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Employment (2)

University of Pennsylvania: Philadelphia, Pennsylvania, US

(Pathology and Laboratory Medicine )
Employment
Source: Self-asserted source
Sílvia Porta

University of Pennsylvania: Philadelphia, PA, US

PI
Employment
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University of Pennsylvania via ORCID Member Portal

Works (20)

Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease.

Acta neuropathologica
2021-12-02 | Journal article
Source: Self-asserted source
Sílvia Porta

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy.

Acta neuropathologica
2021-06-21 | Journal article
Source: Self-asserted source
Sílvia Porta

Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo

Neuropathology and Applied Neurobiology
2021-05-21 | Journal article
Source: Self-asserted source
Sílvia Porta
grade
Preferred source (of 2)‎

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

Science
2020-11-20 | Journal article
Source: Self-asserted source
Sílvia Porta
grade
Preferred source (of 2)‎

Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration.

Brain : a journal of neurology
2020-09-01 | Journal article
Source: Self-asserted source
Sílvia Porta

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

Nature Communications
2018-12 | Journal article
Source: Self-asserted source
Sílvia Porta
grade
Preferred source (of 2)‎

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity.

Nature communications
2018-10-23 | Journal article
Source: Self-asserted source
Sílvia Porta

TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.

Current biology : CB
2017-11-16 | Journal article
Source: Self-asserted source
Sílvia Porta

Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.

Acta neuropathologica
2017-01-27 | Journal article
Source: Self-asserted source
Sílvia Porta

Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases.

Journal of neuropathology and experimental neurology
2015-04-01 | Journal article
Source: Self-asserted source
Sílvia Porta

Increased striatal adenosine A2A receptor levels is an early event in Parkinson's disease-related pathology and it is potentially regulated by miR-34b.

Neurobiology of disease
2014-06-02 | Journal article
Source: Self-asserted source
Sílvia Porta

Upregulation of a small vault RNA (svtRNA2-1a) is an early event in Parkinson disease and induces neuronal dysfunction.

RNA biology
2013-05-01 | Journal article
Source: Self-asserted source
Sílvia Porta

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.

Human molecular genetics
2012-04-17 | Journal article
Source: Self-asserted source
Sílvia Porta

A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.

PLoS genetics
2012-02-23 | Journal article
Source: Self-asserted source
Sílvia Porta

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function.

Human molecular genetics
2011-05-10 | Journal article
Source: Self-asserted source
Sílvia Porta

Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies.

Journal of Alzheimer's disease : JAD
2011-01-01 | Journal article
Source: Self-asserted source
Sílvia Porta

A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing.

Nucleic acids research
2010-06-30 | Journal article
Source: Self-asserted source
Sílvia Porta

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.

Human molecular genetics
2008-01-07 | Journal article
Source: Self-asserted source
Sílvia Porta

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain.

The European journal of neuroscience
2007-09-01 | Journal article
Source: Self-asserted source
Sílvia Porta

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

Human molecular genetics
2007-03-06 | Journal article
Source: Self-asserted source
Sílvia Porta

Peer review (1 review for 1 publication/grant)

Review activity for Acta neuropathologica communications. (1)