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SciProfiles: 2690903

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Employment (5)

Guangzhou Laboratory: Guangzhou, Guangdong, CN

2021-05-01 to present | Associate Investigator
Employment
Source: Self-asserted source
Lihua Chen

BioPharmaceuticals - AstraZeneca: Gothenburg, SE

2017-10-15 to 2021-02-14 | Postdoc Fellow (CVRM)
Employment
Source: Self-asserted source
Lihua Chen

University of Gothenburg: Gothenburg, SE

2013-11-05 to 2017-10-14 | Post-doctor/Researcher (Chemistry and Molecular Biology)
Employment
Source: Self-asserted source
Lihua Chen

Chinese University of Hong Kong: Hong Kong, CN

2009-07-20 to 2010-06-30 | Research Asistant (School of Biomedical Sciences)
Employment
Source: Self-asserted source
Lihua Chen

Guangzhou Institutes of Biomedicine and Health: Guangzhou, CN

2008-07-01 to 2009-06-30 | Research Asistant (Biochemistry)
Employment
Source: Self-asserted source
Lihua Chen

Education and qualifications (3)

The University of Hong Kong School of Biomedical Sciences: Hong Kong, HK

2010-08-01 to 2013-07-31 | PhD (School of Biomedical Sciences)
Education
Source: Self-asserted source
Lihua Chen

Graduate University of Chinease Academy of Science: Guangzhou/Beijing, CN

2005-09-01 to 2008-06-30 | MS (School of Biological Sciences)
Education
Source: Self-asserted source
Lihua Chen

Wuhan University: Wuhan, CN

2001-09-01 to 2005-07-20 | BS (School of Biological Sciences)
Education
Source: Self-asserted source
Lihua Chen

Works (19)

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

eLife
2025-02-10 | Journal article
DOI: 10.7554/eLife.92180.4
Contributors: Xiuling Cao; Xiang Wu; Lei Zhao; Ju Zheng; Xuejiao Jin; Xinxin Hao; Joris Winderickx; Shenkui Liu; Lihua Chen; Beidong Liu
Source: check_circle
Crossref

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

eLife
2025-02-10 | Journal article
DOI: 10.7554/eLife.92180
Contributors: Xiuling Cao; Xiang Wu; Lei Zhao; Ju Zheng; Xuejiao Jin; Xinxin Hao; Joris Winderickx; Shenkui Liu; Lihua Chen; Beidong Liu
Source: check_circle
Crossref

Directed differentiation of pancreatic δ cells from human pluripotent stem cells

Nature Communications
2024-07-27 | Journal article
DOI: 10.1038/s41467-024-50611-7
Contributors: Lihua Chen; Nannan Wang; Tongran Zhang; Feng Zhang; Wei Zhang; Hao Meng; Jingyi Chen; Zhiying Liao; Xiaopeng Xu; Zhuo Ma et al.
Source: check_circle
Crossref

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

Elife
2023-11-22 | Journal article
DOI: 10.7554/elife.92180.1
Contributors: Xiang Wu; Lei Zhao; Ju Zheng; Xuejiao Jin; Xinxin Hao; Joris Winderickx; Shenkui Liu; Lihua Chen; Beidong Liu
Source: Self-asserted source
Lihua Chen

Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection

Biomedicines
2023-03-11 | Journal article
DOI: 10.3390/biomedicines11030856
Contributors: Tongran Zhang; Nannan Wang; Lingqiang Zhu; Lihua Chen; Huisheng Liu
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Lsm7 phase-separated condensates trigger stress granule formation

Nature Communications
2022-06-28 | Journal article
DOI: 10.1038/s41467-022-31282-8
Contributors: Michelle Lindström; Lihua Chen; Shan Jiang; Dan Zhang; Yuan Gao; Ju Zheng; Xinxin Hao; Xiaoxue Yang; Arpitha Kabbinale; Johannes Thoma et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Inhibition of SGLT2 Preserves Function and Promotes Proliferation of Human Islets Cells In Vivo in Diabetic Mice

Biomedicines
2022-01-18 | Journal article
DOI: 10.3390/biomedicines10020203
Part of ISSN: 2227-9059
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

A method for the generation of human stem cell-derived alpha cells

Nature Communications
2020-12 | Journal article
DOI: 10.1038/s41467-020-16049-3
Part of ISSN: 2041-1723
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

No direct effect of SGLT2 activity on glucagon secretion

Diabetologia
2019-06 | Journal article
DOI: 10.1007/s00125-019-4849-6
Part of ISSN: 0012-186X
Part of ISSN: 1432-0428
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases

Oxidative Medicine and Cellular Longevity
2017-04 | Journal article
DOI: 10.1155/2017/1809592
Part of ISSN: 1942-0900
Part of ISSN: 1942-0994
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Combination of Telmisartan and Linagliptin Preserves Pancreatic Islet Cell Function and Morphology in db/db Mice

Pancreas
2016-04 | Journal article
DOI: 10.1097/mpa.0000000000000505
Part of ISSN: 0885-3177
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes

PLOS ONE
2016-01-25 | Journal article
DOI: 10.1371/journal.pone.0147391
Part of ISSN: 1932-6203
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Mediator tail subunits can form amyloid-like aggregates<i>in vivo</i>and affect stress response in yeast

Nucleic Acids Research
2015-09-03 | Journal article
DOI: 10.1093/nar/gkv629
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets

Molecular and Cellular Endocrinology
2015-03 | Journal article
DOI: 10.1016/j.mce.2015.01.029
Part of ISSN: 0303-7207
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets

Diabetes
2013-11-01 | Journal article
DOI: 10.2337/db13-0645
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Lihua Chen

Inhibition of the sodium glucose co-transporter-2: its beneficial action and potential combination therapy for type 2 diabetes mellitus

Diabetes, Obesity and Metabolism
2013-05 | Journal article
DOI: 10.1111/dom.12064
Part of ISSN: 1462-8902
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Effects of Combining Linagliptin Treatment with BI-38335, A Novel SGLT2 Inhibitor, on Pancreatic Islet Function and Inflammation in db/db Mice

Current Molecular Medicine
2012-08-01 | Journal article
DOI: 10.2174/156652412802480970
Part of ISSN: 1566-5240
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells

International Journal of Molecular Medicine
2012-04-23 | Journal article
DOI: 10.3892/ijmm.2012.980
Part of ISSN: 1107-3756
Part of ISSN: 1791-244X
Contributors: Zhi-Xiu Lin
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Estrogen-Related Receptor .ALPHA. Inverse Agonist Enhances Basal Glucose Uptake in Myotubes through Reactive Oxygen Species

Biological and Pharmaceutical Bulletin
2009-07 | Journal article
DOI: 10.1248/bpb.32.1199
Part of ISSN: 0918-6158
Part of ISSN: 1347-5215
Source: Self-asserted source
Lihua Chen
grade
Preferred source (of 2)‎

Peer review (2 reviews for 1 publication/grant)

Review activity for Diabetes, obesity & metabolism. (2)
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