M. Leonor Cancela

ORCID iD
https://orcid.org/0000-0003-3114-6662

Biography

Professor of Molecular Genetics at University of Algarve Director of the Bachelor degreee and of the PhD Program in Biomedical Sciences of the University of Algarve CURRENT RESEARCH INTERESTS Main interests: Molecular, environmental and epigenetic determinants affecting transcription regulation, splicing events, of genes expressed during onset of skeletogenesis in vertebrates. Vitamin K dependent proteins and their effect on cell differentiation and tissue mineralization in normal and pathological conditions, as well as effect on cell proliferation and invasion associated to tumour development, with emphasis on colon cancer. Development of fish, and in particular zebrafish, as model organism for skeletal related human pathologies (Paget disease of bone, osteoporosis) including rare diseases (Keutel syndrome, Mef2c Syndrome Others: Molecular evolution. Biotechnological applications of marine resources including identification of molecules with mineralogenic properties in collaboration with pharmaceutical companies. Development of in vitro and in vivo models to identify environmental pollutants with osteotoxicity. ACADEMIC POSITIONS, INSTITUTION, STARTING DATE: 11/2012-08/2015 President of the Department of Biomedical Sciences and Medicine, University of Algarve 2006-2012: Member of the Steering Committee of the Department of Biomedical Sciences and Medicine, University of Algarve April 2006 on Full Professor, University of Algarve/Dept of Biomedical Sciences and Medicine Jan/April 2000: Visiting Associate Project Scientist, Department of Biology, University of California San Diego, La Jolla, CA, USA. Nov 98/Mar 06: Associate Professor, University of Algarve/FCMA Nov 92/Oct 98: Assistant Professor, University of Algarve/UCTRA PREVIOUS POSITIONS, INSTITUTIONS, DATES IN REVERSE CHRONOLOGICAL ORDER: Jul 91/Oct 92: Assistant Research Biologist, Department of Biology, University of California, San Diego, California, USA. Feb 88/Jun 91: Post Graduate Research Biologist, Department of Biology, University of California, San Diego, California, USA. Jan 86/Jan 88: Post Graduate Research Biochemist, Department of Biochemistry, University of California, Riverside, California, USA. Jul 85/Dec 85: Post Graduate Research Biochemist, INSERM, Hôpital Lariboisière, Paris, France. INVOLVEMENT IN PORTUGUESE RESEARCH INFRASTRUCTURES/ACTIVITIES/SOCIETIES Centre of Marine Sciences: Group BioSkel/Biology of Skeleton (previously named EDGE). Founding member (1995 to present). http://www.ccmar.ualg.pt/home/ Portuguese Society of Biochemistry (SPB): President from Jan 2005-Dec 2008. President of the SPB Council from January 2009-Dec 2012 (www.spb.pt) Portuguese Society of Genetics (SPG): Secretary of the Council (Assembleia Geral) from 2010-2015. President of the Financial Council since May 2015 (http://www.spgenetica.pt/#p=organigrama INSTRUCT European Platform: Member of Portuguese Scientific Council (http://www.structuralbiology.eu/resources/country/portugal?tab=orgs) Founding member of UALG-CCMAR Start up GenoGla diagnostics (http://www.genogla.com/) and Technozeb (member of scientific advisory board), which is part of Technophage SA (http://www.technophage.pt/).
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