; Chen, Li-Nan; Liao, Menghui; Zhang, Liyan; Xi, Kun; Guo, Jiamin; Shen, Cangsong; Shen, Dan-Dan; Cai, Pengjun; Shen, Qingya et al.
Source: check_circle
Web of Science Researcher Profile Sync

Molecular insights into the atypical activation mechanism of GPR156 in maintaining auditory function

BioRxiv
2024 | Journal article
DOI: 10.1101/2024.03.07.581839
WOSUID: PPRN:88055189
Contributors: Ma, Xiangyu; Chen, Li-Nan; Liao, Menghui; Zhang, Liyan; Xi, Kun; Guo, Jiamin; Shen, Cangsong; Shen, Dan-Dan; Cai, Pengjun; Shen, Qingya et al.
Source: check_circle
Web of Science Researcher Profile Sync

Structural basis of orientated asymmetry in a mGlu heterodimer

Nature Communications
2024 | Journal article
DOI: 10.1038/S41467-024-54744-7
WOSUID: WOS:001367613400023
Contributors: Huang, Weizhu; Jin, Nan; Guo, Jia; Shen, Cangsong; Xu, Chanjuan; Xi, Kun; Bonhomme, Leo; Quast, Robert B.; Shen, Dan-Dan; Qin, Jiao et al.
Source: check_circle
Web of Science Researcher Profile Sync

Structure-based design of non-hypertrophic apelin receptor modulator

Cell
2024 | Journal article
DOI: 10.1016/J.CELL.2024.02.004
WOSUID: WOS:001215073300001
Contributors: Wang, Wei-Wei; Ji, Su-Yu; Zhang, Wenjia; Zhang, Junxia; Cai, Chenxi; Hu, Rubi; Zang, Shao-Kun; Miao, Luwei; Xu, Haomang; Chen, Li-Nan et al.
Source: check_circle
Web of Science Researcher Profile Sync

The future of G protein-coupled receptor therapeutics: Apelin receptor acts as a prototype for the advancement of precision drug design

Clinical and Translational Medicine
2024 | Journal article
DOI: 10.1002/CTM2.70120
WOSUID: WOS:001374953600001
Contributors: Wang, Wei-Wei; Ji, Su-Yu; Xu, Ping; Zhang, Yan; Zhang, Yan
Source: check_circle
Web of Science Researcher Profile Sync

The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis

Advanced Science
2024 | Journal article
DOI: 10.1002/ADVS.202406421
WOSUID: WOS:001334665800001
Contributors: Sun, Shumin; Xie, Enjun; Xu, Shan; Ji, Suyu; Wang, Shufen; Shen, Jie; Wang, Rong; Shen, Xinyi; Su, Yunxing; Song, Zijun et al.
Source: check_circle
Web of Science Researcher Profile Sync

WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc

Proceedings of the National Academy of Sciences
2024 | Journal article
DOI: 10.1073/PNAS.2407904121
WOSUID: WOS:001349484100001
Contributors: Jiang, Li; Qi, Xuxin; Lai, Minshan; Zhou, Jiahao; Yuan, Meng; You, Jieqiong; Liu, Qiang; Pan, Jinchang; Zhao, Luyao; Ying, Meidan et al.
Source: check_circle
Web of Science Researcher Profile Sync

Structural basis of tethered agonism and G protein coupling of protease-activated receptors

Cell Research
2024-07-12 | Journal article
DOI: 10.1038/s41422-024-00997-2
Contributors: Jia Guo; Yun-Li Zhou; Yixin Yang; Shimeng Guo; Erli You; Xin Xie; Yi Jiang; Chunyou Mao; H. Eric Xu; Yan Zhang
Source: check_circle
Crossref

Is AlphaFold a perfect experimental assistant of psychiatric drug discovery in precision psychiatry era?

Asian Journal of Psychiatry
2022 | Journal article
DOI: 10.1016/J.AJP.2022.103305
WOSUID: WOS:000880152100003
Contributors: Fu, Yaoyang; Zhu, Yiyi; Zhang, Yan; Hu, Shaohua
Source: check_circle
Web of Science Researcher Profile Sync

Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation

Nature Communications
2022-10-21 | Journal article
DOI: 10.1038/s41467-022-34009-x
Contributors: Xiuwen Zhai; Chunyou Mao; Qingya Shen; Shaokun Zang; Dan-Dan Shen; Huibing Zhang; Zhaohong Chen; Gang Wang; Changming Zhang; Yan Zhang et al.
Source: check_circle
Crossref

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

2021-06-22 | Other
DOI: 10.1101/2021.06.21.449233
Contributors: Huibing Zhang; Li-Nan Chen; Dehua Yang; Chunyou Mao; Qingya Shen; Wenbo Feng; Dan-Dan Shen; Antao Dai; Shanshan Xie; Yan Zhou et al.
Source: check_circle
Crossref

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Nature Communications
2020-12 | Journal article
DOI: 10.1038/s41467-020-17933-8
Part of ISSN: 2041-1723
Source: Self-asserted source
Yan Zhang

Structural basis of GPBAR activation and bile acid recognition

Nature
2020-07-22 | Journal article
DOI: 10.1038/s41586-020-2569-1
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Yan Zhang

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science
2020-06-26 | Journal article
DOI: 10.1126/science.abc1560
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Source: Self-asserted source
Yan Zhang

Cryo-EM structures of inactive and active GABAB receptor

Cell Research
2020-06-03 | Journal article
DOI: 10.1038/s41422-020-0350-5
Part of ISSN: 1001-0602
Part of ISSN: 1748-7838
Source: Self-asserted source
Yan Zhang

Cell active and functionally-relevant small-molecule agonists of calcitonin receptor

Bioorganic Chemistry
2020-03 | Journal article
DOI: 10.1016/j.bioorg.2020.103596
Part of ISSN: 0045-2068
Source: Self-asserted source
Yan Zhang

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

Molecular Cell
2020-02 | Journal article
DOI: 10.1016/j.molcel.2020.01.013
Part of ISSN: 1097-2765
Source: Self-asserted source
Yan Zhang

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

Molecular Cell
2020-02 | Journal article
DOI: 10.1016/j.molcel.2020.01.012
Part of ISSN: 1097-2765
Source: Self-asserted source
Yan Zhang

A complex structure of arrestin-2 bound to a G protein-coupled receptor

Cell Research
2019-12 | Journal article
DOI: 10.1038/s41422-019-0256-2
Part of ISSN: 1001-0602
Part of ISSN: 1748-7838
Source: Self-asserted source
Yan Zhang

Conformational transitions of a neurotensin receptor 1–Gi1 complex

Nature
2019-08 | Journal article
DOI: 10.1038/s41586-019-1337-6
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Yan Zhang

Structure and dynamics of the active human parathyroid hormone receptor-1

Science
2019-04-12 | Journal article
DOI: 10.1126/science.aav7942
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Source: Self-asserted source
Yan Zhang

Structural insights into the activation of metabotropic glutamate receptors

Nature
2019-02 | Journal article
DOI: 10.1038/s41586-019-0881-4
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Yan Zhang

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

Cell
2018-08 | Journal article
DOI: 10.1016/j.cell.2018.07.020
Part of ISSN: 0092-8674
Source: Self-asserted source
Yan Zhang
grade
Preferred source (of 2)‎

Structure of the µ-opioid receptor–Gi protein complex

Nature
2018-06 | Journal article
DOI: 10.1038/s41586-018-0219-7
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Yan Zhang
grade
Preferred source (of 3)‎

Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel.

Structure (London, England : 1993)
2018-02 | Journal article
DOI: 10.1016/j.str.2018.01.013
PMID: 29456023
Contributors: Zhang Y; Hong S; Ruangprasert A; Skiniotis G; Dunham CM
Source: Self-asserted source
Yan Zhang via Europe PubMed Central

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin

Nature Communications
2017-12 | Journal article
DOI: 10.1038/s41467-017-01664-4
Part of ISSN: 2041-1723
Source: Self-asserted source
Yan Zhang
grade
Preferred source (of 2)‎

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

Nature
2017-06 | Journal article
DOI: 10.1038/nature22394
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Yan Zhang
grade
Preferred source (of 2)‎

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Nature
2017-06 | Journal article
DOI: 10.1038/nature22327
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Yan Zhang
grade
Preferred source (of 2)‎

2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania

Cell Reports
2016-07 | Journal article
DOI: 10.1016/j.celrep.2016.06.014
Part of ISSN: 2211-1247
Source: Self-asserted source
Yan Zhang
grade
Preferred source (of 2)‎

Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis

Scientific Reports
2015-10 | Journal article
DOI: 10.1038/srep12744
Part of ISSN: 2045-2322
Source: Self-asserted source
Yan Zhang

Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptide

Acta Crystallographica Section F Structural Biology Communications
2015-08-01 | Journal article
DOI: 10.1107/s2053230x15011085
Part of ISSN: 2053-230X
Source: Self-asserted source
Yan Zhang

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.

Protein & cell
2014-06 | Journal article
DOI: 10.1007/s13238-014-0078-4
PMID: 24952722
PMC: PMC4225485
Contributors: Zhang Y; Yang H; Guo X; Rong N; Song Y; Xu Y; Lan W; Zhang X; Liu M; Xu Y et al.
Source: Self-asserted source
Yan Zhang via Europe PubMed Central

Cysteine 397 plays important roles in the folding of the neuron-restricted silencer factor/RE1-silencing transcription factor

Biochemical and Biophysical Research Communications
2011-10 | Journal article
DOI: 10.1016/j.bbrc.2011.09.045
Part of ISSN: 0006-291X
Source: Self-asserted source
Yan Zhang

Highly Efficient Production of Soluble Proteins from Insoluble Inclusion Bodies by a Two-Step-Denaturing and Refolding Method

PLoS ONE
2011-07-29 | Journal article
DOI: 10.1371/journal.pone.0022981
Part of ISSN: 1932-6203
Source: Self-asserted source
Yan Zhang

Peer review (23 reviews for 10 publications/grants)

Review activity for Cell discovery. (2)
Review activity for Cell research (6)
Review activity for Cell. (4)
Review activity for Nature chemical biology. (2)
Review activity for Nature communications (2)
Review activity for Neuron. (2)
Review activity for PLoS biology. (1)
Review activity for Proceedings of the National Academy of Sciences of the United States of America. (1)
Review activity for Signal transduction and targeted therapy. (1)
Review activity for Trends in pharmacological sciences. (2)
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