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Metastasis, Fibroblasts, Breast Cancer, Immunosuppression, Mesenchymal Stem Cells, Myeloid Cells
United States

Biography

Guangwen “Gary” Ren, Ph.D. has a broad background in cancer immunology and tumor microenvironment and his research group mainly focuses on elucidating how stromal cells and myeloid cells modulate the anti-tumor immunity in cancer treatment resistance and metastatic relapse.

Activities

Employment (4)

Tufts University: Medford, Massachusetts, US

2024-12 to present | Associate Professor (joint appointment, research track) (Immunology)
Employment
Source: Self-asserted source
Guangwen Ren

The Jackson Laboratory: Bar Harbor, Maine, US

2023-03 to present | Associate Professor
Employment
Source: Self-asserted source
Guangwen Ren

Tufts University: Medford, Massachusetts, US

2017-07 to 2024-11 | Assistant Professor (joint appointment) (Medicine)
Employment
Source: Self-asserted source
Guangwen Ren

The Jackson Laboratory: Bar Harbor, ME, US

2016-10 to 2023-02 | Assistant Professor
Employment
Source: Self-asserted source
Guangwen Ren

Education and qualifications (3)

Princeton University: Princeton, New Jersey, US

2012-12 to 2016-10 | Postdoctoral Associate and Associate Research Scholar (Molecular Biology)
Education
Source: Self-asserted source
Guangwen Ren

Rutgers, The State University of New Jersey: New Brunswick, New Jersey, US

2009-06 to 2012-11 | Research Teaching Specialist III (Child health institute of New Jersey)
Education
Source: Self-asserted source
Guangwen Ren

Rutgers: New Brunswick, New Jersey, US

2004-09 to 2009-06 | PhD (Immunology)
Education
Source: Self-asserted source
Guangwen Ren

Professional activities (6)

Cancer and Metastasis Reviews: New York, US

2023-07 to present | Associate Editor
Service
Source: Self-asserted source
Guangwen Ren

AACR: Philadelphia, Pennsylvania, US

2017 to present
Membership
Source: Self-asserted source
Guangwen Ren

NIH: Bethesda, Maryland, US

2020 | NIH/NCI The Method to Extend Research in Time (MERIT) (R37) Award
Distinction
Source: Self-asserted source
Guangwen Ren

DOD: Washington, District of Columbia, US

2018 | DoD Breast Cancer Research Program Breakthrough Award
Distinction
Source: Self-asserted source
Guangwen Ren

NIH: Bethesda, Maryland, US

2014 | NIH/NCI K99/R00 Pathway to Independence Award
Distinction
Source: Self-asserted source
Guangwen Ren

DOD: Washington, District of Columbia, US

2013 | DoD Breast Cancer Postdoctoral Fellowship Award
Distinction
Source: Self-asserted source
Guangwen Ren

Funding (6)

Lung Resident Mesenchymal Cells in the Pre-Metastatic Niche Formation

2021-04-01 to 2026-03-31 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: R01CA251433
Source: Self-asserted source
Guangwen Ren via DimensionsWizard

The Role of Lung Resident Mesenchymal Stem Cells in Post-Chemotherapy Lung Metastases of Breast Cancer

2020-02-04 to 2027-01-31 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: R37CA237307
Source: Self-asserted source
Guangwen Ren via DimensionsWizard

Mesenchymal Stem Cell-Based Therapy for Treatment of Bone Metastases in Breast Cancer

2018-04-01 to 2021-03-31 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
GRANT_NUMBER:

W81XWH-18-1-0013

Source: Self-asserted source
Guangwen Ren via DimensionsWizard

Mesenchymal Stromal Cells and Stromal Fibroblasts in Radiotherapy Resistance

2017-02-15 to 2020-01-31 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: R00CA188093
Source: Self-asserted source
Guangwen Ren via DimensionsWizard

Mesenchymal Stromal Cells and Stromal Fibroblasts in Radiotherapy Resistance

2014-07-01 to 2016-10-31 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: K99CA188093
Source: Self-asserted source
Guangwen Ren via DimensionsWizard

Metastasis-Associated Mesenchymal Stromal Cells in Organtropic Metastasis of Breast Cancer

2013-09-01 to 2014-07-01 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
GRANT_NUMBER:

W81XWH-13-1-0260

Source: Self-asserted source
Guangwen Ren via DimensionsWizard

Works (47)

Combination Organelle Mitochondrial Endoplasmic Reticulum Therapy (COMET) for Multidrug Resistant Breast Cancer

Journal of Controlled Release
2023 | Journal article
EID:

2-s2.0-85173140401

Part of ISSN: 18734995 01683659
Contributors: Milane, L.S.; Dolare, S.; Ren, G.; Amiji, M.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis

Science Immunology
2023 | Journal article
EID:

2-s2.0-85148322643

Part of ISSN: 24709468
Contributors: Gong, Z.; Li, Q.; Shi, J.; Li, P.; Hua, L.; Shultz, L.D.; Ren, G.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier
grade
Preferred source (of 2)‎

An Artifact in Intracellular Cytokine Staining for Studying T Cell Responses and Its Alleviation

Frontiers in Immunology
2022 | Journal article
EID:

2-s2.0-85124235802

Part of ISSN: 16643224
Contributors: Gong, Z.; Li, Q.; Shi, J.; Ren, G.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Editorial: Stromal and immune microenvironment in breast cancer metastasis

Frontiers in Immunology
2022 | Journal article
EID:

2-s2.0-85144247855

Part of ISSN: 16643224
Contributors: Lu, X.; Liu, X.; Celià-Terrassa, T.; Ren, G.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

GZMK<sup>high</sup> CD8<sup>+</sup> T effector memory cells are associated with CD15<sup>high</sup> neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Nature Communications
2022 | Journal article
EID:

2-s2.0-85141565395

Part of ISSN: 20411723
Contributors: Tiberti, S.; Catozzi, C.; Croci, O.; Ballerini, M.; Cagnina, D.; Soriani, C.; Scirgolea, C.; Gong, Z.; He, J.; Macandog, A.D. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Cell Metabolism
2022 | Journal article
EID:

2-s2.0-85143548377

Part of ISSN: 19327420 15504131
Contributors: Gong, Z.; Li, Q.; Shi, J.; Liu, E.T.; Shultz, L.D.; Ren, G.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

Immunity
2022 | Journal article
EID:

2-s2.0-85135145367

Part of ISSN: 10974180 10747613
Contributors: Gong, Z.; Li, Q.; Shi, J.; Wei, J.; Li, P.; Chang, C.-H.; Shultz, L.D.; Ren, G.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.

Nature immunology
2020-09-21 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.

Nature communications
2020-09-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 3)‎

Mesenchymal stem cells: From regeneration to cancer.

Pharmacology & therapeutics
2019-04-16 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Cre Driver Mice Targeting Macrophages.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Genetic Models of Macrophage Depletion.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy.

Cancer cell
2017-12-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization

Scientific Reports
2015 | Journal article
EID:

2-s2.0-84940655924

Part of ISSN: 20452322
Contributors: Yang, M.; Liu, Y.; Ren, G.; Shao, Q.; Gao, W.; Sun, J.; Wang, H.; Ji, C.; Li, X.; Zhang, Y. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Bone metastasis and the metastatic niche.

Journal of molecular medicine (Berlin, Germany)
2015-08-15 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells

Stem Cells
2014 | Journal article
EID:

2-s2.0-84894562060

Part of ISSN: 10665099 15494918
Contributors: Chen, Q.; Shou, P.; Zhang, L.; Xu, C.; Zheng, C.; Han, Y.; Li, W.; Huang, Y.; Zhang, X.; Shao, C. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment

Cancer Research
2014 | Journal article
EID:

2-s2.0-84896503768

Part of ISSN: 15387445 00085472
Contributors: Ling, W.; Zhang, J.; Yuan, Z.; Ren, G.; Zhang, L.; Chen, X.; Rabson, A.B.; Roberts, A.I.; Wang, Y.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

P53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation

Oncogene
2014 | Journal article
EID:

2-s2.0-84904630964

Part of ISSN: 14765594 09509232
Contributors: Huang, Y.; Yu, P.; Li, W.; Ren, G.; Roberts, A.I.; Cao, W.; Zhang, X.; Su, J.; Chen, X.; Chen, Q. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species

Cell Death and Differentiation
2014 | Journal article
EID:

2-s2.0-84893824227

Part of ISSN: 13509047 14765403
Contributors: Su, J.; Chen, X.; Huang, Y.; Li, W.; Li, J.; Cao, K.; Cao, G.; Zhang, L.; Li, F.; Roberts, A.I. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.

Cancer cell
2014-09-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

A novel subset of helper T cells promotes immune responses by secreting GM-CSF

Cell Death and Differentiation
2013 | Journal article
EID:

2-s2.0-84887623036

Part of ISSN: 13509047 14765403
Contributors: Zhang, J.; Roberts, A.I.; Liu, C.; Ren, G.; Xu, G.; Zhang, L.; Devadas, S.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

MiR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding protein 2

Journal of Biological Chemistry
2013 | Journal article
EID:

2-s2.0-84876584007

Part of ISSN: 00219258 1083351X
Contributors: Xu, C.; Ren, G.; Cao, G.; Chen, Q.; Shou, P.; Zheng, C.; Du, L.; Han, X.; Jiang, M.; Yang, Q. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties.

Oncogene
2013-09-30 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

A one-two punch of miR-126/126* against metastasis.

Nature cell biology
2013-03-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

A two-hit model of autoimmunity: Lymphopenia and unresponsiveness to TGF-β signaling

Cellular and Molecular Immunology
2012 | Journal article
EID:

2-s2.0-84866079997

Part of ISSN: 16727681
Contributors: L'Huillier, A.; Ren, G.; Shi, Y.; Zhang, J.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Concise review: Mesenchymal stem cells and translational medicine: Emerging issues

Stem Cells Translational Medicine
2012 | Journal article
EID:

2-s2.0-84872026216

Part of ISSN: 21576580 21576564
Contributors: Ren, G.; Chen, X.; Dong, F.; Li, W.; Ren, X.; Zhang, Y.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Mesenchymal stem cells: A double-edged sword in regulating immune responses

Cell Death and Differentiation
2012 | Journal article
EID:

2-s2.0-84865184497

Part of ISSN: 13509047 14765403
Contributors: Li, W.; Ren, G.; Huang, Y.; Su, J.; Han, Y.; Li, J.; Chen, X.; Cao, K.; Chen, Q.; Shou, P. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Regulation of Th1/Th2 polarization by tissue inhibitor of metalloproteinase-3 via modulating dendritic cells

Blood
2012 | Journal article
EID:

2-s2.0-84861204062

Part of ISSN: 15280020 00064971
Contributors: Shao, Q.; Ning, H.; Lv, J.; Liu, Y.; Zhao, X.; Ren, G.; Feng, A.; Xie, Q.; Sun, J.; Song, B. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα.

Cell stem cell
2012-11-15 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

How mesenchymal stem cells interact with tissue immune responses.

Trends in immunology
2012-01-07 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Stem cells deployed for bone repair hijacked by T cells.

Cell stem cell
2012-01-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Adhesion molecules: Key players in mesenchymal stem cell-mediated immunosuppression

Cell Adhesion and Migration
2011 | Journal article
EID:

2-s2.0-78650820946

Part of ISSN: 19336926 19336918
Contributors: Ren, G.; Roberts, A.I.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid

Stem Cell Research and Therapy
2011 | Journal article
EID:

2-s2.0-79961239386

Part of ISSN: 17576512
Contributors: Krause, C.D.; Izotova, L.S.; Ren, G.; Yuan, Z.-R.; Shi, Y.; Chen, C.-C.; Ron, Y.; Pestka, S.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Mouse mandible contains distinctive mesenchymal stem cells

Journal of Dental Research
2011 | Journal article
EID:

2-s2.0-79952063283

Part of ISSN: 00220345 15440591
Contributors: Yamaza, T.; Ren, G.; Akiyama, K.; Chen, C.; Shi, Y.; Shi, S.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

The putative cannabinoid receptor GPR55 promotes cancer cell proliferation

Oncogene
2011 | Journal article
EID:

2-s2.0-78651381618

Part of ISSN: 09509232 14765594
Contributors: Hu, G.; Ren, G.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Mesenchymal stem cells: A new strategy for immunosuppression and tissue repair

Cell Research
2010 | Journal article
EID:

2-s2.0-77952094325

Part of ISSN: 10010602 17487838
Contributors: Shi, Y.; Hu, G.; Su, J.; Li, W.; Chen, Q.; Shou, P.; Xu, C.; Chen, X.; Huang, Y.; Zhu, Z. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression.

Journal of immunology (Baltimore, Md. : 1950)
2010-02-03 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) Cells.

Stem cells (Dayton, Ohio)
2010-01-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation (The Journal of Experimental Medicine (2009), 206, 11, (2407-2416))

Journal of Experimental Medicine
2009 | Journal article
EID:

2-s2.0-76149138214

Part of ISSN: 00221007 15409538
Contributors: Das, J.; Ren, G.; Zhang, L.; Roberts, A.I.; Zhao, X.; Bothwell, A.L.M.; Van Kaer, L.; Shi, Y.; Das, G.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.

The Journal of experimental medicine
2009-09-28 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression.

Stem cells (Dayton, Ohio)
2009-08-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNγ and TNF by producing nitric oxide

Biochemical and Biophysical Research Communications
2008 | Journal article
EID:

2-s2.0-51449096654

Part of ISSN: 0006291X 10902104
Contributors: Xu, G.; Zhang, Y.; Zhang, L.; Ren, G.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide.

Journal of immunology (Baltimore, Md. : 1950)
2008-09-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.

Cell stem cell
2008-02-01 | Journal article
Source: Self-asserted source
Guangwen Ren
grade
Preferred source (of 2)‎

Immunosuppressive properties of cloned bone marrow mesenchymal stem cells

Cell Research
2007 | Journal article
EID:

2-s2.0-33947309773

Part of ISSN: 10010602 17487838
Contributors: Xu, G.; Zhang, L.; Ren, G.; Yuan, Z.; Zhang, Y.; Zhao, R.C.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells

Biochemical and Biophysical Research Communications
2007 | Journal article
EID:

2-s2.0-34547791338

Part of ISSN: 0006291X 10902104
Contributors: Xu, G.; Zhang, Y.; Zhang, L.; Ren, G.; Shi, Y.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: What we do and don't know

Cell Research
2006 | Conference paper
EID:

2-s2.0-32644479365

Part of ISSN: 10010602 17487838
Contributors: Shi, Y.; Liu, C.H.; Roberts, A.I.; Das, J.; Xu, G.; Ren, G.; Zhang, Y.; Zhang, L.; Zeng, R.Y.; Tan, H.S.W. et al.
Source: Self-asserted source
Guangwen Ren via Scopus - Elsevier