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Loop profile: 727549
ResearcherID: X-9553-2019

Keywords

Dendritic Cells, Rheumatoid arthritis, Innate Immunity, NF-kB, Molecular Immunology

Countries

United Kingdom

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Employment (4)

University of Glasgow: Glasgow, Glasgow, GB

2016-10-01 to present | Research Associate (Institute of Infection, Immunity & Inflammation)
Employment
Source: Self-asserted source
Domenico Somma

Newcastle University: Newcastle upon Tyne, Tyne and Wear, GB

2016-02-01 to 2016-09-01 | Research Associate (Institute for Cell and Molecular Biosciences)
Employment
Source: Self-asserted source
Domenico Somma

Università degli Studi di Napoli Federico II: Napoli, Campania, IT

2013 to 2016 | Postdoctoral Fellow (Dept. Molecular Medicine and Medical Biotech)
Employment
Source: Self-asserted source
Domenico Somma

Università degli Studi di Napoli Federico II: Napoli, Campania, IT

2010 to 2013 | PhD (Dept. Cellular and Molecular Biology and Pathology)
Employment
Source: Self-asserted source
Domenico Somma

Education and qualifications (3)

University of Naples Federico II: Naples, Campania, IT

2010 to 2013 | PhD in Molecular Oncology and Endocrinology
Education
Source: Self-asserted source
Domenico Somma

University of Naples Federico II: Naples, Campania, IT

2007 to 2009 | MSc in Medical Biotecnology
Education
Source: Self-asserted source
Domenico Somma

University of Naples Federico II: Naples, Campania, IT

2003 to 2007 | Bachelor in Biotecnology
Education
Source: Self-asserted source
Domenico Somma

Works (17)

PROS1 released by human lung basal cells upon SARS-CoV-2 infection facilitates epithelial cell repair and limits inflammation

2024-09-13 | Preprint
DOI: 10.1101/2024.09.11.612489
Contributors: Theodoros Simakou; Agnieszka M Szemiel; Lucy MacDonald; Karen Kerr; Jack Frew; Marcus Doohan; Katy Diallo; Domenico Somma; Olympia M Hardy; Aziza Elmesmari et al.
Source: check_circle
Crossref

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid Arthritis

2024-07-19 | Preprint
DOI: 10.1101/2024.07.17.600758
Contributors: Lucy MacDonald; Aziza Elmesmari; Domenico Somma; Jack Frew; Clara Di Mario; Roopa Madhu; Audrey Paoletti; Theodoros Simakou; Olympia M. Hardy; Barbara Tolusso et al.
Source: check_circle
Crossref

miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation.

Clinical and experimental immunology
2022-04-01 | Journal article
DOI: 10.1093/cei/uxab016
PMID: 35020867
PMC: PMC8982969
Contributors: Olsson AM; Povoleri GAM; Somma D; Ridley ML; Tatiana Rizou; Lalnunhlimi S; Macdonald L; Rajasekhar M; Martinez-Nunez RT; Kurowska-Stolarska M et al.
Source: Self-asserted source
Domenico Somma

Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of <i>NFKB1</i> Knockout THP1 Cells.

Frontiers in immunology
2021-10-13 | Journal article
DOI: 10.3389/fimmu.2021.669906
PMID: 34721373
PMC: PMC8548695
Contributors: Somma D; Fatma Olcay Kok; Kerrigan D; Christine A Wells; Carmody RJ
Source: Self-asserted source
Domenico Somma

COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes

JCI Insight
2021-07-08 | Journal article
DOI: 10.1172/jci.insight.147413
Contributors: Lucy MacDonald; Stefano Alivernini; Barbara Tolusso; Aziza Elmesmari; Domenico Somma; Simone Perniola; Annamaria Paglionico; Luca Petricca; Silvia L. Bosello; Angelo Carfì et al.
Source: check_circle
Crossref

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.

Nature medicine
2020-06-29 | Journal article
DOI: 10.1038/s41591-020-0939-8
PMID: 32601335
Contributors: STEFANO ALIVERNINI; Lucy MacDonald; Elmesmari A; Finlay S; barbara tolusso; Maria Rita Gigante; Luca Petricca; Clara Di Mario; Bui L; Simone Perniola et al.
Source: Self-asserted source
Domenico Somma

The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.

The Journal of biological chemistry
2020-06-25 | Journal article
DOI: 10.1074/jbc.ra120.014113
PMID: 32587091
PMC: PMC7450122
Contributors: Mitxitorena I; Somma D; Jennifer P Mitchell; Lepistö M; Christian Tyrchan; Emma Smith; Kiely PA; Walden H; Karen Keeshan; Ruaidhri Carmody
Source: Self-asserted source
Domenico Somma

The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.

Proceedings of the National Academy of Sciences of the United States of America
2019-11-26 | Journal article
DOI: 10.1073/pnas.1900408116
PMID: 31772019
PMC: PMC6926074
Contributors: Patricia Collins; Somma D; Kerrigan D; Herrington F; Keeshan K; Nibbs RJB; Ruaidhri Carmody
Source: Self-asserted source
Domenico Somma

The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80

Nucleic Acids Research
2019-10-10 | Journal article
DOI: 10.1093/nar/gkz873
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Domenico Somma

Sphingosine Kinases promote IL-17 expression in human T lymphocytes

Scientific reports
2018 | Journal article
Source: Self-asserted source
Domenico Somma

Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7

Aquatic Toxicology
2016 | Journal article
Source: Self-asserted source
Domenico Somma

Heat shock induces the expression of pro-inflammatory cytokines in human Achilles tendon tenocytes.

Journal of biological regulators and homeostatic agents
2016 | Journal article
Source: Self-asserted source
Domenico Somma

Novel STAT 1 gain-of-function mutation and suppurative infections

Pediatric Allergy and Immunology
2016 | Journal article
Source: Self-asserted source
Domenico Somma

Targeted next-generation sequencing revealed MYD88 deficiency in a child with chronic yersiniosis and granulomatous lymphadenitis

Journal of Allergy and Clinical Immunology
2016 | Journal article
Source: Self-asserted source
Domenico Somma

CIKS/DDX3X interaction controls the stability of the Zc3h12a mRNA induced by IL-17

The Journal of Immunology
2015 | Journal article
Source: Self-asserted source
Domenico Somma

Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase i inhibitor or radiation

Cytometry Part A
2014 | Journal article
Source: Self-asserted source
Domenico Somma

NGAL controls the metastatic potential of anaplastic thyroid carcinoma cells

The Journal of Clinical Endocrinology & Metabolism
2013 | Journal article
Source: Self-asserted source
Domenico Somma

Peer review (22 reviews for 4 publications/grants)

Review activity for Cells. (4)
Review activity for Frontiers in immunology. (2)
Review activity for Frontiers in pharmacology. (5)
Review activity for Pharmacological research. (11)
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