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ResearcherID: B-4795-2010
Scopus Author ID: 7401677810

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Employment (4)

National Institute of Environmental Health Sciences: Durham, NC, US

2018-08-07 to present | Senior Principal Investigator (Reproductive Developmental Biology Laboratory)
Employment
Source: Self-asserted source
Hung-Chang Humphrey Yao

National Institute of Environmental Health Sciences: Durham, NC, US

2010-08-09 to present | Principal Investigator (Reproductive Developmental Biology Laboratory)
Employment
Source: Self-asserted source
Hung-Chang Humphrey Yao

University of Illinois System: Urbana, IL, US

2009-07-07 to 2010-08-07 | Associate Professor (Comparative Biosciences)
Employment
Source: Self-asserted source
Hung-Chang Humphrey Yao

University of Illinois System: Urbana, IL, US

2003-01-03 to 2009-07-06 | Assistant Professor (Comparative Biosciences)
Employment
Source: Self-asserted source
Hung-Chang Humphrey Yao

Education and qualifications (4)

Duke University: Durham, NC, US

2000-01-03 to 2002-12-10 | Postdoctoral Fellow (Cell Biology)
Education
Source: Self-asserted source
Hung-Chang Humphrey Yao

University of Illinois System: Urbana, IL, US

1996-11-13 to 1999-11-15 | Ph.D. (Animal Sciences)
Education
Source: Self-asserted source
Hung-Chang Humphrey Yao

University of Illinois System: Urbana, IL, US

1994-08-19 to 1996-11-13 | M.S. (Animal Sciences)
Education
Source: Self-asserted source
Hung-Chang Humphrey Yao

Fu Jen Catholic University: Taipei, TW

1985-09-03 to 1989-06-06 | B.S. (Biology)
Education
Source: Self-asserted source
Hung-Chang Humphrey Yao

Funding (4)

Novel Methods to Assess Effects of Bisphenol A (BPA) & Phthalates on Child Development

2010-02-15 to 2014-02-14 | Grant
Environmental Protection Agency (Washington, US)
URL: https://grants.uberresearch.com/501100001589/R834593/Novel-Methods-to-Assess-Effects-of-Bisphenol-A-BPA-Phthalates-on-Child-Development
GRANT_NUMBER: R834593
Source: Self-asserted source
Hung-Chang Humphrey Yao via DimensionsWizard

Cell Fate Determination in Fetal Testes

2009-09-30 to 2010-08-31 | Grant
National Institute of Child Health and Human Development (Bethesda, US)
GRANT_NUMBER:

R01HD059961
Source: Self-asserted source
Hung-Chang Humphrey Yao

Unveil a Novel Pathway in Mammalian Ovary Development

2005-01-01 to 2010-11-30 | Grant
National Institute of Child Health and Human Development (Bethesda, US)
URL: https://grants.uberresearch.com/100000071/R01HD046861/Unveil-a-Novel-Pathway-in-Mammalian-Ovary-Development
GRANT_NUMBER: 5R01HD046861-05
Source: Self-asserted source
Hung-Chang Humphrey Yao via DimensionsWizard
grade
Preferred source (of 2)‎

Impacts of Genetic and Environmental Factors on Reproductive Organ Development

Source: Self-asserted source
Hung-Chang Humphrey Yao via DimensionsWizard

Works (50 of 79)

Items per page:
Page 1 of 2

Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

eLife
2025-03-10 | Journal article
DOI: 10.7554/eLife.96591
Contributors: Adriana K Alexander; Karina F Rodriguez; Yu-Ying Chen; Ciro Amato; Martin A Estermann; Barbara Nicol; Xin Xu; Humphrey HC Yao
Source: check_circle
Crossref

Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

eLife
2025-03-10 | Journal article
DOI: 10.7554/eLife.96591.3
Contributors: Adriana K Alexander; Karina F Rodriguez; Yu-Ying Chen; Ciro Amato; Martin A Estermann; Barbara Nicol; Xin Xu; Humphrey HC Yao
Source: check_circle
Crossref

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

2025-01-29 | Preprint
DOI: 10.7554/eLife.96591.2
Contributors: Adriana K Alexander; Karina F Rodriguez; Yu-Ying Chen; Ciro M Amato; Martin A Estermann; Barbara Nicol; Xin Xu; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Generation of a Nr2f2-driven inducible Cre mouse to target interstitial cells in the reproductive system

2025-01-22 | Preprint
DOI: 10.1101/2025.01.22.634276
Contributors: Paula R Brown; Martin A Estermann; Artiom Gruzdev; Gregory J Scott; Thomas B Hagler; Manas K Ray; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

An extragenital cell population contributes to urethra closure during mouse penis development

Science Advances
2024-12-06 | Journal article
DOI: 10.1126/sciadv.adp0673
Contributors: Ciro Maurizio Amato; Xin Xu; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Characterization of urethra closure in female neonatal mice at histological and molecular levels

Reproduction
2024-08-27 | Journal article
DOI: 10.1530/REP-24-0239
Contributors: Abigail S Kitakule; Ciro M Amato; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

2024-05-21 | Preprint
DOI: 10.7554/eLife.96591.1
Contributors: Adriana K. Alexander; Karina F. Rodriguez; Yu-Ying Chen; Ciro M. Amato; Martin A. Estermann; Xin Xu; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

2024-02-21 | Preprint
DOI: 10.1101/2024.02.19.581036
Contributors: Adriana K. Alexander; Karina F. Rodriguez; Yu-Ying Chen; Ciro M. Amato; Martin A. Estermann; Barbara Nicol; Xin Xu; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

New uses for an old technique: live imaging on the slice organ culture to study reproductive processes

2024-02-03 | Other
DOI: 10.1093/biolre/ioae023
Contributors: Humphrey H.-C. Yao; Ciro Maurizio Amato
Source: check_circle
Crossref

An extra-genital cell population contributes to urethra closure during mouse penis development

2023-11-11 | Preprint
DOI: 10.1101/2023.11.09.564741
Contributors: Ciro Maurizio Amato; Xin Xu; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract

PNAS Nexus
2022-09-01 | Journal article
DOI: 10.1093/pnasnexus/pgac182
Contributors: Fei Zhao; Sara A Grimm; Shua Jia; Humphrey Hung-Chang Yao; Marisa Bartolomei
Source: check_circle
Crossref

Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B

Nature Communications
2022-07-15 | Journal article
DOI: 10.1038/s41467-022-31486-y
Contributors: Karina F. Rodriguez; Paula R. Brown; Ciro M. Amato; Barbara Nicol; Chia-Feng Liu; Xin Xu; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Contribution of the Wolffian duct mesenchyme to the formation of the female reproductive tract

2022-02-18 | Preprint
DOI: 10.1101/2022.02.16.480738
Contributors: Fei Zhao; Sara A Grimm; Shua Jia; Humphrey Hung-Chang Yao
Source: check_circle
Crossref

Constitutive expression of Steroidogenic factor‐1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice

The FASEB Journal
2021-08 | Journal article
DOI: 10.1096/fj.202100304R
Contributors: Emmi Rotgers; Barbara Nicol; Karina Rodriguez; Saniya Rattan; Jodi A. Flaws; Humphrey Hung‐Chang Yao
Source: check_circle
Crossref

Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads

Development
2020-03-15 | Journal article
DOI: 10.1242/dev.183814
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Increased FOXL2 Expression Alters Uterine Structures and Functions

2020-03-07 | Preprint
DOI: 10.1101/2020.03.06.981266
Contributors: Rong Li; San-Pin Wu; Lecong Zhou; Barbara Nicol; John P. Lydon; Humphrey H-C Yao; Francesco J. DeMayo
Source: check_circle
Crossref

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

Nature Communications
2019-12 | Journal article
DOI: 10.1038/s41467-019-13060-1
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

A tale of two tracts: history, current advances, and future directions of research on sexual differentiation of reproductive tracts†

Biology of Reproduction
2019-09-01 | Journal article
DOI: 10.1093/biolre/ioz079
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Patterns, Profiles, and Parsimony: dissecting transcriptional signatures from minimal single-cell RNA-seq output with SALSA

2019-02-28 | Other
DOI: 10.1101/551762
Contributors: Oswaldo A. Lozoya; Kathryn S. McClelland; Brian Papas; Jian-Liang Li; Humphrey H-C Yao
Source: check_circle
Crossref

At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad

Endocrine Reviews
2018 | Journal article
DOI: 10.1210/er.2018-00010
WOSUID:

WOS:000448057900009
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Reproductive, Physiological, and Molecular Outcomes in Female Mice Deficient in Dhh and Ihh

Endocrinology
2018 | Journal article
DOI: 10.1210/en.2018-00095
WOSUID:

WOS:000438614000008
Contributors: Liu, Chang; Rodriguez, Karina F.; Brown, Paula R.; Yao, Humphrey H. -C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via ResearcherID

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis

Scientific Reports
2018-12 | Journal article
DOI: 10.1038/s41598-018-27843-x
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 3)‎

Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads

Human Molecular Genetics
2018-12-15 | Journal article
DOI: 10.1093/hmg/ddy312
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

A new mouse line for cell ablation by diphtheria toxin subunit A controlled by a Cre-dependent FLEx switch

Genesis
2017 | Journal article
DOI: 10.1002/dvg.23067
Part of WOSUID:

WOS:000413344300001
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Cell-based computational model of early ovarian development in mice

Biology of Reproduction
2017 | Journal article
Part of DOI: 10.1093/biolre/iox089
WOSUID:

WOS:000414584000004
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Leveraging Online Resources to Prioritize Candidate Genes for Functional Analyses: Using the Fetal Testis as a Test Case

Sexual Development
2017 | Journal article
DOI: 10.1159/000455113
WOSUID:

WOS:000395907200001
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice

Toxicological Sciences
2017 | Journal article
DOI: 10.1093/toxsci/kfx019
WOSUID:

WOS:000402861100003
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice

Science
2017-08-18 | Journal article
DOI: 10.1126/science.aai9136
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Effects of in utero exposure to arsenic during the second half of gestation on reproductive end points and metabolic parameters in female CD-1 mice

Environmental Health Perspectives
2016 | Journal article
DOI: 10.1289/ehp.1509703
EID:

2-s2.0-84959266402
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Response to “comment on ‘effects of in utero exposure to arsenic during the second half of gestation on reproductive end points and metabolic parameters in female CD-1 Mice’”

Environmental Health Perspectives
2016 | Journal article
DOI: 10.1289/ehp.1511181
EID:

2-s2.0-84959274716
Contributors: Rodriguez, K.F.; Ungewitter, E.K.; Crespo-Mejias, Y.; Liu, C.; Nicol, B.; Kissling, G.E.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Transcription Factor GLIS3: A New and Critical Regulator of Postnatal Stages of Mouse Spermatogenesis

Stem Cells
2016 | Journal article
DOI: 10.1002/stem.2449
WOSUID:

WOS:000387034000014
Contributors: Kang, Hong Soon; Chen, Liang-Yu; Lichti-Kaiser, Kristin; Liao, Grace; Gerrish, Kevin; Bortner, Carl D.; Yao, Humphrey H. -C.; Eddy, Edward M.; Jetten, Anton M.
Source: Self-asserted source
Hung-Chang Humphrey Yao via ResearcherID

Mapping lineage progression of somatic progenitor cells in the mouse fetal testis

Development
2016-10-15 | Journal article
DOI: 10.1242/dev.135756
Source: Self-asserted source
Hung-Chang Humphrey Yao
grade
Preferred source (of 2)‎

Gonadal identity in the absence of pro-testis factor SOX9 and pro-ovary factor beta-catenin in mice

Biology of Reproduction
2015 | Journal article
DOI: 10.1095/biolreprod.115.131276
EID:

2-s2.0-84941559891
Contributors: Nicol, B.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier
grade
Preferred source (of 2)‎

Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells

Nature Communications
2015 | Journal article
DOI: 10.1038/ncomms7934
EID:

2-s2.0-84928974874
Contributors: Liu, C.; Peng, J.; Matzuk, M.M.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Building an ovary: Insights into establishment of somatic cell lineages in the mouse

Sexual Development
2014 | Journal article
DOI: 10.1159/000358072
EID:

2-s2.0-84925343191
Contributors: Nicol, B.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Loss of Smad4 in sertoli and leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice

Biology of Reproduction
2014 | Journal article
DOI: 10.1095/biolreprod.113.111393
EID:

2-s2.0-84899905846
Contributors: Archambeault, D.R.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Dynamic changes in fetal Leydig cell populations influence adult Leydig cell populations in mice

FASEB Journal
2013 | Journal article
DOI: 10.1096/fj.12-225060
EID:

2-s2.0-84879643328
Contributors: Barsoum, I.B.; Kaur, J.; Ge, R.S.; Cooke, P.S.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

A Transcriptome-Wide Screen for mRNAs Enriched in Fetal Leydig Cells: CRHR1 Agonism Stimulates Rat and Mouse Fetal Testis Steroidogenesis

PLoS ONE
2012 | Journal article
DOI: 10.1371/journal.pone.0047359
EID:

2-s2.0-84868146597
Contributors: McDowell, E.N.; Kisielewski, A.E.; Pike, J.W.; Franco, H.L.; Yao, H.-C.; Johnson, K.J.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

How to make a gonad: Cellular mechanisms governing formation of the testes and ovaries

Sexual Development
2012 | Journal article
DOI: 10.1159/000338612
EID:

2-s2.0-84871195155
Contributors: Ungewitter, E.K.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Investigating the origins of somatic cell populations in the perinatal mouse ovaries using genetic lineage tracing and immunohistochemistry

Methods in Molecular Biology
2012 | Book
DOI: 10.1007/978-1-61779-436-0_16
EID:

2-s2.0-84862964910
Contributors: Liu, C.; Paczkowski, M.; Othman, M.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice

Molecular and Cellular Endocrinology
2012 | Journal article
DOI: 10.1016/j.mce.2012.04.004
EID:

2-s2.0-84864335369
Contributors: Huang, C.C.J.; Liu, C.; Yao, H.H.C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Sex and hedgehog: Roles of genes in the hedgehog signaling pathway in mammalian sexual differentiation

Chromosome Research
2012 | Journal article
DOI: 10.1007/s10577-011-9254-z
EID:

2-s2.0-84857305662
Contributors: Franco, H.L.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells

Biology of Reproduction
2011 | Journal article
DOI: 10.1095/biolreprod.110.088997
EID:

2-s2.0-79956278061
Contributors: Barsoum, I.; Yao, H.H.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Testicular somatic cells, not gonocytes, are the major source of functional activin a during testis morphogenesis

Endocrinology
2011 | Journal article
DOI: 10.1210/en.2011-1288
EID:

2-s2.0-80054961912
Contributors: Archambeault, D.R.; Tomaszewski, J.; Childs, A.J.; Anderson, R.A.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion

Proceedings of the National Academy of Sciences of the United States of America
2010 | Journal article
DOI: 10.1073/pnas.1000318107
EID:

2-s2.0-77953740874
Contributors: Archambeault, D.R.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Building pathways for ovary organogenesis in the mouse embryo

Current Topics in Developmental Biology
2010 | Book
DOI: 10.1016/S0070-2153(10)90007-0
EID:

2-s2.0-77955322829
Contributors: Liu, C.-F.; Liu, C.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro

Toxicology and Applied Pharmacology
2010 | Journal article
DOI: 10.1016/j.taap.2009.10.011
EID:

2-s2.0-71049151925
Contributors: Gupta, R.K.; Singh, J.M.; Leslie, T.C.; Meachum, S.; Flaws, J.A.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Diverse functions of hedgehog signaling in formation and physiology of steroidogenic organs

Molecular Reproduction and Development
2010 | Journal article
DOI: 10.1002/mrd.21174
EID:

2-s2.0-77954477962
Contributors: Huang, C.-C.J.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Fetal Leydig cells: Progenitor cell maintenance and differentiation

Journal of Andrology
2010 | Journal article
DOI: 10.2164/jandrol.109.008318
EID:

2-s2.0-77749246519
Contributors: Barsoum, I.B.; Yao, H.H.-C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier

Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary

BMC Developmental Biology
2010 | Journal article
DOI: 10.1186/1471-213X-10-66
EID:

2-s2.0-77953320735
Contributors: Huang, C.-C.J.; Yao, H.H.C.
Source: Self-asserted source
Hung-Chang Humphrey Yao via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (17 reviews for 8 publications/grants)

Review activity for Biology of reproduction. (3)
Review activity for BMC biology. (1)
Review activity for Cell research (1)
Review activity for eLife (1)
Review activity for Endocrinology (2)
Review activity for Nature (2)
Review activity for Nature communications (4)
Review activity for PLoS biology. (3)
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