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thiol, proteasome, peroxiredoxin, enzyme kinetics, host-pathogen
Germany, Uruguay

Activities

Employment (6)

HMU Health and Medical University Potsdam GmbH: Potsdam, Brandenburg, DE

2022-04-01 to present | Lecturer and Researcher (Biochemistry)
Employment
Source: Self-asserted source
Martín Hugo

Leibniz Institute for Analytical Sciences - ISAS: Dortmund, DE

2021-02-01 to 2022-03-31 | Postdoctoral Researcher (Sulfaging)
Employment
Source: Self-asserted source
Martín Hugo

Instituto de Investigacion Sanitaria del Hospital Princesa: Madrid, Madrid, ES

2019-05-14 to 2021-01-30 | Postdoctoral Researcher
Employment
Source: Self-asserted source
Martín Hugo

The German Institute of Human Nutrition (DIfE): Nuthetal, Brandenburg, DE

2014-01-31 to 2018 | Postdoctoral researcher (Molecular Toxicology)
Employment
Source: Self-asserted source
Martín Hugo

Agencia Nacional de Investigación e Innovación: Montevideo, UY

2010 to 2013 | PhD Fellow
Employment
Source: Self-asserted source
Martín Hugo

Universidad de la República: Montevideo, UY

2007 to 2011 | Instructor in Biochemistry (Biochemistry)
Employment
Source: Self-asserted source
Martín Hugo

Education and qualifications (2)

Neue Fische GmbH: Hamburg, Hamburg, DE

2019-02-04 to 2019-04-30 | Trainee in Data Science
Qualification
Source: Self-asserted source
Martín Hugo

Universidad de la República Uruguay: Montevideo, Montevideo, UY

2009 to 2014 | PhD in Biological Sciences (CEINBIO)
Education
Source: Self-asserted source
Martín Hugo

Works (25)

Protein thiol alterations drive aberrant phase separation in aging

2023-11-08 | Preprint
Contributors: Thibaut Vignane; Martín Hugo; Christian Hoffmann; Antionia Katsouda; Jovan Petric; Han Wang; Marko Miler; Ferran Comas; Dunja Petrovic; Suyuan Chen et al.
Source: Self-asserted source
Martín Hugo

Accumulation of polyubiquitinated proteins: A consequence of early inactivation of the 26S proteasome

Free Radical Biology and Medicine
2020-11 | Journal article
Contributors: Sandra Reeg; José P. Castro; Martin Hugo; Tilman Grune
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent.

Antioxidants (Basel, Switzerland)
2020-02-21 | Journal article
Source: Self-asserted source
Martín Hugo
grade
Preferred source (of 3)‎

Trypanothione Functions in Kinetoplastida

Glutathione
2018-09-03 | Book chapter
Part of ISBN: 9781351261760
Source: Self-asserted source
Martín Hugo

Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts.

Free radical biology & medicine
2018-03-14 | Journal article
Source: Self-asserted source
Martín Hugo
grade
Preferred source (of 3)‎

Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly.

Redox biology
2018-02-22 | Journal article
Source: Self-asserted source
Martín Hugo
grade
Preferred source (of 3)‎

Proteostasis, oxidative stress and aging.

Redox biology
2017-07 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence.

Redox biology
2017-04 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Mitochondrial contribution to lipofuscin formation.

Redox biology
2017-04 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol.

Molecular Medicine
2017-03 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP).

Proceedings of the National Academy of Sciences of the United States of America
2017-02 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite.

Proceedings of the National Academy of Sciences of the United States of America
2017-01 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase.

Free radical biology & medicine
2016-12 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis.

Biochemistry
2015-12 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.

The Journal of Biological Chemistry
2014-05 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer.

The Journal of Biological Chemistry
2014-05 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis.

The Journal of Biological Chemistry
2014-02 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Peroxynitrite as a Cytotoxic Effector Against Trypanosoma Cruzi: Oxidative Killing and Antioxidant Resistance Mechanisms

Trypanosomatid Diseases: Molecular Routes to Drug Discovery
2013 | Book chapter
EID:

2-s2.0-84875712750

Contributors: Trujillo, M.; Alvarez, M.N.; Piacenza, L.; Hugo, M.; Peluffo, G.; Radi, R.
Source: Self-asserted source
Martín Hugo via Scopus - Elsevier

Peroxynitrite as a Cytotoxic Effector AgainstTrypanosoma Cruzi: Oxidative Killing and Antioxidant Resistance Mechanisms

Trypanosomatid Diseases
2013 | Book chapter
SOURCE-WORK-ID:

cv-prod-id-1956496

Contributors: Trujillo, Madia; Alvarez, María Noel; Piacenza, Lucía; Hugo, Martín; Peluffo, Gonzalo; Radi, Rafael
Source: check_circle
CIÊNCIAVITAE

Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids.

Biochimica et biophysica acta
2013-05 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Thiol-Dependent Peroxidases in Mycobacterium tuberculosis Antioxidant Defense

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli
2012 | Book chapter
SOURCE-WORK-ID:

cv-prod-id-1956593

Contributors: Hugo, Martn; Radi, Rafael; Trujillo, Madia
Source: check_circle
CIÊNCIAVITAE

Hydroperoxide and peroxynitrite reductase activity of poplar thioredoxin-dependent glutathione peroxidase 5: kinetics, catalytic mechanism and oxidative inactivation.

The Biochemical journal
2012-03 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation.

Free radical biology & medicine
2011-07 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics.

Biochemistry
2009-10 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎

The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2.

Archives of biochemistry and biophysics
2009-04 | Journal article
Source: Self-asserted source
Martín Hugo via Europe PubMed Central
grade
Preferred source (of 3)‎