Personal information

Websites & social links

http://www.aston.ac.uk/lhs/staff/az-index/dr-alex-cheong/
Aston University profile page

Other IDs

Scopus Author ID: 7003847640
ResearcherID: E-5049-2011
Scopus Author ID: 7003847640
Researcher ID: E-5049-2011

Keywords

gene regulation, hypoxia, mathematical model, systems biology

Activities

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Employment (1)

Aston University: Birmingham, GB

Employment
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Aston Research Explorer

Works (37)

A biphasic model of lifespan in nematode Caenorhabditis elegans worm

Royal Society Open Science
2023-02-01 | Journal article | Author
DOI: 10.1098/rsos.220991
SOURCE-WORK-ID:

d229f81f-a1a1-44bf-aaeb-d0354ea12fc4

EID:

2-s2.0-85147563415

PMID: 36756060
Contributors: Suhayl Mulla; Adele R. Ludlam; Aiman Elragig; Cathy Slack; Zita Balklava; Michael Stich; Alex Cheong
Source: check_circle
Aston Research Explorer

Acquisition of temporal HIF transcriptional activity using a secreted luciferase assay

Methods in Molecular Biology
2018-01-13 | Book chapter | Author
DOI: 10.1007/978-1-4939-7665-2_4
SOURCE-WORK-ID:

8fc1efa6-7d35-4f17-9231-e43d4d7719bc

EID:

2-s2.0-85040862374
Contributors: Miguel A.S. Cavadas; Cormac T. Taylor; Alex Cheong
Source: check_circle
Aston Research Explorer

Three-factor models versus time series models

Mathematical Medicine and Biology
2017-07 | Journal article | Author
DOI: 10.1093/imammb/dqw001
SOURCE-WORK-ID:

57ab7543-9b99-4a04-a6f8-4772125bd6f4

PMID: 27079221
EID:

2-s2.0-85033598174
Contributors: Till D. Frank; Anatoly Kiyatkin; Alex Cheong; Boris N. Kholodenko
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The regulation of transcriptional repression in hypoxia

Experimental Cell Research
2017-07-15 | Journal article | Author
DOI: 10.1016/j.yexcr.2017.02.024
SOURCE-WORK-ID:

c82bda06-5f97-4712-a2c0-2b2df49fa6c0

EID:

2-s2.0-85013391502
Contributors: Miguel A.S. Cavadas; Alex Cheong; Cormac T. Taylor
Source: check_circle
Aston Research Explorer

Hydroxylases regulate intestinal fibrosis through the suppression of ERK mediated TGF-β1 signaling

Gastrointestinal and Liver Physiology
2016-12-01 | Journal article | Author
DOI: 10.1152/ajpgi.00229.2016
SOURCE-WORK-ID:

ece0d232-889d-4b89-a360-9be87ed61179

EID:

2-s2.0-85006279493
Contributors: Mario Cabrero Manresa; Murtaza M. Tambuwala; Praveen Rhadakrishnan; Jonathan M. Harnoss; Eric Brown; Miguel A. Cavadas; Ciara E. Keogh; Alex Cheong; Kim E. Barrett; Eoin P. Cummins et al.
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Aston Research Explorer

REST is a hypoxia-responsive transcriptional repressor

Scientific Reports
2016-08-17 | Journal article | Author
DOI: 10.1038/srep31355
SOURCE-WORK-ID:

a1afadec-c18e-4a71-9606-dfe703bbf704

EID:

2-s2.0-84982113280
Contributors: Miguel A.S. Cavadas; Marion Mesnieres; Bianca Crifo; Mario C. Manresa; Andrew C. Selfridge; Ciara E. Keogh; Zsolt Fabian; Carsten C. Scholz; Karen A. Nolan; Liliane M.A. Rocha et al.
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Aston Research Explorer

Non-linear dynamics in transcriptional regulation

Nonlinear Dynamics in Biological Systems
2016-07-21 | Book chapter | Author
DOI: 10.1007/978-3-319-33054-9_3
SOURCE-WORK-ID:

3cd74404-cbe2-406f-b21f-a742e23332a0

EID:

2-s2.0-85046230600

Part of ISBN: 978-3-319-33054-9
Part of ISBN: 978-3-319-33053-2
Contributors: Till D. Frank; Miguel A.S. Cavadas; Lan K. Nguyen; Alex Cheong
Source: check_circle
Aston Research Explorer

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia

Scientific Reports
2015-12-09 | Journal article | Author
DOI: 10.1038/srep17851
SOURCE-WORK-ID:

55581eb1-2395-4a79-92a3-4d0259dc87c4

EID:

2-s2.0-84949562886
Contributors: Miguel A.S. Cavadas; Marion Mesnieres; Bianca Crifo; Mario C. Manresa; Andrew C. Selfridge; Carsten C. Scholz; Eoin P. Cummins; Alex Cheong; Cormac T. Taylor
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Aston Research Explorer

Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate

Cellular and Molecular Life Sciences
2015-02-20 | Journal article | Author
DOI: 10.1007/s00018-015-1850-1
SOURCE-WORK-ID:

9364d52f-bc73-4913-a15f-0a8f5eba2412

EID:

2-s2.0-84929706297
Contributors: Lan K. Nguyen; Miguel A.S. Cavadas; Boris N. Kholodenko; Till D. Frank; Alex Cheong
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Aston Research Explorer

Monitoring of transcriptional dynamics of HIF and NFκB activities

Bioluminescent imaging
2014 | Book chapter | Author
DOI: 10.1007/978-1-62703-718-1_8
SOURCE-WORK-ID:

8c30d626-5064-4579-bae9-0d3ab922d82c

PMID: 24166371
EID:

2-s2.0-84934444905

Part of ISBN: 978-1-62703-718-1
Part of ISBN: 978-1-62703-717-4
Contributors: Miguel A.S. Cavadas; Alex Cheong
Source: check_circle
Aston Research Explorer

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

Journal of the Royal Society, Interface / the Royal Society
2014 | Journal article
DOI: 10.1098/rsif.2014.0383
Part of ISSN: 1742-5662
Contributors: Dobrzynski, Maciej; Nguyen, Lan K; Birtwistle, Marc R; von Kriegsheim, Alexander; Blanco Fernandez, Alfonso; Cheong, Alex; Kolch, Walter; Kholodenko, Boris N
Source: Self-asserted source
Alex Cheong via ResearcherID
grade
Preferred source (of 2)‎

Hypoxia-inducible factor (HIF) network

Cell Communication and Signaling
2013 | Journal article | Author
DOI: 10.1186/1478-811X-11-42
SOURCE-WORK-ID:

690e3f08-c5c8-4be5-9195-bdeed09e074c

PMID: 23758895
EID:

2-s2.0-84878706261
Contributors: Miguel A.S. Cavadas; Lan K. Nguyen; Alex Cheong
Source: check_circle
Aston Research Explorer

Regulation of IL-1β-induced NFκB by hydroxylases links key hypoxic and inflammatory signaling pathways

Proceedings of the National Academy of Sciences
2013-11-12 | Journal article | Author
DOI: 10.1073/pnas.1309718110
SOURCE-WORK-ID:

34821f7e-b215-4a3e-a496-6a6590ab12a8

PMID: 24145445
EID:

2-s2.0-84887501809
Contributors: Carsten C. Scholz; Miguel A.S. Cavadas; Murtaza M. Tambuwala; Emily Hams; Javier Rodríguez; Alexander von Kriegsheim; Philip Cotter; Ulrike Bruning; Padraic G. Fallon; Alex Cheong et al.
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Aston Research Explorer

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

Journal of Cell Science
2013-03-15 | Journal article | Author
DOI: 10.1242/jcs.119974
DOI: 10.1242/jcs.167304
SOURCE-WORK-ID:

5fa11e7d-1c4f-4a07-ac31-61de3f60c6d6

PMID: 23390316
EID:

2-s2.0-84877917354
Contributors: Lan K. Nguyen; Miguel A.S. Cavadas; Carsten C. Scholz; Susan F. Fitzpatrick; Ulrike Bruning; Eoin P. Cummins; Murtaza M. Tambuwala; Mario C. Manresa; Boris N. Kholodenko; Cormac T. Taylor et al.
Source: check_circle
Aston Research Explorer

Catching transcriptional regulation by thermostatistical modeling

Physical Biology
2012 | Journal article
DOI: 10.1088/1478-3975/9/4/045007
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 3)‎

Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO 2 sensing and signaling

Journal of Biological Chemistry
2012 | Journal article
DOI: 10.1074/jbc.M112.347971
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

MicroRNA-155 promotes resolution of hypoxia-inducible factor 1α activity during prolonged hypoxia

Molecular and Cellular Biology
2011 | Journal article
DOI: 10.1128/MCB.01276-10
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers

Cardiovascular Research
2011 | Journal article
DOI: 10.1093/cvr/cvq305
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Small Ubiquitin-related Modifier (SUMO)-1 promotes glycolysis in hypoxia

Journal of Biological Chemistry
2011 | Journal article
DOI: 10.1074/jbc.M110.115931
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Robotic multiwell planar patch-clamp for native and primary mammalian cells

Nature Protocols
2009 | Journal article
DOI: 10.1038/nprot.2008.230
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 3)‎

Local delivery of the K Ca3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis

Arteriosclerosis, Thrombosis, and Vascular Biology
2008 | Journal article
DOI: 10.1161/ATVBAHA.107.155796
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Quantitative RT-PCR methods for investigation of low copy potassium channel gene expression in native murine arteries

Methods in Molecular Biology
2008 | Journal article
DOI: 10.1007/978-1-59745-526-8-2
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier

Quantitative RT-PCR methods for investigation of low copy potassium channel gene expression in native murine arteries

Potassium Channels
2008 | Book chapter | Author
DOI: 10.1007/978-1-59745-526-8_2
SOURCE-WORK-ID:

dfc7e36a-8354-427a-9687-4cd8f3151cfd

EID:

2-s2.0-60349103090

PMID: 18998081
Part of ISBN: 978-1-59745-526-8
Part of ISBN: 9781934115657
Contributors: Alex Cheong; Samuel J. Fountain; David J. Beech
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Aston Research Explorer

Kv1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress

American Journal of Physiology - Heart and Circulatory Physiology
2007 | Journal article
DOI: 10.1152/ajpheart.00637.2007
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility

Circulation Research
2006 | Journal article
DOI: 10.1161/01.RES.0000225284.36490.a2
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Potassium channels at the beginnings of cell proliferation

Journal of Physiology
2006 | Journal article
DOI: 10.1113/jphysiol.2005.101873
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Upregulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia

Circulation Research
2006 | Journal article
DOI: 10.1161/01.RES.0000204724.29685.db
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation

Molecular Cell
2005 | Journal article
DOI: 10.1016/j.molcel.2005.08.030
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 3)‎

Regulation of arterial tone by KV1 potassium channels.

Circulation research
2005 | Journal article
EID: 2-s2.0-24944461226
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Functional up-regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle

Journal of Physiology
2004 | Journal article
DOI: 10.1113/jphysiol.2003.058594
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Activation thresholds of Kv, BK and CLca channels in smooth muscle cells in pial precapillary arterioles

Journal of Vascular Research
2002 | Journal article
DOI: 10.1159/000057761
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Discrete store-operated calcium influx into an intracellular compartment in rabbit arteriolar smooth muscle

Journal of Physiology
2002 | Journal article
DOI: 10.1113/jphysiol.2002.023366
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Expression and function of native potassium channel (Kvα1) subunits in terminal arterioles of rabbit

Journal of Physiology
2001 | Journal article
DOI: 10.1111/j.1469-7793.2001.00691.x
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Kvα1 channels in murine arterioles: Differential cellular expression and regulation of diameter

American Journal of Physiology - Heart and Circulatory Physiology
2001 | Journal article
EID: 2-s2.0-0034834911
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier
grade
Preferred source (of 2)‎

Block of human aorta Kir6.1 by the vascular K(ATP) channel inhibitor U37883A

British Journal of Pharmacology
1999 | Journal article
DOI: 10.1038/sj.bjp.0702862
Source: Self-asserted source
Alex Cheong via Scopus - Elsevier

Less REST, More Vascular Disease? Regulation of Cell Cycle and Migration of Vascular Smooth Muscle Cells

Journal article
DOI: 10.4161/cc.5.2.2310
Source: Self-asserted source
Alex Cheong
grade
Preferred source (of 3)‎

NFκB and HIF display synergistic behaviour during hypoxic inflammation

Journal article
DOI: 10.1007/s00018-011-0876-2
Source: Self-asserted source
Alex Cheong
grade
Preferred source (of 3)‎
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