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Employment (2)

Universitat Pompeu Fabra: Barcelona, Catalunya, ES

2022-03-01 to present | Postdoctoral Researcher (Stembryo Lab)
Employment
Source: Self-asserted source
Joshua David Frenster

NYU Langone Health: New York, NY, US

2014 to present | PhD Student (Placantonakis Lab)
Employment
Source: Self-asserted source
Joshua David Frenster

Education and qualifications (3)

NYU Langone Health: New York, NY, US

2014-08-01 to 2021-01-15 | PhD
Education
Source: Self-asserted source
Joshua David Frenster

New York University: NY, NY, US

2014-09 to 2017-01 | MSc (Sackler Institute/Grossman School of Medicine)
Education
Source: Self-asserted source
Joshua David Frenster

Jacobs University: Bremen, DE

2011-08 to 2014-06 | BSc
Education
Source: Self-asserted source
Joshua David Frenster

Works (23)

N2B27 media formulations influence gastruloid development

2025-03-16 | Preprint
DOI: 10.1101/2025.03.15.643474
Contributors: Tina Balayo; Sharna Lunn; Pau Pascual-Mas; Ulla-Maj Fiuza; Amruta Vasudevan; Joshua D. Frenster; Hannah Y. Galloon; Raquel Flores Peirats; Alfonso Martinez Arias; André Dias et al.
Source: check_circle
Crossref

A mosaic gastruloid model highlights the developmental stage-specific restriction of cell competition in mammalian pre-gastrulation

2025-01-25 | Preprint
DOI: 10.1101/2025.01.25.634859
Contributors: J.D. Frenster; S. Babin; J.B. Josende Garcia; P. Casani Galdon; P. Pascual-Mas; G. Robertson; J. Garcia Ojalvo; A. Martinez Arias
Source: check_circle
Crossref

Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.

Cell reports
2024-05-16 | Journal article
DOI: 10.1016/j.celrep.2024.114229
PMID: 38758649
PMC: PMC11209873
Contributors: Stephan G; Haddock S; Wang S; Hediye Erdjument-Bromage; Liu W; Ravn-Boess N; Frenster JD; Bready D; Cai J; Ronnen R et al.
Source: Self-asserted source
Joshua David Frenster

The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.

Cell reports
2023-11-08 | Journal article
DOI: 10.1016/j.celrep.2023.113374
PMID: 37938973
PMC: PMC10841603
Contributors: Ravn-Boess N; Roy N; Hattori T; Bready D; Donaldson H; Lawson C; Lapierre C; Korman A; Rodrick T; Liu E et al.
Source: Self-asserted source
Joshua David Frenster

PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.

Cell reports
2023-06-23 | Journal article
DOI: 10.1016/j.celrep.2023.112679
PMID: 37354459
PMC: PMC10445595
Contributors: Frenster JD; Hediye Erdjument-Bromage; Stephan G; Ravn-Boess N; Wang S; Liu W; Bready D; Wilcox J; Kieslich B; Jankovic M et al.
Source: Self-asserted source
Joshua David Frenster

Activation of the adhesion G protein-coupled receptor GPR133 (ADGRD1) by antibodies targeting its N-terminus

Journal of Biological Chemistry
2022-04 | Journal article
DOI: 10.1016/j.jbc.2022.101949
Part of ISSN: 0021-9258
Source: Self-asserted source
Joshua David Frenster
grade
Preferred source (of 2)‎

The H3K36me2 writer-reader dependency in H3K27M-DIPG.

Science advances
2021-07-14 | Journal article
DOI: 10.1126/sciadv.abg7444
PMID: 34261657
PMC: PMC8279504
Source: Self-asserted source
Joshua David Frenster
grade
Preferred source (of 2)‎

The H3K36me2 writer-reader dependency in H3K27M-DIPG

2021-01-06 | Preprint
DOI: 10.1101/2021.01.06.425580
Contributors: Jia-Ray Yu; Gary LeRoy; Devin Bready; Joshua D. Frenster; Ricardo Saldaña-Meyer; Ying Jin; Nicolas Descostes; James M. Stafford; Dimitris G. Placantonakis; Danny Reinberg
Source: check_circle
Crossref

Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling.

The Journal of biological chemistry
2021-01-01 | Journal article
DOI: 10.1016/j.jbc.2021.100798
PMID: 34022221
PMC: PMC8215292
Source: Self-asserted source
Joshua David Frenster
grade
Preferred source (of 2)‎

Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling

2020-12-08 | Preprint
DOI: 10.1101/2020.12.08.415398
Contributors: Joshua D. Frenster; Gabriele Stephan; Niklas Ravn-Boess; Devin Bready; Jordan Wilcox; Bjoern Kieslich; Caroline Wilde; Norbert Sträter; Giselle R. Wiggin; Ines Liebscher et al.
Source: check_circle
Crossref

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy.

eLife
2020-09-10 | Journal article
DOI: 10.7554/elife.52253
PMID: 32909947
PMC: PMC7556869
Source: Self-asserted source
Joshua David Frenster

<i>In vitro</i> evidence for glioblastoma cell death in temperatures found in the penumbra of laser-ablated tumors.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
2020-07-01 | Journal article
DOI: 10.1080/02656736.2020.1774082
PMID: 32672127
Source: Self-asserted source
Joshua David Frenster
grade
Preferred source (of 2)‎

Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes.

Neuro-oncology advances
2020-04-28 | Journal article
DOI: 10.1093/noajnl/vdaa053
PMID: 32642706
PMC: PMC7262742
Source: Self-asserted source
Joshua David Frenster

Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research
2018-11-05 | Journal article
DOI: 10.1158/1078-0432.ccr-18-2312
PMID: 30397180
Source: Self-asserted source
Joshua David Frenster

Bioluminescent In Vivo Imaging of Orthotopic Glioblastoma Xenografts in Mice.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7659-1_15
PMID: 29392701
Source: Self-asserted source
Joshua David Frenster

Establishing Primary Human Glioblastoma Tumorsphere Cultures from Operative Specimens.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7659-1_4
PMID: 29392690
Source: Self-asserted source
Joshua David Frenster

Isolation of Glioblastoma Stem Cells with Flow Cytometry.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7659-1_5
PMID: 29392691
Source: Self-asserted source
Joshua David Frenster

Lentiviral Transduction of Primary Human Glioblastoma Cultures.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7659-1_6
PMID: 29392692
Source: Self-asserted source
Joshua David Frenster

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.

Cell reports
2017-10-01 | Journal article
DOI: 10.1016/j.celrep.2017.10.009
PMID: 29091765
PMC: PMC5687844
Source: Self-asserted source
Joshua David Frenster

GPR133 Promotes Glioblastoma Growth in Hypoxia.

Neurosurgery
2017-09-01 | Journal article
DOI: 10.1093/neuros/nyx227
PMID: 28899043
PMC: PMC6433437
Source: Self-asserted source
Joshua David Frenster

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

Oncotarget
2017-05-23 | Journal article
DOI: 10.18632/oncotarget.18117
PMID: 29029402
PMC: PMC5630302
Source: Self-asserted source
Joshua David Frenster

GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth.

Oncogenesis
2016-10-24 | Journal article
DOI: 10.1038/oncsis.2016.63
PMID: 27775701
PMC: PMC5117849
Source: Self-asserted source
Joshua David Frenster

Adult Primary Spinal Epidural Extraosseous Ewing's Sarcoma: A Case Report and Review of the Literature.

Case reports in neurological medicine
2016-08-17 | Journal article
DOI: 10.1155/2016/1217428
PMID: 27610254
PMC: PMC5005550
Source: Self-asserted source
Joshua David Frenster
grade
Preferred source (of 2)‎

Peer review (2 reviews for 2 publications/grants)

Review activity for Neuroscience bulletin. (1)
Review activity for Signal transduction and targeted therapy. (1)
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