Personal information

Emails & domains

Verified email domains

Other IDs

Loop profile: 896344
SciProfiles: 322468
Scopus Author ID: 55450479000

Keywords

Skin tissue engineering, regenerative medicine, adipose stem cells, vascularization

Countries

Switzerland

Activities

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Employment (3)

Tissue Biology Research Unit, University Children's Hospital Zurich: Schlieren, ZH, CH

2020-08-01 to present | Group Leader and Deputy Head (University Children's Hospital)
Employment
Source: Self-asserted source
Agnes S. Klar

Tissue Biology Research Unit, University Children's Hospital Zurich: Schlieren, ZH, CH

2017-09-01 to 2022-09-01 | Senior Researcher
Employment
Source: Self-asserted source
Agnes S. Klar

Tissue Biology Research Unit, University Children's Hospital Zurich: Schlieren, ZH, CH

2014-08-01 to 2020-07-20 | Postdoc
Employment
Source: Self-asserted source
Agnes S. Klar

Professional activities (10)

Sex & Gender Commission, Medical Faculty, University of Zurich: Zurich, CH

2023-06-01 to present
Membership
Source: Self-asserted source
Agnes S. Klar

COST Association: CA21108: European Network for Skin Engineering and Modeling: Brussels, BE

2023-06-01 to present | Working Group 2 Member
Membership
Source: Self-asserted source
Agnes S. Klar

AcademiaNet, The Portal to Excellent Women Academics: Bern, CH

2023-01-01 to present
Membership
Source: Self-asserted source
Agnes S. Klar

COST Association: CA20117 - Converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer (Mye-InfoBank): Brussels, BE

2022-03-01 to present | Management Committee Member
Membership
Source: Self-asserted source
Agnes S. Klar

Frontiers in Transplantation: Basel, CH

2022-01-01 to present | Editorial Membership (Review Editor)
Membership
Source: Self-asserted source
Agnes S. Klar

Frontiers in Bioengineering and Biotechnology: Basel, CH

2022 to present | Editorial Membership (Review Editor )
Membership
Source: Self-asserted source
Agnes S. Klar

Frontiers Bioengineering and Biotechnology, Frontiers Publisher: Lausanne, CH

2022-01-01 to present | Member of Editorial Board
Invited position
Source: Self-asserted source
Agnes S. Klar

Biomedicines, MDPI Publisher: Basel, CH

2022-01-01 to present | Editorial Board Member
Invited position
Source: Self-asserted source
Agnes S. Klar

Biomolecules, MDPI Publisher: Basel, CH

2022-11-01 | Biomolecules, Best Paper Award 2022
Distinction
Source: Self-asserted source
Agnes S. Klar

Pediatric Surgical Group Inc: London, GB

2017-09-01 | First Prize for the “Best Scientific Research Paper” at the XXXth International Symposium on Pediatric Surgical Research, India
Distinction
Source: Self-asserted source
Agnes S. Klar

Funding (8)

CHITOCARE: Peptide-Chitosan Composites as New Biomaterials for Diabetic Wound Care with Peptide Power and Hydrogel Magic!

2025-05 to present | Grant
Innosuisse – Swiss Innovation Agency (Bern, CH)
Source: Self-asserted source
Agnes S. Klar

DermoVasc: the unique vascularized skin graft for clinical treatment of venous leg ulcers

2024-03 to 2025-09 | Grant
Innosuisse – Swiss Innovation Agency (Bern, Bern, CH)
URL: https://www.aramis.admin.ch/Grunddaten/?ProjectID=54382
GRANT_NUMBER:

114.278.1 IP-LS
Source: Self-asserted source
Agnes S. Klar

Role of CD200-CD200 receptor interactions in human diabetic skin wounds

2023-05 to 2027-05 | Grant
Swiss National Science Foundation (Bern, CH)
URL: https://data.snf.ch/grants/grant/213354
GRANT_NUMBER:

IZCOZ0_213354

Source: Self-asserted source
Agnes S. Klar

Application of the microfluidic device for the cultivation of three-dimensional blood and lymphatic vessels in vitro

2023-04 to 2026-04 | Grant
Foundation for Research in Science and the Humanities (Zurich, CH)
URL: https://www.research.uzh.ch/en/funding/researchers/stwf.html
GRANT_NUMBER:

STWF-23-006
Source: Self-asserted source
Agnes S. Klar

Role of LGR5 and LGR6 in the regulation of human epithelial stem cell niche in the interfollicular epidermis

2022-05 to 2026-05 | Grant
Swiss National Science Foundation (Bern, CH)
URL: https://data.snf.ch/grants/grant/207793
GRANT_NUMBER:

310030_207793

Source: Self-asserted source
Agnes S. Klar

Development of a human cell-based in vitro platform to assess efficacy and safety of drug candidates for the treatment of metabolic disorders

2022-03 to 2024-08 | Grant
Innosuisse – Swiss Innovation Agency (Bern, CH)
URL: https://www.aramis.admin.ch/Texte/?ProjectID=50134
GRANT_NUMBER:

59502.1 IP-LS
Source: Self-asserted source
Agnes S. Klar

Role of macrophages on vascularisation and repair/regeneration of bio-engineered human skin

2020-10 to 2025-08 | Grant
European Commission (Brussel, BE)
URL: https://skinterm.eu/
GRANT_NUMBER:

955722
Source: Self-asserted source
Agnes S. Klar

The role of dermal white adipose tissue (dWAT) in skin homeostasis and wound healing

2020-01 to 2022-01 | Grant
Olga Mayenfisch Stiftung (Zurich, CH)
Source: Self-asserted source
Agnes S. Klar

Works (48)

Combining bioengineered human skin with bioprinted cartilage for ear reconstruction.

Science advances
2023-10 | Journal article
DOI: 10.1126/sciadv.adh1890
PMID: 37792948
PMC: PMC10550230
Contributors: Zielinska D; Fisch P; Moehrlen U; Finkielsztein S; Linder T; Zenobi-Wong M; Biedermann T; Klar AS
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

The expression pattern of cytokeratin 6a in epithelial cells of different origin in dermo-epidermal skin substitutes in vivo.

Biotechnology journal
2023-10 | Journal article
DOI: 10.1002/biot.202300246
PMID: 37766482
Contributors: Michalak-Micka K; Tenini C; Böttcher-Haberzeth S; Mazzone L; Pontiggia L; Klar AS; Moehrlen U; Biedermann T
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

Characterization of Distinct Chondrogenic Cell Populations of Patients Suffering from Microtia Using Single-Cell Micro-Raman Spectroscopy

Biomedicines
2023-09 | Journal article | Author
DOI: 10.3390/biomedicines11092588
Contributors: Dominika Zielinska; Hesham K. Yosef; Tilo Zollitsch; Johann Kern; Yvonne Jakob; David Gvaramia; Nicole Rotter; Luca Pontiggia; Ueli Moehrlen; Thomas Biedermann et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Effects of an Adipose Mesenchymal Stem Cell-Derived Conditioned medium and TGF-β1 on Human Keratinocytes In Vitro

International Journal of Molecular Sciences
2023-09 | Journal article | Author
DOI: 10.3390/ijms241914726
Contributors: Hyrije Ademi; Katarzyna Michalak-Micka; Ueli Moehrlen; Thomas Biedermann; Agnes S. Klar
Source: check_circle
Multidisciplinary Digital Publishing Institute

CD146 expression profile in human skin and pre-vascularized dermo-epidermal skin substitutes in vivo.

Journal of biological engineering
2023-01 | Journal article
DOI: 10.1186/s13036-023-00327-x
PMID: 36721239
PMC: PMC9890844
Contributors: Nanni M; Rütsche D; Bächler C; Pontiggia L; Klar AS; Moehrlen U; Biedermann T
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

Scientific Reports
2022-12 | Journal article
DOI: 10.1038/s41598-022-05309-5
Part of ISSN: 2045-2322
Contributors: Agnes S. Klar
Source: Self-asserted source
Agnes S. Klar

Human fetal skin derived merkel cells display distinctive characteristics <i>in vitro</i> and in bio-engineered skin substitutes <i>in vivo</i>.

Frontiers in bioengineering and biotechnology
2022-09 | Journal article
DOI: 10.3389/fbioe.2022.983870
PMID: 36185452
PMC: PMC9520781
Contributors: Michalak-Micka K; Rütsche D; Mazzone L; Büchler VL; Moehrlen U; Klar AS; Biedermann T
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

Characterization of a melanocyte progenitor population in human interfollicular epidermis.

Cell reports
2022-03 | Journal article
DOI: 10.1016/j.celrep.2022.110419
PMID: 35235792
Contributors: Michalak-Mićka K; Büchler VL; Zapiórkowska-Blumer N; Biedermann T; Klar AS
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

Expression Profile of CD157 Reveals Functional Heterogeneity of Capillaries in Human Dermal Skin

Biomedicines
2022-03 | Journal article | Author
DOI: 10.3390/biomedicines10030676
Contributors: Katarzyna Michalak-Micka; Dominic Rütsche; Lukas Johner; Ueli Moehrlen; Thomas Biedermann; Agnes S. Klar
Source: check_circle
Multidisciplinary Digital Publishing Institute

The Role of CD200&ndash;CD200 Receptor in Human Blood and Lymphatic Endothelial Cells in the Regulation of Skin Tissue Inflammation

Cells
2022-03 | Journal article | Author
DOI: 10.3390/cells11061055
Contributors: Dominic Rütsche; Katarzyna Michalak-Micka; Dominika Zielinska; Hannah Moll; Ueli Moehrlen; Thomas Biedermann; Agnes S. Klar
Source: check_circle
Multidisciplinary Digital Publishing Institute

Bioprinting and plastic compression of large pigmented and vascularized human dermo-epidermal skin substitutes by means of a new robotic platform.

Journal of tissue engineering
2022-01 | Journal article
DOI: 10.1177/20417314221088513
PMID: 35495096
PMC: PMC9044789
Contributors: Pontiggia L; Van Hengel IA; Klar A; Rütsche D; Nanni M; Scheidegger A; Figi S; Reichmann E; Moehrlen U; Biedermann T
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

Biomedicines
2022-01 | Journal article | Author
DOI: 10.3390/biomedicines10010118
Contributors: Shima Tavakoli; Marta A. Kisiel; Thomas Biedermann; Agnes S. Klar
Source: check_circle
Multidisciplinary Digital Publishing Institute

Outcomes of multiple gestation births compared to singleton: analysis of multicenter KID database.

Maternal health, neonatology and perinatology
2021-10 | Journal article
DOI: 10.1186/s40748-021-00135-5
PMID: 34711283
PMC: PMC8554969
Contributors: Kalikkot Thekkeveedu R; Dankhara N; Desai J; Klar AL; Patel J
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

Bioengineering a prevascularized human tri-layered skin substitute containing a hypodermis.

Acta biomaterialia
2021-07-21 | Journal article
DOI: 10.1016/j.actbio.2021.07.033
PMID: 34303011
Source: Self-asserted source
Agnes S. Klar

Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds.

Science advances
2021-06 | Journal article
DOI: 10.1126/sciadv.abg5968
PMID: 34117069
PMC: PMC8195482
Contributors: Haimson B; Meir O; Sudakevitz-Merzbach R; Elberg G; Friedrich S; Lovell PV; Paixão S; Klein R; Mello CV; Klar A
Source: Self-asserted source
Agnes S. Klar via Europe PubMed Central

Bioengineered Skin Substitutes: Advances and Future Trends

Applied Sciences
2021-02-07 | Journal article
DOI: 10.3390/app11041493
Part of ISSN: 2076-3417
Source: Self-asserted source
Agnes S. Klar

Advanced Hydrogels as Wound Dressings

Biomolecules
2020-08 | Journal article | Author
DOI: 10.3390/biom10081169
Contributors: Shima Tavakoli; Agnes S. Klar
Source: check_circle
Multidisciplinary Digital Publishing Institute

Development of bacterial resistance during treatment with topical gentamicin for chronic rhinosinusitis in patients with cystic fibrosis and primary ciliary dyskinesis. Retrospective case series.

Otolaryngologia polska = The Polish otolaryngology
2020-01-01 | Journal article
DOI: 10.5604/01.3001.0013.7851
PMID: 32398382
Source: Self-asserted source
Agnes S. Klar

Isolation and Culture of Human Dermal Fibroblasts

Skin Tissue Engineering
2019 | Book chapter
DOI: 10.1007/978-1-4939-9473-1_6
Part of ISBN: 9781493994724
Part of ISBN: 9781493994731
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Agnes S. Klar

Impact of human mesenchymal cells of different body site origins on the maturation of dermo-epidermal skin substitutes

Pediatric Surgery International
2019-01 | Journal article
DOI: 10.1007/s00383-018-4383-5
Source: Self-asserted source
Agnes S. Klar

Induction of angiogenic and inflammation-associated dermal biomarkers following acute UVB exposure on bio-engineered pigmented dermo-epidermal skin substitutes in vivo

Pediatric Surgery International
2019-01 | Journal article
DOI: 10.1007/s00383-018-4384-4
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Microvascular Networks and Models, In vitro Formation

Vascularization for Tissue Engineering and Regenerative Medicine
2018 | Book chapter
DOI: 10.1007/978-3-319-21056-8_9-1
Part of ISBN: 9783319210568
Part of ISBN: 9783319210568
Source: Self-asserted source
Agnes S. Klar

Polyisocyanopeptide hydrogels: A novel thermo-responsive hydrogel supporting pre-vascularization and the development of organotypic structures

Acta Biomaterialia
2018-04 | Journal article
DOI: 10.1016/j.actbio.2018.01.042
Part of ISSN: 1742-7061
Source: Self-asserted source
Agnes S. Klar

Characterization of M1 and M2 polarization of macrophages in vascularized human dermo-epidermal skin substitutes in vivo

Pediatric Surgery International
2018-02 | Journal article
DOI: 10.1007/s00383-017-4179-z
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

The expression pattern of keratin 24 in tissue-engineered dermo-epidermal human skin substitutes in an in vivo model

Pediatric Surgery International
2018-02 | Journal article
DOI: 10.1007/s00383-017-4198-9
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

UVB exposure of a humanized skin model reveals unexpected dynamic of keratinocyte proliferation and Wnt inhibitor balancing

Journal of Tissue Engineering and Regenerative Medicine
2018-02 | Journal article
DOI: 10.1002/term.2519
Part of ISSN: 1932-6254
Source: Self-asserted source
Agnes S. Klar

Skin Tissue Engineering: Application of Adipose-Derived Stem Cells

BioMed Research International
2017 | Journal article
DOI: 10.1155/2017/9747010
Part of ISSN: 2314-6133
Part of ISSN: 2314-6141
Source: Self-asserted source
Agnes S. Klar

Wundheilung und Wundmanagement

Plastische Chirurgie bei Kindern und Jugendlichen
2017 | Book chapter
DOI: 10.1007/978-3-662-51391-0_16
Part of ISBN: 9783662513903
Part of ISBN: 9783662513910
Source: Self-asserted source
Agnes S. Klar

Human Adipose Mesenchymal Cells Inhibit Melanocyte Differentiation and the Pigmentation of Human Skin via Increased Expression of TGF-β1

Journal of Investigative Dermatology
2017-12 | Journal article
DOI: 10.1016/j.jid.2017.06.027
Part of ISSN: 0022-202X
Source: Self-asserted source
Agnes S. Klar

Comparison of in vivo immune responses following transplantation of vascularized and non-vascularized human dermo-epidermal skin substitutes

Pediatric Surgery International
2017-03 | Journal article
DOI: 10.1007/s00383-016-4031-x
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Myelinated and unmyelinated nerve fibers reinnervate tissue-engineered dermo-epidermal human skin analogs in an in vivo model

Pediatric Surgery International
2016-12 | Journal article
DOI: 10.1007/s00383-016-3978-y
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Functional Analysis of Vascularized Collagen/Fibrin Templates by MRI In Vivo

Tissue Engineering Part C: Methods
2016-08 | Journal article
DOI: 10.1089/ten.tec.2016.0035
Part of ISSN: 1937-3384
Part of ISSN: 1937-3392
Source: Self-asserted source
Agnes S. Klar

Characterization of vasculogenic potential of human adipose-derived endothelial cells in a three-dimensional vascularized skin substitute

Pediatric Surgery International
2016-01 | Journal article
DOI: 10.1007/s00383-015-3808-7
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing

PLOS ONE
2015-10-08 | Journal article
DOI: 10.1371/journal.pone.0139221
Part of ISSN: 1932-6203
Source: Self-asserted source
Agnes S. Klar

The Influence of Stromal Cells on the Pigmentation of Tissue-Engineered Dermo-Epidermal Skin Grafts

Tissue Engineering Part A
2015-03 | Journal article
DOI: 10.1089/ten.tea.2014.0327
Part of ISSN: 1937-3341
Part of ISSN: 1937-335X
Source: Self-asserted source
Agnes S. Klar

Characterization of pigmented dermo-epidermal skin substitutes in a long-termin vivoassay

Experimental Dermatology
2015-01 | Journal article
DOI: 10.1111/exd.12570
Part of ISSN: 0906-6705
Source: Self-asserted source
Agnes S. Klar

Long-term expression pattern of melanocyte markers in light- and dark-pigmented dermo-epidermal cultured human skin substitutes

Pediatric Surgery International
2015-01 | Journal article
DOI: 10.1007/s00383-014-3622-7
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Differential expression of granulocyte, macrophage, and hypoxia markers during early and late wound healing stages following transplantation of tissue-engineered skin substitutes of human origin

Pediatric Surgery International
2014-12 | Journal article
DOI: 10.1007/s00383-014-3616-5
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

De Novo Epidermal Regeneration Using Human Eccrine Sweat Gland Cells: Higher Competence of Secretory over Absorptive Cells

Journal of Investigative Dermatology
2014-06 | Journal article
DOI: 10.1038/jid.2014.30
Part of ISSN: 0022-202X
Source: Self-asserted source
Agnes S. Klar

Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells

Biomaterials
2014-06 | Journal article
DOI: 10.1016/j.biomaterials.2014.02.049
Part of ISSN: 0142-9612
Source: Self-asserted source
Agnes S. Klar

Analysis of blood and lymph vascularization patterns in tissue-engineered human dermo-epidermal skin analogs of different pigmentation

Pediatric Surgery International
2014-02 | Journal article
DOI: 10.1007/s00383-013-3451-0
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Tissue engineering of skin: human tonsil-derived mesenchymal cells can function as dermal fibroblasts

Pediatric Surgery International
2014-02 | Journal article
DOI: 10.1007/s00383-013-3454-x
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Tissue-engineered dermo-epidermal skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation

Pediatric Surgery International
2014-02 | Journal article
DOI: 10.1007/s00383-013-3446-x
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Complexation and Sequestration of BMP-2 from an ECM Mimetic Hyaluronan Gel for Improved Bone Formation

PLoS ONE
2013-10-22 | Journal article
DOI: 10.1371/journal.pone.0078551
Part of ISSN: 1932-6203
Source: Self-asserted source
Agnes S. Klar

Evaluation of Injectable Constructs for Bone Repair with a Subperiosteal Cranial Model in the Rat

PLoS ONE
2013-08-13 | Journal article
DOI: 10.1371/journal.pone.0071683
Part of ISSN: 1932-6203
Source: Self-asserted source
Agnes S. Klar

Expression of MAGE-C1/CT7 and selected cancer/testis antigens in ovarian borderline tumours and primary and recurrent ovarian carcinomas

Virchows Archiv
2013-05 | Journal article
DOI: 10.1007/s00428-013-1395-3
Part of ISSN: 0945-6317
Part of ISSN: 1432-2307
Source: Self-asserted source
Agnes S. Klar

Optimizing in vitro culture conditions leads to a significantly shorter production time of human dermo-epidermal skin substitutes

Pediatric Surgery International
2013-03 | Journal article
DOI: 10.1007/s00383-013-3268-x
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

“Trooping the color”: restoring the original donor skin color by addition of melanocytes to bioengineered skin analogs

Pediatric Surgery International
2013-03 | Journal article
DOI: 10.1007/s00383-012-3217-0
Part of ISSN: 0179-0358
Part of ISSN: 1437-9813
Source: Self-asserted source
Agnes S. Klar

Peer review (11 reviews for 9 publications/grants)

Review activity for Advanced healthcare materials (2)
Review activity for Biomedicines. (1)
Review activity for Communications biology. (2)
Review activity for Diagnostics. (1)
Review activity for International journal of molecular sciences. (1)
Review activity for iScience. (1)
Review activity for Molecules. (1)
Review activity for Nature communications (1)
Review activity for Pharmaceutics. (1)
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