Personal information

Keywords

Organic Chemistry, Medicinal Chemistry, Chemical Biology, Bioorganic Chemistry

Biography

Professor
Department of Chemistry
University of South Florida

Activities

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Employment (1)

University of South Florida: Tampa, US

2009-06-01 to present | Professor (Chemistry)
Employment
Source: Self-asserted source
Jianfeng Cai

Education and qualifications (3)

Yale University: New Haven, CT, US

2007-06-01 to 2009-05-31 | Postdoc. (Chemistry)
Education
Source: Self-asserted source
Jianfeng Cai

Washington University in St. Louis: MO, MO, US

2002-08-01 to 2006-10-30 | Ph.D. (Chemistry)
Education
Source: Self-asserted source
Jianfeng Cai

Nanjing University: Nanjing, Jiangsu, CN

1993-09-01 to 2000-06-30 | BS. and MS. (Chemistry)
Education
Source: Self-asserted source
Jianfeng Cai

Works (48)

Cationic Catalysts as a New Strategy to Catalyze N-Carboxyanhydrides Polymerization

ACS Central Science
2025-03-26 | Journal article
DOI: 10.1021/acscentsci.4c01926
Contributors: Haohui Ye; Jianfeng Cai
Source: check_circle
Crossref

Recent exploration of γ-AApeptide based antimicrobial peptide mimics as potential therapeutics towards drug-resistant bacteria

Exploration of Drug Science
2025-02-19 | Journal article
DOI: 10.37349/eds.2025.100888
Contributors: Jarais Fontaine; Jianfeng Cai
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Crossref

Development of Low‐Toxicity Antimicrobial Polycarbonates Bearing Lysine Residues.

Chemistry – A European Journal
2024-11-04 | Journal article
DOI: 10.1002/chem.202402302
Contributors: Ruixuan Gao; Menglin Xue; Ning Shen; Xue Zhao; Justin C. Zhang; Chuanhai Cao; Jianfeng Cai
Source: check_circle
Crossref

Imidazole‐Rich, Four‐Armed Host‐Defense Peptidomimetics as Promising Narrow‐Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections

Advanced Healthcare Materials
2024-10 | Journal article
DOI: 10.1002/adhm.202400664
Contributors: Yuwei Zheng; Jiaying Chi; Jiayu Ou; Ling Jiang; Liqing Wang; Rui Luo; Yilang Yan; Zejun Xu; Tingting Peng; Jianfeng Cai et al.
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Crossref

Antimicrobial Guanidinylate Polycarbonates Show Oral In Vivo Efficacy Against Clostridioides Difficile

Advanced Healthcare Materials
2024-06 | Journal article
DOI: 10.1002/adhm.202303295
Contributors: Menglin Xue; Soumyadeep Chakraborty; Ruixuan Gao; Shaohui Wang; Meng Gu; Ning Shen; Lulu Wei; Chuanhai Cao; Xingmin Sun; Jianfeng Cai
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Crossref

Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity

Journal of Medicinal Chemistry
2023-09-28 | Journal article
DOI: 10.1021/acs.jmedchem.3c01412
Contributors: Songyi Xue; Wei Xu; Lei Wang; Ling Xu; Laurent Calcul; Peng Teng; Lu Lu; Shibo Jiang; Jianfeng Cai
Source: check_circle
Crossref

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

ACS Applied Materials & Interfaces
2023-09-13 | Journal article
DOI: 10.1021/acsami.3c06394
Contributors: Ali Azmy; Xue Zhao; Giasemi K. Angeli; Claire Welton; Parth Raval; Lukasz Wojtas; Nourdine Zibouche; G. N. Manjunatha Reddy; Pantelis N. Trikalitis; Jianfeng Cai et al.
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Crossref

Development of the Safe and Broad‐Spectrum Aldehyde and Ketoamide Mpro inhibitors Derived from the Constrained α, γ‐AA Peptide Scaffold

Chemistry – A European Journal
2023-06-22 | Journal article
DOI: 10.1002/chem.202300476
Contributors: Lei Wang; Chunlong Ma; Michael Dominic Sacco; Songyi Xue; Mentalla Mahmoud; Laurent Calcul; Yu Chen; Jun Wang; Jianfeng Cai
Source: check_circle
Crossref

Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy To Combat Bacterial Resistance

Journal of Medicinal Chemistry
2023-02-23 | Journal article
DOI: 10.1021/acs.jmedchem.2c00757
Contributors: Peng Teng; Haodong Shao; Bo Huang; Junqiu Xie; Sunliang Cui; Kairong Wang; Jianfeng Cai
Source: check_circle
Crossref

Novel Feleucin-K3-Derived Peptides Modified with Sulfono-γ-AA Building Blocks Targeting Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus Infections

Journal of Medicinal Chemistry
2023-01-26 | Journal article
DOI: 10.1021/acs.jmedchem.2c01396
Contributors: Xiaomin Guo; Tiantian Yan; Jing Rao; Yingying An; Xin Yue; Xiaokang Miao; Rui Wang; Wangsheng Sun; Jianfeng Cai; Junqiu Xie
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Crossref

Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix

Journal of Medicinal Chemistry
2023-01-12 | Journal article
DOI: 10.1021/acs.jmedchem.2c01459
Contributors: Li Zhou; In Ho Jeong; Songyi Xue; Menglin Xue; Lei Wang; Sihao Li; Ruochuan Liu; Geon Ho Jeong; Xiaoyu Wang; Jianfeng Cai et al.
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Crossref

Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

ACS Applied Materials & Interfaces
2023-01-11 | Journal article
DOI: 10.1021/acsami.2c19904
Contributors: Xueying Ge; Fangchao Jiang; Minghui Wang; Meng Chen; Yiming Li; Joshua Phipps; Jianfeng Cai; Jin Xie; Jane Ong; Viktor Dubovoy et al.
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Crossref

Development of SOS1 Inhibitor-Based Degraders to Target KRAS-Mutant Colorectal Cancer

Journal of Medicinal Chemistry
2022-12-22 | Journal article
DOI: 10.1021/acs.jmedchem.2c01300
Contributors: Yujia Bian; Diego Alem; Francisca Beato; Tara L. Hogenson; Xinrui Yang; Kun Jiang; Jianfeng Cai; Wen Wee Ma; Martin Fernandez-Zapico; Aik Choon Tan et al.
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Crossref

Sulfono‐γ‐AApeptides as Protein Helical Domain Mimetics to Manipulate the Angiogenesis

ChemBioChem
2022-11-18 | Journal article
DOI: 10.1002/cbic.202200298
Contributors: Songyi Xue; Lei Wang; Jianfeng Cai
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Crossref

Development of Lipo-γ-AA Peptides as Potent Antifungal Agents

Journal of Medicinal Chemistry
2022-06-09 | Journal article
DOI: 10.1021/acs.jmedchem.2c00595
Contributors: Xing Zhang; Minghui Wang; Xiaodi Zhu; Yan Peng; Tiwei Fu; Chang-Hua Hu; Jianfeng Cai; Guojian Liao
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Crossref

A Perfect Pair: Stabilized Black Phosphorous Nanosheets Engineering with Antimicrobial Peptides for Robust Multidrug Resistant Bacteria Eradication

Advanced Healthcare Materials
2022-05 | Journal article
DOI: 10.1002/adhm.202101846
Contributors: Jintao Fu; Ting Liu; Xiaoqian Feng; Yixian Zhou; Minglong Chen; Wenhao Wang; Yiting Zhao; Chao Lu; Guilan Quan; Jianfeng Cai et al.
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Crossref

Using proteomimetics to switch angiogenic signaling

Acta Pharmaceutica Sinica B
2022-03 | Journal article
DOI: 10.1016/j.apsb.2022.01.016
Contributors: Peng Teng; Jianfeng Cai
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Modulating Angiogenesis by Proteomimetics of Vascular Endothelial Growth Factor

Journal of the American Chemical Society
2022-01-12 | Journal article
DOI: 10.1021/jacs.1c09571
Contributors: Sami Abdulkadir; Chunpu Li; Wei Jiang; Xue Zhao; Peng Sang; Lulu Wei; Yong Hu; Qi Li; Jianfeng Cai
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Crossref

Poly(l-ornithine)-Grafted Zinc Phthalocyanines as Dual-Functional Antimicrobial Agents with Intrinsic Membrane Damage and Photothermal Ablation Capacity

ACS Infectious Diseases
2021-10-08 | Journal article
DOI: 10.1021/acsinfecdis.1c00392
Contributors: Maochao Zheng; Huanchang Lin; Wancong Zhang; Shijie Tang; Daojun Liu; Jianfeng Cai
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Crossref

Peptidomimetic-based antibody surrogate for HER2

Acta Pharmaceutica Sinica B
2021-09 | Journal article
DOI: 10.1016/j.apsb.2021.04.016
Contributors: Mengmeng Zheng; Chunpu Li; Mi Zhou; Ru Jia; Fengyu She; Lulu Wei; Feng Cheng; Qi Li; Jianfeng Cai; Yan Wang
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Crossref

Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives

Bioactive Materials
2021-07 | Journal article
DOI: 10.1016/j.bioactmat.2020.12.001
Contributors: Maochao Zheng; Miao Pan; Wancong Zhang; Huanchang Lin; Shenlang Wu; Chao Lu; Shijie Tang; Daojun Liu; Jianfeng Cai
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Crossref

Discovery of α-Helix-Mimicking Sulfono-γ-AApeptides as p53−MDM2 Inhibitors

Future Medicinal Chemistry
2021-06 | Journal article
DOI: 10.4155/fmc-2021-0044
Contributors: Yan Shi; Peng Sang; Jianfeng Cai
Source: check_circle
Crossref

Introduction to Antibacterial Biomaterials

Biomaterials Science
2020 | Journal article
DOI: 10.1039/D0BM90100H
Contributors: Jianfeng Cai; Runhui Liu
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Crossref

Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents

Journal of Medicinal Chemistry
2020-12-24 | Journal article
DOI: 10.1021/acs.jmedchem.0c00171
Contributors: Minghui Wang; Ruixuan Gao; Mengmeng Zheng; Peng Sang; Chunpu Li; En Zhang; Qi Li; Jianfeng Cai
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Crossref

Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein–Protein Interactions

Journal of Medicinal Chemistry
2020-11-12 | Journal article
DOI: 10.1021/acs.jmedchem.0c01638
Contributors: Yan Shi; Peng Sang; Junhao Lu; Pirada Higbee; Lihong Chen; Leixiang Yang; Timothy Odom; Gary Daughdrill; Jiandong Chen; Jianfeng Cai
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Crossref

Unnatural Amino‐Acid‐Based Star‐Shaped Poly(l‐Ornithine)s as Emerging Long‐Term and Biofilm‐Disrupting Antimicrobial Peptides to Treat Pseudomonas aeruginosa‐Infected Burn Wounds

Advanced Healthcare Materials
2020-10 | Journal article
DOI: 10.1002/adhm.202000647
Contributors: Miao Pan; Chao Lu; Maochao Zheng; Wen Zhou; Fuling Song; Weidong Chen; Fen Yao; Daojun Liu; Jianfeng Cai
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Crossref

Sulfono-γ-AApeptides as Helical Mimetics: Crystal Structures and Applications

Accounts of Chemical Research
2020-10-20 | Journal article
DOI: 10.1021/acs.accounts.0c00482
Contributors: Peng Sang; Yan Shi; Bo Huang; Songyi Xue; Timothy Odom; Jianfeng Cai
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Crossref

Rational Design and Synthesis of Right-Handed d-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein–Protein Interactions

The Journal of Organic Chemistry
2020-08-21 | Journal article
DOI: 10.1021/acs.joc.0c00996
Contributors: Peng Sang; Yan Shi; Pirada Higbee; Minghui Wang; Sami Abdulkadir; Junhao Lu; Gary Daughdrill; Jiandong Chen; Jianfeng Cai
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Crossref

The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1

Science Advances
2020-05-15 | Journal article
DOI: 10.1126/sciadv.aaz4988
Contributors: Peng Sang; Zhihong Zhou; Yan Shi; Candy Lee; Zaid Amso; David Huang; Timothy Odom; Vân T.B. Nguyen-Tran; Weijun Shen; Jianfeng Cai
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Crossref

Small Molecules with Membrane-Active Antibacterial Activity

ACS Applied Materials & Interfaces
2020-05-13 | Journal article
DOI: 10.1021/acsami.9b20161
Contributors: Mi Zhou; Mengmeng Zheng; Jianfeng Cai
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Crossref

Structural Superiority of Guanidinium-Rich, Four-Armed Copolypeptides: Role of Multiple Peptide–Membrane Interactions in Enhancing Bacterial Membrane Perturbation and Permeability

ACS Applied Materials & Interfaces
2020-04-22 | Journal article
DOI: 10.1021/acsami.0c02752
Contributors: Jing Wang; Chao Lu; Yin Shi; Xiaoqian Feng; Biyuan Wu; Guilin Zhou; Guilan Quan; Xin Pan; Jianfeng Cai; Chuanbin Wu
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Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC00857H
Contributors: Wenchao Chu; Yi Yang; Shangshang Qin; Jianfeng Cai; Mengmeng Bai; Hongtao Kong; En Zhang
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Crossref

The Activity of Small Urea‐γ‐AApeptides Toward Gram‐Positive Bacteria

ChemMedChem
2019-12-04 | Journal article
DOI: 10.1002/cmdc.201900520
Contributors: Ma Su; Yan Shi; Minghui Wang; Ruixuan Gao; Jianfeng Wu; Hai Xu; Chuanwu Xi; Jianfeng Cai
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Synthesis and Bioactivities of New Membrane-Active Agents with Aromatic Linker: High Selectivity and Broad-Spectrum Antibacterial Activity

ACS Infectious Diseases
2019-09-13 | Journal article
DOI: 10.1021/acsinfecdis.9b00078
Contributors: Wenchao Chu; Yi Yang; Jianfeng Cai; Hongtao Kong; Mengmeng Bai; Xiangjing Fu; Shangshang Qin; En Zhang
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Crossref

Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

Angewandte Chemie
2019-06-03 | Journal article
DOI: 10.1002/ange.201903259
Contributors: Peng Teng; Geoffrey M. Gray; Mengmeng Zheng; Sylvia Singh; Xiaopeng Li; Lukasz Wojtas; Arjan van der Vaart; Jianfeng Cai
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Orthogonal Halogen‐Bonding‐Driven 3D Supramolecular Assembly of Right‐Handed Synthetic Helical Peptides

Angewandte Chemie International Edition
2019-06-03 | Journal article
DOI: 10.1002/anie.201903259
Contributors: Peng Teng; Geoffrey M. Gray; Mengmeng Zheng; Sylvia Singh; Xiaopeng Li; Lukasz Wojtas; Arjan van der Vaart; Jianfeng Cai
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Crossref

Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

Proceedings of the National Academy of Sciences
2019-05-28 | Journal article
DOI: 10.1073/pnas.1819663116
Contributors: Peng Sang; Min Zhang; Yan Shi; Chunpu Li; Sami Abdulkadir; Qi Li; Haitao Ji; Jianfeng Cai
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Crossref

Cyclic Peptidomimetics as Inhibitor for miR-155 Biogenesis

Molecular Pharmaceutics
2019-02-04 | Journal article
DOI: 10.1021/acs.molpharmaceut.8b01247
Contributors: Hao Yan; Mi Zhou; Umesh Bhattarai; Yabin Song; Mengmeng Zheng; Jianfeng Cai; Fu-Sen Liang
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Sulfono-γ-AA modified peptides that inhibit HIV-1 fusion

Organic & Biomolecular Chemistry
2018 | Journal article
DOI: 10.1039/C8OB02159G
Contributors: Olapeju Bolarinwa; Meng Zhang; Erin Mulry; Min Lu; Jianfeng Cai
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Nano‐Sized Lipidated Dendrimers as Potent and Broad‐Spectrum Antibacterial Agents

Macromolecular Rapid Communications
2018-12 | Journal article
DOI: 10.1002/marc.201800622
Contributors: Mussie Gide; Alekhya Nimmagadda; Ma Su; Minghui Wang; Peng Teng; Chunpu Li; Ruixuan Gao; Hai Xu; Qi Li; Jianfeng Cai
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Crossref

Bis‐Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile

ChemMedChem
2018-07-18 | Journal article
DOI: 10.1002/cmdc.201800240
Contributors: Chunhui Li; Peng Teng; Zhong Peng; Peng Sang; Xingmin Sun; Jianfeng Cai
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Crossref

Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents

Journal of Medicinal Chemistry
2018-04-12 | Journal article
DOI: 10.1021/acs.jmedchem.7b01704
Contributors: Youhong Niu; Minghui Wang; Yafei Cao; Alekhya Nimmagadda; Jianxing Hu; Yanfen Wu; Jianfeng Cai; Xin-Shan Ye
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Crossref

Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential

Chem. Commun.
2017 | Journal article
DOI: 10.1039/C7CC07285F
Contributors: Peng Teng; Alekhya Nimmagadda; Ma Su; Yuzhu Hong; Ning Shen; Chunpu Li; Ling-Yu Tsai; Jessica Cao; Qi Li; Jianfeng Cai
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Crossref

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Journal of Medicinal Chemistry
2017-10-26 | Journal article
DOI: 10.1021/acs.jmedchem.7b00847
Contributors: Ma Su; Donglin Xia; Peng Teng; Alekhya Nimmagadda; Chao Zhang; Timothy Odom; Annie Cao; Yong Hu; Jianfeng Cai
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Supersnowflakes: Stepwise Self-Assembly and Dynamic Exchange of Rhombus Star-Shaped Supramolecules

Journal of the American Chemical Society
2017-06-21 | Journal article
DOI: 10.1021/jacs.7b01326
Contributors: Zhe Zhang; Heng Wang; Xu Wang; Yiming Li; Bo Song; Olapeju Bolarinwa; R. Alexander Reese; Tong Zhang; Xu-Qing Wang; Jianfeng Cai et al.
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Right-Handed Helical Foldamers Consisting of De Novo d-AApeptides

Journal of the American Chemical Society
2017-05-31 | Journal article
DOI: 10.1021/jacs.7b03007
Contributors: Peng Teng; Ning Ma; Darrell Cole Cerrato; Fengyu She; Timothy Odom; Xiang Wang; Li-June Ming; Arjan van der Vaart; Lukasz Wojtas; Hai Xu et al.
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Membrane Disruption Mechanism of a Prion Peptide (106–126) Investigated by Atomic Force Microscopy, Raman and Electron Paramagnetic Resonance Spectroscopy

The Journal of Physical Chemistry B
2017-05-18 | Journal article
DOI: 10.1021/acs.jpcb.7b02772
Contributors: Jianjun Pan; Prasana K. Sahoo; Annalisa Dalzini; Zahra Hayati; Chinta M. Aryal; Peng Teng; Jianfeng Cai; Humberto Rodriguez Gutierrez; Likai Song
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Structure and Function of AApeptides

Biochemistry
2017-01-24 | Journal article
DOI: 10.1021/acs.biochem.6b01132
Contributors: Olapeju Bolarinwa; Alekhya Nimmagadda; Ma Su; Jianfeng Cai
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Peer review (284 reviews for 34 publications/grants)

Review activity for Accounts of chemical research. (4)
Review activity for ACS applied bio materials. (9)
Review activity for ACS applied materials & interfaces. (25)
Review activity for ACS applied nano materials. (3)
Review activity for ACS applied polymer materials. (5)
Review activity for ACS biomaterials science & engineering. (2)
Review activity for ACS central science. (3)
Review activity for ACS chemical biology. (6)
Review activity for ACS chemical neuroscience. (1)
Review activity for ACS combinatorial science. (4)
Review activity for ACS infectious diseases. (19)
Review activity for ACS macro letters. (3)
Review activity for ACS medicinal chemistry letters. (5)
Review activity for ACS nano. (4)
Review activity for ACS omega. (25)
Review activity for ACS sustainable chemistry & engineering. (2)
Review activity for ACS synthetic biology. (1)
Review activity for Analytical chemistry. (1)
Review activity for Biochemistry. (1)
Review activity for Bioconjugate chemistry. (9)
Review activity for Biomacromolecules. (14)
Review activity for Chemical research in toxicology. (1)
Review activity for Chemical reviews. (1)
Review activity for Chemistry of materials. (1)
Review activity for Journal of medicinal chemistry. (81)
Review activity for Journal of natural products. (2)
Review activity for Journal of organic chemistry. (10)
Review activity for Journal of the American Chemical Society. (13)
Review activity for Langmuir : (3)
Review activity for Macromolecules. (3)
Review activity for Molecular pharmaceutics. (8)
Review activity for Nano letters. (2)
Review activity for Nature communications (1)
Review activity for Organic letters. (12)
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