Personal information
Biography
Takuro Miyazaki is an associate professor in the Department of Biochemistry, Showa University School of Medicine in Tokyo, Japan. He received his undergraduate from Showa University School of Pharmacy. He obtained Ph.D. in 2009 from Showa University School of Pharmacy, with a thesis on calcium homeostasis and mechanotransduction in vascular endothelial cells. In 2011, he was recruited as faculty at Showa University School of Medicine.
His research interests are the field of intracellular protein catabolism, in particular their impact on vascular functions. He discovered that calpain-2, an intracellular calcium-dependent protease, in vascular endothelial cells associates with the pathogenesis of atherosclerosis (Miyazaki T et al. Circulation. 2011;124:2522-2532), and identified that calpain dysregulation is responsible for the pathological angiogenesis, such as tumor angiogenesis and retinopathy (Miyazaki T et al. Circ Res. 2015;116:1170-1181). More recent, he identified that calpain-6, an atypical non-proteolytic calpain, participates in cholesterol uptake in macrophages, thereby accelerating atherosclerosis development (Miyazaki T et al. J Clin Invest. 2016;126:3417-3432).
His work has been awarded with several prestigious prizes, among them the Young Investigator’s Award of the Japan Atherosclerosis Society in 2012 and the Young Investigator’s Award of the Japanese Vascular Biology and Medicine Organization in 2013. He is councilor of the Japan Atherosclerosis Society and the Japanese Vascular Biology and Medicine Organization.
Selected articles (*Corresponding author)
1. Akasu R, Miyazaki T*. et al. Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis. J Biol Chem. 2022;298:101953.
2. Miyazaki T*, Haraguchi S, et al. Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing. FASEB J. 2019;33:2037-2046.
3. Miyazaki T*, Tonami K, et al. Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. J Clin Invest. 2016;126:3417-3432.
4. Miyazaki T*, Taketomi Y. et al. Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells. Circ Res. 2015;116:1170-1181.
5. Kigawa Y, Miyazaki T*. et al. NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2014;34:2413-20.
6. Koya T, Miyazaki T*. et al. Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol. 2012;303:H96-H105.
7. Miyazaki T*, Taketomi Y. et al. m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis. Circulation. 2011;124:2522-2532.
8. Miyazaki T*, Kimura Y. et al. Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion. Stroke. 2011;42:1097-1104.
9. Miyazaki T*, Honda K. et al. m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions. Cardiovasc Res. 2010 85:530-541.
10. Miyazaki T*, Honda K. et al. Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity. Am J Physiol Cell Physiol. 2007;293:C1216-C1225.
11. Miyazaki T*, Honda K. et al. Modulation of Ca2+ transients in cultured endothelial cells in response to fluid flow through αv integrin. Life Sci. 2007;81:1421-1430.
12. Miyazaki T*, Ohata H. et al. Spontaneous and flow-induced Ca2+ transients in retracted regions in endothelial cells. Biochem Biophys Res Commun. 2001;281:172-179.