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Scopus Author ID: 8851987700
Scopus Author ID: 8851987700
Loop profile: 837388

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Employment (10)

University of Dundee: N/A, GB

2024-07-01 to present | Academic, Reader (Teaching and Research) (Cancer Research)
Employment
Source: check_circle
University of Dundee

University of Dundee: N/A, GB

2023-11-01 to 2024-06-30 | Academic, Reader (Teaching and Research) (Cellular Medicine)
Employment
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University of Dundee

University of Dundee: N/A, GB

2021-07-06 to 2023-10-31 | Academic, Senior Lecturer (Teaching and Research) (Cellular Medicine)
Employment
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University of Dundee

University of Dundee: N/A, GB

2020-05-05 to 2021-07-08 | Academic, Lecturer (Teaching and Research) (Cellular Medicine)
Employment
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University of Dundee

University of Dundee: N/A, GB

2020-05-05 to 2021-07-05 | Academic, Lecturer (Teaching and Research) (Cellular Medicine)
Employment
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University of Dundee

University of Dundee: N/A, GB

2018-06-01 to 2020-06-12 | Academic, Discovery Fellowship (Cellular Medicine)
Employment
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University of Dundee

University of Dundee: N/A, GB

2018-06-01 to 2020-05-04 | Academic, Discovery Fellowship (Cellular Medicine)
Employment
Source: check_circle
University of Dundee

University of Dundee: N/A, GB

2015-08-01 to 2018-05-31 | Academic, Discovery Fellowship (Cancer Research)
Employment
Source: check_circle
University of Dundee

University of Dundee: N/A, GB

2015-08-01 to 2018-05-23 | Academic, Discovery Fellowship (Cancer Research)
Employment
Source: check_circle
University of Dundee

University of Dundee: N/A, GB

2013-08-01 to 2015-07-31 | Academic, Discovery Fellowship (Division of Cancer Research)
Employment
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University of Dundee

Funding (1)

HIPK2 as a novel determinant of cancer therapeutic resistance

2017-02-01 to 2023-01-31 | Grant
Cancer Research UK (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.6848494
GRANT_NUMBER:

CRUK-A22869
Source: Self-asserted source
Laureano de la Vega via DimensionsWizard

Works (38)

Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Nature Communications
2024-05-15 | Journal article | Author
DOI: 10.1038/s41467-024-48422-x
SOURCE-WORK-ID:

031c6e64-cb04-4fa3-813b-15f0b4b2d550

PMID: 38750019
EID:

2-s2.0-85193395304
Contributors: Naziia Kurmasheva; Aida Said; Boaz Wong; Priscilla Kinderman; Xiaoying Han; Anna H.F. Rahimic; Alena Kress; Madalina E. Carter-Timofte; Emilia Holm; Demi van der Horst et al.
Source: check_circle
University of Dundee

Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation

Free Radical Biology and Medicine
2023-11-01 | Journal article | Author
DOI: 10.1016/j.freeradbiomed.2023.09.009
SOURCE-WORK-ID:

38ddb505-8742-482a-b1da-660af35a5849

PMID: 37714439
EID:

2-s2.0-85171303139

PMID: 37714439
Contributors: Sharadha Dayalan Naidu; Plamena R. Angelova; Elena V. Knatko; Chiara Leonardi; Miroslav Novak; Laureano de la Vega; Ian Ganley; Andrey Y. Abramov; Albena Dinkova-Kostova
Source: check_circle
University of Dundee

Dual inhibition of HSF1 and DYRK2 impedes cancer progression

Bioscience Reports
2023-01-31 | Journal article
DOI: 10.1042/bsr20222102
Part of ISSN: 0144-8463
Part of ISSN: 1573-4935
Contributors: Vasudha Tandon; Rita Moreno; Kira Allmeroth; Jean Quinn; Sandra E. Wiley; Lynden G. Nicely; Martin S. Denzel; Joanne Edwards; Laureano de la Vega; Sourav Banerjee
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1

Free Radical Biology and Medicine
2022-10 | Journal article | Author
DOI: 10.1016/j.freeradbiomed.2022.08.041
Part of ISSN: 0891-5849
Contributors: Rita Moreno; Laura Casares; Maureen Higgins; Kevin X. Ali; Tadashi Honda; Clotilde Wiel; Volkan I. Sayin; Albena T. Dinkova-Kostova; Laureano de la Vega
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Nature Metabolism
2022-06-02 | Journal article | Author
DOI: 10.1038/s42255-022-00577-x
Part of ISSN: 2522-5812
Contributors: Fangfang Chen; Walid A. M. Elgaher; M. Winterhoff; Konrad Büssow; Fakhar ul Hassnain Waqas; E. Graner; Y. Pires-Afonso; L. Casares Perez; Laureano de la Vega; N. Sahini et al.
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

Redox Biology
2022-05 | Journal article
DOI: 10.1016/j.redox.2022.102291
Part of ISSN: 2213-2317
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

A Nrf-2 Stimulatory Hydroxylated Cannabidiol Derivative from Hemp (Cannabis sativa)

Journal of Natural Products
2022-03-22 | Journal article
DOI: 10.1021/acs.jnatprod.1c01198
Part of ISSN: 0163-3864
Part of ISSN: 1520-6025
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Pirin, an Nrf2-regulated protein, is overexpressed in human colorectal tumors

Antioxidants
2022-01-28 | Journal article | Author
DOI: 10.3390/antiox11020262
SOURCE-WORK-ID:

641130db-d35c-4c6e-9d59-d67b31fe10cd

EID:

2-s2.0-85123517675

PMID: 35204145
Contributors: Ying Zhang; Elena V. Knatko; Maureen Higgins; Sharadha Dayalan Naidu; Gillian Smith; Tadashi Honda; Laureano de la Vega; Albena Dinkova-Kostova
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival.

Cell death and differentiation
2021-08-06 | Journal article
DOI: 10.1038/s41418-021-00845-5
PMID: 34363019
PMC: PMC8738746
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks

Cancers
2021-07-19 | Journal article | Author
DOI: 10.3390/cancers13143618
SOURCE-WORK-ID:

e86bcf84-d395-4f08-93be-12a66a65a259

PMID: 34298830
EID:

2-s2.0-85110267394
Contributors: Julia Busch; Rita Moreno; Laureano de la Vega; Vera Vivian Saul; Susanne Bacher; Felix von Zweydorf; Marius Ueffing; Axel Weber; Christian Johannes Gloeckner; Uwe Linne et al.
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Emerging roles of DYRK2 in cancer

Journal of Biological Chemistry
2021-01 | Journal article
DOI: 10.1074/jbc.rev120.015217
Part of ISSN: 0021-9258
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Regiodivergent Synthesis of ortho‐ and para‐Cannabinoquinones

European Journal of Organic Chemistry
2020-12-31 | Journal article
DOI: 10.1002/ejoc.202001258
Part of ISSN: 1434-193X
Part of ISSN: 1099-0690
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress.

Cell death and differentiation
2020-12-02 | Journal article
DOI: 10.1038/s41418-020-00686-8
PMID: 33268814
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

iScience
2020-10 | Journal article
DOI: 10.1016/j.isci.2020.101638
Part of ISSN: 2589-0042
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

Biomolecules
2020-10 | Journal article
DOI: 10.3390/biom10101365
SOURCE-WORK-ID:

2e2ed62e-46b2-4ca5-ae0e-1c1b3529ea2a

EID:

2-s2.0-85091577791

EID:

2-s2.0-85091577791

PMID: 32992842
Contributors: Laura Torrente Fernandez; Gunjit Maan; Asma Oumkaltoum Rezig; Jean Quinn; Angus Jackson; Andrea Grilli; Laura Casares; Ying Zhang; Evgeny Kulesskiy; Jani Saarela et al.
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

Redox Biology
2020-10 | Journal article
DOI: 10.1016/j.redox.2020.101689
ISSN: 2213-2317
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.

Proceedings of the National Academy of Sciences of the United States of America
2019-11-21 | Journal article
DOI: 10.1073/pnas.1912033116
PMID: 31754034
PMC: PMC6900511
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells.

Chemical research in toxicology
2019-11-20 | Journal article
DOI: 10.1021/acs.chemrestox.9b00399
PMID: 31746589
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2.

Cellular and molecular life sciences : CMLS
2019-10-11 | Journal article
DOI: 10.1007/s00018-019-03309-9
PMID: 31605148
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1.

Redox biology
2019-09-05 | Journal article
DOI: 10.1016/j.redox.2019.101321
PMID: 31518892
PMC: PMC6742916
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner.

Phytomedicine : international journal of phytotherapy and phytopharmacology
2019-08-05 | Journal article
DOI: 10.1016/j.phymed.2019.153062
PMID: 31409554
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 2)‎

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

Oncogene
2017-11-02 | Journal article
DOI: 10.1038/onc.2017.221
SOURCE-WORK-ID:

1d761e86-5559-46f5-8b13-9598d86252a5

PMID: 28692050
PMID: 28692050
EID:

2-s2.0-85032962106
Contributors: Laura Torrente; Carlos Sanchez; Rita Moreno Dorta; Sudhir Chowdhry; Paula Cabello; Kyoichi Isono; Haruhiko Koseki; Tadashi Honda; John Hayes; Albena Dinkova-Kostova et al.
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

Scientific Reports
2017-09-08 | Journal article | Author
DOI: 10.1038/s41598-017-11262-5
SOURCE-WORK-ID:

068b68b4-05fe-4a72-9d7c-8d5d57721fbb

PMID: 28887499
EID:

2-s2.0-85028974944

PMID: 28887499
Contributors: Sharadha Dayalan Naidu; Dina Dikovskaya; Egle Gaurilcikaite; Elena Knatko; Zachary R. Healy; Hema Mohan; Glenn Koh; Axel Laurell; Graeme Ball; David Olagnier et al.
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Molecular and Cellular Biology
2016-09-15 | Journal article | Author
DOI: 10.1128/MCB.00292-16
SOURCE-WORK-ID:

bd82de08-4ea1-477b-b5ed-d4ca0b69e0ff

PMID: 27354066
PMID: 27354066
EID:

2-s2.0-84988336071
Contributors: Sharadha Dayalan Naidu; Calum Sutherland; Ying Zhang; Ana Risco; Laureano de la Vega; Christopher J Caunt; C James Hastie; Douglas J Lamont; Laura Torrente; Sudhir Chowdhry et al.
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

New insights into the role of histone deacetylases as coactivators of inflammatory gene expression

Antioxidants & Redox Signaling
2015-07-01 | Journal article | Author
DOI: 10.1089/ars.2013.5750
SOURCE-WORK-ID:

59f62173-194e-4d9e-b5f9-5e5700251219

EID:

2-s2.0-84935023810

PMID: 24359078
Contributors: Michael Lienhard Schmitz; Laureano de la Vega
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage

Nucleic Acids Research
2013-06 | Journal article | Author
DOI: 10.1093/nar/gkt262
SOURCE-WORK-ID:

0d5c1952-d13e-4d7c-b9c9-31272e5615da

EID:

2-s2.0-84878870624

PMID: 23620283
Contributors: Laureano de la Vega; Juliane Hornung; Elizabeth Kremmer; Maja Milanovic; M. Lienhard Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

Journal of Molecular Cell Biology
2013-02 | Journal article | Author
DOI: 10.1093/jmcb/mjs053
SOURCE-WORK-ID:

56215bac-76e2-44e3-b45f-17c725478678

PMID: 23000554
EID:

2-s2.0-84874332563
Contributors: Vera V. Saul; Laureano de la Vega; Maja Milanovic; Marcus Krüger; Thomas Braun; Karin Fritz-Wolf; Katja Becker; M. Lienhard Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

Molecular Cell
2012-05-25 | Journal article | Author
DOI: 10.1016/j.molcel.2012.03.003
SOURCE-WORK-ID:

38664f37-77fa-47b5-87e2-11bb41387f97

EID:

2-s2.0-84861452914

PMID: 22503103
Contributors: Laureano de la Vega; I. Grishina; R. Moreno; M. Krüger; T. Braun; M.L. Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Control of nuclear HIPK2 localization and function by a SUMO interaction motif

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2011-02 | Journal article | Author
DOI: 10.1016/j.bbamcr.2010.11.022
SOURCE-WORK-ID:

7f7d7166-1084-4a74-a84d-bb833ccf3a62

EID:

2-s2.0-78650957031

PMID: 21145359
Contributors: Laureano de la Vega; Katrin Fröbius; Rita Moreno; Marco A. Calzado; Hui Geng; M. Lienhard Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation

Biological Chemistry
2009-10 | Journal article | Author
DOI: 10.1515/BC.2009.112
SOURCE-WORK-ID:

9167d2e8-96c1-491c-a3fe-3a6b8e99ebd4

PMID: 19642869
EID:

2-s2.0-70349327703
Contributors: Marco A. Calzado; Laureano de la Vega; Eduardo Muñoz; M. Lienhard Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

From top to bottom

Cell Cycle
2009-06-01 | Journal article | Author
DOI: 10.4161/cc.8.11.8597
SOURCE-WORK-ID:

5a3d4c85-1773-4e03-81d6-a376f8972c1a

PMID: 19448429
EID:

2-s2.0-66749092056
Contributors: Marco A Calzado; Laureano de la Vega; Eduardo Munoz; M. Lienhard Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

Nature Cell Biology
2009-01 | Journal article | Author
DOI: 10.1038/ncb1816
SOURCE-WORK-ID:

ab1647ca-2f43-4e3e-9b2a-7c48328d2395

EID:

2-s2.0-58149354210

PMID: 19043406
Contributors: M.A. Calzado; Laureano de la Vega; A. Möller; D.D.L. Bowtell; M.L. Schmitz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

A bacterial small molecule undermining immune response signaling

ChemBioChem
2008-11-03 | Journal article | Author
DOI: 10.1002/cbic.200800562
SOURCE-WORK-ID:

7b39edd9-81eb-44eb-b403-cb79ced6252f

PMID: 18823058
EID:

2-s2.0-59449095339
Contributors: M. Lienhard Schmitz; Laureano de la Vega
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein

Journal of Molecular Biology
2007-09-14 | Journal article | Author
DOI: 10.1016/j.jmb.2007.06.075
SOURCE-WORK-ID:

7c0d2b6b-f0a9-49da-ab16-c04e5f83b477

PMID: 17669424
EID:

2-s2.0-34547938116
Contributors: Laureano de la Vega; Gonzalo Sánchez-Duffhues; Manuel Fresno; M. Lienhard Schmitz; Eduardo Muñoz; Marco A. Calzado
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine.

Journal of immunology (Baltimore, Md. : 1950)
2005-09-01 | Journal article
DOI: 10.4049/jimmunol.175.6.3990
PMID: 16148147
Source: Self-asserted source
Laureano de la Vega
grade
Preferred source (of 3)‎

The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway

Biochemical Pharmacology
2005-08-01 | Journal article | Author
DOI: 10.1016/j.bcp.2005.04.031
SOURCE-WORK-ID:

a6ad24e0-4ddd-434c-8ca7-b6a4a547b7de

PMID: 15922994
EID:

2-s2.0-21344464499
Contributors: Laureano de la Vega; Eduardo Muñoz; Marco A. Calzado; Klaus Lieb; Eduardo Candelario-Jalil; Harald Gschaidmeir; Lothar Färber; Wolfgang Mueller; Thomas Stratz; Bernd L. Fiebich
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

Immunosuppressive activity of endovanilloids

Journal of Immunology
2004-02-15 | Journal article | Author
DOI: 10.4049/jimmunol.172.4.2341
SOURCE-WORK-ID:

8343f514-2590-43dc-bc49-3bd8c1f91856

PMID: 14764703
EID:

2-s2.0-0842321782
Contributors: Rocío Sancho; Antonio Macho; Laureano de la Vega; Marco A. Calzado; Bernd L. Fiebich; Giovanni Appendino; Eduardo Muñoz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎

The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway

British Journal of Pharmacology
2003-11 | Journal article | Author
DOI: 10.1038/sj.bjp.0705532
SOURCE-WORK-ID:

3fcb4ad7-8913-4ade-ae69-c8c7ebb9bd00

PMID: 14530215
EID:

2-s2.0-0345257345
Contributors: Rocío Sancho; Laureano de la Vega; Giovanni Appendino; Vincenzo Di Marzo; Antonio Macho; Eduardo Muñoz
Source: check_circle
University of Dundee
grade
Preferred source (of 2)‎
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