Personal information

Websites & social links

Københavns Universitet profile page

Activities

Collapse all

Employment (1)

Københavns Universitet: København K, DK

Employment
Source: check_circle
University of Copenhagen

Works (40)

Protein fibrillation from another small angle—SAXS data analysis of developing systems

Small Angle Scattering Part B: Methods for Structural Interpretation
2023 | Book chapter
DOI: 10.1016/bs.mie.2022.09.025
Part of ISBN: 9780323991810
Part of ISSN: 0076-6879
Contributors: Annette Eva Langkilde; Bente Vestergaard
Source: Self-asserted source
Annette Eva Langkilde

Monomeric α‐synuclein activates the plasma membrane calcium pump

The EMBO Journal
2023-11-02 | Journal article | Author
DOI: 10.15252/embj.2022111122
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Contributors: Antoni Kowalski; Cristine Betzer; Sigrid Larsen; Emil Gregersen; Estella Newcombe; Montaña Caballero-Bermejo; Viktor Wisniewski Bendtsen; Jorin Diemer; Christina V Ernstsen; Shweta Jain et al.
Source: Self-asserted source
Annette Eva Langkilde

Targeting NOX2 with Bivalent Small-Molecule p47phox–p22phox Inhibitors

Journal of Medicinal Chemistry
2023-10-19 | Journal article | Author
DOI: 10.1021/acs.jmedchem.3c01548
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Jie Zang; Felix Peters; Yves Cambet; Eugenia Cifuentes-Pagano; Munira Mohamed Shishay Hissabu; Christopher M. Dustin; Lars Henrik Svensson; Martin Mariboe Olesen; Mathias Feldt Lomholt Poulsen; Stig Jacobsen et al.
Source: Self-asserted source
Annette Eva Langkilde

Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons

Cell & Bioscience
2023-09-14 | Journal article
DOI: 10.1186/s13578-023-01105-4
Part of ISSN: 2045-3701
Contributors: Altair Brito Dos Santos; Siganya Thaneshwaran; Lara Kamal Ali; César Ramón Romero Leguizamón; Yang Wang; Morten Pilgaard Kristensen; Annette E. Langkilde; Kristi A. Kohlmeier
Source: Self-asserted source
Annette Eva Langkilde

Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

The Biophysicist
2023-03-23 | Journal article | Author
DOI: 10.35459/tbp.2022.000221
Part of ISSN: 2578-6970
Contributors: Karen Skriver; Signe A. Sjørup; Annette Eva Langkilde; Evanthia Balouka; Caspar S. Christensen; Kathrine Carbel; Jens N. V. Decker; David N. Essenbæk; Justus F. Gräf; Camilla H. Jessen et al.
Source: Self-asserted source
Annette Eva Langkilde

Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils.

Methods in molecular biology (Clifton, N.J.)
2023-01-01 | Journal article
DOI: 10.1007/978-1-0716-2597-2_22
PMID: 36310213
Contributors: Skamris T; Vestergaard B; Madsen KL; Annette Eva Langkilde; Foderà V
Source: Self-asserted source
Annette Eva Langkilde

Protein fibrillation from another small angle: Sample preparation and SAXS data collection

Methods in Enzymology
2022 | Book chapter
DOI: 10.1016/bs.mie.2022.08.041
Part of ISSN: 0076-6879
Contributors: Bente Vestergaard; Annette Eva Langkilde
Source: Self-asserted source
Annette Eva Langkilde

Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

Cellular and Molecular Life Sciences
2022-08 | Journal article
DOI: 10.1007/s00018-022-04467-z
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Contributors: Altair B. Dos Santos; Line K. Skaanning; Siganya Thaneshwaran; Eyd Mikkelsen; Cesar R. Romero-Leguizamón; Thomas Skamris; Morten P. Kristensen; Annette Eva Langkilde; Kristi A. Kohlmeier
Source: Self-asserted source
Annette Eva Langkilde

Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases.

Journal of translational medicine
2022-05-13 | Journal article
DOI: 10.1186/s12967-022-03420-9
PMID: 35562704
Source: Self-asserted source
Annette Eva Langkilde

The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme

Acta Crystallographica Section D Structural Biology
2021-12-01 | Journal article
DOI: 10.1107/s2059798321010950
Part of ISSN: 2059-7983
Source: Self-asserted source
Annette Eva Langkilde

Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

Biomolecules
2021-08 | Journal article | Author
DOI: 10.3390/biom11081173
Contributors: Estella Newcombe; Catarina B. Fernandes; Jeppe E. Lundsgaard; Inna Brakti; Kresten Lindorff-Larsen; Annette Eva Langkilde; Karen Skriver; Birthe Kragelund
Source: check_circle
Multidisciplinary Digital Publishing Institute

α-Synuclein Responses in the Laterodorsal Tegmentum, the Pedunculopontine Tegmentum, and the Substantia Nigra: Implications for Early Appearance of Sleep Disorders in Parkinson's Disease.

Journal of Parkinson's disease
2021-06-14 | Journal article
DOI: 10.3233/jpd-212554
PMID: 34151857
Source: Self-asserted source
Annette Eva Langkilde

Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods.

Frontiers in molecular biosciences
2021-04-22 | Journal article
DOI: 10.3389/fmolb.2021.654333
PMID: 33968988
PMC: PMC8100456
Source: Self-asserted source
Annette Eva Langkilde

Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets.

Structure (London, England : 1993)
2021-04-10 | Journal article
DOI: 10.1016/j.str.2021.03.017
PMID: 33862013
Source: Self-asserted source
Annette Eva Langkilde

Structural insights into protein folding, stability and activity using <i>in vivo</i> perdeuteration of hen egg-white lysozyme.

IUCrJ
2021-03-06 | Journal article
DOI: 10.1107/s2052252521001299
PMID: 33953924
Source: Self-asserted source
Annette Eva Langkilde

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

Biomolecules
2020-08 | Journal article | Author
DOI: 10.3390/biom10081192
Contributors: Line Koch Skaanning; Angelo Santoro; Thomas Skamris; Jacob Hertz Martinsen; Anna Maria D’Ursi; Saskia Bucciarelli; Bente Vestergaard; Katrine Bugge; Annette Eva Langkilde; Birthe Kragelund
Source: check_circle
Multidisciplinary Digital Publishing Institute

Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2020-04-11 | Journal article
DOI: 10.1096/fj.202000107r
PMID: 32277854
Source: Self-asserted source
Annette Eva Langkilde

The structural basis of fungal glucuronoyl esterase activity on natural substrates.

Nature communications
2020-02-24 | Journal article
DOI: 10.1038/s41467-020-14833-9
PMID: 32094331
Source: Self-asserted source
Annette Eva Langkilde

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.

Journal of medicinal chemistry
2020-01-23 | Journal article
DOI: 10.1021/acs.jmedchem.9b01492
PMID: 31922756
Source: Self-asserted source
Annette Eva Langkilde

Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.

Journal of immunology (Baltimore, Md. : 1950)
2020-01-22 | Journal article
DOI: 10.4049/jimmunol.1900494
PMID: 31969389
Source: Self-asserted source
Annette Eva Langkilde

Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

Biochemistry
2019-12-03 | Journal article
DOI: 10.1021/acs.biochem.9b00925
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Annette Eva Langkilde

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene.

Nature communications
2018-05 | Journal article
DOI: 10.1038/s41467-018-04116-9
PMID: 29743480
PMC: PMC5943278
Contributors: Seuring C; Ayyer K; Filippaki E; Barthelmess M; Longchamp JN; Ringler P; Pardini T; Wojtas DH; Coleman MA; Dörner K et al.
Source: Self-asserted source
Annette Eva Langkilde via Europe PubMed Central

Noninvasive Structural Analysis of Intermediate Species During Fibrillation: An Application of Small-Angle X-Ray Scattering.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7816-8_14
PMID: 29886536
Source: Self-asserted source
Annette Eva Langkilde

Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization

Pharmaceutical Research
2016-03 | Journal article | Author
DOI: 10.1007/s11095-015-1821-0
SOURCE-WORK-ID:

f444ae8a-08c2-4688-860a-9f4cebb69514

PMID: 26563206
EID:

2-s2.0-84957579771
Contributors: Thomas Skamris; Xinsheng Tian; Matthias Thorolfsson; Hanne Sophie Karkov; Hanne B Rasmussen; Annette Eva Langkilde; Bente Vestergaard
Source: check_circle
University of Copenhagen

Formation of covalent di-tyrosine dimers in recombinant α-synuclein.

Intrinsically disordered proteins
2015 | Journal article
DOI: 10.1080/21690707.2015.1071302
PMID: 28232892
PMC: PMC5314896
Contributors: van Maarschalkerweerd A; Pedersen MN; Peterson H; Nilsson M; Nguyen T; Skamris T; Rand K; Vetri V; Langkilde AE; Vestergaard B
Source: Self-asserted source
Annette Eva Langkilde via Europe PubMed Central

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

Acta Crystallographica. Section D: Biological Crystallography
2015-04 | Journal article | Author
DOI: 10.1107/S1399004715001674
SOURCE-WORK-ID:

ca68a610-11c6-4e8b-926f-5b734ef40fcb

PMID: 25849399
EID:

2-s2.0-84927653764
Contributors: Annette Eva Langkilde; Kyle L Morris; Louise C Serpell; Dmitri I Svergun; Bente Vestergaard
Source: check_circle
University of Copenhagen

In-depth analysis of subclass-specific conformational preferences of IgG antibodies

IUCrJ
2015-01-01 | Journal article | Author
DOI: 10.1107/S205225251402209X
SOURCE-WORK-ID:

68d7f3cd-3382-4b85-8ad9-bf2be865410a

EID:

2-s2.0-84940928369

PMID: 25610623
Contributors: Xinsheng Tian; Bente Vestergaard; Matthias Thorolfsson; Zhiru Yang; Hanne B. Rasmussen; Annette Eva Langkilde
Source: check_circle
University of Copenhagen

Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers

Biomacromolecules
2014-10-13 | Journal article | Author
DOI: 10.1021/bm500937p
SOURCE-WORK-ID:

9357a677-9eff-4201-bf08-d62c43d595f4

PMID: 25210839
EID:

2-s2.0-84907970156
Contributors: Andreas van Maarschalkerweerd; Valeria Vetri; Annette Eva Langkilde; Vito Foderà; Bente Vestergaard
Source: check_circle
University of Copenhagen

Small-Angle X-ray Scattering Screening Complements Conventional Biophysical Analysis

Journal of Pharmaceutical Sciences
2014-06 | Journal article | Author
DOI: 10.1002/jps.23964
SOURCE-WORK-ID:

87102355-9611-4900-a6ca-88e0845cb78c

PMID: 24700358
EID:

2-s2.0-84901276478
Contributors: Xinsheng Tian; Annette Eva Langkilde; Matthias Thorolfsson; Hanne B Rasmussen; Bente Vestergaard
Source: check_circle
University of Copenhagen

Wildtype and A30P mutant alpha-synuclein form different fibril structures

P L o S One
2013 | Journal article | Author
DOI: 10.1371/journal.pone.0067713
SOURCE-WORK-ID:

2b6d9c5e-608d-410d-a39b-95fd86d20b79

EID:

2-s2.0-84879804769
Contributors: Søren Bang Nielsen; Francesca Macchi; Samuele Raccosta ; Annette Eva Langkilde; Lise Giehm; Anders Højbo Kyrsting; Anna Sigrid P. Svane; Mauro Manno; Gunna Christiansen; Niels Christian Nielsen et al.
Source: check_circle
University of Copenhagen

Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria

Journal of Biological Chemistry
2012 | Journal article | Author
DOI: 10.1074/jbc.M112.348839
SOURCE-WORK-ID:

5a468feb-464b-408f-8258-c5601c078722

PMID: 22570492
EID:

2-s2.0-84863630102
Contributors: Thomas M Clausen; Stig Christoffersen; Madeleine Dahlbäck; Annette Eva Langkilde; Kamilla E Jensen; Mafalda Resende; Mette Ø Agerbæk; Daniel Andersen; Besim Berisha; Sisse B Ditlev et al.
Source: check_circle
University of Copenhagen

Structural characterization of prefibrillar intermediates and amyloid fibrils by small-angle X-ray scattering

2012 | Book chapter | Author
DOI: 10.1007/978-1-61779-551-0_10
SOURCE-WORK-ID:

26f06de7-5ed7-4299-8e96-dab320a9195f

EID:

2-s2.0-84864582163

PMID: 22528088
Part of ISBN: 978-1-61779-551-0
Part of ISBN: 978-1-61779-550-3
Contributors: Annette Eva Langkilde; Bente Vestergaard
Source: check_circle
University of Copenhagen

The first lesson in the classroom - getting students engaged in active learning process

2011 | Book chapter | Author
SOURCE-WORK-ID:

ae77a5b9-a623-4db5-9f16-f959dd0884fc
Contributors: Annette Eva Langkilde
Source: check_circle
University of Copenhagen

Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

F E B S Letters
2009 | Journal article | Author
DOI: 10.1016/j.febslet.2009.05.040
SOURCE-WORK-ID:

9e29e330-30ea-11df-8ed1-000ea68e967b

PMID: 19481541
EID:

2-s2.0-68549141378
Contributors: Annette Eva Langkilde; Bente Vestergaard
Source: check_circle
University of Copenhagen

Sparing the ortho-position in nucleophilic aromatic substitution-specific displacement of the 4-SePh group in 2,4-bis(phenylseleno)nitrobenzene

Heteroatom Chemistry
2009 | Journal article | Author
DOI: 10.1002/hc.20519
SOURCE-WORK-ID:

f5974790-9b2d-11df-928f-000ea68e967b

EID:

2-s2.0-65549119591
Contributors: Nicolai Stuhr-Hansen; Thorstein Finn Götze; Lars Henriksen; theis solling; Annette Eva Langkilde; Henning Osholm Sørensen
Source: check_circle
University of Copenhagen

High resolution X-ray diffraction of macromolecular crystals

2008 | Dissertation or Thesis | Author
SOURCE-WORK-ID:

4abea470-dd6b-11dd-b5fc-000ea68e967b
Contributors: Annette Eva Langkilde
Source: check_circle
University of Copenhagen

Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

Acta Crystallographica. Section D: Biological Crystallography
2008 | Journal article | Author
DOI: 10.1107/S0907444908017083
SOURCE-WORK-ID:

4257ce80-648d-11dd-8d9f-000ea68e967b

EID:

2-s2.0-47749114186

PMID: 18645234
Contributors: Annette Eva Langkilde; Søren Martin Kristensen; Leila Lo Leggio; Anne Mølgaard; Jan H. Jensen; Andrew R. Houk; Jens-Christian Navarro Poulsen; Sine Ydun Larsen; S Kauppinen
Source: check_circle
University of Copenhagen

Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates

Dalton Transactions (Print Edition)
2005 | Journal article | Author
SOURCE-WORK-ID:

819964c0-74c3-11db-bee9-02004c4f4f50

EID:

2-s2.0-20044380335
Contributors: Rasmus Barfod; Jette Eriksen; Bernard T. Golding; Anders Hammershøi; Thomas Amos Jacobsen; Annette Eva Langkilde; Sine Larsen; O. Mønsted; Alan M. Sargeson; Henning Osholm Sørensen
Source: check_circle
University of Copenhagen

Structures of three salts of phthalic acid; variation in crystal packing and geometry of the hydrogen phthalate ion

Acta Crystallographica
2004 | Journal article | Author
SOURCE-WORK-ID:

2a00d030-74c4-11db-bee9-02004c4f4f50

EID:

2-s2.0-13844305717
Contributors: Annette Eva Langkilde; Dennis Madsen; Sine Larsen
Source: check_circle
University of Copenhagen

Diastereomeric salts of lactic acid and 1-phenylethylamine, their structures and relative stabilities

Acta Crystallographica. Section B: Structural Science
2002 | Journal article | Author
SOURCE-WORK-ID:

c3d07700-74c5-11db-bee9-02004c4f4f50

EID:

2-s2.0-0040673684
Contributors: Annette Eva Langkilde; Jette Oddershede; Sine Larsen
Source: check_circle
University of Copenhagen

Peer review (1 review for 1 publication/grant)

Review activity for Molecular pharmaceutics. (1)
How many people are using ORCID?