Personal information

Biography

Dr David Arnold is an NIHR Academic Clinical Lecturer in Respiratory Medicine at the University of Bristol and a Respiratory Registrar at North Bristol NHS Trust. ​

His research interests include respiratory infection, specifically pleural infection, COVID-19 and pneumonia, and malignant pleural disease including mesothelioma. His PhD, funded by the NIHR Doctoral Research Fellowship programme, focused on novel management of pleural infection to reduce the burden on patients and the health system.​

At the start of the COVID-19 pandemic David co-led a multicentre observational study of patients admitted with COVID-19 (DISCOVER study), the results of which have contributed to national guidance. He was also part of the AERATOR study team, funded by an NIHR Rapid COVID call, a cross-collaborative project assessing aerosol emission from medical procedures.​ He is leading a large multicentre randomised trial to assess the impact of giving aspirin to patients admitted to hospital with pneumonia, the ASPECT trial.

Dr Arnold chairs the South-west Respiratory Registrar Research Network, which was the first regional research network for respiratory trainees in the UK and sits on the UK Pleural Society committee.​

Activities

Employment (4)

University of Bristol Medical School: Bristol, Bristol, GB

2016-12-01 to present | NIHR Doctoral Research Fellowship (Academic Respiratory Department )
Employment
Source: Self-asserted source
David Arnold

University of Bristol: Bristol, Bristol, GB

2016-08-03 to present | Academic Clinical Fellow (Respiratory) (School of Clinical Sciences)
Employment
Source: Self-asserted source
David Arnold

The University of Bristol: Bristol, GB

2024-08-08 to 2029-08-07 | Academic , NIHR Clinical Research Fellow (Bristol Medical School (THS))
Employment
Source: check_circle
University of Bristol - PURE

University of Bristol: Bristol, Bristol, GB

2012-08-01 to 2014-08-06 | Academic Foundation Doctor (School of Clinical Sciences)
Employment
Source: Self-asserted source
David Arnold

Education and qualifications (1)

Cardiff University: Cardiff, Cardiff, GB

2006-08-01 to 2012-07-01 | MBBCh (Medicine)
Education
Source: Self-asserted source
David Arnold

Funding (10)

Developing a Priority Setting Partnership with the James Lind Alliance on Respiratory Infection

2023-12 to present | Grant
Southmead Hospital Charity (Bristol, GB)
Source: Self-asserted source
David Arnold

DEXACELL: Dexamethasone as an adjunctive therapy for the management of cellulitis - a randomised controlled trial in urgent secondary care

2023-04 to present | Grant
National Institute for Health and Care Research (Leeds, GB)
Source: Self-asserted source
David Arnold

Change in suPAR levels during pleural infection treatment

2022-04 to present | Award
NIHR Bristol Biomedical Research Centre (Bristol, GB)
Source: Self-asserted source
David Arnold

Aspirin after hospitalisation with Pneumonia to prevent cardiovascular Events randomised Controlled Trial (ASPECT)

2021-09 to 2025-09 | Grant
National Institute for Health Research (Leeds, GB)
GRANT_NUMBER: NIHR132968
Source: Self-asserted source
David Arnold

Examining the impact of hospitalisation and long-term symptoms from COVID-19 through semi-structured interviews

2020-11 to present | Grant
NHS Hospital Charities Funding (Bristol, GB)
Source: Self-asserted source
David Arnold

AERosolisation And Transmission Of SARS-CoV-2 in Healthcare Settings (AERATOR)

2020-08 to 2021-08 | Grant
National Institute for Health Research (London, GB)
Source: Self-asserted source
David Arnold

DIagnostic and Severity markers of COVID-19 to Enable Rapid triage (DISCOVER) study

2020-05 to 2022-12 | Award
Southmead Hospital Charity (Bristol, GB)
Source: Self-asserted source
David Arnold

The metagenomics of pleural empyema (MOPE) study

2019-04 to 2020-04 | Grant
David Telling Charitable Trust (Bristol, GB)
Source: Self-asserted source
David Arnold

Ambulatory Strategies in Pleural Infection

2018-12 to 2022-02 | Grant
National Institute for Health Research (Leeds, GB)
GRANT_NUMBER: DRF-2018-11-ST2-065
Source: Self-asserted source
David Arnold

Study on the value of serial serum mesothelin to monitor mesothelioma

2018-04 to present | Grant
Fujirebio (Belgium) (Ghent, BE)
Source: Self-asserted source
David Arnold

Works (50 of 70)

Items per page:
Page 1 of 2

Antibiotic pharmacokinetics in infected pleural effusions

Thorax
2024-09 | Journal article
Contributors: David T Arnold; Liam Read; Oliver Waddington; Fergus W Hamilton; Sonia Patole; Jessica Hughes; Alice Milne; Alan Noel; Mark Bayliss; Nicholas A Maskell et al.
Source: check_circle
Crossref

Understanding post-hospitalised patients’ experiences of long-COVID

Journal of Health Psychology
2024-08-22 | Journal article | Author
SOURCE-WORK-ID:

6d80308a-c89d-4c17-a97b-86c88dec53be

EID:

2-s2.0-85201934203

Contributors: Alice Milne; David Arnold; Andrew J Moore
Source: check_circle
University of Bristol - PURE

Parapneumonic effusions related to Streptococcus pneumoniae

BMJ Open Respiratory Research
2024-02-19 | Journal article | Author
SOURCE-WORK-ID:

34a88a10-b939-48c6-a97a-eccd8b8fd41c

EID:

2-s2.0-85159452158

Contributors: Catherine Hyams; David Arnold; Robyn Heath; Zahin Amin-Chowdhury; David Hettle; Gabriella Ruffino; Paul North; Charli Grimes; Norman K Fry; Philip Williams et al.
Source: check_circle
University of Bristol - PURE

Bad research is not all bad

Trials
2023-12 | Other | Author
SOURCE-WORK-ID:

a529ff67-d136-4086-85bd-a8f6d5b2b922

EID:

2-s2.0-85174519709

Contributors: Fergus Hamilton; David Arnold; Richard Lilford
Source: check_circle
University of Bristol - PURE

Antibiotic pharmacokinetics in infected pleural effusions

2023-09-10 | Preprint
Contributors: David T Arnold; Liam Read; Oliver Waddington; Fergus W Hamilton; Sonia Patole; Jessica Hughes; Alice Milne; Alan Noel; Mark Bayliss; Nick A Maskell et al.
Source: check_circle
Crossref

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

eLife
2023-06-13 | Journal article | Author
SOURCE-WORK-ID:

0deb8b26-9a76-4663-9f1d-40706175dbc4

EID:

2-s2.0-85162982354

Contributors: Marianna Santopaolo; Michaela Gregorova; Fergus Hamilton; David Arnold; Anna E Long; Aurora Lacey; Alice Halliday; Holly E Baum; Kristy Hamilton; Rachel Milligan et al.
Source: check_circle
University of Bristol - PURE

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death

PLoS Medicine
2023-01-30 | Journal article | Author
SOURCE-WORK-ID:

dbb3ae12-9da6-4a36-b593-77144ea25576

EID:

2-s2.0-85148113269

Contributors: Fergus Hamilton; Matt Thomas; David Arnold; Thomas Michael Palmer; Ed Moran; Alexander J Mentzer; nick maskell; Kenneth Baillie; Charlotte Summers; Aroon Hingorani et al.
Source: check_circle
University of Bristol - PURE

Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19

Life Science Alliance
2022-12-13 | Journal article | Author
SOURCE-WORK-ID:

e46e69b7-1a6a-4b70-a727-0108539acfc1

EID:

2-s2.0-85145955875

Contributors: Christopher M Rice; Philip Lewis; Fernando M Ponce-Garcia; Willem Gibbs; Sarah Groves; Drinalda Cela; Fergus Hamilton; David Arnold; Catherine Hyams; Elizabeth Oliver et al.
Source: check_circle
University of Bristol - PURE

Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2

Frontiers in Immunology
2022-11-09 | Journal article | Author
SOURCE-WORK-ID:

379110c3-08e6-432c-9161-5b397d81d92d

EID:

2-s2.0-85142653396

Contributors: Alice Halliday; Anna E Long; Holly E Baum; Amy Thomas; Kathryn L Shelley; Elizabeth H Oliver; Kapil Gupta; Ore Francis; Maia Kavanagh Williamson; Natalie D Di Bartolo et al.
Source: check_circle
University of Bristol - PURE

Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3activation in patients with COVID-19

2022-10-12 | Preprint
Contributors: Lucy J. Goudswaard; Christopher M. Williams; Jawad Khalil; Kate L. Burley; Fergus Hamilton; David Arnold; Alice Milne; Phil A. Lewis; Kate J. Heesom; Stuart J. Mundell et al.
Source: check_circle
Crossref
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Response to

Journal of medical imaging and radiation oncology
2022-10-01 | Journal article | Author
SOURCE-WORK-ID:

1ff43cae-2140-4df4-aff0-7dbfff62311c

EID:

2-s2.0-85137239544

Contributors: Ciléin Kearns; David Arnold; Peter Caswell-Smith
Source: check_circle
University of Bristol - PURE

A feasibility randomised trial comparing therapeutic thoracentesis to chest tube insertion for the management of pleural infection

BMC Pulmonary Medicine
2022-08-30 | Journal article | Author
SOURCE-WORK-ID:

7fd70e5b-d3ca-4d75-a4a5-ee4b8ac872cf

EID:

2-s2.0-85136990224

Contributors: David Arnold; Emma Tucker; Anna Morley; Alice Milne; Louise Stadon; Sonia Patole; George W Nava; steven walker; nick maskell
Source: check_circle
University of Bristol - PURE

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: Findings from a Mendelian randomisation study

medRxiv
2022-07-15 | Working paper | Author
SOURCE-WORK-ID:

41e2d720-aa34-4457-aefd-fab72138cd33

Contributors: Fergus Hamilton; Matt Thomas; David Arnold; Thomas Michael Palmer; Ed Moran; Alexander J Mentzer; nick maskell; J Kenneth Baillie; Charlotte Summers; Aroon Dinesh Hingorani et al.
Source: check_circle
University of Bristol - PURE

Evaluation of perturbed iron-homeostasis in a prospective cohort of patients with COVID-19

Wellcome Open Research
2022-06-21 | Journal article | Author
SOURCE-WORK-ID:

f7b9a9ec-bc97-4f1b-be73-ee057cd7047d

EID:

2-s2.0-85135058611

Contributors: Joe N Frost; Fergus Hamilton; David Arnold; Karen T Elvers; Akshay Shah; Andrew E Armitage; Alice Milne; Jorgen McKernon; Marie Attwood; Yi-Ling Chen et al.
Source: check_circle
University of Bristol - PURE

Corticosteroids for Pleural Infection: Should We STOPPE Studying?

American Journal of Respiratory and Critical Care Medicine
2022-05-01 | Journal article
Contributors: David T. Arnold; Nick A. Maskell
Source: check_circle
Crossref

Letter to the Editor

Microbial Drug Resistance
2022-05-01 | Journal article | Author
SOURCE-WORK-ID:

28800296-4465-4c04-ac87-0d915509fc64

EID:

2-s2.0-85130643934

Contributors: Alasdair Macgowan; Fergus Hamilton; Mark Bayliss; Liam Read; Marie Attwood; Alan Noel; Maha Albur; Sally Grier; Anna Morley; David Arnold et al.
Source: check_circle
University of Bristol - PURE

Lymphocyte predominance in blood, pleural fluid, and tumour stroma; a prognostic marker in pleural mesothelioma

BMC Pulmonary Medicine
2022-04-30 | Journal article | Author
SOURCE-WORK-ID:

a9a3f51a-1415-46d3-8829-eedf28864783

EID:

2-s2.0-85129343594

Contributors: Duneesha De Fonseka; David Arnold; Anna J Morley; Mary Brett; Nidhi Bhatt; Anthony Edey; Richard Daly; Anna C Bibby; nick maskell
Source: check_circle
University of Bristol - PURE

Aerosol emission from the respiratory tract: an analysis of aerosol generation from oxygen delivery systems

Thorax
2022-03 | Journal article
Contributors: Fergus W Hamilton; Florence K A Gregson; David T Arnold; Sadiyah Sheikh; Kirsty Ward; Jules Brown; Ed Moran; Carrie White; Anna J Morley; Bryan R Bzdek et al.
Source: check_circle
Crossref
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Are aerosols generated during lung function testing in patients and healthy volunteers? Results from the AERATOR study

Thorax
2022-03 | Journal article
Contributors: Sadiyah Sheikh; Fergus W Hamilton; George W Nava; Florence K A Gregson; David T Arnold; Colleen Riley; Jules Brown; Jonathan P Reid; Bryan R Bzdek; Nicholas A Maskell et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

Coughs and sneezes spread diseases: but do ‘aerosol generating’ procedures?

Thorax
2022-03 | Journal article
Contributors: David T Arnold; Fergus W Hamilton; Ed Moran
Source: check_circle
Crossref
grade
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Higher levels of von Willebrand Factor in hospitalised patient plasma provides an explanation for the association of ABO blood group and secretor status with COVID19 severity

Transfusion Medicine
2022-03-24 | Other | Author
SOURCE-WORK-ID:

e7c63743-00b4-45f5-b778-86b93d1c39de

EID:

2-s2.0-85127096751

Contributors: Tosti J Mankelow; Allison Blair; David Arnold; Fergus Hamilton; Kathleen Gillespie; David J Anstee; Ash Toye
Source: check_circle
University of Bristol - PURE

Parapneumonic effusions related toStreptococcus pneumoniae: serotype and disease severity trends from 2006 to 2018 in Bristol, UK

2022-03-16 | Preprint
Contributors: Catherine Hyams; David T Arnold; Robyn Heath; Zahin Amin-Chowdhury; David Hettle; Gabriella Ruffino; Paul North; Charli Grimes; Norman K Fry; Philip Williams et al.
Source: check_circle
Crossref

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling

Clinical Science
2021-11-22 | Journal article | Author
SOURCE-WORK-ID:

9019d244-6a2f-40fd-8461-c33ec130e93f

EID:

2-s2.0-85121841223

Contributors: Elisa Avolio; Michele Carrabba; Rachel Milligan; Maia Kavanagh Williamson; Antonio Paolo Beltrami; Kapil Gupta; Karen T Elvers; Monica Gamez; Rebecca Foster; Kathleen Gillespie et al.
Source: check_circle
University of Bristol - PURE

Impact of dexamethasone on persistent symptoms of COVID-19: an observational study

[]
2021-11-20 | Preprint
Source: Self-asserted source
David Arnold
grade
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Standard pleural interventions are not high-risk aerosol generating procedures

European Respiratory Journal
2021-10-01 | Journal article | Author
SOURCE-WORK-ID:

05a77ff8-4e8d-40c5-8d38-a8b84bd8a87c

EID:

2-s2.0-85118846731

Contributors: David Arnold; Florence K A Gregson; Sadiyah Sheikh; Fergus Hamilton; Hugh Welch; Alexandra Dipper; George William Nava; AERATOR group; James Dodd; Amelia O Clive et al.
Source: check_circle
University of Bristol - PURE

Symptoms After COVID-19 Vaccination in Patients With Persistent Symptoms After Acute Infection: A Case Series

Annals of Internal Medicine
2021-09 | Journal article
Contributors: David T. Arnold; Alice Milne; Emma Samms; Louise Stadon; Nick A. Maskell; Fergus W. Hamilton
Source: check_circle
Crossref

Is convalescent plasma futile in COVID-19?

International Journal of Infectious Diseases
2021-08 | Journal article | Author
SOURCE-WORK-ID:

480ef02d-479d-4c20-8c96-90906548592e

EID:

2-s2.0-85110578643

Contributors: Fergus Hamilton; David Arnold; Richard Lilford; Todd Lee; Karla Hemming
Source: check_circle
University of Bristol - PURE

Randomised trial of indwelling pleural catheters for refractory transudative pleural effusions

The European respiratory journal
2021-08-19 | Journal article | Author
SOURCE-WORK-ID:

301b5d71-eaa5-4d4f-8e42-33002e2ba0d8

EID:

2-s2.0-85125291021

Contributors: steven walker; Oliver Bintcliffe; Emma Keenan; Louise Stadon; Matthew Evison; Mohammed Haris; Thapas Nagarajan; Alex West; Alina Ionescu; Benjamin Prudon et al.
Source: check_circle
University of Bristol - PURE

Predicting outcomes of COVID-19 from admission biomarkers: a prospective UK cohort study

Emergency Medicine Journal
2021-07 | Journal article
Contributors: David T Arnold; Marie Attwood; Shaney Barratt; Anna Morley; Karen T Elvers; Jorgen McKernon; Charmaine Donald; Adrian Oates; Alan Noel; Alasdair MacGowan et al.
Source: check_circle
Crossref
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Epidemiology of pleural empyema in English hospitals and the impact of influenza

The European respiratory journal
2021-06-17 | Journal article | Author
SOURCE-WORK-ID:

d5627ec6-614f-4613-a1e9-7d2a82f608d6

EID:

2-s2.0-85108583006

Contributors: David Arnold; Fergus Hamilton; Tim Morris; Tim Suri; Anna Morley; Vicky Frost; Ian B Vipond; Andrew Medford; Rupert Payne; Peter Muir et al.
Source: check_circle
University of Bristol - PURE

Aerosol generating procedures: are they of relevance for transmission of SARS-CoV-2?

Lancet Respiratory Medicine
2021-05-06 | Other | Author
SOURCE-WORK-ID:

54a0332a-36c7-42e1-b812-387bfd6154f0

EID:

2-s2.0-85109570440

Contributors: Fergus Hamilton; David Arnold; Bryan Bzdek; James Dodd; Andrew Shrimpton; nick maskell; Flo K A Gregson; Sadiyah Sheikh; Mark Gormley; Julian M Brown et al.
Source: check_circle
University of Bristol - PURE

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

Thorax
2021-04 | Journal article
Contributors: David T Arnold; Fergus W Hamilton; Alice Milne; Anna J Morley; Jason Viner; Marie Attwood; Alan Noel; Samuel Gunning; Jessica Hatrick; Sassa Hamilton et al.
Source: check_circle
Crossref
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Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeks

PLOS ONE
2021-04-29 | Journal article
Contributors: David T. Arnold; Won-Il Choi; Charmaine Donald; Max Lyon; Fergus W. Hamilton; Anna J. Morley; Marie Attwood; Alexandra Dipper; Shaney L. Barratt
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Standard pleural interventions are not high-risk aerosol generating procedures

2021-04-19 | Other
Contributors: DT Arnold; FKA Gregson; S Sheikh; FW Hamilton; H Welch; A Dipper; GW Nava; JW Dodd; AO Clive; BR Bzdek et al.
Source: check_circle
Crossref

Is convalescent plasma futile in COVID-19? A Bayesian re-analysis of the RECOVERY randomised controlled trial

2021-04-05 | Other
Contributors: FW Hamilton; TC Lee; DT Arnold; R Lilford; K Hemming
Source: check_circle
Crossref

Are vaccines safe in patients with Long COVID? A prospective observational study

2021-03-12 | Other
Contributors: DT Arnold; A Milne; E Samms; L Stadon; NA Maskell; FW Hamilton
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Risk and mitigation of aerosolisation from lung function testing: results from the AERATOR study

2021-03-08 | Other
Contributors: S Sheikh; F Hamilton; GW Nava; F Gregson; D Arnold; C Riley; J Brown; B Bzdek; J Reid; N Maskell et al.
Source: check_circle
Crossref

Hydroxychloroquine serum concentrations in non-critical care patients infected with SARS-CoV-2

Journal of global antimicrobial resistance
2021-03-01 | Journal article | Author
SOURCE-WORK-ID:

1f888042-42c0-45b3-8259-f0eac38e052a

EID:

2-s2.0-85099637436

Contributors: Alasdair MacGowan; Fergus Hamilton; Mark Bayliss; Liam Read; Marie Attwood; Alan Noel; Sally Grier; Anna Morley; David Arnold; Nicholas Maskell
Source: check_circle
University of Bristol - PURE

Association of prior lymphopenia with mortality in pneumonia: a cohort study in UK primary care

British Journal of General Practice
2021-02-30 | Journal article
Contributors: Fergus Hamilton; David Arnold; Rupert Payne
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Aerosol emission from the respiratory tract: an analysis of relative risks from oxygen delivery systems

2021-02-01 | Other
Contributors: F Hamilton; F Gregson; D Arnold; S Sheikh; K Ward; J Brown; E Moran; C White; A Morley; B Bzdek et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia

eLife
2020-12-17 | Journal article
Contributors: Michaela Gregorova; Daniel Morse; Tarcisio Brignoli; Joseph Steventon; Fergus Hamilton; Mahableshwar Albur; David Arnold; Matthew Thomas; Alice Halliday; Holly Baum et al.
Source: check_circle
Crossref
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Aspirin reduces cardiovascular events in patients with pneumonia

European Respiratory Journal
2020-09-17 | Journal article | Author
SOURCE-WORK-ID:

0f0a61bb-2903-4bc4-b54a-cc5b7fca0364

EID:

2-s2.0-85101028059

Contributors: Fergus Hamilton; David Arnold; William Henley; Rupert Payne
Source: check_circle
University of Bristol - PURE

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up; results from a prospective UK cohort

2020-08-14 | Other
Contributors: DT Arnold; FW Hamilton; A Milne; A Morley; J Viner; M Attwood; A Noel; S Gunning; J Hatrick; S Hamilton et al.
Source: check_circle
Crossref

Kinetics and performance of the Abbott architect SARS-CoV-2 IgG antibody assay

Journal of Infection
2020-07 | Journal article
Part of ISSN: 0163-4453
Source: Self-asserted source
David Arnold
grade
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Investigation of a unilateral pleural effusion: What CT scan coverage is optimal?

Thorax
2020-06 | Journal article
Contributors: Tom Syer; David T Arnold; Sonia Patole; John Harvey; Andrew Medford; Nicholas A Maskell; Anthony Edey
Source: check_circle
Crossref
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Blood parameters measured on admission as predictors of outcome for COVID-19; a prospective UK cohort study

2020-06-29 | Other
Contributors: DT Arnold; M Attwood; S Barratt; K Elvers; A Morley; A Noel; A MacGowan; NA Maskell; F Hamilton
Source: check_circle
Crossref

Hydroxychloroquine serum concentrations in non-critical care patients infected with SARS CoV 2

[]
2020-06-23 | Preprint
Source: Self-asserted source
David Arnold

Pleural Fluid suPAR Levels Predict the Need for Invasive Management in Parapneumonic Effusions

American Journal of Respiratory and Critical Care Medicine
2020-06-15 | Journal article
Contributors: David T. Arnold; Fergus W. Hamilton; Karen T. Elvers; Stuart W. Frankland; Natalie Zahan-Evans; Sonia Patole; Andrew Medford; Rahul Bhatnagar; Nicholas A. Maskell
Source: check_circle
Crossref
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Accuracy of clinical coding of pleural empyema: A validation study

Journal of Evaluation in Clinical Practice
2020-02 | Journal article
Contributors: Fergus Hamilton; David Arnold
Source: check_circle
Crossref
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Epstein–Barr virus in pleural effusions: protagonist or pretender?

European Respiratory Journal
2019-10 | Journal article
Part of ISSN: 0903-1936
Part of ISSN: 1399-3003
Source: Self-asserted source
David Arnold
grade
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Items per page:
Page 1 of 2

Peer review (2 reviews for 2 publications/grants)

Review activity for Chest. (1)
Review activity for Emergency medicine journal. (1)