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Education and qualifications (2)

University of Michigan Medical School: Ann Arbor, MI, US

1998-05 to 1999-08 | Postdoctoral Research Fellow (Anesthesiology; Pharmacology)
Education
Source: Self-asserted source
Mei-Chuan Ko

University of Michigan: Ann Arbor, MI, US

1998-05-19 | Ph.D. (Biopsychology)
Education
Source: Self-asserted source
Mei-Chuan Ko

Works (50 of 132)

Items per page:
Page 1 of 3

Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics

Drugs
2023-06 | Journal article
DOI: 10.1007/s40265-023-01878-5
Contributors: Huiping Ding; Norikazu Kiguchi; MaryBeth Dobbins; E. Alfonso Romero-Sandoval; Shiroh Kishioka; Mei-Chuan Ko
Source: check_circle
Crossref

Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.

Neuropharmacology
2022-11 | Journal article
DOI: 10.1016/j.neuropharm.2022.109328
PMID: 36356937
Contributors: Ding H; Kiguchi N; Mabry KM; Kishioka S; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.

Biochemical pharmacology
2022-02 | Journal article
DOI: 10.1016/j.bcp.2022.114972
PMID: 35189108
Contributors: Kiguchi N; Ding H; Park SH; Mabry KM; Kishioka S; Shiozawa Y; Alfonso Romero-Sandoval E; Peters CM; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Enhanced antidepressant-like effects of a delta opioid receptor agonist, SNC80, in rats under inflammatory pain.

Pharmacology, biochemistry, and behavior
2022-01 | Journal article
DOI: 10.1016/j.pbb.2022.173341
PMID: 35104493
Contributors: Chen CM; Ding H; Mabry KM; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse

Journal of Neuroscience Research
2022-01 | Journal article
DOI: 10.1002/jnr.24624
Contributors: Norikazu Kiguchi; Huiping Ding; Mei‐Chuan Ko
Source: check_circle
Crossref
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Potential therapeutic targets for the treatment of opioid abuse and pain.

Advances in pharmacology (San Diego, Calif.)
2021-11 | Journal article
DOI: 10.1016/bs.apha.2021.09.002
PMID: 35341570
Contributors: Kiguchi N; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.

Neuron
2021-07 | Journal article
DOI: 10.1016/j.neuron.2021.06.015
PMID: 34473953
Contributors: Luo X; Chen O; Wang Z; Bang S; Ji J; Lee SH; Huh Y; Furutani K; He Q; Tao X et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Characterization of early Alzheimer’s-like pathological alterations in non-human primates with aging: a pilot study

2021-07-22 | Other
DOI: 10.1101/2021.07.21.453246
Contributors: Hannah Jester; Saahj Gosrani; Huiping Ding; Xueyan Zhou; Mei-Chuan Ko; Tao Ma
Source: check_circle
Crossref

PD-1 in hippocampal neurons regulates excitability, synaptic plasticity, and cognition

2021-07-14 | Other
DOI: 10.1101/2021.07.13.451894
Contributors: Junli Zhao; Sangsu Bang; Aidan McGinnis; Kenta Furutani; Changyu Jiang; Alexus Roberts; Christopher R Donnelly; Qianru He; Mei-Chuan Ko; Haichen Wang et al.
Source: check_circle
Crossref

Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates.

Anesthesiology
2021-06 | Journal article
DOI: 10.1097/aln.0000000000003848
PMID: 34237134
Contributors: Ding H; Trapella C; Kiguchi N; Hsu FC; Caló G; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.

Pharmacology research & perspectives
2021-05 | Journal article
DOI: 10.1002/prp2.790
PMID: 34000759
PMC: PMC8128314
Contributors: Kiguchi N; Fukazawa Y; Saika A; Uta D; Saika F; Nakamura TY; Ko MC; Kishioka S
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine.

Gastroenterology
2021-04 | Journal article
DOI: 10.1053/j.gastro.2021.03.049
PMID: 33819485
Contributors: Chen Y; Wang ZL; Yeo M; Zhang QJ; López-Romero AE; Ding HP; Zhang X; Zeng Q; Morales-Lázaro SL; Moore C et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications.

Biochemical pharmacology
2021-03 | Journal article
DOI: 10.1016/j.bcp.2021.114520
PMID: 33741328
Contributors: Park SH; Eber MR; Fonseca MM; Patel CM; Cunnane KA; Ding H; Hsu FC; Peters CM; Ko MC; Strowd RE et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

Science Translational Medicine
2021-02-03 | Journal article
DOI: 10.1126/scitranslmed.abc3774
Contributors: Eileen Nguyen; Grace Lim; Huiping Ding; Junichi Hachisuka; Mei-Chuan Ko; Sarah E. Ross
Source: check_circle
Crossref

[Therapeutic potentials of safe opioid analgesics targeting nociceptin/orphanin FQ peptide receptor].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
2021-01 | Journal article
DOI: 10.1254/fpj.20106
PMID: 33952840
Contributors: Kiguchi N; Kishioka S; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

STING controls nociception via type I interferon signalling in sensory neurons.

Nature
2021-01 | Journal article
DOI: 10.1038/s41586-020-03151-1
PMID: 33442058
Contributors: Donnelly CR; Jiang C; Andriessen AS; Wang K; Wang Z; Ding H; Zhao J; Luo X; Lee MS; Lei YL et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Translational value of non-human primates in opioid research.

Experimental neurology
2021-01 | Journal article
DOI: 10.1016/j.expneurol.2021.113602
PMID: 33453211
Contributors: Ding H; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates.

Handbook of experimental pharmacology
2020-12 | Journal article
DOI: 10.1007/164_2020_419
PMID: 33274403
Contributors: Ko MC; Husbands SM
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics

Current Topics in Medicinal Chemistry
2020-12-03 | Journal article
DOI: 10.2174/1568026620666200508082615
Contributors: Norikazu Kiguchi; Huiping Ding; Shiroh Kishioka; Mei-Chuan Ko
Source: check_circle
Crossref

Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.

British journal of anaesthesia
2020-08 | Journal article
DOI: 10.1016/j.bja.2020.06.057
PMID: 32819621
Contributors: Ding H; Kiguchi N; Perrey DA; Nguyen T; Czoty PW; Hsu FC; Zhang Y; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.

Cell Reports
2020-04 | Journal article
DOI: 10.1016/j.celrep.2020.03.036
PMID: 32268102
Contributors: Mishra SK; Wheeler JJ; Pitake S; Ding H; Jiang C; Fukuyama T; Paps JS; Ralph P; Coyne J; Parkington M et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.

Neuropharmacology
2020-03 | Journal article
DOI: 10.1016/j.neuropharm.2020.108025
PMID: 32142790
Contributors: Kiguchi N; Uta D; Ding H; Uchida H; Saika F; Matsuzaki S; Fukazawa Y; Abe M; Sakimura K; Ko MC et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates.

Science translational medicine
2020-02 | Journal article
DOI: 10.1126/scitranslmed.aaw6471
PMID: 32075945
Contributors: Wang Z; Jiang C; He Q; Matsuda M; Han Q; Wang K; Bang S; Ding H; Ko MC; Ji RR
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
Preferred source (of 3)‎

Preface

Handbook of Experimental Pharmacology
2019 | Book
EID:

2-s2.0-85069483414

Part of ISBN:

18650325 01712004
Contributors: Ko, M.-C.; Caló, G.
Source: Self-asserted source
Mei-Chuan Ko via Scopus - Elsevier

The Nociceptin/Orphanin FQ Peptide Receptor

Handbook of Experimental Pharmacology
2019 | Book
DOI: 10.1007/978-3-030-20186-9
Part of ISSN: 0171-2004
Contributors: Mei-Chuan Ko; Girolamo Caló
Source: Self-asserted source
Mei-Chuan Ko via Crossref Metadata Search

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2019-04 | Journal article
DOI: 10.1038/s41386-019-0390-z
PMID: 30970376
Contributors: Flynn SM; Epperly PM; Davenport AT; Cami-Kobeci G; Husbands SM; Ko MC; Czoty PW
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Effects of NOP-Related Ligands in Nonhuman Primates.

Handbook of experimental pharmacology
2019-03 | Journal article
DOI: 10.1007/164_2019_211
PMID: 30879202
Contributors: Kiguchi N; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.

British journal of anaesthesia
2019-02 | Journal article
DOI: 10.1016/j.bja.2018.10.065
PMID: 30916003
Contributors: Kiguchi N; Ding H; Cami-Kobeci G; Sukhtankar DD; Czoty PW; DeLoid HB; Hsu FC; Toll L; Husbands SM; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons.

Acta dermato-venereologica
2019-02 | Journal article
DOI: 10.2340/00015555-3143
PMID: 30734045
Contributors: Ehling S; Fukuyama T; Ko MC; Olivry T; Bäumer W
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Spinal GRP mediates itch in nonhuman primates

PAIN RESEARCH
2018 | Journal article
DOI: 10.11154/pain.33.308
Part of ISSN: 0915-8588
Contributors: Norikazu Kiguchi; Shiroh Kishioka; Mei–Chuan Ko
Source: Self-asserted source
Mei-Chuan Ko via Crossref Metadata Search

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.

Science translational medicine
2018-08 | Journal article
DOI: 10.1126/scitranslmed.aar3483
PMID: 30158150
Contributors: Ding H; Kiguchi N; Yasuda D; Daga PR; Polgar WE; Lu JJ; Czoty PW; Kishioka S; Zaveri NT; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Synthesis of Enantiopure PZM21: A Biased Agonist of the Mu-Opioid Receptor

European Journal of Organic Chemistry
2018-07 | Journal article
DOI: 10.1002/ejoc.201800517
Part of ISSN: 1434-193X
Contributors: David Perrey; Dehui Zhang; Thuy Nguyen; F. Ivy Carroll; Mei-Chuan Ko; Yanan Zhang
Source: Self-asserted source
Mei-Chuan Ko via Crossref Metadata Search
grade
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Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys.

Journal of diabetes
2018-05 | Journal article
DOI: 10.1111/1753-0407.12780
PMID: 29749036
Contributors: Ding H; Kiguchi N; Kishioka S; Ma T; Peters CM; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.

Biochimica et biophysica acta
2017-01 | Journal article
DOI: 10.1016/j.bbadis.2016.10.007
PMID: 27751964
PMC: PMC5154845
Contributors: Kiguchi N; Ding H; Peters CM; Kock ND; Kishioka S; Cline JM; Wagner JD; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).

European journal of pharmacology
2017-01 | Journal article
DOI: 10.1016/j.ejphar.2016.11.026
PMID: 27871910
PMC: PMC5183561
Contributors: Cerlesi MC; Ding H; Bird MF; Kiguchi N; Ferrari F; Malfacini D; Rizzi A; Ruzza C; Lambert DG; Ko MC et al.
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Central N/OFQ-NOP Receptor System in Pain Modulation.

Advances in pharmacology (San Diego, Calif.)
2016 | Journal article
DOI: 10.1016/bs.apha.2015.10.001
PMID: 26920014
PMC: PMC4944813
Contributors: Kiguchi N; Ding H; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.

Proceedings of the National Academy of Sciences of the United States of America
2016-09 | Journal article
DOI: 10.1073/pnas.1605295113
PMID: 27573832
PMC: PMC5027459
Contributors: Ding H; Czoty PW; Kiguchi N; Cami-Kobeci G; Sukhtankar DD; Nader MA; Husbands SM; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.

The Journal of pharmacology and experimental therapeutics
2016-03 | Journal article
DOI: 10.1124/jpet.115.229997
PMID: 26669425
PMC: PMC4767390
Contributors: Kiguchi N; Sukhtankar DD; Ding H; Tanaka K; Kishioka S; Peters CM; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.

2015 | Journal article
DOI:

10.1038/srep11676

PMID:

26119696
Contributors: Lee H; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
Preferred source (of 2)‎

Neuraxial opioid-induced itch and its pharmacological antagonism.

2015 | Journal article
DOI:

10.1007/978-3-662-44605-8_17

PMID:

25861787
Contributors: Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys.

British journal of pharmacology
2015-07 | Journal article
DOI: 10.1111/bph.13150
PMID: 25828800
PMC: PMC4507167
Contributors: Rizzi A; Sukhtankar DD; Ding H; Hayashida K; Ruzza C; Guerrini R; Calò G; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.

British journal of pharmacology
2015-07 | Journal article
DOI: 10.1111/bph.13124
PMID: 25752320
PMC: PMC4500367
Contributors: Ding H; Hayashida K; Suto T; Sukhtankar DD; Kimura M; Mendenhall V; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages.

2015-06 | Journal article
DOI:

10.1016/j.jphs.2015.04.009

PMID:

26012743
Contributors: Kiguchi N; Saika F; Kobayashi Y; Ko MC; Kishioka S
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
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Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.

2014-12 | Journal article
DOI:

10.1016/j.ejphar.2014.10.029

PMID:

25446568
Contributors: Sukhtankar DD; Lagorio CH; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
Preferred source (of 2)‎

Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.

British journal of pharmacology
2014-08 | Journal article
DOI: 10.1111/bph.12744
PMID: 24762001
PMC: PMC4128043
Contributors: Schröder W; Lambert DG; Ko MC; Koch T
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
Preferred source (of 2)‎

Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.

2014-04 | Journal article
DOI: 10.1007/s00213-013-3341-0
PMID: 24217900
PMC: PMC3954905
Contributors: Sukhtankar DD; Lee H; Rice KC; Ko MC
Source: Self-asserted source
Mei-Chuan Ko via Europe PubMed Central
grade
Preferred source (of 2)‎

Roles of Central Opioid Receptor Subtypes in Regulating Itch Sensation

Itch
2014-01 | Other
DOI: 10.1201/b16573-26
Part of ISBN: 9781466505438
Part of ISSN: 2154-5723
Contributors: Mei-Chuan Ko
Source: Self-asserted source
Mei-Chuan Ko via Crossref Metadata Search

[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist

British Journal of Pharmacology
2013 | Journal article
DOI:

10.1111/j.1476-5381.2012.02115.x
Contributors: Molinari, S.; Camarda, V.; Rizzi, A.; Marzola, G.; Salvadori, S.; Marzola, E.; Molinari, P.; McDonald, J.; Ko, M. C.; Lambert, D. G. et al.
Source: Self-asserted source
Mei-Chuan Ko via ResearcherID
grade
Preferred source (of 2)‎

Effects of Spinally Administered Bifunctional Nociceptin/Orphanin FQ Peptide Receptor/mu-Opioid Receptor Ligands in Mouse Models of Neuropathic and Inflammatory Pain

Journal of Pharmacology and Experimental Therapeutics
2013 | Journal article
DOI:

10.1124/jpet.113.203984
Contributors: Sukhtankar, Devki D.; Zaveri, Nurulain T.; Husbands, Stephen M.; Ko, Mei-Chuan
Source: Self-asserted source
Mei-Chuan Ko via ResearcherID
grade
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INHIBITORY EFFECTS OF DYNORPHIN-A ON SPINALLY ADMINISTERED BETA-ENDORPHIN-AND GRP-INDUCED SCRATCHING IN NONHUMAN PRIMATES

Acta Dermato-Venereologica
2013 | Journal article
Contributors: Lee, Heeseung; Ko, Mei-Chuan
Source: Self-asserted source
Mei-Chuan Ko via ResearcherID
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