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Scopus Author ID: 7005465519

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The Rockefeller University: New York, NY, US

2015-09 to present | Professor and Head of Laboratory (Laboratory of Molecular Electron Microscopy)
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Thomas Walz

Works (50 of 231)

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Page 1 of 5

Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

eLife
2024-09-02 | Journal article
DOI: 10.7554/eLife.90851.3
Contributors: Po-Lin Chiu; Juan D Orjuela; Bert L de Groot; Camilo Aponte Santamaría; Thomas Walz
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Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

eLife
2024-09-02 | Journal article
DOI: 10.7554/eLife.90851
Contributors: Po-Lin Chiu; Juan D Orjuela; Bert L de Groot; Camilo Aponte Santamaría; Thomas Walz
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An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding

Blood Advances
2024-08-27 | Journal article
DOI: 10.1182/bloodadvances.2024013177
Contributors: Lu Wang; Jialing Wang; Jihong Li; Thomas Walz; Barry S. Coller
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Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

2024-06-26 | Preprint
DOI: 10.7554/eLife.90851.2
Contributors: Po-Lin Chiu; Juan D. Orjuela; Bert L. de Groot; Camilo Aponte-Santamaría; Thomas Walz
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Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

2023-09-28 | Preprint
DOI: 10.7554/eLife.90851.1
Contributors: Po-Lin Chiu; Juan D. Orjuela; Bert L. de Groot; Camilo Aponte-Santamaría; Thomas Walz
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The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex

2023-08-22 | Preprint
DOI: 10.1101/2023.08.22.554360
Contributors: Ryan Q. Notti; Fei Yi; Søren Heissel; Martin W. Bush; Zaki Molvi; Pujita Das; Henrik Molina; Christopher A. Klebanoff; Thomas Walz
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WITHDRAWN: Cholesterol mechanically stabilizes aquaporin-0 arrays by strengthening the association of adjacent tetramers

2023-05-19 | Preprint
DOI: 10.1101/2023.05.17.541099
Contributors: Juan D. Orjuela; Po-Lin Chiu; Thomas Walz; Bert L. de Groot; Camilo Aponte-Santamaría
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Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

2023-05-18 | Preprint
DOI: 10.1101/2023.05.16.540959
Contributors: Po-Lin Chiu; Juan D. Orjuela; Bert L. de Groot; Camilo Aponte-Santamaría; Thomas Walz
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POT1 recruits and regulates CST–Polα/Primase at human telomeres

2023-05-09 | Preprint
DOI: 10.1101/2023.05.08.539880
Contributors: Sarah W. Cai; Hiroyuki Takai; Thomas Walz; Titia de Lange
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Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

Nature Communications
2022-10-27 | Journal article
DOI: 10.1038/s41467-022-34008-y
Contributors: Shuang Yang; Giorgos Hiotis; Yi Wang; Junjian Chen; Jia-huai Wang; Mikyung Kim; Ellis L. Reinherz; Thomas Walz
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Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state

Nature Structural & Molecular Biology
2022-08 | Journal article
DOI: 10.1038/s41594-022-00766-y
Contributors: Sarah W. Cai; John C. Zinder; Vladimir Svetlov; Martin W. Bush; Evgeny Nudler; Thomas Walz; Titia de Lange
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Shelterin is a dimeric complex with extensive structural heterogeneity

Proceedings of the National Academy of Sciences
2022-08-02 | Journal article
DOI: 10.1073/pnas.2201662119
Contributors: John C. Zinder; Paul Dominic B. Olinares; Vladimir Svetlov; Martin W. Bush; Evgeny Nudler; Brian T. Chait; Thomas Walz; Titia de Lange
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Native-like environments afford novel mechanistic insights into membrane proteins

Trends in Biochemical Sciences
2022-07 | Journal article
DOI: 10.1016/j.tibs.2022.02.008
Contributors: Ryan Q. Notti; Thomas Walz
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Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack

2022-05-09 | Preprint
DOI: 10.1101/2022.05.09.491169
Contributors: Shuang Yang; Giorgos Hiotis; Yi Wang; Junjian Chen; Jia-huai Wang; Mikyung Kim; Ellis L. Reinherz; Thomas Walz
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Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

2022-01-24 | Preprint
DOI: 10.1101/2022.01.24.477420
Contributors: John C Zinder; Paul Dominic B Olinares; Vladimir Svetlov; Martin W Bush; Evgeny Nudler; Brian T Chait; Thomas Walz; Titia de Lange
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Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars

Antibiotics
2021-11-26 | Journal article
DOI: 10.3390/antibiotics10121455
Contributors: Aqsa Shaheen; Anam Tariq; Mazhar Iqbal; Osman Mirza; Abdul Haque; Thomas Walz; Moazur Rahman
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Characterization of the multidrug efflux transporter styMdtM from Salmonella enterica serovar Typhi

Proteins: Structure, Function, and Bioinformatics
2021-09 | Journal article
DOI: 10.1002/prot.26141
Contributors: Aqsa Shaheen; Fouzia Ismat; Mazhar Iqbal; Abdul Haque; Zaheer Ul‐Haq; Osman Mirza; Rita De Zorzi; Thomas Walz; Moazur Rahman
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Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels

Proceedings of the National Academy of Sciences
2021-09-07 | Journal article
DOI: 10.1073/pnas.2104820118
Contributors: Charles D. Cox; Yixiao Zhang; Zijing Zhou; Thomas Walz; Boris Martinac
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Visualization of the mechanosensitive ion channel MscS under membrane tension

Nature
2021-02-18 | Journal article
DOI: 10.1038/s41586-021-03196-w
Contributors: Yixiao Zhang; Csaba Daday; Ruo-Xu Gu; Charles D. Cox; Boris Martinac; Bert L. de Groot; Thomas Walz
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Pre-termination Transcription Complex: Structure and Function

Molecular Cell
2021-01 | Journal article
DOI: 10.1016/j.molcel.2020.11.013
Contributors: Zhitai Hao; Vitaly Epshtein; Kelly H. Kim; Sergey Proshkin; Vladimir Svetlov; Venu Kamarthapu; Binod Bharati; Alexander Mironov; Thomas Walz; Evgeny Nudler
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A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Cell
2020 | Journal article
DOI: 10.1016/j.cell.2020.09.051
EID:

2-s2.0-85094202809

Part of ISSN: 10974172 00928674
Contributors: Mashtalir, N.; Suzuki, H.; Farrell, D.P.; Sankar, A.; Luo, J.; Filipovski, M.; D'Avino, A.R.; St. Pierre, R.; Valencia, A.M.; Onikubo, T. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Cryo-electron microscopy structure of the αiIbβ3-abciximab complex

Arteriosclerosis, Thrombosis, and Vascular Biology
2020 | Journal article
DOI: 10.1161/ATVBAHA.119.313671
EID:

2-s2.0-85081166661

Part of ISSN: 15244636 10795642
Contributors: Nešić, D.; Zhang, Y.; Spasic, A.; Li, J.; Provasi, D.; Filizola, M.; Walz, T.; Coller, B.S.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Dominant role of aIIbb3 in platelet interactions with cross-linked fibrin fragment D-dimer

Blood Advances
2020 | Journal article
DOI: 10.1182/bloodadvances.2020001545
EID:

2-s2.0-85088371196

Part of ISSN: 24739537 24739529
Contributors: Buitrago, L.; Zafar, H.; Zhang, Y.; Li, J.; Walz, T.; Coller, B.S.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β<inf>1</inf>-Adrenergic Receptor

Molecular Cell
2020 | Journal article
DOI: 10.1016/j.molcel.2020.08.001
EID:

2-s2.0-85090205426

Part of ISSN: 10974164 10972765
Contributors: Su, M.; Zhu, L.; Zhang, Y.; Paknejad, N.; Dey, R.; Huang, J.; Lee, M.-Y.; Williams, D.; Jordan, K.D.; Eng, E.T. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery

Molecular Cell
2020 | Journal article
DOI: 10.1016/j.molcel.2019.11.005
EID:

2-s2.0-85079385409

Part of ISSN: 10974164 10972765
Contributors: Zhang, Y.; Sun, Y.; Shi, Y.; Walz, T.; Tong, L.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Structure of an active human histone pre-mRNA 3′-end processing machinery

Science
2020 | Journal article
DOI: 10.1126/science.aaz7758
EID:

2-s2.0-85079083545

Part of ISSN: 10959203 00368075
Contributors: Sun, Y.; Zhang, Y.; Aik, W.S.; Yang, X.-C.; Marzluff, W.F.; Walz, T.; Dominski, Z.; Tong, L.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin

Proceedings of the National Academy of Sciences
2020-12 | Journal article
DOI: 10.1073/pnas.2003395117
Contributors: Rachel Leicher; Eva J. Ge; Xingcheng Lin; Matthew J. Reynolds; Wenjun Xie; Thomas Walz; Bin Zhang; Tom W. Muir; Shixin Liu
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Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

Nature Communications
2020-11-20 | Journal article
DOI: 10.1038/s41467-020-19735-4
Contributors: Yiming Niu; Hiroshi Suzuki; Christopher J. Hosford; Thomas Walz; Joshua S. Chappie
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Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1

Proceedings of the National Academy of Sciences
2020-08-04 | Journal article
DOI: 10.1073/pnas.2002792117
Contributors: Keith J. Mickolajczyk; Paul Dominic B. Olinares; Yiming Niu; Nan Chen; Sara E. Warrington; Yusuke Sasaki; Thomas Walz; Brian T. Chait; Tarun M. Kapoor
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Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes

eLife
2020-06-08 | Journal article
DOI: 10.7554/eLife.55954
Contributors: Shuang Yang; Kriti Bahl; Hui-Ting Chou; Jonathan Woodsmith; Ulrich Stelzl; Thomas Walz; Maxence V Nachury
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New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins

eLife
2020-03-03 | Journal article
DOI: 10.7554/eLife.53530
Contributors: Gabriella Angiulli; Harveer Singh Dhupar; Hiroshi Suzuki; Irvinder Singh Wason; Franck Duong Van Hoa; Thomas Walz
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Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

2020-01-31 | Preprint
DOI: 10.1101/2020.01.30.927467
Contributors: Yiming Niu; Hiroshi Suzuki; Christopher J. Hosford; Thomas Walz; Joshua S. Chappie
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An ensemble of flexible conformations underlies mechanotransduction by the cadherin–catenin adhesion complex

Proceedings of the National Academy of Sciences of the United States of America
2019 | Journal article
DOI: 10.1073/pnas.1911489116
EID:

2-s2.0-85073727683

Part of ISSN: 10916490 00278424
Contributors: Bush, M.; Alhanshali, B.M.; Qian, S.; Stanley, C.B.; Heller, W.T.; Matsui, T.; Weiss, T.M.; Nicholl, I.D.; Walz, T.; Callaway, D.J.E. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Novel Pure αvβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

ACS Pharmacology and Translational Science
2019 | Journal article
DOI: 10.1021/acsptsci.9b00041
EID:

2-s2.0-85087732052

Part of ISSN: 25759108
Contributors: Li, J.; Fukase, Y.; Shang, Y.; Zou, W.; Muñoz-Félix, J.M.; Buitrago, L.; Van Agthoven, J.; Zhang, Y.; Hara, R.; Tanaka, Y. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach

Structure
2019 | Journal article
DOI: 10.1016/j.str.2019.06.006
EID:

2-s2.0-85071379774

Part of ISSN: 18784186 09692126
Contributors: Chou, H.-T.; Apelt, L.; Farrell, D.P.; White, S.R.; Woodsmith, J.; Svetlov, V.; Goldstein, J.S.; Nager, A.R.; Li, Z.; Muller, J. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

ATG2 transports lipids to promote autophagosome biogenesis

Journal of Cell Biology
2019-06-03 | Journal article
DOI: 10.1083/jcb.201811139
Contributors: Diana P. Valverde; Shenliang Yu; Venkata Boggavarapu; Nikit Kumar; Joshua A. Lees; Thomas Walz; Karin M. Reinisch; Thomas J. Melia
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Cryo-EM structure of the insect olfactory receptor Orco

Nature
2018 | Journal article
DOI: 10.1038/s41586-018-0420-8
EID:

2-s2.0-85052097458

Part of ISSN: 14764687 00280836
Contributors: Butterwick, J.A.; del Mármol, J.; Kim, K.H.; Kahlson, M.A.; Rogow, J.A.; Walz, T.; Ruta, V.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Molecular basis for the recognition of the human AAUAAA polyadenylation signal

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
DOI: 10.1073/pnas.1718723115
EID:

2-s2.0-85041959711

Part of ISSN: 10916490 00278424
Contributors: Sun, Y.; Zhang, Y.; Hamilton, K.; Manley, J.L.; Shi, Y.; Walz, T.; Tong, L.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

Scientific Reports
2018 | Journal article
DOI: 10.1038/s41598-018-24501-0
EID:

2-s2.0-85045873515

Part of ISSN: 20452322
Contributors: Arndt, J.W.; Qian, F.; Smith, B.A.; Quan, C.; Kilambi, K.P.; Bush, M.W.; Walz, T.; Pepinsky, R.B.; Bussière, T.; Hamann, S. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis

Cell
2018 | Journal article
DOI: 10.1016/j.cell.2018.09.015
EID:

2-s2.0-85055075099

Part of ISSN: 10974172 00928674
Contributors: Chen, Z.; Suzuki, H.; Kobayashi, Y.; Wang, A.C.; DiMaio, F.; Kawashima, S.A.; Walz, T.; Kapoor, T.M.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

Nature Structural & Molecular Biology
2018-07 | Journal article
DOI: 10.1038/s41594-018-0085-x
Contributors: Nicholas O. Bodnar; Kelly H. Kim; Zhejian Ji; Thomas E. Wales; Vladimir Svetlov; Evgeny Nudler; John R. Engen; Thomas Walz; Tom A. Rapoport
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Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

Journal of Cell Biology
2018-05-07 | Journal article
DOI: 10.1083/jcb.201711047
Contributors: Theresia Gutmann; Kelly H. Kim; Michal Grzybek; Thomas Walz; Ünal Coskun
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6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase

Molecular Cell
2017 | Journal article
DOI: 10.1016/j.molcel.2017.09.006
EID:

2-s2.0-85030536620

Part of ISSN: 10974164 10972765
Contributors: Chen, J.; Wassarman, K.M.; Feng, S.; Leon, K.; Feklistov, A.; Winkelman, J.T.; Li, Z.; Walz, T.; Campbell, E.A.; Darst, S.A.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble

Biochemistry
2017 | Journal article
DOI: 10.1021/acs.biochem.7b00302
EID:

2-s2.0-85027996465

Part of ISSN: 15204995 00062960
Contributors: Pepinsky, B.; Gong, B.-J.; Gao, Y.; Lehmann, A.; Ferrant, J.; Amatucci, J.; Sun, Y.; Bush, M.; Walz, T.; Pederson, N. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Architecture of the human PI4KIIIα lipid kinase complex

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1718471115
EID:

2-s2.0-85039698579

Part of ISSN: 10916490 00278424
Contributors: Lees, J.A.; Zhang, Y.; Oh, M.S.; Schauder, C.M.; Yu, X.; Baskin, J.M.; Dobbs, K.; Notarangelo, L.D.; De Camilli, P.; Walz, T. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

Nature Communications
2017 | Journal article
DOI: 10.1038/s41467-017-01575-4
EID:

2-s2.0-85034731597

Part of ISSN: 20411723
Contributors: Ait-Bouziad, N.; Lv, G.; Mahul-Mellier, A.-L.; Xiao, S.; Zorludemir, G.; Eliezer, D.; Walz, T.; Lashuel, H.A.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change

Journal of Structural Biology
2017 | Journal article
DOI: 10.1016/j.jsb.2017.05.005
EID:

2-s2.0-85019620409

Part of ISSN: 10958657 10478477
Contributors: Kalbermatter, D.; Chiu, P.-L.; Jeckelmann, J.-M.; Ucurum, Z.; Walz, T.; Fotiadis, D.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Macromolecular Assemblies of the Mammalian Circadian Clock

Molecular Cell
2017 | Journal article
DOI: 10.1016/j.molcel.2017.07.017
EID:

2-s2.0-85028818973

Part of ISSN: 10974164 10972765
Contributors: Aryal, R.P.; Kwak, P.B.; Tamayo, A.G.; Gebert, M.; Chiu, P.-L.; Walz, T.; Weitz, C.J.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

eLife
2017 | Journal article
DOI: 10.7554/eLife.29795
EID:

2-s2.0-85032955906

Part of ISSN: 2050084X
Contributors: Chen, B.; Chou, H.-T.; Brautigam, C.A.; Xing, W.; Yang, S.; Henry, L.; Doolittle, L.K.; Walz, T.; Rosen, M.K.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier

Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0

Biophysical Journal
2017 | Journal article
DOI: 10.1016/j.bpj.2017.01.026
EID:

2-s2.0-85015050678

Part of ISSN: 15420086 00063495
Contributors: Saboe, P.O.; Rapisarda, C.; Kaptan, S.; Hsiao, Y.-S.; Summers, S.R.; De Zorzi, R.; Dukovski, D.; Yu, J.; de Groot, B.L.; Kumar, M. et al.
Source: Self-asserted source
Thomas Walz via Scopus - Elsevier
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