Personal information

Emails & domains

Verified email domains

Websites & social links

Google scholar

Other IDs

Loop profile: 798579
Scopus Author ID: 57211185535

Keywords

Cancer Epigenetics, Methylation, Epithelial Ovarian Cancer, Cell free DNA , Liquid biopsies, Head and Neck cancer, Cancer Genomics, Genetics, Biomarker

Countries

India, United States

Activities

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Employment (1)

South Asian University: New Delhi, Delhi, IN

2013-08 to 2014-05 | Project fellow (Faculty of Life Sciences & Biotechnology (FLSB))
Employment
Source: Self-asserted source
Alka Singh

Education and qualifications (4)

The University of Chicago: Chicago, IL, US

2021-07-01 to present | Post Doc (Medicine)
Education
Source: Self-asserted source
Alka Singh

Motilal Nehru National Institute of Technology Allahabad : Allahabad, Uttar Pradesh, IN

2014-07-22 to present | PhD (Biotechnology)
Education
Source: Self-asserted source
Alka Singh

Banasthali University: Jaipur, Rajasthan, IN

2010-07-05 to 2012-06-30 | M.Sc (Applied Microbiology and Biotechnology)
Education
Source: Self-asserted source
Alka Singh

University of Allahabad Faculty of Science: Allahabad, Uttar Pradesh, IN

2007-07 to 2010-06 | B.Sc (Science)
Education
Source: Self-asserted source
Alka Singh

Professional activities (5)

American Association for Cancer Research: Philadelphia, PA, US

Global Scholar-in training award 2021
Distinction
Source: Self-asserted source
Alka Singh

University of Chicago: Chicago, IL, US

2022-08-01 to present | Steering committee member, BSD Office of Postdoctoral Affairs (BSD Medicine)
Service
Source: Self-asserted source
Alka Singh

University of Chicago: Chicago, IL, US

2022-08-01 to present | Welcome committee Chair, BSD Office of Postdoctoral Affairs (BSD Medicine)
Service
Source: Self-asserted source
Alka Singh

National Postdoctoral Association: Washington D.C., District of Columbia, US

2021-07-01 to present | Affiliate NPA membership (Medicine)
Membership
Source: Self-asserted source
Alka Singh

American Association for Cancer Research: Philadelphia, PA, US

2019-08-15 to present | Associate
Membership
Source: Self-asserted source
Alka Singh

Funding (5)

Ultra-deep sequencing of mitochondrial genome to explore the dynamic mutational changes associated with oral cavity squamous cell carcinoma progression

2023-04 to present | Award
Division of Biological Sciences, Office of Postdoctoral Affairs, University of Chicago (Chicago, IL, US)
Source: Self-asserted source
Alka Singh

Developing an ultra-sensitive and accurate automated analytical pipeline for tumor-specific variants calling in saliva of patients with oral cancer

2022-07 to 2023-06 | Grant
Provost Global Faculty award (Chicago, IL, US)
Source: Self-asserted source
Alka Singh

“Exploration of epigenetic biomarkers towards developing a multiplex assay for early diagnosis of epithelial ovarian carcinoma”

2018-05 to 2021 | Award
Council of Scientific and Industrial Research, India (New Delhi, New Delhi, IN)
GRANT_NUMBER:

(09/1032(0015)/2K18-EMR-1)
Source: Self-asserted source
Alka Singh

DNA methylation of SOX1 & HOXA9 as a biomarker for early detection of ovarian cancer in cell free DNA.

Award
Indian Council of Medical Research (New Delhi, New Delhi, IN)
GRANT_NUMBER:

No.3/2/TG-109 |HRD-2019 (9)
Source: Self-asserted source
Alka Singh

DNA methylation of SOX1 & HOXA9 as a biomarker for early detection of ovarian cancer in cell free DNA.

Award
Council of Scientific and Industrial Research, India (New Delhi, IN)
GRANT_NUMBER:

Ref No.TG/11199/19-HRD
Source: Self-asserted source
Alka Singh

Works (15)

Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer

npj Precision Oncology
2024-05-23 | Journal article
DOI: 10.1038/s41698-024-00606-w
Contributors: Thomas F. Cyberski; Alka Singh; Michael Korzinkin; Vasudha Mishra; Frank Pun; Le Shen; Claudia Wing; Xiangying Cheng; Brandon Baird; Yuxuan Miao et al.
Source: check_circle
Crossref

A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer

Nature Communications
2022-08-17 | Journal article
DOI: 10.1038/s41467-022-31859-3
Part of ISSN: 2041-1723
Contributors: Manijeh GOLDBERG; Aaron Manzi; Amritpreet Birdi; Brandon Laporte; Peter Conway; Stefanie Cantin; Vasudha Mishra; Alka Singh; Alexander Pearson; Eric R. Goldberg et al.
Source: Self-asserted source
Alka Singh

AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Cell Death & Disease
2022-08-05 | Journal article
DOI: 10.1038/s41419-022-05133-9
Part of ISSN: 2041-4889
Contributors: Renata Ferrarotto; Vasudha Mishra; Elad Herz; Adar Yaacov; Oz Solomon; Rami Rauch; Adi Mondshine; Maria Motin; Tal Leibovich-Rivkin; Matti Davis et al.
Source: Self-asserted source
Alka Singh

Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far?

Oncology Reviews
2022-02-22 | Journal article
DOI: 10.4081/oncol.2022.549
Part of ISSN: 1970-5565
Part of ISSN: 1970-5557
Contributors: Sophia Uddin; Alka Singh; Vasudha Mishra; Nishant Agrawal; Zhen Gooi; Evgeny Izumchenko
Source: Self-asserted source
Alka Singh

Application of liquid biopsy as multi-functional biomarkers in head and neck cancer

British Journal of Cancer
2021-12-07 | Journal article
DOI: 10.1038/s41416-021-01626-0
Part of ISSN: 0007-0920
Part of ISSN: 1532-1827
Source: Self-asserted source
Alka Singh

Evaluation of the Diagnostic Potential of Candidate Hypermethylated Genes in Epithelial Ovarian Cancer in North Indian Population

Frontiers in Molecular Biosciences
2021-10-28 | Journal article
DOI: 10.3389/fmolb.2021.719056
Part of ISSN: 2296-889X
Source: Self-asserted source
Alka Singh

A robust and interpretable gene signature for predicting the lymph node status of primary T1 / T2 oral cavity squamous cell carcinoma

International Journal of Cancer
2021-10-14 | Journal article
DOI: 10.1002/ijc.33828
Part of ISSN: 0020-7136
Part of ISSN: 1097-0215
Source: Self-asserted source
Alka Singh

Abstract 480: Aberrant promoter hypermethylation of HIC1 and SOX1 in circulating cell free DNA as a potential biomarker for noninvasive early detection of ovarian cancer

AACR annual meeting 2021
2021-07 | Conference abstract
DOI: DOI: 10.1158/1538-7445.AM2021-480
Source: Self-asserted source
Alka Singh

Detection of aberrant methylation of HOXA9 and HIC1 through multiplex MethyLight assay in serum DNA for the early detection of epithelial ovarian cancer

International Journal of Cancer
2020-09-15 | Journal article
DOI: 10.1002/ijc.32984
Contributors: Alka Singh; Sameer Gupta; Jaydeep A. Badarukhiya; Manisha Sachan
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Abstract A13: DNA methylation of SOX1 and HOXA9 as a biomarker for early detection of ovarian cancer in cell-free DNA

Poster Presentations - Proffered Abstracts
2020-06-01 | Conference abstract
DOI: 10.1158/1557-3265.liqbiop20-a13
Source: Self-asserted source
Alka Singh

Epigenetic Biomarkers in the Management of Ovarian Cancer: Current Prospectives

Frontiers in Cell and Developmental Biology
2019-09-19 | Journal article
DOI: 10.3389/fcell.2019.00182
Part of ISSN: 2296-634X
Source: Self-asserted source
Alka Singh

HOXA9 and SOX1 - a promising DNA methylation based diagnostic biomarker for epithelial ovarian cancer

Canadian Journal of Biotechnology
2017-10-05 | Journal article
DOI: 10.24870/cjb.2017-a53
Part of ISSN: 2560-8304
Source: Self-asserted source
Alka Singh

Development of a multiplex MethyLight assay for the detection of DAPK1 and SOX1 methylation in epithelial ovarian cancer in a north Indian population

Genes & Genetic Systems
2016 | Journal article
DOI: 10.1266/ggs.15-00051
Part of ISSN: 1341-7568
Part of ISSN: 1880-5779
Source: Self-asserted source
Alka Singh

Methylation of the Sox9 and Oct4 promoters and its correlation with gene expression during testicular development in the laboratory mouse

Genetics and Molecular Biology
2016-07-04 | Journal article
DOI: 10.1590/1678-4685-gmb-2015-0172
Part of ISSN: 1678-4685
Part of ISSN: 1415-4757
Source: Self-asserted source
Alka Singh

Hypo/unmethylated promoter status of Cdk2 gene correlates with its over-expression in ovarian cancer in north Indian population.

Cellular and molecular biology (Noisy-le-Grand, France)
2016-01-22 | Journal article
PMID: 26828990
Source: Self-asserted source
Alka Singh

Peer review (6 reviews for 4 publications/grants)

Review activity for Journal of translational medicine. (3)
Review activity for Metabolism open. (1)
Review activity for Nature communications (1)
Review activity for Translational medicine communications. (1)
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