Personal information

Electron Microscopy, CryoEM, Virus, Toxin
United States

Biography

Structural biologist and biochemist with strong expertise in protein expression (bacteria and insects cell), protein purification and cryo-EM.
Experience in structure determination, protein analytic characterization using calorimetry and other analytical techniques and biochemical assays for enzyme kinetics.
Working on Virus and toxins

Activities

Employment (2)

Vanderbilt University Medical Center: Nashville, TN, US

2019-08 to present | Cryo-EM specialist - Senior Scientist (Vanderbilt Vaccine Center (VVC))
Employment
Source: Self-asserted source
Elad Binshtein

Vanderbilt University: Nashville, TN, US

2016-08 to 2019-08 (Center for Structure Biology (CSB))
Employment
Source: Self-asserted source
Elad Binshtein

Education and qualifications (4)

Vanderbilt University: Nashville, Tennessee, US

2011-11 to 2016-08 | Postdoctoral Fellowship
Education
Source: Self-asserted source
Elad Binshtein

Ben-Gurion University of the Negev Department of Life Sciences: Beer-Sheva, IL

2006-09 to 2010-09 | PhD
Education
Source: Self-asserted source
Elad Binshtein

Ben-Gurion University of the Negev Department of Life Sciences: Beer-Sheva, IL

2005-09 to 2006-09 | MS
Education
Source: Self-asserted source
Elad Binshtein

Ben-Gurion University of the Negev Department of Life Sciences: Beer-Sheva, IL

1999-08 to 2002-09 | BS
Education
Source: Self-asserted source
Elad Binshtein

Works (30)

Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV

Journal of Clinical Investigation
2024-11-26 | Journal article
Contributors: Naveenchandra Suryadevara; Nurgun Kose; Sandhya Bangaru; Elad Binshtein; Jennifer Munt; David R. Martinez; Alexandra Schäfer; Luke Myers; Trevor D. Scobey; Robert H. Carnahan et al.
Source: check_circle
Crossref

Computationally restoring the potency of a clinical antibody against Omicron

Nature
2024-05-23 | Journal article
Contributors: Thomas A. Desautels; Kathryn T. Arrildt; Adam T. Zemla; Edmond Y. Lau; Fangqiang Zhu; Dante Ricci; Stephanie Cronin; Seth J. Zost; Elad Binshtein; Suzanne M. Scheaffer et al.
Source: check_circle
Crossref

Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses

Nature Communications
2023-09-13 | Journal article
Contributors: Nathaniel S. Chapman; Ruben J. G. Hulswit; Jonna L. B. Westover; Robert Stass; Guido C. Paesen; Elad Binshtein; Joseph X. Reidy; Taylor B. Engdahl; Laura S. Handal; Alejandra Flores et al.
Source: check_circle
Crossref

Structures of the Insecticidal Toxin Complex Subunit XptA2 Highlight Roles for Flexible Domains

International Journal of Molecular Sciences
2023-08-25 | Journal article
Contributors: Cole L. Martin; David W. Chester; Christopher D. Radka; Lurong Pan; Zhengrong Yang; Rachel C. Hart; Elad M. Binshtein; Zhao Wang; Lisa Nagy; Lawrence J. DeLucas et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

2022-10 | Preprint
Contributors: Desautels TA; Arrildt KT; Zemla AT; Lau EY; Zhu F; Ricci D; Cronin S; Zost SJ; Binshtein E; Scheaffer SM et al.
Source: Self-asserted source
Elad Binshtein via Europe PubMed Central

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

2022-07 | Preprint
Contributors: Engdahl TB; Binshtein E; Brocato RL; Kuzmina NA; Principe LM; Kwilas SA; Kim RK; Chapman NS; Porter MS; Guardado-Calvo P et al.
Source: Self-asserted source
Elad Binshtein via Europe PubMed Central

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region.

PLoS pathogens
2022-05 | Journal article
Contributors: Schoeder CT; Gilchuk P; Sangha AK; Ledwitch KV; Malherbe DC; Zhang X; Binshtein E; Williamson LE; Martina CE; Dong J et al.
Source: Self-asserted source
Elad Binshtein via Europe PubMed Central

Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge

Journal of Experimental Medicine
2022-04-04 | Journal article
Contributors: Natasha M. Kafai; Lauren E. Williamson; Elad Binshtein; Soila Sukupolvi-Petty; Christina L. Gardner; Jaclyn Liu; Samantha Mackin; Arthur S. Kim; Nurgun Kose; Robert H. Carnahan et al.
Source: check_circle
Crossref

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

2022-01 | Preprint
Contributors: Suryadevara N; Shiakolas AR; VanBlargan LA; Binshtein E; Chen RE; Case JB; Kramer KJ; Armstrong E; Myers L; Trivette A et al.
Source: Self-asserted source
Elad Binshtein via Europe PubMed Central
grade
Preferred source (of 3)‎

Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypes

2022-01 | Preprint
Contributors: Chen EC; Gilchuk P; Zost SJ; Ilinykh PA; Binshtein E; Huang K; Myers L; Bonissone S; Day S; Kona CR et al.
Source: Self-asserted source
Elad Binshtein via Europe PubMed Central

Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

Cell Reports
2021 | Journal article
EID:

2-s2.0-85114033108

Part of ISSN: 22111247
Contributors: Doyle, M.P.; Kose, N.; Borisevich, V.; Binshtein, E.; Amaya, M.; Nagel, M.; Annand, E.J.; Armstrong, E.; Bombardi, R.; Dong, J. et al.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

bioRxiv
2021 | Other
EID:

2-s2.0-85102232769

Part of ISSN: 26928205
Contributors: Doyle, M.P.; Kose, N.; Borisevich, V.; Binshtein, E.; Amaya, M.; Nagel, M.; Annand, E.J.; Armstrong, E.; Bombardi, R.; Dong, J. et al.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

bioRxiv
2021 | Other
EID:

2-s2.0-85101712591

Part of ISSN: 26928205
Contributors: Dong, J.; Zost, S.J.; Greaney, A.J.; Starr, T.N.; Dingens, A.S.; Chen, E.C.; Chen, R.E.; Case, J.B.; Sutton, R.E.; Gilchuk, P. et al.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Nature Microbiology
2021 | Journal article
EID:

2-s2.0-85115229551

Part of ISSN: 20585276
Contributors: Dong, J.; Zost, S.J.; Greaney, A.J.; Starr, T.N.; Dingens, A.S.; Chen, E.C.; Chen, R.E.; Case, J.B.; Sutton, R.E.; Gilchuk, P. et al.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

2021-05-03 | Preprint
Contributors: Elaine C. Chen; Pavlo Gilchuk; Seth J. Zost; Naveenchandra Suryadevara; Emma S. Winkler; Carly R. Cabel; Elad Binshtein; Rachel E. Sutton; Jessica Rodriguez; Samuel Day et al.
Source: check_circle
Crossref
grade
Preferred source (of 4)‎

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Cell
2021-04 | Journal article
Part of ISSN: 0092-8674
EID:

2-s2.0-85100708422

Part of ISSN: 26928205
EID:

2-s2.0-85103368842

Part of ISSN: 10974172 00928674
Source: Self-asserted source
Elad Binshtein
grade
Preferred source (of 3)‎

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

bioRxiv
2020 | Other
EID:

2-s2.0-85102723537

Part of ISSN: 26928205
Contributors: Zost, S.J.; Gilchuk, P.; Case, J.B.; Binshtein, E.; Chen, R.E.; Reidy, J.X.; Trivette, A.; Nargi, R.S.; Sutton, R.E.; Suryadevara, N. et al.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Cell
2020-12 | Journal article
Contributors: Lauren E. Williamson; Theron Gilliland, Jr.; Pramod K. Yadav; Elad Binshtein; Robin Bombardi; Nurgun Kose; Rachel S. Nargi; Rachel E. Sutton; Clarissa L. Durie; Erica Armstrong et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition

2020-09-10 | Other
Contributors: Allison J. Greaney; Tyler N. Starr; Pavlo Gilchuk; Seth J. Zost; Elad Binshtein; Andrea N. Loes; Sarah K. Hilton; John Huddleston; Rachel Eguia; Katharine H.D. Crawford et al.
Source: check_circle
Crossref
grade
Preferred source (of 6)‎

Potently neutralizing and protective human antibodies against SARS-CoV-2

Nature
2020-08-20 | Journal article
Contributors: Seth J. Zost; Pavlo Gilchuk; James Brett Case; Elad Binshtein; Rita E. Chen; Joseph P. Nkolola; Alexandra Schäfer; Joseph X. Reidy; Andrew Trivette; Rachel S. Nargi et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

Nature Medicine
2020-07-10 | Journal article
Part of ISSN: 1078-8956
Part of ISSN: 1546-170X
EID:

2-s2.0-85102605745

Part of ISSN: 26928205
EID:

2-s2.0-85087684502

Source: Self-asserted source
Elad Binshtein
grade
Preferred source (of 3)‎

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

2020-06-05 | Preprint
Contributors: Bing Han; Jason C. Porta; Jessica L. Hanks; Yelena Peskova; Elad Binshtein; Kelly Dryden; Derek P. Claxton; Hassane S. Mchaourab; Erkan Karakas; Melanie D. Ohi et al.
Source: check_circle
Crossref
grade
Preferred source (of 5)‎

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes

Structure
2020-04 | Journal article
EID:

2-s2.0-85095555528

Part of ISSN: 26928205
Part of ISSN: 0969-2126
EID:

2-s2.0-85082696295

Part of ISSN: 18784186 09692126
Source: Self-asserted source
Elad Binshtein
grade
Preferred source (of 3)‎

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

Immunity
2018 | Journal article
EID:

2-s2.0-85053075312

Contributors: Gilchuk, P.; Kuzmina, N.; Ilinykh, P.A.; Huang, K.; Gunn, B.M.; Bryan, A.; Davidson, E.; Doranz, B.J.; Turner, H.L.; Fusco, M.L. et al.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins

PLOS Pathogens
2018-02-22 | Journal article
Contributors: Jarrod J. Mousa; Kanta Subbarao; Elad Binshtein; Stacey Human; Rachel H. Fong; Gabriela Alvarado; Benjamin J. Doranz; Martin L. Moore; Melanie D. Ohi; James E. Crowe
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Crossref
grade
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While the revolution will not be crystallized, biochemistry reigns supreme

Protein Science
2017 | Journal article
EID:

2-s2.0-84990834238

Contributors: Takizawa, Y.; Binshtein, E.; Erwin, A.L.; Pyburn, T.M.; Mittendorf, K.F.; Ohi, M.D.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Cryo-electron microscopy and the amazing race to atomic resolution

Biochemistry
2015 | Journal article
EID:

2-s2.0-84930646533

Contributors: Binshtein, E.; Ohi, M.D.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Glyoxylate carboligase: A unique thiamin diphosphate-dependent enzyme that can cycle between the 4′-aminopyrimidinium and 1′,4′- iminopyrimidine tautomeric forms in the absence of the conserved glutamate

Biochemistry
2012 | Journal article
EID:

2-s2.0-84867456040

Contributors: Nemeria, N.; Binshtein, E.; Patel, H.; Balakrishnan, A.; Vered, I.; Shaanan, B.; Barak, Z.; Chipman, D.; Jordan, F.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Origin of the specificities of acetohydroxyacid synthases and glyoxylate carboligase

Journal of Molecular Catalysis B: Enzymatic
2009 | Journal article
EID:

2-s2.0-70349499352

Contributors: Chipman, D.M.; Barak, Z.; Shaanan, B.; Vyazmensky, M.; Binshtein, E.; Belenky, I.; Temam, V.; Steinmetz, A.; Golbik, R.; Tittmann, K.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier

Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes

Nature Chemical Biology
2008 | Journal article
EID:

2-s2.0-38349004540

Contributors: Kaplun, A.; Binshtein, E.; Vyazmensky, M.; Steinmetz, A.; Barak, Z.; Chipman, D.M.; Tittmann, K.; Shaanan, B.
Source: Self-asserted source
Elad Binshtein via Scopus - Elsevier