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Employment (1)

Osaka Medical and Pharamaceutical University: Takatsuki, Osaka, JP

2014-04-01 to present | Assistant Professor (Biochemistry)
Employment
Source: Self-asserted source
Kenji Fukui

Education and qualifications (1)

Osaka University: Toyonaka, Osaka, JP

1998-04-01 to 2006-03-31 | PhD (Biology)
Education
Source: Self-asserted source
Kenji Fukui

Works (48)

ATP binding controls the molecular function of bacterial MutS2 by mediating closure of the dimeric clamp structure

Structure
2025-03 | Journal article
DOI: 10.1016/j.str.2025.03.003
Contributors: Kenji Fukui; Takeshi Murakawa; Nobumasa Hino; Naoyuki Kondo; Takato Yano
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Crossref

The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions

DNA Repair
2025-01 | Journal article
DOI: 10.1016/j.dnarep.2024.103804
Contributors: Satoshi Yoshioka; Hirochika Kurazono; Koki Ohshita; Kenji Fukui; Masaharu Takemura; Shin-Ichiro Kato; Kouhei Ohnishi; Takato Yano; Taisuke Wakamatsu
Source: check_circle
Crossref

Nerve Enlargement in Patients with INF2 Variants Causing Peripheral Neuropathy and Focal Segmental Glomerulosclerosis

Biomedicines
2025-01-08 | Journal article
DOI: 10.3390/biomedicines13010127
Contributors: Quynh Tran Thuy Huong; Linh Tran Nguyen Truc; Hiroko Ueda; Kenji Fukui; Koichiro Higasa; Yoshinori Sato; Shinichi Takeda; Motoshi Hattori; Hiroyasu Tsukaguchi
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Crossref
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Preferred source (of 2)‎

dUTP pyrophosphatases from hyperthermophilic eubacterium and archaeon: Structural and functional examinations on the suitability for PCR application

Protein Science
2024-11 | Journal article
DOI: 10.1002/pro.5185
Contributors: Kenji Fukui; Naoyuki Kondo; Takeshi Murakawa; Seiki Baba; Takashi Kumasaka; Takato Yano
Source: check_circle
Crossref

Identification of a Catalytic Lysine Residue Conserved Among GHKL ATPases: MutL, GyrB, and MORC

Journal of Molecular Biology
2024-05 | Journal article
DOI: 10.1016/j.jmb.2024.168575
Contributors: Kenji Fukui; Yuki Fujii; Takato Yano
Source: check_circle
Crossref

An extensive ion-pair/hydrogen-bond network contributes to the thermostability of the MutL ATPase domain from Aquifex aeolicus

FEMS Microbiology Letters
2024-01-09 | Journal article
DOI: 10.1093/femsle/fnae020
Contributors: Ayaka Shibuya; Maki Yokote; Atsushi Suzuki; Kenji Fukui; Takato Yano
Source: check_circle
Crossref

Catalytic mechanism of the zinc-dependent MutL endonuclease reaction

Life Science Alliance
2023-10 | Journal article
DOI: 10.26508/lsa.202302001
Contributors: Kenji Fukui; Tatsuya Yamamoto; Takeshi Murakawa; Seiki Baba; Takashi Kumasaka; Takato Yano
Source: check_circle
Crossref

Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8

Journal of Structural Biology
2022-12 | Journal article
DOI: 10.1016/j.jsb.2022.107904
Contributors: Maya Nakatani; Shun-ya Nakahara; Kenji Fukui; Momoka Urano; Yuki Fujii; Takeshi Murakawa; Seiki Baba; Takashi Kumasaka; Hiroki Okanishi; Yoshikatsu Kanai et al.
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Crossref

Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction

Structure
2022-07 | Journal article
DOI: 10.1016/j.str.2022.03.014
Contributors: Kenji Fukui; Masao Inoue; Takeshi Murakawa; Seiki Baba; Takashi Kumasaka; Takato Yano
Source: check_circle
Crossref

Identification of general acid catalyst for the ATPase activity of Lynch syndrome-related MutL homologs

2021-07-10 | Other
DOI: 10.1101/2021.07.09.451751
Contributors: Kenji Fukui; Yuki Fujii; Takato Yano
Source: check_circle
Crossref

Catalytic properties and crystal structure of UDP-galactose 4-epimerase-like l-threonine 3-dehydrogenase from Phytophthora infestans.

Enzyme and microbial technology
2020-06-24 | Journal article
DOI: 10.1016/j.enzmictec.2020.109627
PMID: 32912687
Source: Self-asserted source
Kenji Fukui

A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL.

The Journal of biological chemistry
2020-06-22 | Journal article
DOI: 10.1074/jbc.ra120.013576
PMID: 32571878
Source: Self-asserted source
Kenji Fukui

Biochemical characterization of mismatch-binding protein MutS1 and nicking endonuclease MutL from a euryarchaeon Methanosaeta thermophila.

DNA repair
2019-01-25 | Journal article
DOI: 10.1016/j.dnarep.2019.01.005
PMID: 30711824
Source: Self-asserted source
Kenji Fukui

The GIY-YIG endonuclease domain of Arabidopsis MutS homolog 1 specifically binds to branched DNA structures.

FEBS letters
2018-11-08 | Journal article
DOI: 10.1002/1873-3468.13279
PMID: 30372520
Source: Self-asserted source
Kenji Fukui

Resistance to UV Irradiation Caused by Inactivation of nurA and herA Genes in Thermus thermophilus.

Journal of bacteriology
2018-07-25 | Journal article
DOI: 10.1128/jb.00201-18
PMID: 29844033
PMC: PMC6060359
Source: Self-asserted source
Kenji Fukui

Multiple zinc ions maintain the open conformation of the catalytic site in the DNA mismatch repair endonuclease MutL from Aquifex aeolicus.

FEBS letters
2018-04-22 | Journal article
DOI: 10.1002/1873-3468.13050
PMID: 29645090
Source: Self-asserted source
Kenji Fukui

A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP<sub>1-1</sub>).

Chemical communications (Cambridge, England)
2017-10-01 | Journal article
DOI: 10.1039/c7cc05829b
PMID: 28848941
Source: Self-asserted source
Kenji Fukui

Archaeal MutS5 tightly binds to Holliday junction similarly to eukaryotic MutSγ.

The FEBS journal
2017-09-04 | Journal article
DOI: 10.1111/febs.14204
PMID: 28834211
Source: Self-asserted source
Kenji Fukui

Indispensable residue for uridine binding in the uridine-cytidine kinase family.

Biochemistry and biophysics reports
2017-07-08 | Journal article
DOI: 10.1016/j.bbrep.2017.07.002
PMID: 28955773
PMC: PMC5614712
Source: Self-asserted source
Kenji Fukui

Crystal structure and DNA-binding property of the ATPase domain of bacterial mismatch repair endonuclease MutL from Aquifex aeolicus.

Biochimica et biophysica acta. Proteins and proteomics
2017-06-29 | Journal article
DOI: 10.1016/j.bbapap.2017.06.024
PMID: 28668638
Source: Self-asserted source
Kenji Fukui

High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway.

Scientific reports
2017-06-22 | Journal article
DOI: 10.1038/s41598-017-03567-2
PMID: 28642545
PMC: PMC5481443
Source: Self-asserted source
Kenji Fukui

The Lon protease-like domain in the bacterial RecA paralog RadA is required for DNA binding and repair.

The Journal of biological chemistry
2017-04-21 | Journal article
DOI: 10.1074/jbc.m116.770180
PMID: 28432121
PMC: PMC5465501
Source: Self-asserted source
Kenji Fukui

Structural Insights into l-Tryptophan Dehydrogenase from a Photoautotrophic Cyanobacterium, Nostoc punctiforme.

Applied and environmental microbiology
2016-12-30 | Journal article
DOI: 10.1128/aem.02710-16
PMID: 27815281
PMC: PMC5203629
Source: Self-asserted source
Kenji Fukui

Proteome-wide identification of lysine succinylation in thermophilic and mesophilic bacteria.

Biochimica et biophysica acta. Proteins and proteomics
2016-11-23 | Journal article
DOI: 10.1016/j.bbapap.2016.11.009
PMID: 27888076
Source: Self-asserted source
Kenji Fukui

Structural Features and Functional Dependency on β-Clamp Define Distinct Subfamilies of Bacterial Mismatch Repair Endonuclease MutL.

The Journal of biological chemistry
2016-07-01 | Journal article
DOI: 10.1074/jbc.m116.739664
PMID: 27369079
PMC: PMC5016104
Source: Self-asserted source
Kenji Fukui

Roles of Mn-catalase and a possible heme peroxidase homologue in protection from oxidative stress in Thermus thermophilus.

Extremophiles : life under extreme conditions
2015-05-22 | Journal article
DOI: 10.1007/s00792-015-0753-2
PMID: 25997395
Source: Self-asserted source
Kenji Fukui

[Regulatory mechanism for DNA mismatch repair endonuclease].

Seikagaku. The Journal of Japanese Biochemical Society
2015-04-01 | Journal article
PMID: 26571579
Source: Self-asserted source
Kenji Fukui

Small-angle X-ray scattering analysis reveals the ATP-bound monomeric state of the ATPase domain from the homodimeric MutL endonuclease, a GHKL phosphotransferase superfamily protein.

Extremophiles : life under extreme conditions
2015-03-26 | Journal article
DOI: 10.1007/s00792-015-0745-2
PMID: 25809295
Source: Self-asserted source
Kenji Fukui

NMR characterization of the interaction of the endonuclease domain of MutL with divalent metal ions and ATP.

PloS one
2014-06-05 | Journal article
DOI: 10.1371/journal.pone.0098554
PMID: 24901533
PMC: PMC4047009
Source: Self-asserted source
Kenji Fukui

The role of ribonucleases in regulating global mRNA levels in the model organism Thermus thermophilus HB8.

BMC genomics
2014-05-19 | Journal article
DOI: 10.1186/1471-2164-15-386
PMID: 24884843
PMC: PMC4229858
Source: Self-asserted source
Kenji Fukui

MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner.

The FEBS journal
2013-06-18 | Journal article
DOI: 10.1111/febs.12344
PMID: 23679952
Source: Self-asserted source
Kenji Fukui

Thermostable Mismatch-Recognizing Protein MutS Suppresses Nonspecific Amplification during Polymerase Chain Reaction (PCR).

International journal of molecular sciences
2013-03-21 | Journal article
DOI: 10.3390/ijms14036436
PMID: 23519109
PMC: PMC3634412
Source: Self-asserted source
Kenji Fukui

In vivo, in vitro, and x-ray crystallographic analyses suggest the involvement of an uncharacterized triose-phosphate isomerase (TIM) barrel protein in protection against oxidative stress.

The Journal of biological chemistry
2011-10-07 | Journal article
DOI: 10.1074/jbc.m111.293886
PMID: 21984829
PMC: PMC3308873
Source: Self-asserted source
Kenji Fukui

Characterization of C- and N-terminal domains of Aquifex aeolicus MutL endonuclease: N-terminal domain stimulates the endonuclease activity of C-terminal domain in a zinc-dependent manner.

Bioscience reports
2011-10-01 | Journal article
DOI: 10.1042/bsr20100116
PMID: 20961292
Source: Self-asserted source
Kenji Fukui

Evidence for ATP-dependent structural rearrangement of nuclease catalytic site in DNA mismatch repair endonuclease MutL.

The Journal of biological chemistry
2011-09-26 | Journal article
DOI: 10.1074/jbc.m111.277335
PMID: 21953455
PMC: PMC3234979
Source: Self-asserted source
Kenji Fukui

Structure and Function of the Small MutS-Related Domain.

Molecular biology international
2011-07-19 | Journal article
DOI: 10.4061/2011/691735
PMID: 22091410
PMC: PMC3200294
Source: Self-asserted source
Kenji Fukui

Crystal structure of the tandem-type universal stress protein TTHA0350 from Thermus thermophilus HB8.

Journal of biochemistry
2011-05-18 | Journal article
DOI: 10.1093/jb/mvr057
PMID: 21593057
Source: Self-asserted source
Kenji Fukui

An alkyltransferase-like protein from Thermus thermophilus HB8 affects the regulation of gene expression in alkylation response.

Journal of biochemistry
2011-04-29 | Journal article
DOI: 10.1093/jb/mvr052
PMID: 21531768
Source: Self-asserted source
Kenji Fukui

Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.

PloS one
2011-04-28 | Journal article
DOI: 10.1371/journal.pone.0019053
PMID: 21552516
PMC: PMC3084264
Source: Self-asserted source
Kenji Fukui

Molecular mechanisms of the whole DNA repair system: a comparison of bacterial and eukaryotic systems.

Journal of nucleic acids
2010-10-14 | Journal article
DOI: 10.4061/2010/179594
PMID: 20981145
PMC: PMC2957137
Source: Self-asserted source
Kenji Fukui

DNA mismatch repair in eukaryotes and bacteria.

Journal of nucleic acids
2010-07-27 | Journal article
DOI: 10.4061/2010/260512
PMID: 20725617
PMC: PMC2915661
Source: Self-asserted source
Kenji Fukui

A novel single-stranded DNA-specific 3'-5' exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways.

Nucleic acids research
2010-05-10 | Journal article
DOI: 10.1093/nar/gkq350
PMID: 20457749
PMC: PMC2943613
Source: Self-asserted source
Kenji Fukui

Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression.

The Journal of biological chemistry
2008-10-06 | Journal article
DOI: 10.1074/jbc.m806755200
PMID: 18838375
PMC: PMC2662267
Source: Self-asserted source
Kenji Fukui

Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL.

The Journal of biological chemistry
2008-02-29 | Journal article
DOI: 10.1074/jbc.m800110200
PMID: 18310077
Source: Self-asserted source
Kenji Fukui

Analysis of a nuclease activity of catalytic domain of Thermus thermophilus MutS2 by high-accuracy mass spectrometry.

Nucleic acids research
2007-08-07 | Journal article
DOI: 10.1093/nar/gkm575
PMID: 17686785
PMC: PMC1976465
Source: Self-asserted source
Kenji Fukui

Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology.

Nature methods
2007-02-18 | Journal article
DOI: 10.1038/nmeth1007
PMID: 17322893
Source: Self-asserted source
Kenji Fukui

Nuclease activity of the MutS homologue MutS2 from Thermus thermophilus is confined to the Smr domain.

Nucleic acids research
2007-01-10 | Journal article
DOI: 10.1093/nar/gkl735
PMID: 17215294
PMC: PMC1807967
Source: Self-asserted source
Kenji Fukui

Thermus thermophilus MutS2, a MutS paralogue, possesses an endonuclease activity promoted by MutL.

Journal of biochemistry
2004-03-01 | Journal article
DOI: 10.1093/jb/mvh045
PMID: 15113836
Source: Self-asserted source
Kenji Fukui
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