Maria B. Asparuhova (0000-0003-2773-1324)

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PD Dr. Maria B. Asparuhova is head of the Laboratory of Oral Cell Biology and lecturer at the School of Dental Medicine, University of Bern, Switzerland since 2016. Dr. Asparuhova has received her Master of Science degree in Molecular Biology and Biochemistry at the University of Sofia, Bulgaria, her PhD degree in Cellular and Biomedical Sciences from the Faculty of Science, University of Bern, Switzerland, and a habilitation in Biomedical Sciences from the Faculty of Medicine, University of Bern, Switzerland. After a postdoctoral training in the Laboratory of Prof. Dr. D. Schümperli (University of Bern) in the field of RNA-based therapeutics for viral and genetic diseases, she spent 8 years working as a Senior Scientist in cancer research at the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland (affiliated with the Novartis Institutes for Biomedical Research and the University of Basel).
Currently, PD Dr. Asparuhova leads her own research group in the field of regenerative medicine. Her laboratory performs research for two departments, the Department of Oral Surgery and Stomatology, chaired by Prof. Dr. V. Chappuis and the Department of Periodontology, chaired by Prof. Dr. A. Sculean. Dr. Asparuhova's research answers mechanistic questions related to oral hard and soft tissue regeneration including functional characterization of autogenous bone, extraction socket soft tissue, connective tissue grafts, bioactive substances and regenerative materials. The Laboratory of Oral Cell Biology has attracted considerable peer-reviewed funding and has published a number of high-impact publications in the fields of periodontology and implant dentistry.

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University of Bern: Bern, CH

2016 to present | Research Group Leader (Department of Periodontology and Department of Oral Surgery and Stomatology)

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Maria B. Asparuhova

https://orcid.org/0000-0003-2773-1324

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University of Bern: Bern, CH

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University of Bern: Bern, CH

Professional activities (1)

University of Bern: Bern, CH

Works (22)

Biofunctionalization of Collagen Barrier Membranes with Bone-Conditioned Medium, as a Natural Source of Growth Factors, Enhances Osteoblastic Cell Behavior

Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

Local Concentrations of TGF-β1 and IGF-1 Appear Determinant in Regulating Bone Regeneration in Human Postextraction Tooth Sockets

The Biologic Power of Autogenous Bone Grafts

Positive Effects of Three-Dimensional Collagen-Based Matrices on the Behavior of Osteoprogenitors.

A Novel Volume-Stable Collagen Matrix Induces Changes in the Behavior of Primary Human Oral Fibroblasts, Periodontal Ligament, and Endothelial Cells

Cellular responses to deproteinized bovine bone mineral biofunctionalized with bone-conditioned medium

Enhanced Wound Healing Potential of Primary Human Oral Fibroblasts and Periodontal Ligament Cells Cultured on Four Different Porcine-Derived Collagen Matrices

Adsorption and Release of Growth Factors from Four Different Porcine-Derived Collagen Matrices

Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts.

Activity of two hyaluronan preparations on primary human oral fibroblasts

Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity.

Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling.

SAP domain-dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients.

The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress.

Megakaryoblastic leukemia protein-1 (MKL1): Increasing evidence for an involvement in cancer progression and metastasis.

Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress.

Development and characterization of a triple combination gene therapy vector inhibiting HIV-1 multiplication.

Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping.

Antisense derivatives of U7 and other small nuclear RNAs as tools to modify pre-mRNA splicing patterns

Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A.