Dr Ismail Sebina (0000-0003-3232-3472)

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Biography

Dr Ismail Sebina is a Research Fellow at the Frazer Institute-The University of Queensland, under the mentorship of Prof. Gabrielle Belz. He holds a PhD in immunology from The University of Queensland (awarded in 2017) and a Master’s degree in the Immunology of Infectious Diseases from the London School of Hygiene and Tropical Medicine (LSHTM; UK). He has contributed to discovery and translational immunological research in several laboratories across the USA, the UK, Uganda, and Australia, implementing studies in both preclinical mouse models and humans. He completed six years of rigorous postdoctoral training in immunology at the University of Washington (USA) and QIMR Berghofer Medical Research institute (QIMR Berghofer; Australia). He has demonstrated a strong record of publications in high-impact journals such as Immunity, The Lancet Global Health, Science Immunology, JCI and PNAS. He has regularly presented his findings at national and international conferences (e.g. Keystone Symposium and ASI), furthering his engagement with the scientific community. Dr. Sebina's primary research focus revolves around uncovering the mechanisms that underpin natural and vaccine-induced immunity to infections. With a passion for improving maternal, newborn, and child health, he also explores novel immunological strategies that have the potential to revolutionize healthcare practices in this area.

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University of Queensland: QLD, QLD, AU

2023-07-01 to present | Research Fellow (Immunology)

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Dr Ismail Sebina

https://orcid.org/0000-0003-3232-3472

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Biography

Activities

Employment (7)

University of Queensland: QLD, QLD, AU

QIMR Berghofer Medical Research Institute: Herston, QLD, AU

University of Washington: Seattle, WA, US

University of Queensland: Brisbane, QLD, AU

QIMR Berghofer Medical Research Institute: Herston, QLD, AU

MRC/UVRI Uganda Research Unit On AIDS: Entebbe, Wakiso, UG

MRC/UVRI Uganda Research Unit On AIDS: Entebbe, Wakiso, UG

Education and qualifications (3)

University of Queensland: Brisbane, QLD, AU

London School of Hygiene and Tropical Medicine: London, London, GB

Makerere University: Kampala, Kampala, UG

Professional activities (4)

Thoracic Society of Australia and New Zealand: Sydney, NSW, AU

Society for Mucosal Immunology: Milwaukee, Wisconsin, US

Australasian society for immunology: Brisbane, QLD, AU

British Society for Immunology: London, GB

Funding (1)

Circulating B lymphocytes as biomarkers for latent tuberculosis infection status in Uganda

Works (38)

CXCR3<SUP>+</SUP> effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection

Whole transcriptome profiling of placental pathobiology in SARS-CoV-2 pregnancies identifies placental dysfunction signatures

A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

Research funding for newborn health and stillbirths 2011-20: a systematic analysis of levels and trends

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

Whole transcriptome profiling of placental pathobiology in SARS-CoV-2 pregnancies identifies placental dysfunction signatures

IFN-λ Diminishes the Severity of Viral Bronchiolitis in Neonatal Mice by Limiting NADPH Oxidase-Induced PAD4-Independent NETosis

Synergism and Antagonism of Bacterial-Viral Coinfection in the Upper Respiratory Tract

Targeting the P2Y<sub>13</sub> Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens.

The Contribution of Neutrophils to the Pathogenesis of RSV Bronchiolitis.

Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma.

PAG1 limits allergen-induced type 2 inflammation in the murine lung.

Mycobacterium tuberculosis infection boosts B cell responses to unrelated pathogens

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells.

Determinants of Gammaherpesvirus Shedding in Saliva Among Ugandan Children and Their Mothers

Effects of type I interferons in malaria

Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage <i>Plasmodium</i> Infection

Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage <i>Plasmodium</i> parasites in vivo

Host-mediated impairment of parasite maturation during blood-stage <i>Plasmodium</i> infection

IL-6 promotes CD4<SUP>+</SUP> T-cell and B-cell activation during <i>Plasmodium</i> infection

Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves T<sub>H</sub>1/T<sub>FH</sub> fate bifurcation in malaria

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage <i>Plasmodium</i> Infection

Resolving T helper cell fate decisions using single-cell RNA-sequencing

Coinfection with Blood-Stage <i>Plasmodium</i> Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung

Reduced erythrocyte susceptibility and increased host clearance of young parasites slows <i>Plasmodium</i> growth in a murine model of severe malaria

Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection

Circulating B-Lymphocytes as Potential Biomarkers of Tuberculosis Infection Activity

Type I IFN signaling in CD8<SUP>-</SUP> DCs impairs Th1-dependent malaria immunity

Risk Factors for Seropositivity to Kaposi Sarcoma-Associated Herpesvirus Among Children in Uganda

Determining <i>Mycobacterium tuberculosis</i> Infection among BCG-Immunised Ugandan Children by T-SPOT.TB and Tuberculin Skin Testing

Long-Lived Memory B-Cell Responses following BCG Vaccination

Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women

Temporal mixture modelling of single-cell RNA-seq data resolves a CD4+ T cell fate bifurcation

Peer review (2 reviews for 2 publications/grants)