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Technical University of Munich: Munich, Bavaria, DE

2024-04-14 to present | Postdoc (CeMM)
Employment
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Severin Lechner

Works (10)

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

Nature Biotechnology
2025-03 | Journal article
DOI: 10.1038/s41587-024-02218-y
Contributors: Stephan Eckert; Nicola Berner; Karl Kramer; Annika Schneider; Julian Müller; Severin Lechner; Sarah Brajkovic; Amirhossein Sakhteman; Christian Graetz; Jonas Fackler et al.
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Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Nature Communications
2024-11-25 | Journal article
DOI: 10.1038/s41467-024-54409-5
Contributors: Martin P. Schwalm; Johannes Dopfer; Adarsh Kumar; Francesco A. Greco; Nicolas Bauer; Frank Löhr; Jan Heering; Sara Cano-Franco; Severin Lechner; Thomas Hanke et al.
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A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics

The EMBO Journal
2023-12 | Journal article
DOI: 10.15252/embj.2023114665
Contributors: Johanna Tüshaus; Amirhossein Sakhteman; Severin Lechner; Matthew The; Eike Mucha; Christoph Krisp; Jürgen Schlegel; Claire Delbridge; Bernhard Kuster
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High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells

Molecular & Cellular Proteomics
2023-09 | Journal article
DOI: 10.1016/j.mcpro.2023.100632
Contributors: Johannes Krumm; Elissaveta Petrova; Severin Lechner; Julia Mergner; Hans-Henning Boehm; Alessandro Prestipino; Dominik Steinbrunn; Marshall L. Deline; Lisa Koetzner; Christina Schindler et al.
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Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Nature Communications
2023-06-15 | Journal article
DOI: 10.1038/s41467-023-39151-8
Contributors: Severin Lechner; Raphael R. Steimbach; Longlong Wang; Marshall L. Deline; Yun-Chien Chang; Tobias Fromme; Martin Klingenspor; Patrick Matthias; Aubry K. Miller; Guillaume Médard et al.
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Chemoproteomic target deconvolution of lipoic acid reveals Histone Deacetylases as the main targets

2022-12-02 | Preprint
DOI: 10.21203/rs.3.rs-2277181/v1
Contributors: Bernhard Kuster; Severin Lechner; Raphael Steimbach; Longlong Wang; Patrick Matthias; Aubry Miller; Guillaume Medard
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Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition

European Journal of Medicinal Chemistry
2022-10 | Journal article
DOI: 10.1016/j.ejmech.2022.114594
Contributors: Carina Glas; Eli Naydenova; Severin Lechner; Nathalie Wössner; Liu Yang; Johannes C.B. Dietschreit; Hongyan Sun; Manfred Jung; Bernhard Kuster; Christian Ochsenfeld et al.
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Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Journal of the American Chemical Society
2022-10-19 | Journal article
DOI: 10.1021/jacs.2c05030
Contributors: Raphael R. Steimbach; Corey J. Herbst-Gervasoni; Severin Lechner; Tracy Murray Stewart; Glynis Klinke; Johannes Ridinger; Magalie N. E. Géraldy; Gergely Tihanyi; Jackson R. Foley; Ulrike Uhrig et al.
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Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Nature Chemical Biology
2022-08 | Journal article
DOI: 10.1038/s41589-022-01112-5
Contributors: Severin Lechner; Martin Ian P. Malgapo; Christian Grätz; Raphael R. Steimbach; Agnes Baron; Patrick Rüther; Simon Nadal; Carmen Stumpf; Christina Loos; Xin Ku et al.
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Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Nature Chemical Biology
2022-08 | Journal article
DOI: 10.1038/s41589-022-01015-5
Contributors: Severin Lechner; Martin Ian P. Malgapo; Christian Grätz; Raphael R. Steimbach; Agnes Baron; Patrick Rüther; Simon Nadal; Carmen Stumpf; Christina Loos; Xin Ku et al.
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