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Works (46)

Bioflavonoid luteolin prevents sFlt‐1 release via HIF‐1α inhibition in cultured human placenta

The FASEB Journal
2023-08 | Journal article
DOI: 10.1096/fj.202300611R
Contributors: Adrian C. Eddy; Chun Yi Chiang; Augustine Rajakumar; Frank T. Spradley; Patricia Dauer; Joey P. Granger; Sarosh Rana
Source: check_circle
Crossref

Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia.

International journal of molecular sciences
2021-10-19 | Journal article
DOI: 10.3390/ijms222011261
PMID: 34681920
PMC: PMC8541176
Source: Self-asserted source
Frank Spradley
grade
Preferred source (of 3)‎

Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats

American Journal of Physiology-Heart and Circulatory Physiology
2021-05-01 | Journal article
DOI: 10.1152/ajpheart.00724.2019
Contributors: Ana C. Palei; Hunter L. Martin; Barbara A. Wilson; Christopher D. Anderson; Joey P. Granger; Frank T. Spradley
Source: check_circle
Crossref

Chronic CNS-mediated cardiometabolic actions of leptin: potential role of sex differences

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
2021-02-01 | Journal article
DOI: 10.1152/ajpregu.00027.2020
Contributors: Alexandre A. da Silva; Mark A. Pinkerton; Frank T. Spradley; Ana C. Palei; John E. Hall; Jussara M. do Carmo
Source: check_circle
Crossref

Circulating Total Cell-Free DNA Levels Are Increased in Hypertensive Disorders of Pregnancy and Associated with Prohypertensive Factors and Adverse Clinical Outcomes.

International journal of molecular sciences
2021-01-08 | Journal article
DOI: 10.3390/ijms22020564
PMID: 33429954
PMC: PMC7826953
Source: Self-asserted source
Frank Spradley
grade
Preferred source (of 3)‎

Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction.

Comprehensive Physiology
2020-12-09 | Journal article
DOI: 10.1002/cphy.c200008
PMID: 33295016
PMC: PMC7959189
Source: Self-asserted source
Frank Spradley

A rat model of orthopedic injury-induced hypercoagulability and fibrinolytic shutdown.

The journal of trauma and acute care surgery
2020-11-01 | Journal article
DOI: 10.1097/ta.0000000000002924
PMID: 32890345
PMC: PMC7897415
Source: Self-asserted source
Frank Spradley

Administration of recombinant human placental growth factor decreases blood pressure in obese hypertensive pregnant rats.

Journal of hypertension
2020-11-01 | Journal article
DOI: 10.1097/hjh.0000000000002528
PMID: 32618892
PMC: PMC7544658
Source: Self-asserted source
Frank Spradley

Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats.

Pregnancy hypertension
2020-10-23 | Journal article
DOI: 10.1016/j.preghy.2020.10.008
PMID: 33161224
PMC: PMC7904643
Source: Self-asserted source
Frank Spradley

High-fat diet from parental generation exaggerates body and adipose tissue weights in pregnant offspring

PLOS ONE
2020-08-20 | Journal article
DOI: 10.1371/journal.pone.0237708
Contributors: Frank T. Spradley; Christopher Torrens
Source: check_circle
Crossref

Utero-placental vascular remodeling during late gestation in Sprague-Dawley rats.

Pregnancy hypertension
2020-03-03 | Journal article
DOI: 10.1016/j.preghy.2020.02.007
PMID: 32172168
PMC: PMC7246036
Source: Self-asserted source
Frank Spradley

Targeting inflammation to reduce seizure severity in an experimental model of eclampsia.

Hypertension research : official journal of the Japanese Society of Hypertension
2020-01-14 | Journal article
DOI: 10.1097/aog.0000000000003176
PMID: 31932641
Source: Self-asserted source
Frank Spradley

Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats.

Hypertension (Dallas, Tex. : 1979)
2019-05-01 | Journal article
DOI: 10.1161/hypertensionaha.118.12454
PMID: 30827146
PMC: PMC6458081
Source: Self-asserted source
Frank Spradley

Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats.

Physiological reports
2019-04-01 | Journal article
DOI: 10.14814/phy2.14038
PMID: 30963715
PMC: PMC6453821
Source: Self-asserted source
Frank Spradley

Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia.

Journal of hypertension
2019-03-01 | Journal article
DOI: 10.1097/hjh.0000000000001901
PMID: 30160658
PMC: PMC6355368
Source: Self-asserted source
Frank Spradley

Melanocortin-4 Receptor Deficiency Attenuates Placental Ischemia-Induced Hypertension in Pregnant Rats.

Hypertension (Dallas, Tex. : 1979)
2019-01-01 | Journal article
DOI: 10.1161/hypertensionaha.118.12028
PMID: 30571561
PMC: PMC6309903
Source: Self-asserted source
Frank Spradley

Role of melanocortin 4 receptor in hypertension induced by chronic intermittent hypoxia.

Acta physiologica (Oxford, England)
2018-12-23 | Journal article
DOI: 10.1111/apha.13222
PMID: 30466186
PMC: PMC6416058
Source: Self-asserted source
Frank Spradley

Adrenergic receptor blockade attenuates placental ischemia-induced hypertension

Physiological Reports
2018-09 | Journal article
DOI: 10.14814/phy2.13814
Contributors: Frank T. Spradley; Ying Ge; B. Peyton Haynes; Joey P. Granger; Christopher D. Anderson
Source: check_circle
Crossref

Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet.

American journal of physiology. Regulatory, integrative and comparative physiology
2018-09-26 | Journal article
DOI: 10.1152/ajpregu.00197.2018
PMID: 30256681
PMC: PMC6425636
Source: Self-asserted source
Frank Spradley
grade
Preferred source (of 2)‎

The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia.

Current hypertension reports
2018-04-10 | Journal article
DOI: 10.1007/s11906-018-0828-4
PMID: 29637419
PMC: PMC6064647
Source: Self-asserted source
Frank Spradley

Developmental origins of nonalcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.

American journal of physiology. Endocrinology and metabolism
2018-03-06 | Journal article
DOI: 10.1152/ajpendo.00394.2017
PMID: 29509436
PMC: PMC6293166
Source: Self-asserted source
Frank Spradley
grade
Preferred source (of 2)‎

Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells.

American journal of physiology. Regulatory, integrative and comparative physiology
2017-12-06 | Journal article
DOI: 10.1152/ajpregu.00370.2017
PMID: 29212810
PMC: PMC5899255
Source: Self-asserted source
Frank Spradley
grade
Preferred source (of 2)‎

Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet.

American journal of hypertension
2017-03-01 | Journal article
DOI: 10.1093/ajh/hpw153
PMID: 28391290
PMC: PMC5861551
Source: Self-asserted source
Frank Spradley

Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats.

American journal of physiology. Regulatory, integrative and comparative physiology
2017-02-15 | Journal article
DOI: 10.1152/ajpregu.00510.2016
PMID: 28202440
PMC: PMC5451567
Source: Self-asserted source
Frank Spradley

Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia.

American journal of physiology. Regulatory, integrative and comparative physiology
2016-11-30 | Journal article
DOI: 10.1152/ajpregu.00440.2016
PMID: 27903516
PMC: PMC5283940
Source: Self-asserted source
Frank Spradley

Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats.

Journal of hypertension
2016-10-01 | Journal article
DOI: 10.1097/hjh.0000000000001059
PMID: 27467764
PMC: PMC5310251
Source: Self-asserted source
Frank Spradley

Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats.

American journal of physiology. Regulatory, integrative and comparative physiology
2016-08-17 | Journal article
DOI: 10.1152/ajpregu.00285.2016
PMID: 27534879
PMC: PMC5130576
Source: Self-asserted source
Frank Spradley

Optimizing inhibition of the renin-angiotensin system in hypertension.

Journal of hypertension
2016-05-01 | Journal article
DOI: 10.1097/hjh.0000000000000895
PMID: 27027379
Source: Self-asserted source
Frank Spradley

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension.

Hypertension (Dallas, Tex. : 1979)
2016-02-01 | Journal article
DOI: 10.1161/hypertensionaha.115.06783
PMID: 26831193
PMC: PMC4786447
Source: Self-asserted source
Frank Spradley

Dahl SS rats demonstrate enhanced aortic perivascular adipose tissue-mediated buffering of vasoconstriction through activation of NOS in the endothelium.

American journal of physiology. Regulatory, integrative and comparative physiology
2015-11-25 | Journal article
DOI: 10.1152/ajpregu.00469.2014
PMID: 26608658
PMC: PMC4796750
Source: Self-asserted source
Frank Spradley

Immune Mechanisms Linking Obesity and Preeclampsia.

Biomolecules
2015-11-12 | Journal article
DOI: 10.3390/biom5043142
PMID: 26569331
PMC: PMC4693273
Source: Self-asserted source
Frank Spradley

Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.

American journal of physiology. Regulatory, integrative and comparative physiology
2015-10-07 | Journal article
DOI: 10.1152/ajpregu.00178.2015
PMID: 26447211
PMC: PMC4698403
Source: Self-asserted source
Frank Spradley

Chronic hyperleptinemia results in the development of hypertension in pregnant rats.

American journal of physiology. Regulatory, integrative and comparative physiology
2015-03-11 | Journal article
DOI: 10.1152/ajpregu.00286.2014
PMID: 25761697
PMC: PMC4436978
Source: Self-asserted source
Frank Spradley

Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling.

Journal of neurophysiology
2015-02-25 | Journal article
DOI: 10.1152/jn.00911.2014
PMID: 25717164
PMC: PMC4416609
Source: Self-asserted source
Frank Spradley

Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats.

American journal of physiology. Regulatory, integrative and comparative physiology
2015-02-18 | Journal article
DOI: 10.1152/ajpregu.00411.2014
PMID: 25695289
PMC: PMC4398855
Source: Self-asserted source
Frank Spradley

Reduced uterine perfusion pressure induces hypertension in the pregnant mouse.

American journal of physiology. Regulatory, integrative and comparative physiology
2014-10-08 | Journal article
DOI: 10.1152/ajpregu.00268.2014
PMID: 25298513
PMC: PMC4254941
Source: Self-asserted source
Frank Spradley

The heme oxygenases: important regulators of pregnancy and preeclampsia.

American journal of physiology. Regulatory, integrative and comparative physiology
2014-06-04 | Journal article
DOI: 10.1152/ajpregu.00132.2014
PMID: 24898840
PMC: PMC4187186
Source: Self-asserted source
Frank Spradley

Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats.

Physiological reports
2013-11-05 | Journal article
DOI: 10.1002/phy2.145
PMID: 24400147
PMC: PMC3871460
Source: Self-asserted source
Frank Spradley

Mycophenolate mofetil prevents high-fat diet-induced hypertension and renal glomerular injury in Dahl SS rats.

Physiological reports
2013-11-05 | Journal article
DOI: 10.1002/phy2.137
PMID: 24400139
PMC: PMC3871452
Source: Self-asserted source
Frank Spradley

Obese melanocortin-4 receptor-deficient rats exhibit augmented angiogenic balance and vasorelaxation during pregnancy.

Physiological reports
2013-09-01 | Journal article
DOI: 10.1002/phy2.81
PMID: 24159378
PMC: PMC3804345
Source: Self-asserted source
Frank Spradley

Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors.

American journal of hypertension
2013-08-16 | Journal article
DOI: 10.1093/ajh/hpt137
PMID: 23955606
PMC: PMC3816628
Source: Self-asserted source
Frank Spradley

Recent advances in the understanding of the pathophysiology of preeclampsia.

Hypertension (Dallas, Tex. : 1979)
2013-07-29 | Journal article
DOI: 10.1161/hypertensionaha.113.00588
PMID: 23897068
PMC: PMC3856636
Source: Self-asserted source
Frank Spradley

Pathophysiology of hypertension in pre-eclampsia: a lesson in integrative physiology.

Acta physiologica (Oxford, England)
2013-05-07 | Journal article
DOI: 10.1111/apha.12106
PMID: 23590594
PMC: PMC3687012
Source: Self-asserted source
Frank Spradley

Short-term hypercaloric diet induces blunted aortic vasoconstriction and enhanced vasorelaxation via increased nitric oxide synthase 3 activity and expression in Dahl salt-sensitive rats.

Acta physiologica (Oxford, England)
2012-11-26 | Journal article
DOI: 10.1111/apha.12025
PMID: 23176108
PMC: PMC3897252
Source: Self-asserted source
Frank Spradley

Changing standard chow diet promotes vascular NOS dysfunction in Dahl S rats.

American journal of physiology. Regulatory, integrative and comparative physiology
2011-10-26 | Journal article
DOI: 10.1152/ajpregu.00482.2011
PMID: 22031779
PMC: PMC3349380
Source: Self-asserted source
Frank Spradley

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats.

American journal of physiology. Heart and circulatory physiology
2010-12-10 | Journal article
DOI: 10.1152/ajpheart.00393.2010
PMID: 21148769
PMC: PMC3064310
Source: Self-asserted source
Frank Spradley

Peer review (28 reviews for 4 publications/grants)

Review activity for Biology of sex differences. (5)
Review activity for Journal of molecular medicine. (1)
Review activity for Molecular medicine. (1)
Review activity for PloS one. (21)
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